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考虑制动、荷载转移、纵坡的雨天小客车弯道安全车速模型

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重庆交通大学学报（自然科学版） 2024年第2期43卷 75-83页

作者：许金良曾卓穆明浩俄广迅长安大学公路学院陕西西安710054 山东高速集团有限公司创新研究所山东济南250101

为了确定降雨环境下小客车弯道安全车速,基于瞬时轴线,建立了考虑纵坡、制动加速度及轮胎荷载转移的小客车侧滑速度模型;通过实地采集不同水膜厚度下的摩擦系数,得到了这二者之间的回归方程;结合摩擦椭圆原理,得到了考虑制动、驾驶人行... 详细信息

为了确定降雨环境下小客车弯道安全车速,基于瞬时轴线,建立了考虑纵坡、制动加速度及轮胎荷载转移的小客车侧滑速度模型;通过实地采集不同水膜厚度下的摩擦系数,得到了这二者之间的回归方程;结合摩擦椭圆原理,得到了考虑制动、驾驶人行为特性的综合摩擦系数分配方法;提出确定弯道车速的计算流程图,得到了不同降雨强度下以横向侧滑和纵向停车为指标的弯道车速。研究结果表明:当水膜厚度为0时,得到的侧滑速度值比点质量模型低35%左右;当水膜厚度小于2 mm时,摩擦系数降低最快,对车速影响最大;当水膜厚度大于2 mm时,摩擦系数变化幅度小且规律不明显;降雨对小客车弯道安全车速影响显著,仅小雨时就会导致车速平均降低15%左右;取一般最小半径计算时,不同降雨强度下的纵向停车速度均小于横向侧滑速度。

关键词：交通工程降雨环境摩擦系数车辆侧滑弯道车速

cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1203-1215页

作者： Yuhui Gao Shi Yu mengdan Chen Xun Wang Lei Pan Bin Wei guangxun meng School of Life Sciences Shanghai UniversityShanghai200444China The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghai200031China Shanghai Blood Center Shanghai200051China Pasteurien College Soochow UniversitySuzhou215006JiangsuChina Nanjing Advanced Academy of Life and Health Nanjing211135JiangsuChina Department of Basic Research Guangzhou LaboratoryGuangzhou International Bio-lslandGuangzhou 510o05 GuangdongChina

The innate immune responses,including inflammasome activation,are paramount for host defense against pathogen infection.In contrast to canonical and noncanonical inflammasome activation,in this study,heat-killed gram-negative bacteria(HK bacteria)were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes,and they caused a moderate amount of IL-1βto be released from cells.Time course experiments showed that this alternative inflammasome response was finished within a few hours.Further analysis showed that the intrinsically limited NLRP3 inflammasome activation response was due to the negative regulation of caspase-8 by the short isoform of cFLIP(cFLIPs),which was activated by NF-κB.In contrast,overexpressed cFLIPS,but not overexpressed cFLIPL,inhibited the activation of caspase-8 and the release of IL-1βin response to HK bacteria infection in human monocytes.Furthermore,we demonstrated that TAK1 activity mediated the expression of cFLIPs and was upstream and essential for the caspase-8 cleavage induced by HK bacteria in human monocytes.The functional specificity of cFLIPs and TAK1 revealed unique responses of human monocytes to a noninvasive pathogen,providing novel insights into an alternative regulatory pathway of NLRP3 inflammasome activation.

关键词： cFLIPS gram-negative bacteria NLRP3 inflammasome human monocyte

影响多发性骨髓瘤预后的分子生物学异常研究进展

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海南医学院学报 2024年第12期30卷 947-951页

作者：李妙雨高娅娅高广勋解放军空军军医大学西京医院血液内科陕西西安710032 陕西中医药大学陕西咸阳712046

多发性骨髓瘤(multiple myeloma,MM)是一种以单克隆浆细胞异常增生和多灶性骨骼受累为特征的浆细胞肿瘤,多发于中老年人。随着免疫靶向治疗的飞速发展,可用于MM患者的治疗药物及联合方案越来越多样化,MM目前仍不可治愈。近些年由于核型... 详细信息

