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Blood Science 2022年第3期4卷 161-163页

作者： hao Zhang Guoyu meng Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai JiaoTong University School of Medicine and School of Life Sciences and BiotechnologyShanghai JiaoTong UniversityShanghaiChina

B-cell acute lymphoblastic leukemia(B-ALL)is a malignant tumor originating from B-lineage lymphoid precursor cells.The incidence of B-ALL is about 80%in childhood acute leukemia and 20%in adults.In recent years,with standardized treatment guided by risk stratification,the long-term disease-free survival rate of children is about 80%,while that of adults is less than 40%.However,the specific pathogenesis of the newly identified B-ALL and the targeted therapy strategies have not been vigorously investigated.In this review,we highlight the recent breakthroughs in mechanistic studies and novel therapeutic options in DUX4-and MEF2D-subtype B-ALLs.

关键词： B-ALL DUX4/IGH fusion MEF2D fusion Targeted therapy ZNF384 fusion

Base-Promoted Formylation and N-Difluoromethylation of Azaindoles with Ethyl Bromodifluoroacetate as a Carbon Source

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Chinese Journal of Chemistry 2021年第6期39卷 1477-1482页

作者： Yang Li Ning Sun Cai-Lin Zhang Meng Hao Xi'an Key Laboratory of Textile Chemical Engineering Auxiliaries School of Environmental and Chemical EngineeringXi'an Polytechnic UniversityXi'anShaanxi 710048China

We reported for the first time that ethyl bromodifluoroacetate directly reacts with azaindole without transition metal catalysis to produce a difluoromethyl protected 5-aldehyde group product in one step.It is worth mentioning that the reacted aldehyde group is only formed at the 5 position.In addition,this method has good substrate applicability and functional group tolerance.Finally,we also carried out some mechanism auxiliary experiments,which confirmed that the aldehyde-based carbon comes from ethyl bromodifluoroacetate.

关键词： Azaindoles C1 building blocks Difluoromethylene Hydrolysis Synthetic methods

Nonlinear Dynamic Characteristics of Turbulent Non-Premixed Acoustically Perturbed Swirling Flames

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Journal of Thermal Science 2022年第3期31卷 882-894页

作者： ZHOU hao TAO Chengfei meng Sheng CEN Kefa State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China

The main objective of this article was to experimentally investigate the dynamic response of diffusion flame under acoustic excitation in a laboratory-scale burner.Two parametric variations of the burner,the burner inlet length and variation of the airflow rate,were studied.Experimental results were analyzed through nonlinear time series analysis and several resonance characteristics were obtained.Results indicate that the flame-acoustic resonance only appears under certain frequencies together with the fuel tube vibration.Resonance characteristics of the combustion chamber and air inlet in the non-premixed burner indicate quasi-periodic or limit cycle oscillations,respectively.Flame-acoustic resonance would trigger the frequency and amplitude mode-transition in burners.Moreover,the intermittency of flame heat release was observed under variation of inlet length and airflow rate in the burner;the 445 mm case shows more frequency peaks and fluctuations than the 245 mm one.Four typical flame forms were examined during the flame-acoustic resonance conditions,evolves from wrinkled flames to diverged flames,then evolves to reattached flames and finally to blow-off flames.This study proposed the practical application of nonlinear time-series analysis method as a detection tool for flame-acoustic resonance in laboratory non-premixed burners,which could contribute to the detection and prevention of potential thermoacoustic instabilities or resonance structure failures of industrial boilers.Finally,this study demonstrates an alternative to conventional linear tool for the characterization of nonlinear acoustic resonance in industrial boilers.

关键词： flame-acoustic resonance non-linear time series analysis non-premixed burners intermittency dynamic characteristics

Energy-absorbing porous materials:Bioinspired architecture and fabrication

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Nano Research 2024年第2期17卷 679-690页

作者： Junheng Zhao meng Li Jiewei Chen Weiwei Gao hao Bai State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310058China

Energy-absorbing materials are widely used in transportations,sports,and the military applications.Particularly,porous materials,including natural and artificial materials,have attracted tremendous attentions due to their light weight and excellent energy absorption capability.This review summarizes the recent progresses in the natural and artificial energy-absorbing porous materials.First,we review the typical natural porous materials including cuttlebone,bighorn sheep horn,pomelo peel,and sunflower stem pith.The architectures,energy absorption abilities,and mechanisms of these typical natural materials and their bioinspired materials are summarized.Then,we provide a review on the fabrication methods of artificial energy-absorbing porous materials,such as conventional foaming and three-dimensional(3D)printing.Finally,we address the challenges and prospects for the future development of energy-absorbing porous materials.More importantly,our review provides a direct guidance for the design and fabrication of energy-absorbing porous materials required for various engineering applications.

