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Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidentical hematopoietic stem cell transplantation in acute myeloid leukemia

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Frontiers of Medicine 2019年第6期13卷 667-679页

作者： meng lv Xiaohui Zhang Lanping Xu Yu Wang Chenhua Yan Huan Chen Yuhong Chen Wei Han Fengrong Wang Jingzhi Wang Kaiyan Liu Xiaojun Huang Xiaodong Mo Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100044China

Chronic graft-versus-host disease(cGVHD)is a major complication following unmanipulated haploidentical hematopoietic stem cell transplantation(haplo-HSCT).We aimed to identify the risk factors for cGVHD in patients who underwent anti-thymocyte globulin-based haplo-HSCT for acute myeloid leukemia(n=280).The diagnosis of cGVHD was in accordance with the National Institutes of Health consensus criteria.A total of 169 patients suffered from *** patients who had 3 loci mismatched had a higher 8-year incidence of cGVHD(total,66.0%vs.53.7%,P=0.031;moderate to severe,42.4%vs.30.1%,P=0.036)than the patients who had 1 to 2 loci *** patients who had maternal donors had a higher 8-year incidence of moderate to severe cGVHD(49.2%vs.32.9%,P=0.024)compared with the patients who had other *** patients who had grades III to IV acute GVHD(aGVHD)had higher 8-year incidence of cGVHD(total,88.0%vs.50.4%,P<0.001;moderate to severe,68.0%vs.27.0%,P<0.001)compared with the patients without *** multivariate analysis,grades III to IV aGVHD was the only independent risk factor for ***,further interventions should be considered in patients with severe aGVHD to prevent cGVHD.

关键词： acute graft-versus-host disease chronic graft-versus-host disease National Institutes of Health consensus criteria acute myeloid leukemia anti-thymocyte globulin

Wmatrix-based Study of Translator's Style——A Case Analysis of Two English Versions of The True Story of Ah Q

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海外英语 2017年第16期 103-104页

作者：吕萌中国石油大学(北京)

With the help of Wmatrix, this paper attempts to compare and analyze the the two English versions from the level of word frequency, POS, semantic domain to differentiate the translator's style. It's found that the translation inside is characterized by diversified words, verbalization and foreignization, whereas the translation outside is featured as simple words, nominalization,and explicitation.

关键词： Wmatrix Translator’s style The True Story of Ah Q

Glucocorticoid and glycolysis inhibitors cooperatively abrogate acute graft-versus-host disease

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Science China(Life Sciences) 2023年第3期66卷 528-544页

作者： Qi Wen Zheng-Li Xu Yu Wang meng lv Yang Song Zhong-Shi Lyv Tong Xing Lan-Ping Xu Xiao-Hui Zhang Xiao-Jun Huang Yuan Kong Peking University People's Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationCollaborative Innovation Center of HematologyPeking UniversityBeijing 100044China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100044China

Although glucorticosteroids(GCs)are the standard first-line therapy for acute graft-versus-host disease(a Gv HD),nearly 50%of a Gv HD patients have no response to *** role of T cell metabolism in murine a Gv HD was recently ***,whether GCs and metabolism regulators could cooperatively suppress T cell alloreactivity and ameliorate a Gv HD remains to be *** glycolysis,characterized by elevated 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3),and higher rates of glucose consumption and lactate production were found in Tcells from a Gv HD *** upregulation of PFKFB3 induced T cell proliferation and differentiation into proinflammatory *** a humanized mouse model,PFKFB3-overexpressing or PFKFB3-silenced T cells aggravated or prevented a Gv HD,***,our integrated data from patient samples in vitro,in a humanized xenogeneic murine model of a Gv HD and graft-versus-leukaemia(GVL)demonstrate that GCs combined with a glycolysis inhibitor could cooperatively reduce the alloreactivity of T cells and ameliorate a Gv HD without loss of GVL ***,the current study indicated that glycolysis is critical for T cell activation and induction of human a Gv ***,the regulation of glycolysis offers a potential pathogenesis-oriented therapeutic strategy for a Gv HD *** combined with glycolysis inhibitors promises to be a novel first-line combination therapy for a Gv HD patients.

