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地震事件分类识别软件

地震 2024年第2期44卷 104-119页

作者：王婷婷边银菊任梦依杨千里侯晓琳中国地震局地球物理研究所北京100081

非天然地震事件分类是地震监测业务部门的日常工作之一。本研究主要针对地震、爆炸和矿震的分类问题,在地震波数据处理、特征提取和人工智能综合分类的研究基础上,基于Qt开发框架,结合Python、 Matlab等多种编程语言,开发了一个具有良... 详细信息

非天然地震事件分类是地震监测业务部门的日常工作之一。本研究主要针对地震、爆炸和矿震的分类问题,在地震波数据处理、特征提取和人工智能综合分类的研究基础上,基于Qt开发框架,结合Python、 Matlab等多种编程语言,开发了一个具有良好的可移植性和可扩展性、具有自主知识产权的地震分类识别软件。该软件可以部署在不同操作系统上,由七个模块组成:地震数据导入模块、数据处理模块、特征提取模块、综合分类模块、特征分析模块、当量估算模块和结果分析模块。软件集成了多种时频特征提取技术和人工智能分类方法,形成了较为完整的地震类型判定流程。软件内置的地震事件分类模型准确率高于90%,适用范围较广,已推广应用于多个地震监测部门,并取得了较好的应用成果,提高了对非天然地震的快速分析能力。

关键词：非天然地震事件分类 Qt开发框架特征提取人工智能方法

Development of N-doped carbons from zeolite-templating route as potential electrode materials for symmetric supercapacitors

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1482-1492页

作者： meng ren Cheng-yun Zhang Yue-lin Wang Jin-jun Cai Hunan Key Laboratory of Environment Friendly Chemical Process Technology School of Chemical Engineering Xiangtan University State Key Laboratory of Powder Metallurgy Central South University School of Engineering Materials & Science Queen Mary University of London

N-doped carbons were fabricated from zeolite-templated carbon via modification with melamine and mild KOH activation. The N-doping treatment and KOH activation slightly lowered the surface areas of pristine zeolite-templated carbon; nonetheless, N-doped carbons with a lower surface area exhibited much higher capacitance and cycling stability as fabricated into symmetric supercapacitor. Significantly, N-doped carbon obtained at 700°C showed a capacitance of 45.7 F/g at 0.1 A/g and 42.0 F/g at 10 A/g for the fabricated supercapacitor with 6 M KOH electrolyte, with 92% retention of initial capacitance as current density increased up to 100-fold. This performance was attributed to the dual contribution of electric double-layer capacitance and pseudo-capacitance. The assembled supercapacitor also exhibited excellent cycling stability, with 91% capacitance retention at 10 A/g after 10000 cycles.

关键词： zeolite template porous carbon nitrogen-doping chemical activation supercapacitor

Ultralow-strain Ti substituted Mn-vacancy layered oxides with enhanced stability for sodium-ion batteries

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Journal of Energy Chemistry 2021年第12期30卷 351-357,I0008页

作者： Yanchen Liu Chenchen Wang meng ren Hengyi Fang Zhuoliang Jiang Fujun Li Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China

Anionic redox reaction(ARR) in layered manganese-based oxide cathodes has been considered as an effective strategy to improve the energy density of sodium-ion ***-vacancy layered oxides deliver a high ARR-related capacity with small voltage hysteresis,however,they are limited by rapid capacity degradation and poor rate capability,which arise from inferior structure changes due to repeated redox of lattice ***,redox-inactive Ti^(4+)is introduced to substitute partial Mn^(4+)to form Na_(2) Ti_(0.5)Mn_(2.5)O_7(Na_(4/7)[□_(1/7)Ti_(1/7)Mn_(5/7)]O_(2),□ for Mn vacancies),which can effectively restrain unfavorable interlayer gliding of Na2 Mn307 at high charge voltages,as reflected by an ultralow-strain volume variation of 0.11%.There is no irreversible O_(2) evolution observed in Na_(2) Ti_(0.5)Mn_(2.5)O_7 upon charging,which stabilizes the lattice oxygen and ensures the overall structural *** exhibits increased capacity retention of 79.1% after 60 cycles in Na_(2) Ti_(0.5)Mn_(2.5)O_7(17.1% in Na_(2) Mn_(3) O_7) and good rate capability(92.1 mAh g^(-1) at 0.5 A g^(-1)).This investigation provides new insights into designing high-performance cathode materials with reversible ARR and structural stability for SIBs.

