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A Li_(3)P nanoparticle dispersion strengthened ultrathin Li metal electrode for high energy density rechargeable batteries

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Nano Research 2024年第5期17卷 4031-4038页

作者： lin Fu Xiancheng Wang bao Zhang Zihe Chen Yuanjian Li Yongming sun Provincial Guizhou Key Laboratory of Green Chemical and Clean Energy Technology School of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering Agency for Science Technology and Research(A*STAR)Singapore 138634Singapore

Achievement of lithium(Li)metal anode with thin thickness(e.g.,≤30µm)is highly desirable for rechargeable high energy density ***,the fabrication and application of such thin Li metal foil electrode remain challenging due to the poor mechanical processibility and inferior electrochemical performance of metallic ***,mechanico-chemical synthesis of robust ultrathin Li/Li_(3)P(LLP)composite foils(~15µm)is demonstrated by employing repeated mechanical rolling/stacking operations using red P and metallic Li as raw *** in-situ formed Li+-conductive Li_(3)P nanoparticles in metallic Li matrix and their tight bonding strengthen the mechanical durability and enable the successful fabrication of free-standing ultrathin Li metal composite ***,it also reduces the electrochemical Li nucleation barrier and homogenizes Li plating/stripping *** matching to high-voltage LiCoO_(2),the full cell with a low negative/positive(N/P)capacity ratio of~1.5 offers a high energy density of~522 W·h·kg^(-1) at 0.5 C based on the mass of cathode and *** into account its facile manufacturing,potentially low cost,and good electrochemical performance,we believe that such an ultrathin composite Li metal foil design with nanoparticle-dispersion-strengthened mechanism may boost the development of high energy density Li metal batteries.

关键词： lithium metal anode high energy density battery mechanico-chemical synthesis ultrathin Li/Li_(3)P composite foil low negative/positive capacity ratio

Long-term Evolution of Solar Activity and Prediction of the Following Solar Cycles

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Research in Astronomy and Astrophysics 2024年第3期24卷 194-204页

作者： Pei-Xin Luo bao-lin Tan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Solar activities have a great impact on modern high-tech systems,such as human aerospace activities,satellite communication and navigation,deep space exploration,and related scientific ***,studying the long-term evolution trend of solar activity and accurately predicting the future solar cycles are highly *** on the wavelet transform and empirical function fitting of the longest recorded data of the annual average relative sunspot number(ASN)series of 323 yr to date,this work decisively verifies the existence of the solar century cycles and confirms that its length is about 104.0 yr,and the magnitude has a slightly increasing trend on the timescale of several hundred *** on this long-term evolutionary trend,we predict solar cycles 25 and26 by using phase similar prediction *** for solar cycle 25,its maximum ASN will be about146.7±33.40,obviously stronger than solar cycle *** peak year will occur approximately in 2024,and the period will be about 11±1 *** for solar cycle 26,it will start around 2030,and reach its maximum between2035 and 2036,with maximum ASN of about 133.0±3.200,and period of about 10 yr.

关键词： sun activity-sun evolution-(sun) sunspots-methods data analysis

Automatic detection of breast lesions in automated 3D breast ultrasound with cross-organ transfer learning

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 239-251页

作者： lingyun bao Zhengrui HUANG Zehui lin Yue sun Hui CHEN You LI Zhang LI Xiaochen YUAN lin XU Tao TAN Affiliated Hangzhou First People's Hospital School of MedicineWestlake UniversityHangzhou 330100China Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Pathology Department Changsha First HospitalChangsha 410073China Radiology Department Changsha First HospitalChangsha 410073China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of Image Measurement and Vision Navigation Changsha 410073China School of Information Science and Technology Shanghaitech UniversityShanghai 201210China

Background Deep convolutional neural networks have garnered considerable attention in numerous machine learning applications,particularly in visual recognition tasks such as image and video *** is a growing interest in applying this technology to diverse applications in medical image *** three dimensional Breast Ultrasound is a vital tool for detecting breast cancer,and computer-assisted diagnosis software,developed based on deep learning,can effectively assist radiologists in ***,the network model is prone to overfitting during training,owing to challenges such as insufficient training *** study attempts to solve the problem caused by small datasets and improve model detection *** We propose a breast cancer detection framework based on deep learning(a transfer learning method based on cross-organ cancer detection)and a contrastive learning method based on breast imaging reporting and data systems(BI-RADS).Results When using cross organ transfer learning and BIRADS based contrastive learning,the average sensitivity of the model increased by a maximum of 16.05%.Conclusion Our experiments have demonstrated that the parameters and experiences of cross-organ cancer detection can be mutually referenced,and contrastive learning method based on BI-RADS can improve the detection performance of the model.