多发性骨髓瘤(multiple myeloma,MM)是一种以单克隆浆细胞异常增生和多灶性骨骼受累为特征的浆细胞肿瘤,多发于中老年人。随着免疫靶向治疗的飞速发展,可用于MM患者的治疗药物及联合方案越来越多样化,MM目前仍不可治愈。近些年由于核型分析、荧光原位杂交技术、流式细胞术、液体活检等分子生物学检测技术的广泛应用,MM的诊断率大为提高。同时,许多与MM预后相关的基因异常先后被发现。本文旨在总结已知的分子生物学异常与MM预后的关系,为MM患者的诊断、治疗及预后提供新的信息。

关键词：多发性骨髓瘤基因异常预后

线粒体自噬在牙周炎发生发展过程中的研究进展

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国际口腔医学杂志 2024年第1期51卷 68-73页

作者：古丽其合热·阿布来提秦旭朱光勋华中科技大学同济医学院附属同济医院口腔医学中心、华中科技大学同济医学院口腔医学院、口腔颌面发育与再生湖北省重点实验室武汉430030

牙周炎是一种由菌斑生物膜引起牙周支持组织破坏的慢性炎症性疾病,主要以牙龈炎症和牙槽骨进行性破坏为特征。线粒体自噬是通过自噬选择性清除细胞内功能失调或受损的线粒体来调节细胞内稳态的主要机制,在线粒体质量和数量控制中发挥关... 详细信息

牙周炎是一种由菌斑生物膜引起牙周支持组织破坏的慢性炎症性疾病,主要以牙龈炎症和牙槽骨进行性破坏为特征。线粒体自噬是通过自噬选择性清除细胞内功能失调或受损的线粒体来调节细胞内稳态的主要机制,在线粒体质量和数量控制中发挥关键作用。近年来有研究发现:线粒体自噬可以通过抑制牙周炎症反应、降低细胞凋亡、促进牙周韧带干细胞成骨分化等多种途径参与牙周病的发生和发展,为牙周病的治疗提供了有前景的治疗靶点。本文就线粒体自噬的分子机制及其在牙周病发生发展中的作用等方面的研究进展作一综述。

关键词：牙周病线粒体自噬炎症细胞凋亡成骨分化

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中国式现代化的生态意蕴及实践路径

杭州电子科技大学学报（社会科学版） 2024年第1期20卷 55-59页

作者：周光迅刘昱婵杭州电子科技大学马克思主义学院浙江杭州310018 浙江树人大学马克思主义学院浙江杭州310015

作为中国式现代化的科学内涵之一,人与自然和谐共生现代化既是协同推动经济高质量发展和生态环境高水平保护的思想指引,也是全球在人类文明发展新时期要经历的现代化。在生成逻辑上,人与自然和谐共生现代化吸纳和总结了中华传统生态哲... 详细信息

作为中国式现代化的科学内涵之一,人与自然和谐共生现代化既是协同推动经济高质量发展和生态环境高水平保护的思想指引,也是全球在人类文明发展新时期要经历的现代化。在生成逻辑上,人与自然和谐共生现代化吸纳和总结了中华传统生态哲学、马克思主义生态思想、西方生态思潮中的合理养分。基于人与自然和谐共生理念,中国共产党始终坚持以科学的发展观、绿色的生态观和人民至上的价值观为主要内容,具有深厚的生态意蕴。走好中国式现代化新道路,必须坚持将加快社会发展全面绿色转型、强化生态系统综合治理与保护、积极稳妥推进碳达峰碳中和作为基本路径,为中国特色社会主义生态文明建设注入源源不竭的绿色动能,以实现大自然与人类社会的永续发展。

关键词：人与自然和谐共生中国式现代化生态意蕴

The NLRP3 Inflammasome activation in human or mouse cells,sensitivity causes puzzle

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Protein & Cell 2013年第8期4卷 565-568页

作者： Hongbin Wang Liming Mao guangxun meng Unit of Innate Immunity Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200025China Graduate University of Chinese Academy of Sciences Beijing 100039China

SIGNAL 1 ALONE IS ENOUGH TO ACTIVATE THE NLRP3 INFLAMMAOSME IN HUMAN CELLS According to our current understanding,the NLR family,pyrin domain containing 3(NLRP3)infl ammasome activation is generally a two-step process.The fi rst step is priming,in which pathogen associated molecular patterns(PAMPs)such as LPS or pro-inflammatory cytokines such as tumor necrosis factor-α(TNF-α)induced NF-κB activation provides synthesis of pro-IL-1βand NLRP3 proteins.This priming step is considered as signal 1,which makes the cell ready for a second strike to assemble the infl ammasome.Then danger signals such as ATP and MSU provide the signal 2 that promotes formation of the NLRP3 infl ammasome and activates caspase-1.Both of these 2 steps are required in mouse macrophages for the NLRP3 inflammasome activation(Dinarello,2007).