关键词： Mn vacancy Layered oxide cathode Anionic redox reaction Sodium-ion batteries

香叶基香叶基焦磷酸合成酶在肺鳞状细胞癌中的表达及临床意义

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上海交通大学学报（医学版） 2024年第3期44卷 312-324页

作者：王鑫王晓霞李彦庆郑永鑫乌杰任猛贾向东许天祥内蒙古科技大学包头医学院研究生院包头014060 内蒙古自治区人民医院腹部肿瘤外科呼和浩特010017 内蒙古自治区人民医院重症医学科呼和浩特010017 内蒙古医科大学研究生院呼和浩特010000

目的·利用生物信息学和免疫组织化学法探究在肺鳞状细胞癌(lung squamous cell carcinoma,LUSC)组织中香叶基香叶基焦磷酸合成酶(geranylgeranyl diphosphate synthase 1,GGPS1)的表达及其临床意义。方法·首先从UCSC Xena平台下载LUS... 详细信息

目的·利用生物信息学和免疫组织化学法探究在肺鳞状细胞癌(lung squamous cell carcinoma,LUSC)组织中香叶基香叶基焦磷酸合成酶(geranylgeranyl diphosphate synthase 1,GGPS1)的表达及其临床意义。方法·首先从UCSC Xena平台下载LUSC组织与配对正常组织的转录组数据,使用R语言进行数据标准化和差异表达分析,并利用UALCAN数据库进行验证;采用UALCAN和LinkedOmics数据库分析LUSC患者中GGPS1表达与临床病理特征关系;利用Kaplan-Meier Plotter数据库探究LUSC患者GGPS1表达对预后的影响。应用最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)回归分析筛选基因相关系数及风险评分。通过列线图和校正曲线评价GGPS1对LUSC的诊断价值。采用STRING、GeneMANIA数据库构建GGPS1蛋白质相互作用(protein-protein interaction,PPI)网络。运用R语言挑选与GGPS1相关差异基因,并进行基因本体论(Gene Ontology,GO)和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析。采用免疫组织化学法检测LUSC患者GGPS1表达情况,并分析其与临床病理特征和预后的相关性。结果·通过TIMER2.0数据库检索到GGPS1在多数肿瘤中表达均升高,且在LUSC中呈高表达。UCSC Xena、UALCAN数据库中GGPS1在LUSC的表达高于癌旁组织(均P<0.05)。UALCAN和LinkedOmics数据库发现GGPS1在指标分期较晚患者中的表达水平更高,且Kaplan-Meier Plotter数据库显示LUSC患者GGPS1高表达总生存期(overall survival,OS)较短(P<0.05)。基于LASSO回归评估LUSC患者有较好的风险预测效能。构建LUSC患者的个体化预测模型具有最佳预测准确度。GO、KEGG结果显示,GGPS1相关基因主要与蛋白质代谢、调节脂质和胆固醇代谢过程、尼古丁成瘾、磷脂酰肌醇3激酶(phosphatidylinositol3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)、过氧化物酶体增殖物激活受体(peroxisome proliferatoractivated receptors,PPAR)信号通路等有关。GGPS1的代谢功能可能促进肿瘤发生。免疫组化结果提示GGPS1主要定位于细胞质中,且LUSC组织中表达高于癌旁组织(P<0.05),GGPS1高表达与LUSC患者肿瘤大小、淋巴结转移和TNM分期有关(均P<0.05),且GGPS1表达高的患者OS明显短于低表达者(P=0.000)。多因素Cox回归分析提示GGPS1可作为LUSC的独立预后因素。结论·相较于正常肺组织,GGPS1在LUSC中表达显著升高,尤其在肿瘤体积较大、淋巴结转移阳性及晚期的患者中表达升高更明显;且GGPS1过表达是LUSC患者预后差的独立预测因子。GGPS1有望成为新的LUSC诊治和预防的分子靶点。

关键词：香叶基香叶基焦磷酸合成酶肺鳞状细胞癌生物信息学免疫组织化学临床意义

Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

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Chinese Journal of Natural Medicines 2020年第9期18卷 704-713页