关键词： energy-absorbing porous materials natural materials natural structures bioinspired materials

Recent advances in SERS detection of perchlorate

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Frontiers of Chemical Science and Engineering 2017年第3期11卷 448-464页

作者： Jumin hao Xiaoguang meng Center for Environmental Systems Stevens Institute of Technology 1 Castle Point Terrace Hoboken NJ 07030 USA NovelTech JMC Inc. 409 Minnisink Road Suite 208 Totowa NJ 07512 USA

Perchlorate has recently emerged as a wide- spread environmental contaminant of healthy concern. Development of novel detection methods for perchlorate with the potential for field use has been an urgent need. The investigation has shown that surface-enhanced Raman scattering （SERS） technique has great potential to become a practical analysis tool for the rapid screening and routine monitoring of perchlorate in the field, particularly when coupled with portable/handheld Raman spectrometers. In this review article, we summarize progress made in SERS analysis of perchlorate in water and other media with an emphasis on the development of SERS substrates for perchlorate detection. The potential of this technique for fast screening and field testing ofperchlorate-contaminated environmental samples is discussed. The challenges and possible solutions are also addressed, aiming to provide a better understanding on the development directions in the research field.

关键词： perchlorate SERS detection substrate mod-ification nanostructure

Acute severe hepatitis of unknown origin in children:considerations from the perspective of immunology

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World Journal of Pediatrics 2022年第8期18卷 529-532页

作者： Si‑hao Gao meng‑Chun Gong Hong‑Mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Institute of Health Management Southern Medical UniversityGuangzhouChina

Acute severe hepatitis of unknown origin in children,since it was frstly reported in Scotland on March 31,2022,has become an international concern with a high risk of acute liver failure requiring liver transplant.The typical causes for hepatitis have been ruled out and investigations revealed possible relationship between the disease and two potential pathogens,a special form of human adenovirus(HAdV)and severe acute respiratory syndrome coronavirus 2(SARSCoV-2).Acute hepatitis has been reported in children with multisystem infammatory syndrome(MIS-C)and incorporating insights from the immunology perspective is necessary to fully understand this disease.

关键词： Acute acute hepatitis

Isothermal martensitic transformation in Ti-Ni-Cu-Co shape memory alloy:Insight from a thermally activated kinetic model

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Journal of Materials Science & Technology 2023年第29期160卷 34-45页

作者： hao Li Kuishan Sun Xianglong meng Wei Cai Liancheng Zhao School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Recently the isothermal martensitic transformation in shape memory alloys(SMAs)has been reported in many literatures,and several models have been proposed to interpret the isothermal and athermal kinet-ics.However,the underlying mechanisms remain inadequately understood.In this work,the isothermal transformation from B2 to B19 is confirmed in Ti-Ni-Cu-Co melt-spun ribbons at the temperature range between M s and M f.It reaches a saturation point at every isothermal temperature T iso,and the saturation points correspond to the f−T curve at the cooling rate of 0.5 K/min.The experimental results indicate that the isothermal accumulation of martensite is a relaxation process from the transient state to the thermoelastic balance one.A thermally activated kinetic model is developed in this study to characterize the isothermal and athermal kinetics.The model is able to estimate the evolution of martensite volume fraction under any temperature path T(t)and it agrees with the experimental results well.According to the model,the effects of elastic energy,nucleation density,and activation energy on the kinetics are in-vestigated.Among those,a small nucleation density n i as well as a large activation energy Qwill result in a significant isothermal transition.In this work,the slighter isothermal effects originate from the higher value of n i.As for the non-stoichiometric SMAs,the higher value of Qis responsible for the accumula-tion of martensite at the isothermal process.Accordingly,the present work provides a novel view from a kinetic model to understand the isothermal martensitic transformation in SMAs.