关键词： Breast ultrasound Automated 3D breast ultrasound Breast cancers Deep learning Transfer learning Convolutional neural networks Computer-aided diagnosis Cross organ learning

Sea cucumber gut tetrapeptide ameliorates alcoholic gastric damage via restoring mitochondrial dynamics

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Food Science and Human Wellness 2024年

作者： Zhihong Zheng Na sun Jingqi Yang Zhijie bao Songyi lin State Key Laboratory of Marine Food Processing and Safety Control，School of Food Science and Technology， Dalian Polytechnic University National Engineering Research Center of Seafood， School of Food Science and Technology， Dalian Polytechnic University Collaborative Innovation Center of Seafood Deep Processing， Dalian Polytechnic University Liaoning Engineering Research Center of Special Dietary Food， Dalian Polytechnic University

This paper aimed to explore the mechanism of tetrapeptide VTPY in improving alcoholic gastric injury. VTPY has the potential to enhance the growth and movement of normal GES-1 cells. Following ethanol-induced impairment， VTPY effectively improved migration of GES-1 and HUVEC cells， enhanced angiogenesis， eliminated cellular and mitochondrial ROS， inhibited excessive mitochondrial division， enhanced F-actin polymerization and mitochondrial respiratory capacity. To counteract excessive mitochondrial fission， VTPY primarily restores the mitochondria dynamics by reducing the expression of Drp1 and Fis1， while increasing Mfn2. Further studies utilizing inhibitors clarifies that the inhibition of excessive mitochondrial fission can markedly reduce F-actin depolymerization， consequently enhancing cell migration. Additionally， VTPY can inhibit the apoptosis pathway by maintaining potential of mitochondrial membrane， preventing the release of mitochondrial cytochrome c， bolstering the levels of Bcl-XL， while reducing the levels of Bax and cleaved-caspase3. Further investigations using inhibitors demonstrates that excessive mitochondrial fission could activate apoptotic pathway. However， VTPY counteracts this effect and enhance cells viability. Further evidence suggests that VTPY effectively improves ulcer index and pathologic changes， relieves inflammation， enhances the balance of oxidation and anti-oxidation， promotes angiogenesis， improves the expression of mitochondrial dynamics factors， blocks apoptotic pathway， and subsequently ameliorates gastric damage in mice through Fis-1/Bcl-2 pathway.

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Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

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World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-Han Wang bao-Hai Chen Yi sun lin Li Wen-Qing Xiang Ahmed Faisal Ali lin-Xuan Su Hai-Yan Mao Hong-Qiang Shen Qiang Shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information Center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Department of Thoracic&Cardiovascular Surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng sun Ying bao Leijin Mao lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Gansu Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina Hubei Center for Disease Control and Prevention Wuhan CityHubei ProvinceChina Shandong Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Sichuan Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina Anhui Center for Disease Control and Prevention Hefei CityAnhui ProvinceChina Guizhou Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina Hunan Center for Disease Control and Prevention Changsha CityHunan ProvinceChina Jiangsu Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

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精囊在男性性功能中的作用

中华男科学杂志 2024年第3期30卷 195-198页

作者：金保方孙大林东南大学附属中大医院中西医结合男科

精囊是男性生殖系统重要的附属性腺，过去有些学者多关注其在受精过程中的作用，而忽略了与男性性功能的关系。研究发现精囊参与性欲、勃起和射精等多个环节，针对精囊用药治疗性功能障碍，取得了一定的疗效。本文就生理病理以及临床和... 详细信息

精囊是男性生殖系统重要的附属性腺，过去有些学者多关注其在受精过程中的作用，而忽略了与男性性功能的关系。研究发现精囊参与性欲、勃起和射精等多个环节，针对精囊用药治疗性功能障碍，取得了一定的疗效。本文就生理病理以及临床和基础研究方面，论述精囊与性功能的关系，期望能为临床诊治性功能障碍提供新思路。

关键词：精囊性功能障碍性欲低下勃起功能障碍不射精

BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong bao lin Tang Chaoye Wang Chunlei Liu Yukai Wang Yuyan Teng Mohan Zheng Weiping Mu Zhixiang Zuo Yubin Xie Xiaotong Luo Jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

中医药治疗慢性非细菌性前列腺炎的机制研究进展

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中华男科学杂志 2024年第6期30卷 564-568页

作者：孙大林(综述) 金保方(审校) 东南大学附属中大医院中西医结合男科江苏南京210009

慢性非细菌性前列腺炎(CNP)是泌尿男科最常见的疾病之一,病因复杂,复发率高。中医药在治疗CNP中占据重要地位,可以通过多种机制发挥疗效。本文整理了近年来关于中医药治疗CNP的具体机制研究,包括抗感染、抗炎症、调节免疫、改善尿流动... 详细信息

慢性非细菌性前列腺炎(CNP)是泌尿男科最常见的疾病之一,病因复杂,复发率高。中医药在治疗CNP中占据重要地位,可以通过多种机制发挥疗效。本文整理了近年来关于中医药治疗CNP的具体机制研究,包括抗感染、抗炎症、调节免疫、改善尿流动力学、调控内分泌、改善微循环和调节肠道菌群等,以期为临床应用和基础研究提供理论依据。

关键词：慢性非细菌性前列腺炎炎症反应免疫功能微循环障碍菌群失调