关键词： NLRP3 activation cytokines

Micro/nano metal–organic frameworks meet energy chemistry: A review of materials synthesis and applications

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eScience 2023年第2期3卷 32-59页

作者： Zhenyang meng Ziming Qiu Yuxin Shi Shixian Wang guangxun Zhang Yecan Pi Huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityJiangsu 225002China

Micro/nano metal–organic frameworks(MOFs)have attracted significant attention in recent years due to their numerous unique properties,with many synthetic methods and strategies being reported for constructing MOFs with specific micro/nano structures.In addition,the design of micro/nano MOFs for energy storage and conversion applications and the study of the structure–activity relationship have also become research hotspots.Herein,a comprehensive overview of the recent progress on micro/nano MOFs is presented.We begin with a brief introduction to the various synthesis methods for controlling the morphology of micro/nano MOFs.Subsequently,the structure-dependent properties of micro/nano MOFs as electrode materials or catalysts in terms of batteries,supercapacitors,and catalysis are discussed.Finally,the remaining challenges and future perspectives in this field are presented.Overall,this review is expected to inspire the design of advanced micro/nano MOFs for efficient energy storage and conversion technologies.

关键词： Micro/nano MOFs Materials synthesis Energy storage and conversion Catalysis

TAK1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection

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感染微生物与疾病(英文) 2023年第3期5卷 127-136页

作者： Xiankai Cao Kossiwa C.Kokou Shi Yu mengdan Chen Junling Niu HervéLecoeur Eric Prina Gerald F.Späth guangxun meng The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghaiChina Institute Pasteur Paris City UniversityINSERM U1201Molecular Parasitology and Signalling UnitParisFrance Pasteurien College Soochow UniversitySuzhouChina Nanjing Advanced Academy of Life and Health NanjingChina.

Leishmania parasites mainly infect macrophages and may cause severe immunopathologies in their host,which are called leishman-iases.In the current work,we infected human and mouse macrophages in vitro with Leishmania major,an etiological agent of cu-taneous leishmaniasis,and found that inhibition or deletion of the transforming growth factorβ–activated kinase 1(TAK1)gene re-sulted in increased parasite loads.In vivo,following a challenge with L.major,mice with a macrophage-specific deletion of TAK1 showed increased clinical signs and higher parasite loads compared with wild-type controls.TAK1 deficiency in mouse macro-phages led to biased Th2 cell responses during the acute stage of infection,characterized by a decrease in interferon-γexpression,and increased expression of IL-4,IL-5 and IL-10.Finally,we found that,in the late stage of L.major infection,excessive Th2-related cytokines led to high arginase 1 expression in mouse tissues and a significant reduction of NO production both locally and system-ically,resulting in compromised control of Leishmania.These findings suggest that TAK1 plays a vital role in host resistance to Leish-mania infection.

关键词： TAK1 macrophage Leishmania major arginase 1 nitric oxide

Cellular localization of NLRP3 inflammasome

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Protein & Cell 2013年第6期4卷 425-431页

作者： Yan Wang Chen Yang Kairui Mao Shuzhen Chen guangxun meng Bing Sun Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200025China State Key Laboratory of Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of ScienceShanghai 200031China

Infl ammasome is a large protein complex activated upon cellular stress or microbial infection,which triggers maturation of pro-inflammatory cytokines interleukin-1βand interleukin-18 through caspase-1 activation.Nod-like receptor family protein 3(NLRP3)is the most character-ized infl ammasome activated by various stimuli.However,the mechanism of its activation is unclear and its exact cellular localization is still unknown.We examined the potential co-localization of NLRP3 infl ammasome with mi-tochondria and seven other organelles under adenosine triphosphate,nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal micros-copy approach.Our results revealed that the activated endogenous apoptosis-associated speck-like protein containing a CARD(ASC)pyroptosome forms in the cyto-plasm and co-localizes with NLRP3 and caspase-1,but not with any of the organelles screened.This study indicates that the ASC pyroptosome universally localizes within the cytoplasm rather than with any specifi c organelles.

关键词： NLRP3 inflammasome ASC pyroptosome confocal microscopy cytoplasmic