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Amorphous particle deposition and product quality under different conditions in a spray dryer

Particuology 2008年第4期6卷 265-270页

作者： meng wai woo Wan Ramli Wan Daud Siti Masrinda Tasirin Meor Zainal Meor Talib Department of Chemical & Processing Engineering Universiti Kebangsaan Malaysia

Deposition of amorphous particles, as a prevalent problem particularly in the spray drying of fruit and vegetable juices, is due to low-molecular-weight sugars and is strongly dependent on the condition of the particles upon collision with the dryer wall. This paper investigates the condition of the amorphous particles impacting the wall at different drying conditions with the aim of elucidating the deposition mechanism and physical phenomena in the drying chamber. A model sucrose-maltodextrin solution was used to represent the low-molecular-weight sugar. Particle deposits were collected on sampling plates placed inside the dryer for analyses of moisture content, particle rigidity (using SEM) and size distribution. Moisture content was adopted as a general indicator of stickiness. Product particles collected at the bottom of the experimental dryer were found to have higher moisture than particle deposits on samplers inside the dryer. Moisture content profile in the dryer shows that apart from the atomizer region, where particles are relatively wet, particle deposits at other regions exhibit similar lower moisture content. At the highest temperature adopted in the experiments, particles became rubbery suggesting liquid-bridge formation as the dominant deposition mechanism. Further analysis on particles size distribution reveals a particle segregation mechanism whereby smaller particles follow preferentially to the central air stream while larger particles tend to re-circulate in the chamber, as predicted in past CFD simulation. The findings from this work will form the basis and provide validating data for further modeling of wall deposition of amorphous particles in spray drying using CFD.

关键词： Powder handling Amorphous particles Deposition Particle condition Spray drying

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Numerical investigation of droplet pre-dispersion in a monodisperse droplet spray dryer

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Particuology 2018年第3期16卷 44-60页

作者： Jie Xiao Yang Li Oluwafemi Ayodele George Zhihao Li Shujun Yang meng wai woo Winston Duo Wu Xiao Dong Chen Suzhou Key Laboratory of Green Chemical Engineering School of Chemical and Environmental Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu Province 215123 China Department of Chemical Engineering Faculty of Engineering Monash University Clayton Campus Victoria Australia

Monodisperse droplet spray dryers have great advantages in particle formation through spray drying because of their ability to produce uniform sized particles. Experimental analyses of this system have shown that droplets atomized through the piezoceramic nozzle need to be sufficiently well dispersed before entering the drying chamber to achieve sufficiently dried particles. However, the dispersion dynamics cannot be readily observed because of experimental limitations, and key factors influencing the dispersion state currently remain unclear. This study carried out numerical simulations for droplet dispersions in the dispersion chamber, which allow this important process to be visualized. The system- atic and quantitative analyses on the dispersion states provide valuable data for improving the design of the dispersion chamber, and optimizing the spray drying operation.

关键词： Spray drying Monodisperse droplet spray dryer Droplet dispersionCFD simulation Reaction engineering approach (REA) Discrete phase model (DPM)

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Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

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Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz Kin Ng wai Kit Chu Qi Cui Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible *** previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal *** found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 ***,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

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A case of secretory breast carcinoma with ETV6-NTRK3 fusion gene during childhood

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镜湖医学 2024年第1期24卷 62-63,F0004页

作者： TAI wai meng CHAN Kin Iong WONG Peng Hong XU De Li WEN Jian Ming Department of Pathology Kiang Wu HospitalMacao SARChina Department of Surgery Kiang Wu HospitalMacao SARChina

Secretory carcinoma is a rare breast *** report a case of secretory carcinoma occurred in childhood.A 7-year-old girl had a history of a mass in the breast for 4 *** tumor grew slowly and well circumscribed,mimicking benign lesions on *** breast lumpectomy,a diagnosis of secretory carcinoma was made based on its histological morphology,immunohistochemical reaction,and molecular ***,we report the process of diagnosis,and treatment of this rare case.