关键词： allogeneic haematopoietic stem cell transplantation graft versus host disease human T cells glycolysis

Effect of Heat Treatment on Gradient Microstructure and Tensile Property of Laser Powder Bed Fusion Fabricated 15-5 Precipitation Hardening Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 181-195页

作者： Sheng Cao Hongyu Liu Jin Jiang Ke He Binghua lv Hao Zhang Lujie Zhang Jingrong meng Hao Deng Xiaodong Niu Department of Mechanical Engineering College of EngineeringShantou UniversityShantou515063China China State Shipbuilding Co. Ltd.Huangpu Wenchong Shipbuilding Company Ltd.Guangzhou510715China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing100080China Shantou Ruixiang Mould Co. Ltd.Shantou515041China Military Representative Office X of Unit 93147 Deyang618000China China National Erzhong Group Co. Deyang Wanhang Die Forging Co.Ltd.Deyang618013China

This work investigated the gradient microstructure evolution and tensile property of LPBF fabricated 15-5 precipitation hardening stainless steel in post-process direct ageing(DA)and solution treating&ageing(STA).The varied microstructures for austenite and small-sized oxide inclusions at different sample heights in the as-built(AB)condition was generally preserved after DA ***,austenite was almost disappeared,and oxide particle grew significantly after the STA *** a result,the tensile property differences in sample top and bottom for AB and DA conditions did not occur in the STA *** the influence of post-process heat treatment,the STA condition had the highest yield strength due to the highest volume fraction of nano-sized Cu ***,the DA specimen had the highest ultimate tensile strength and elongation owing to the considerable amount of austenite phase and associated transformation induced plasticity effect.

关键词： 15-5 PH stainless steel Laser powder bed fusion Heat treatment Gradient microstructures Tensile properties

AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

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Science China(Life Sciences) 2024年第7期67卷 1468-1478页

作者： Jiang Deng Jia-Cheng Yang Yue Feng Ze-Jing Xu Kamil Kuča meng Liu lv-Hui Sun State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic

Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic *** hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1to the highly toxic exo-AFB1-8,9-epoxide(AFBO)in ***,the transcriptional regulation mechanism of these CYP genes in the liver of chicks in AFB1metabolism remains ***-luciferase reporter assay,bioinformatics and site-directed mutation results indicated that specificity protein 1(SP1)and activator protein-1(AP-1)motifs were located in the core region-1,063/-948,-606/-541 of the CYP1A1 promoter as well as-636/-595,-503/-462,-147/-1 of the CYP2A6 ***,overexpression and decoy oligodeoxynucleotide technologies demonstrated that SP1 and AP-1 were pivotal transcriptional activators regulating the promoter activity of CYP1A1 and ***,bioactivation of AFB1to AFBO could be increased by upregulation of CYP1A1 and CYP2A6 expression,which was trans-activated owing to the upregulation of AP-1,rather than SP1,stimulated by AFB1-induced reactive oxygen ***,nano-selenium could reduce ROS,downregulate AP-1 expression and then decrease the expression of CYP1A1 and CYP2A6,thus alleviating the toxicity of *** conclusion,AP-1 and SP1 played important roles in the transactivation of CYP1A1 and CYP2A6 expression and further bioactivated AFB1to AFBO in chicken liver,which could provide novel targets for the remediation of aflatoxicosis in chicks.

关键词： aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation

A vision for the future of allogeneic hematopoietic stem cell transplantation in the next decade

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Science Bulletin 2022年第19期67卷 1921-1924页

作者： meng lv Norbert Claude Gorin Xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology and Cell Therapy European Society for Blood and Marrow Transplantation Global CommitteeHôpital Saint-Antoine AP-HPParis Sorbonne UniversityParis 75012France Peking-Tsinghua Center for Life Sciences Beijing 100871China

The whole field of hematological malignancies has experienced a huge breakthrough during the past 40 *** methodological progress in cytogenetics(e.g.,fluorescence in situ hybridization,FISH),immunophenotyping(e.g.,multicolor flow cytometers),and molecular biology(with the discovery of numerous tumor molecular markers by polymerase chain reaction and,more recently,next-generation sequencing)has paved the way for the new concept of detecting and monitoring undetectable minimal residual disease(uMRD)and the engineering of multiple new targeted therapies,such as tyrosine kinase inhibitors and various immunotherapies,including monoclonal antibodies combined or not with antitumor agents,bispecific T-cell-engaging(BiTE)antibodies and chimeric antigen receptor T(CAR-T)cells(Supplementary Text 1 online).

