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Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks

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Nano Research 2024年第7期17卷 6502-6508页

作者： tong meng Bo Li Linlin Zeng Xianshun Sun Yupeng Tian Hongping Zhou meng Zhou Dandan Li Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsMinistry of EducationAnhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Accessing high-order multiphoton excited fluorescence(H-MPEF)materials is challenging yet and needs complicated synthesis *** this study,we successfully assembled plasmonic Au nanorods(Au NRs)with multiphoton responsive metalorganic frameworks(MOFs),resulting in a significant several-fold enhancement of *** extent of multiphoton enhancement was found to be strongly dependent on the degree of overlap between the multiphoton excitation wavelength of MOFs and the localized surface plasmon resonance absorbance of Au NRs,indicating the importance of plasmon-induced resonance energy ***,plasmon-induced hot electron transfer played a vital role in enhanced multiphoton activity as ***,the optimum H-MPEF enhancement occurs at the second near-infrared(NIR-II)region,which provides a promising platform for fluorescent *** findings provide a feasible and practical method to fabricate optimized H-MPEF materials for biological imaging using tissue-penetrating NIR-II light.

关键词： metal-organic framework(MOF) plasmon resonance multiphoton activity fluorescence imaging

The role of ubiquitination in tumorigenesis and targeted drug discovery

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2294-2321页

作者： Lu Deng tong meng Lei Chen Wenyi Wei Ping Wang College of Animal Science and Technology Northwest A&F UniversityYangling Shaanxi 712100China Division of Spine Department of OrthopedicsTongji Hospital Affiliated to Tongji University School of Medicine389 Xincun RoadShanghaiChina Division of Laboratory Safety and Services Northwest A&F UniversityYangling Shaanxi 712100China Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA tongji University Cancer Center Shanghai Tenth People’s Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghai 200092China

Ubiquitination,an important type of protein posttranslational modification(PTM),plays a crucial role in controlling substrate degradation and subsequently mediates the“quantity”and“quality”of various proteins,serving to ensure cell homeostasis and guarantee life *** regulation of ubiquitination is multifaceted and works not only at the transcriptional and posttranslational levels(phosphorylation,acetylation,methylation,etc.)but also at the protein level(activators or repressors).When regulatory mechanisms are aberrant,the altered biological processes may subsequently induce serious human diseases,especially various types of *** tumorigenesis,the altered biological processes involve tumor metabolism,the immunological tumor microenvironment(TME),cancer stem cell(CSC)stemness and so *** regard to tumor metabolism,the ubiquitination of some key proteins such as RagA,mTOR,PTEN,AKT,c-Myc and P53 significantly regulates the activity of the mTORC1,AMPK and PTEN-AKT signaling *** addition,ubiquitination in the TLR,RLR and STING-dependent signaling pathways also modulates the ***,the ubiquitination of core stem cell regulator triplets(Nanog,Oct4 and Sox2)and members of the Wnt and Hippo-YAP signaling pathways participates in the maintenance of CSC *** on the altered components,including the proteasome,E3 ligases,E1,E2 and deubiquitinases(DUBs),many molecular targeted drugs have been developed to combat *** them,small molecule inhibitors targeting the proteasome,such as bortezomib,carfilzomib,oprozomib and ixazomib,have achieved tangible *** addition,MLN7243 and MLN4924(targeting the E1 enzyme),Leucettamol A and CC0651(targeting the E2 enzyme),nutlin and MI‐219(targeting the E3 enzyme),and compounds G5 and F6(targeting DUB activity)have also shown potential in preclinical cancer *** this review,we summarize the latest progress in understanding the substrates for ubiquitination and their special functions

关键词： metabolism ubiquitin targeted

Neonatal hyperinsulinism with an ABCC8 mutation:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2254-2259页

作者： meng-tong Liu Hui-Xia Yang Department of Gynecology and Obstetrics Peking University First HospitalBeijing 100034China