关键词： diagnosis carcinoma lesions

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Radar-based Characteristics and Formation Environment of Supercells in the Landfalling Typhoon Mujigae in 2015

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Advances in Atmospheric Sciences 2022年第5期39卷 802-818页

作者： Lanqiang BAI Zhiyong meng Ruilin ZHOU Guixing CHEN Naigeng WU wai-Kin WONG School of Atmospheric Sciences Sun Yat-sen Universityand Key Laboratory of Tropical Atmosphere-Ocean SystemMinistry of Educationand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Institute of Tropical and Marine Meteorology China Meteorological AdministrationGuangzhou 510640China Hong Kong Observatory Hong Kong 999077China

This study presents the radar-based characteristics and formation environment of supercells spawned by the tornadic landfalling Typhoon Mujigae(2015)in October *** than 100 supercells were identified within a 24-hour period around the time of the typhoon’s landfall,of which three were tornadic with a rotational intensity clearly stronger than those of non-tornadic *** identified supercells were concentrated within a relatively small area in the northeast quadrant beyond 140 km from the typhoon *** supercells were found more likely to form over flat topography and were difficult to maintain in mountainous *** the study period,more supercells formed offshore than *** mesocyclones of the identified supercells were characterized by a small diameter generally less than 5 km and a shallow depth generally less than 4 km above ground *** environmental analysis revealed that the northeast quadrant had the most favorable conditions for the genesis of supercell in this typhoon *** nondimensional supercell composite parameter(SCP)and entraining-SCP(E-SCP)were effective in separating supercell from non-supercell *** though the atmosphere in the typhoon’s northeast quadrant was characterized by an E-SCP/SCP value supportive of supercell organization,orography was an impeditive factor for the supercell *** findings support the use of traditional parameters obtained from midlatitude supercells to assess the supercell potential in a tropical cyclone envelope.

关键词： supercell tropical cyclone atmospheric environment radar meteorology

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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 40-46页

作者： Jeonghun Baek Chun wai Mai Wei meng Lim Lai Chun Wong School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Chemistry School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia

AIM:To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial(ARPE)-19 cells in ***:ARPE-19 cells were cultured in Dulbecco’s Modified Eagle Medium-F-12 supplemented with 10%foetal bovine serum and 1%penicillin–streptomycin in a humidified 5%CO_(2) incubator maintained at 37℃.Cells were treated with 247μmol/L lutein,49μmol/L zeaxanthin and 1%(v/v)of either coconut oil,corn oil,peanut oil,olive oil,sunflower oil,soybean oil,castor oil,or linseed oil for *** and zeaxanthin concentration in the cells were quantified by high performance liquid ***:Among the oils tested,the highest lutein and zeaxanthin uptake was observed with coconut oil while the lowest was observed with linseed ***:ARPE-19 uptake of lutein and zeaxanthin are found to be dependent on the type of oils.

关键词： lutein zeaxanthin adult retinal pigment epithelial-19 cells vegetable oil

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SnO_(2)nanotubes with N-doped carbon coating for advanced Li-ion battery anodes

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Frontiers of Materials Science 2023年第4期17卷 81-91页

作者： Junhai Wang Jiandong Zheng Liping Gao Chunyu meng Jiarui Huang Sang woo Joo School of Material and Chemical Engineering Chuzhou UniversityChuzhou 239000China Key Laboratory of Functional Molecular Solids of the Ministry of Education College of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China School of Mechanical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

Tin dioxide nanotubes with N-doped carbon layer(SnO_(2)/N-C NTs)were synthesized through a MoO3 nanorod-based sacrificial template method,dopamine polymerization and calcination *** to the Li-ion battery,SnO_(2)/N-C NTs exhibited excellent electrochemical properties,with a first discharge capacity of 1722.3 mAh·g^(−1)at 0.1 A·g^(−1)and a high capacity of 1369.3 mAh·g^(−1)over 100 *** superior electrochemical performance is ascribed to the N-doped carbon layer and tubular structure,which effectively improves the electrical conductivity of the composites,accelerates the migration of Li+and electrons,and alleviates the volume change of the anode to a certain extent.