关键词： antibodies monoclonal breakthrough

Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1

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Regenerative Biomaterials 2024年第3期3卷 134-147页

作者： Caiyao Hou Yujue Zhang Zhaoyong lv Yurun Luan Jun Li Chunxiu meng Kun Liu Xin Luo Liyu Chen Fengzhen Liu Department of Materials Science and Engineering Liaocheng UniversityLiaocheng 252000China Liaocheng People's Hospital Liaocheng Hospital Affliated Shandong First Medical UniversityLiaocheng 252000China The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250023China

In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication *** play a central role in mediating immune osteogenesis,exosomes derived from them have osteogenic regulation and can be used as cariers in bone tissue ***,there are problems with exosomal therapy alone,such as poor targeting,and the content of loaded molecules cannot reach the therapeutic *** this study,macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone ***3T3-E1 cells were incubated with the culture supermatants of Mo,M1 and M2 macrophages,and it was found that the culture medium of M2 macrophages had the most significant effects in contributing to ***-throughput sequencing identified that miR-365-2-5p was significantly expressed in exosomes derived from M2 *** incubated MC3T3-E1 with exosomes overexpressing or kmocking down miR-365-2-5p to examine the biological function of exosome miR-365-2-5p on MC3T3-E1 *** findings suggested that miR-365-2-5p secreted by exosomes increased the osteogenesis of ***,miR-365-2-5p had a direct influence over osteogenesis for *** analysis combined with dual luciferase detection indicated that miR-365-2-5p binded to the 3'-UTR of *** summary,exosomes secreted by M2 macrophages targeted OLFML1 through miR-365-2-5p to facilitate osteogenesis.

关键词： macrophage exosomes osteogenesis osteoimmunology

Applications of cold atmospheric plasmas(CAPs)in agriculture:a brief review and the novel development of a radio-frequency CAP jet generator for plant mutation

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Plasma Science and Technology 2022年第9期24卷 1-14页

作者： Heping LI Jing LI Xiting ZHAO Liyan WANG Chuan FANG Nan SU Chong ZHANG Yan XU meng lv Mingjun LI Xinhui XING Department of Engineering Physics Tsinghua UniversityBeijing 100084People’s Republic of China College of Life Sciences Henan Normal UniversityXinxiang 453007People’s Republic of China Biobreeding Research Center Wuxi Research Institute of Applied TechnologiesTsinghua UniversityWuxi 214072People’s Republic of China MOE Key Laboratory of Industrial Biocatalysis Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China Center for Systems and Synthetic Biology Tsinghua UniversityBeijing 100084People’s Republic of China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055People’s Republic of China

Cold atmospheric plasmas(CAPs)have shown great applicability in *** kinds of CAP sources have been studied in agricultural applications to promote plant growth and cure plant *** briefly review the state-of-the-art stimulating effects of atmospheric-pressure dielectricbarrier-discharge(AP-DBD)plasmas,after the direct or indirect treatment of plants for growth promotion and disease *** then discuss the special demands on the characteristics of the CAP sources for their applications in plant mutation *** atmospheric and room temperature plasma(ARTP)jet generator with a large plasma irradiation area,a high enough concentration of chemically reactive species and a low gas temperature is designed for direct plant *** measurements of the electrical,thermal and optical features of the ARTP generator are ***,an ARTP-P(ARTP for plant mutagenesis)mutation breeding machine is developed,and a typical case of plant mutation breeding by the ARTP-P mutation machine is presented using Coreopsis tinctoria *** and agricultural experiments show that the newly-developed ARTP-P mutation breeding machine with a large irradiation area can generate uniform CAP jets with high concentrations of chemically reactive species and mild gas temperatures,and have signiflcant mutagenesis effects on the Coreopsis tinctoria *** ARTP-P mutation breeding machine may provide a platform for systematic studies on mutation mechanisms and results for various plant seeds under different operating conditions in future research.

关键词： cold atmospheric plasma radio-frequency glow discharge mutation plant breeding ARTP agricultural application

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中国早期电影同期录音思维的酝酿与实现

北京电影学院学报 2009年第1期 39-44页

作者：吕甍中国传媒大学南广学院艺术传播系助教

在20世纪初的"无声时代"中,中国电影完成了一个声音意识培养的过程。到有声电影呼之欲出的时候,中国电影的"声音艺术素养"已经相对成熟,自然地进行了一个短暂的过渡。电影同期录音思维的转变过程也一并完成于从无声片到有声片的过渡时... 详细信息

在20世纪初的"无声时代"中,中国电影完成了一个声音意识培养的过程。到有声电影呼之欲出的时候,中国电影的"声音艺术素养"已经相对成熟,自然地进行了一个短暂的过渡。电影同期录音思维的转变过程也一并完成于从无声片到有声片的过渡时期。本文认为,有声思维可以追溯到无声片时期甚至更早,而且有声思维是与电影历史同步的;同期录音占据了整个思维的起始阶段,成为那个时期的主流思潮,并且对电影有声思维的发展有深远的影响。

关键词：无声片有声电影声画同步同期录音