关键词： Shape memory alloys Thermoelastic martensitic transformation Kinetics Thermal activation

Investigation on the evolution characteristics of bed porous structure during iron ore sintering

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Particuology 2023年第3期74卷 35-47页

作者： Jiankang Wang Pengnan Ma Hanxiao meng Fangzheng Cheng hao Zhou State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China

To better understand the evolution characteristics of bed porous structure during iron ore sintering,X-ray computed tomography scanning technology was used to analyze the pore parameters in different areas of the sintering bed.A pore skeleton structure model was established to study the characteristics of the airflow channels in different zones.The absolute permeability of different areas was calculated through simulation,and the corresponding streamline and pressure drop distribution were analyzed.The results show that the porosity of raw material zone,high-temperature zone,and sintered zone increases gradually,which are 37.69%,46.41%,and 55.57%,respectively.The absolute permeability calculation results of the raw material zone and sintered zones are 792.49μm^(2) and 20560.80μm^(2),while the tortuosity is 1.77 and 1.45,respectively.Compared with the raw material zone,the flow streamline in the sintered zone is thicker and denser,the airflow resistance and the pressure drop are minor.

关键词： Flame front Porous bed structure Iron ore sintering

Influence of coke rate on thermal treatment of waste selective catalytic reduction(SCR)catalyst during iron ore sintering

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Chinese Journal of Chemical Engineering 2022年第2期35卷 415-423页

作者： Pengnan Ma Jiankang Wang Hanxiao meng Laiquan Lv hao Fang Kefa Cen hao Zhou State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

Waste selective catalytic reduction(SCR)catalyst as a hazardous waste has a significant impact on the environment and human health.In present study,a novel technology for thermal treatment of waste SCR catalyst was proposed by adding it to sinter mix for iron ore sintering.The influences of coke rate on the flame front propagation,sinter microstructure,and sinter quality during sintering co-processing the waste SCR catalyst process were studied.In situ tests results indicated the maximum sintering bed temperature increased at higher coke rate,indicating more liquid phase generated and higher airflow resistance.The sintering time was longer and the calculated flame front speed dropped at higher coke rate.Sinter microstructure results found the coalescence and reshaping of bubbles were more fully with increasing coke rate.The porosity dropped from 35.28%to 25.66%,the pore average diameter of large pores decreased from 383.76μm to 311.43μm.With increasing coke rate,the sinter indexes of tumbler index,productivity,and yield,increased from 33.2%,9.2 t·m^(-2)·d^(-1),28.9%to 58.0%,36.0 t·m^(-2)·d^(-1),68.9%,respectively.Finally,a comprehensive index was introduced to systematically assess the influence of coke rate on sinter quality,which rose from 100 to 200 when coke rate was increased from 3.5%(mass)to 5.5%(mass).

关键词： Flame front Waste selective catalytic reduction(SCR) catalyst Thermal treatment Iron ore sintering

Green manufacturing for achieving carbon neutrality goal requires innovative technologies:A bibliometric analysis from 1991 to 2022

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Journal of Environmental Sciences 2024年第6期140卷 255-269页

作者： Sheng Zhang Xintian Wang Jiayu Xu Qinqin Chen meng Peng Jiming hao School of Environment Tsinghua UniversityBeijing 100084China School of Environment&Natural Resources Renmin University of ChinaBeijing 100872China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China

Recent years have seen a significant increase in interest in green manufacturing as a key driver of global carbon-neutral efforts and sustainable development.To find the research hotspots of green manufacturing and reveal future research trends,this study reviewed and analyzed research articles from the Web of Science database on green manufacturing from1991 to 2022 using a bibliometric method.The findings indicate a significant rise in the number of articles related to green manufacturing since the 2010s.Moreover,there has been an increase in the involvement of scholars from developing countries such as China and India in this field.Based on the literature review and bibliometric cluster analysis on green manufacturing,we believed that future research may continue following the lines of intelligent technology integration,adoption of frontier engineering techniques,and industry development in line with carbon reduction targets.A framework for future green manufacturing development is proposed,with a focus on Chinese policies.The framework could provide policy implications for developing countries looking to pursue opportunities for development in green manufacturing.

关键词： Green manufacturing Carbon neutrality Sustainable development Innovative technologies China