作者： JING Guang-Chan LIU Di LIU Yu-Qin ZHANG meng ren Deparment of Traditional Chinese Medicine Peking Union Medical Collge HospitalPeking Union Medical Collge and Chinese Academy of Medical SciencesBeijing 100730China Deparment 0f cell resource center Institute of Basic Medical SciencePeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Chinese herbal compound Nao-Fu-Cong(NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine(TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ(60 mg·k^(-1))-induced diabetic rats into control group, diabetic model group and NFC groups(low-dose, medium-dose and high-dose). The primary culture of hippocampal neurons were transferred into different culture media on the third day. The cells were then divided into control group, high-glucose group, NFC(low-dose, medium-dose and high-dose) groups, CHOP si-RNA intervention group, JNK pathway inhibitor SP600125 group and oxidative stress inhibitor N-acetylcysteine(NAC) group. NFC significantly improved the cognitive function of diabetic rats, and had neuroprotective effect on hippocampal neurons cultured in high glucose. Further research results showed that NFC could reduce the apoptosis of hippocampal neurons in rats with diabetic cognitive dysfunction. NFC had inhibitory effects on CHOP/JNK apoptosis pathway induced by high glucose, and also decreased the levels of ROS and increased the mitochondrial membrane potential. These suggested that the neuroprotective effect of NFC might be related to the inhibition of CHOP and JNK apoptotic signaling pathways, and the cross pathway between oxidative stress and mitochondrial damage pathway.

关键词： Nao-Fu-Cong Apoptosis High glucose Hippocampal neurons

Secondary battery inspired ɑ-nickel hydroxide as an efficient Ni-based heterogeneous catalyst for sulfate radical activation

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Science Bulletin 2018年第5期63卷 278-281页

作者： Dongting Yue Xufang Qian meng ren mengyuan Fang Jinping Jia Yixin Zhao School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

Highly reactive radical species play an important role in syn-thetic chemistry, industrial processes, and environmental remedi-ation applications [1,2]. The radicals can be formed by eitherthermal decomposition of highly active oxidants or by catalyticactivation of stable oxidants under mild conditions [2]. Recently,the sulfate radical （.504） with its advantages of strong oxidizingpower, selective reactivity, and stability over a broad range of pHhas emerged as an excellent and versatile oxidant for a variety ofapplication [5].

关键词：中国科学通报英文版

Inhibitory effect of Houttuynia cordata Thunb on LPS-induced retinal microglial activation

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1095-1100页

作者： Ying-Hui Zhang Le-meng ren Xiao-Yun Wang The Second Hospital of Shandong University Shandong UniversityJinan 250033 Shandong ProvinceChina The First Clinical Medical College Lanzhou UniversityLanzhou 730000 Gansu ProvinceChina

AIM: To identify the effect of Houttuynia cordata Thunb(HCT) on lipopolysaccharide(LPS)-induced microglial activation and investigate its possible molecular mechanisms. METHODS: The primary retinal microglial cells were cultured from the retinas of newborn Sprague-Dawley rats and exposed to LPS, and/or HCT with different concentrations. The survival ability of retinal microglia cells was tested by standard MTT method. BrdU cell proliferation assay was used to evaluate the proliferation of retinal microglia. Inflammatory factors in the culture supernatants, including TNF-α, iNOS and IL-1β, were measured using ELISA. Microglia cells’ migration was determined with Transwell migration assay. The total p38-MAPK and phosphorylation of p38-MAPK(p-p38-MAPK) were detected with Western ***: Primary retinal microglia in culture exposed to LPS to induce microglia activation. Pretreatment with HCT significantly inhibited the LPS-induced cell proliferation, but not the cell viability. LPS induced inflammatory reaction in microglia and cell migration. HCT significantly reduced LPS-stimulated release of pro-inflammatory factors and decreased the number of migrating cells substantially in a concentration-dependent manner. Moreover, the protein levels of p-p38 MAPK were identified as the up regulation and co-treatment with HCT obviously inhibited the upregulation of p-p38 MAPK, but had no effect on the levels of total ***: The data suggest that HCT inhibits LPSinduced retinal microglial activation via suppression of the p-p38-MAPK. HCT may be used for the treatment of ocular diseases characterized by over-activated microglia.

关键词： Houttuynia cordata Thunb microglia activation retina inhibitory effect

基于雪岭云杉树轮宽度重建中天山巴仑台地区过去565年7~9月NDVI变化

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第四纪研究 2024年第4期44卷 869-881页

作者：马一凡刘禹宋慧明张权蔡秋芳任萌李珮中国科学院地球环境研究所黄土与第四纪地质国家重点实验室陕西西安710061 中国科学院大学北京100049 中国科学院第四纪科学与全球变化卓越创新中心陕西西安710061 西安交通大学人居环境与建筑工程学院陕西西安710054 西安地球环境创新研究院陕西西安710061 中国-巴基斯坦地球科学研究中心中国科学院和巴基斯坦高等教育委员会伊斯兰堡巴基斯坦45320