关键词： SnO_(2) nanotubes N-doped carbon anode Li-ion battery

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長期吸煙者的肺功能研究

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镜湖医学 2024年第1期24卷 5-7页

作者：韋名揚彭莉馮芷軒張曉戰澳門鏡湖醫院内科中国

目的瞭解長期吸煙對肺功能的影響,並及早發現慢性阻塞性肺病(chronicobstructive pulmonary disease,COPD)。方法2017年5月~2019年12月,對長期吸煙者進行肺通氣功能檢查,對早期COPD和肺功能異常進行篩查。結果吸煙組199例,非吸煙組73例... 详细信息

目的瞭解長期吸煙對肺功能的影響,並及早發現慢性阻塞性肺病(chronicobstructive pulmonary disease,COPD)。方法2017年5月~2019年12月,對長期吸煙者進行肺通氣功能檢查,對早期COPD和肺功能異常進行篩查。結果吸煙組199例,非吸煙組73例完成肺功能檢查。吸煙組的1秒率(FEV1/FVC)和FEV1%Pred明顯低於非吸煙組。兩組肺功能異常檢出異常率分别為46.2%和15.1%,吸煙組明顯高於非吸煙組(χ^(2)=22.04,P<0.01),其中COPD檢出率36.2%(95%CI:29.5%~42.9%);保留比率受損肺功能(Preserved ratio impaired spirometry,PRISm)檢出率10.1%(95%CI:5.8%~14.2%)。非吸煙組COPD檢出率6.8%(95%CI:1.1%~12.6%);PRISm檢出率8.2%(95%CI:5.2%~14.5%),吸煙組COPD檢出率明顯高於非吸煙組。結論長期吸煙人群中肺功能異常率高、可能COPD檢出率高。肺功能檢查有助於早期發現COPD和肺功能異常人群,為慢性肺病的早期防治提供依據。

关键词：吸煙慢性阻塞性肺病肺功能保留比率受損肺功能

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Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases

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World Journal of Gastroenterology 2022年第18期28卷 1934-1945页

作者： Wynne Sim Wei-meng Lim Ling-Wei Hii Chee-Onn Leong Chun-wai Mai School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia School of Pharmacy International Medical UniversityKuala Lumpur 57000Malaysia Center for Cancer and Stem Cell Research Institute for ResearchDevelopmentand InnovationInternational Medical UniversityKuala Lumpur 57000Malaysia AGTC Genomics Kuala Lumpur 57000Malaysia State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical Chemistry Faculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor ***,it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses,thus allowing continuous tumor growth and *** evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic *** with other cancers,pancreatic cancer has a tumor microenvironment that can resist most treatment modalities,including emerging ***,the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients,suggesting that pancreatic cancer has successfully evaded *** this review,we summarize the impact of genetic alteration and epigenetic modification(especially histone deacetylases,HDAC)on immune evasion in pancreatic *** overexpression significantly suppresses tumor suppressor genes,contributing to tumor growth and *** review the evidence on HDAC inhibitors in tumor eradication,improving T cells activation,restoring tumor immunogenicity,and modulating programmed death 1 *** provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.

关键词： Histone acetylation Histone deacetylases inhibitors Immune evasion Pancreatic cancers Pancreatic ductal adenocarcinoma

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Transient-Spatial Pattern Mining of Eddy Current Pulsed Thermography Using Wavelet Transform

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Chinese Journal of Mechanical Engineering 2014年第4期27卷 768-778页

作者： YANG Hailong GAO Bin TIAN Guiyun REN Wenwei woo wai Lok School of Automation Engineering University of Electronic Science and Technology of China School of Electrical and Electronic Engineering Newcastle University

Eddy current pulsed thermography（ECPT） is an emerging Non-destructive testing and evaluation（NDT E） technique, which uses hybrid eddy current and thermography NDT E techniques that enhances the detectability from their compensation. Currently, this technique is limited by the manual selection of proper contrast frames and the issue of improving the efficiency of defect detection of complex structure samples remains a challenge. In order to select a specific frame from transient thermal image sequences to maximize the contrast of thermal variation and defect pattern from complex structure samples, an energy driven approach to compute the coefficient energy of wavelet transform is proposed which has the potential of automatically selecting both optimal transient frame and spatial scale for defect detection using ECPT. According to analysis of the variation of different frequency component and the comparison study of the detection performance of different scale and wavelets, the frame at the end of heating phase is automatically selected as an optimal transient frame for defect detection. In addition, the detection capabilities of the complex structure samples can be enhanced through proper spatial scale and wavelet selection. The proposed method has successfully been applied to low speed impact damage detection of carbon fibre reinforced polymer（CFRP） composite as well as providing the guidance to improve the detectability of ECPT technique.

关键词： non-destructive testing and evaluation composite impact damage detection wavelet transform energy driven approach transient-spatial analysis

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