BACKGROUND Neonatal hyperinsulinism can result from perinatal stress,genetic disorders,or syndromes,which can lead to persistent or intractable hypoglycemia in *** in the ABCC8 gene result in abnormal functioning of potassium channel proteins in pancreaticβ-cells,leading to an overproduction of insulin and congenital *** SUMMARY We report a case of a high-birth-weight infant with postnatal hypoglycemia and hyperinsulinemia,whose mother had pregestational diabetes mellitus with poor glycemic control and whose sister had a similar history at ***-exome sequencing revealed a new mutation in the ABCC8 gene in exon 8(c.1257T>G),which also occurred in his sister and mother;thus,the patient was diagnosed with neonatal hyperinsulinism with an ABCC8 *** oral diazoxide treatment,the child’s blood glucose returned to normal,and the pediatrician gradually discontinued treatment because of the child’s good growth and *** We report a new mutation locus in the ABCC8 *** mutation locus warrants attention for genetic disorders and long-term prognoses of hypoglycemic children.

关键词： Newborn Hypoglycemia Congenital hyperinsulinism ABCC8 Hyperglycemia in pregnancy Case report

Recurrent medullary thyroid carcinoma treated with percutaneous ultrasound-guided radiofrequency ablation:A case report

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World Journal of Clinical Cases 2021年第4期9卷 864-870页

作者： meng-Ying tong Hu-Sha Li Ying Che Department of Ultrasound First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Treatment for neck lymph node metastases after adequate initial surgery in medullary thyroid carcinoma(MTC)has been ***(US)-guided radiofrequency ablation(RFA)has been widely used in recurrent welldifferentiated thyroid ***,we report for the first time the use of RFA in a patient with recurrent *** SUMMARY We report the case of a 56-year-old woman with cervical lymph node metastases of *** years previously,she had undergone a total thyroidectomy and neck lymph node dissection.A neck US revealed many enlarged nodes during the follow-up ***,the serum calcitonin jumped to 198.17 pg/mL,which strongly indicated the recurrence of ***,two metastatic lymph nodes were confirmed by US-guided fine-needle aspiration-cytology and fineneedle aspiration-calcitonin,and then the patient was treated with *** months later,the neck US and a contrast-enhanced US showed obvious shrinkage in the ablation zones,and the serum calcitonin dropped to 11.80 pg/*** This case suggests that RFA may be an effective and safe treatment for local recurrent MTC.

关键词： Medullary thyroid carcinoma Radiofrequency ablation Lymph node metastasis Calcitonin Fine-needle aspiration Case report

The Belt and Road Initiative and China's Export:A Soft Power Perspective

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2020年第3期15卷 313-354页

作者： Jiadong tong Ziliang Yu Jiayun Xu meng tong School of Economics Nankai UniversityTianjin 300371China APEC Study Center Nankai UniversityTianjin 300371China School of Finance Nankai UniversityTianjin 300350China Department of Economics University of BirminghamBirmingham B152TTUK

Using a newly built soft power index,we examine whether and how soft power affects Chinese firm-level export to the Belt and Road(B&R)countries from 2000 to *** find that soft power has significantly positive effects on both export value and export product types for the B&R *** effects are more pronounced than those for non-B&R countries and differ not only between the"Belt"and the"Road"countries but also regional groups,firm ownerships,modes of trade,and *** analysis shows that soft power increases the intensive margin of exports by approximately three times that of the extensive ***,our findings provide a new perspective for understanding both the Belt and Road Initiative(BRI)and the contemporary economic evolution occurring in China.

关键词： Belt and Road Initiative(BRI) soft power export international trade China

Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis

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Chinese Journal of Natural Medicines 2018年第11期16卷 846-855页

作者： meng Zheng-Jie WANG Chao meng Ling-tong BAO Bei-Hua WU Jin-Hui HU Yi-Qiao College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University State Key Laboratory of Pharmaceutical Biotechnology Medical School Nanjing University School of Pharmaceutical Sciences Nanjing Tech University Jiangsu Key Laboratory for High Technology of Traditional Chinese Medicine Formulae Research College of Pharmacy Nanjing University of Chinese Medicine

Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate(STS) is a water-soluble derivative of Tanshinone IIA(TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. STS treatment could significantly decrease the serum levels of C-reactive protein(CRP), procalcitonin(PCT), cardiac troponin Ⅰ(cTn-Ⅰ), cardiac troponin T(cTn-T), and brain natriuretic peptide(BNP) in cecal ligation and puncture(CLP)-induced) septic rats and improve left ventricular function, particularly at 48 and 72 h after CLP. As the pathogenesis of septic myocardial dysfunction is attributable to dysregulated systemic inflammatory responses, several key cytokines, including tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6), interleukin-10(IL-10) and high mobility group protein B1(HMGB1), were detected to reveal the possible mechanism of attenuation of septic myocardial dysfunction after being treated by STS. Our study showed that STS, especially at a high dose(15 mg×kg–1), could efficiently suppress inflammatory responses in myocardium and reduce myocardial necrosis through markedly reducing production of myocardial TNF-α, IL-6 and HMGB1. STS significantly improved the 18-day survival rate of rats with sepsis from 0% to 30%(P < 0.05). Therefore, STS could suppress inflammatory responses and improve left ventricular function in rats with sepsis, suggesting that it may be developed for the treatment of sepsis.

关键词： Sodium tanshinone II A sulfonate Sepsis Cardiac dysfunction Cytokine Cecal ligation and puncture model

A strategy for strengthening chaotic mixing of dual shaft eccentric mixers by changing non-Newtonian fluids kinetic energy distribution

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Chinese Journal of Chemical Engineering 2024年第5期69卷 122-134页

作者： Songsong Wang tong meng Qian Zhang Changyuan Tao Yundong Wang Zequan Li Zuohua Liu School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing 400044China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier for the existing ***,this work reports a convenient strategy that changes the kinetic energy to controllably regulate the flow patterns from radial flow to axial *** showed that the desired velocity distribution and flow patterns could be effectively obtained by varying the number and structure of baffles to change kinetic energy,and a more uniform velocity distribution,which could not be reached normally in standard baffle dual shaft mixers,was easily ***,a comparative analysis of velocity and shear rate distributions is employed to elucidate the mechanism behind the generation of flow patterns in various dual-shaft eccentric ***,there is little difference in the power number of the laminar flow at the same Reynolds number,meaning that the baffle type has no effect on the power consumption,while the power number of both unbaffle and U-shaped baffle mixing systems decreases compared with the standard baffle mixing system in the transition ***,at the same rotational condition,the dimensionless mixing time of the U-shaped baffle mixing system is 15.3%and 7.9%shorter than that of the standard baffle and the unbaffle mixing system,respectively,which shows the advantage of the U-shaped baffle in stirring rate.

关键词： Dual shaft “U-shaped”baffle Flow pattern Mixing time Power demand

Machine learning-based analyses for total ionizing dose effects in bipolar junction transistors

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Nuclear Science and Techniques 2022年第10期33卷 106-116页

作者： Bai-Chuan Wang meng-tong Qiu Wei Chen Chen-Hui Wang Chuan-Xiang Tang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

Machine learning methods have proven to be powerful in various research *** this paper,we show that research on radiation effects could benefit from such methods and present a machine learning-based scientific discovery *** total ionizing dose(TID)effects usually cause gain degradation of bipolar junction transistors(BJTs),leading to functional failures of bipolar integrated ***,many experiments of TID effects on BJTs have been conducted at different laboratories worldwide,producing a large amount of experimental data which provides a wealth of ***,it is difficult to utilize these data *** this study,we proposed a new artificial neural network(ANN)approach to analyze the experimental data of TID effects on BJTs An ANN model was built and trained using data collected from different *** results indicate that the proposed ANN model has advantages in capturing nonlinear correlations and predicting the *** trained ANN model suggests that the TID hardness of a BJT tends to increase with base current I.A possible cause for this finding was analyzed and confirmed through irradiation experiments.

关键词： Total ionizing dose effects Bipolar junction transistor Artificial neural network Machine learning Radiation effects

Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction

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Chinese Chemical Letters 2019年第5期30卷 973-976页

作者： Wei Zhan meng tong Ling Ji Han Zhang Zemei Ge Xin Wang Runtao Li State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University

A continuous-flow synthesis of nitriles by Schmidt reaction has been *** this procedure,a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent *** mild reaction conditions ... 详细信息

关键词： Continuous-flow reaction Aldehydes Schmidt reaction Nitriles Safety