归一化植被指数(NDVI)对分析植被动态及其对气候的响应至关重要,但是对天山地区而言,现有的短时NDVI数据集不能满足长时间尺度的分析需要。因此,本研究利用天山南坡巴仑台地区雪岭云杉样本建立了树轮宽度年表(STD),发现其与7~9月的NDVI... 详细信息

归一化植被指数(NDVI)对分析植被动态及其对气候的响应至关重要,但是对天山地区而言,现有的短时NDVI数据集不能满足长时间尺度的分析需要。因此,本研究利用天山南坡巴仑台地区雪岭云杉样本建立了树轮宽度年表(STD),发现其与7~9月的NDVI显著相关(r=0.69,n=39,p<0.001),在此基础上,设计线性回归模型,重建了研究区1455~2019年7~9月NDVI变化,方差解释量为46%。结果显示,研究区在1455~2019年期间经历了5个植被覆盖高值期和8个植被覆盖低值期,其中1988~2019年植被生长处于历史最高水平;与周边其他重建序列对比结果表明NDVI变化存在空间差异性,中天山区域近30多年来NDVI呈现增加趋势,而西天山则呈现下降趋势;此外,分析表明降水是研究区NDVI的主要影响因素。天山地区降水主要受到海温异常和遥相关的影响,分析结果显示印度洋海温增暖和东大西洋遥相关型(EA)正相位可以使天山地区降水量增加,进而促进研究区植被的生长。该研究对理解中天山植被覆盖的长期动态变化具有一定的参考意义,并为未来植被动态演化预测提供基础数据。

关键词：树轮宽度归一化植被指数(NDVI) 重建中天山

糖尿病肾周脂肪细胞来源小细胞外囊泡促进肾小管上皮细胞上皮-间质转化

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中华内分泌代谢杂志 2024年第7期40卷 586-593页

作者：余君言林嘉彬蔡雷琴林江虹洪晓思杨于霖任萌孙侃中山大学附属孙逸仙纪念医院内分泌科广州510120

目的探讨糖尿病状态下肾周脂肪组织(PRAT)脂肪细胞来源小细胞外囊泡(sEVs)对肾小管上皮细胞的生物行为影响以及其分子机制。方法提取原代db/m、db/db小鼠PRAT脂肪细胞进行体外培养, 收集培养上清并通过超速离心法提取sEVs(NDM-sEVs^(PRA... 详细信息

目的探讨糖尿病状态下肾周脂肪组织(PRAT)脂肪细胞来源小细胞外囊泡(sEVs)对肾小管上皮细胞的生物行为影响以及其分子机制。方法提取原代db/m、db/db小鼠PRAT脂肪细胞进行体外培养, 收集培养上清并通过超速离心法提取sEVs(NDM-sEVs^(PRAT-Adipo), DM-sEVs^(PRAT-Adipo))。将sEVs与人肾小管上皮细胞株(HK-2)细胞孵育, 观察其增殖、凋亡、自噬以及上皮-间质转化(EMT)水平。通过质谱技术分析sEVs蛋白成分, 探讨其作用的分子机制。结果 CCK8结果表明DM-sEVs^(PRAT-Adipo)干预后HK-2细胞的增殖水平与2个对照组(Ctrl组和NDM-sEVs^(PRAT-Adipo)干预组)相比无明显改变。Western印迹法结果表明, 对比2个对照组, DM-sEVs^(PRAT-Adipo)干预组的凋亡(Bcl-2、Cleaved-caspase 3、Caspase 3)和自噬(p62、LC3BⅠ、LC3BⅡ)水平无明显改变。Western印迹法和免疫荧光结果表明, 与2个对照组比较, DM-sEVs^(PRAT-Adipo)干预可上调HK-2的间质细胞标志蛋白(Vimentin、α-SMA、Snail2)表达水平, 下调上皮细胞标志蛋白ZO-1表达水平。sEVs质谱分析结果表明, DM-sEVs^(PRAT-Adipo)与NDM-sEVs^(PRAT-Adipo)的差异蛋白富集于EMT相关通路。其中, DM-sEVs^(PRAT-Adipo)富集血小板反应蛋白(THBS1), 该蛋白与EMT密切相关。结论糖尿病状态下, PRAT来源脂肪细胞分泌sEVs促进肾小管上皮细胞EMT上调, 此过程可能由sEVs中所富集的THBS1介导。

关键词：肾周脂肪组织糖尿病肾病小细胞外囊泡肾小管上皮细胞上皮-间质转化