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Preliminary limits on deviation from the inverse-square law of gravity in the solar system:a power-law parameterization

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Research in Astronomy and Astrophysics 2014年第8期14卷 1019-1028页

作者： meng-yao liu Ze-Hao Zhong Yi-Chen Han Xiao-Yu Wang Zong-Shui Yang Yi Xie School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education

New physics beyond the standard model of particles might cause a deviation from the inverse-square law of gravity. In some theories, it is parameterized by a power-law correction to the Newtonian gravitational force, which might originate from the simultaneous exchange of particles or modified and extended theories of gravity. Using the supplementary advances of the perihelia provided by INPOP 10a （IMCCE, France） and EPM2011 （IAA RAS, Russia） ephemerides, we obtain preliminary limits on this correction. In our estimation, we take the Lense-Thirring effect due to the Sun＇s angular momentum into account. The parameters of the power-law correction and the uncertainty of the Sun＇s quadrupole moment are simultaneously estimated with the method of minimizing X2. From INPOP10a, we find N - 0.605 for the exponent of the power-law correction. However, from EPM2011, we find that, although it yields N = 3.001, the estimated uncertainty in the Sun＇s quadrupole moment is much larger than the value given by current observations. This might be caused by the intrinsic nonlinearity in the power-law correction, which makes the estimation very sensitive to the supplementary advances of the perihelia.

关键词： gravitation- ephemerides- celestial mechanics

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Comprehensive analysis of the relationship between cuproptosisrelated genes and esophageal cancer prognosis

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World Journal of Clinical Cases 2022年第33期10卷 12089-12103页

作者： Hao Xu Qian-Cheng Du Xin-Yu Wang Ling Zhou Jian Wang Ying-Ying Ma meng-yao liu Hua Yu General Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China General Surgery Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China

BACKGROUND Esophageal cancer is one of the most common malignant tumors of the digestive system,with a 5-year survival rate of 15%to 50%.Cuproptosis,a unique kind of cell death driven by protein lipoylation,is strongly connected to mitochondrial *** clinical implications of cuproptosis-related genes in esophageal cancer,however,are mainly *** To identify cuprotosis-related genes that are differentially expressed in esophageal cancer and investigate their prognostic *** With|log fold change|>1 and false discovery rate<0.05 as criteria,the Wilcox test was used to evaluate the differentially expressed genes between 151 tumor tissues and 151 normal esophageal ***-related genes were selected to be linked with prognosis using univariate Cox regression *** were separated into high-and low-expression groups based on their cutoff value of gene expression,and the correlation between the two groups and overall survival or progression-free survival was investigated using the log-rank *** C-index,calibration curve,and receiver operator characteristic(ROC)curve were used to assess a nomogram containing clinicopathological characteristics and cuproptosis-related *** Pyruvate dehydrogenase A1(PDHA1)was found to be highly correlated with prognosis in univariate Cox regression analysis(hazard ratio=22.96,95%confidence interval=3.09-170.73;P=0.002).According to Kaplan-Meier survival curves,low expression of PDHA1 was associated with a better prognosis(log-rank P=0.0007).There was no significant correlation between PDHA1 expression and 22 different types of immune *** necrosis factor superfamily member 15(TNFSF15)(P=3.2×10^(-6);r=0.37),TNFRSF14(P=8.1×10^(-8);r=0.42),H long terminal repeat-associating 2(P=6.0×10^(-8);r=0.42)and galectin 9(P=3.1×10^(-6);r=0.37)were all found to be considerably greater in the high PDHA1 expression group,according to an analysis of genes related to 47 immunological checkp

关键词： Esophageal cancer Cuproptosis Pyruvate dehydrogenase A1 Overall survival Nomogram

Integrative analysis of platelet-related genes for the prognosis of esophageal cancer

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World Journal of Clinical Cases 2022年第33期10卷 12077-12088页

作者： Qian-Cheng Du Xin-Yu Wang Cheng-Kai Hu Ling Zhou Zheng Fu Shun liu Jian Wang Ying-Ying Ma meng-yao liu Hua Yu Department of Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Department of General Surgery Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China

BACKGROUND Every year,esophageal cancer is responsible for 509000 deaths and around 572000 new cases *** esophageal cancer treatment options have advanced,patients still have a dismal 5-year survival *** To investigate the relationship between genes associated to platelets and the prognosis of esophageal *** We searched differentially expressed genes for changes between 151 tumor tissues and 653 normal,healthy tissues using the“limma”*** develop a prediction model of platelet-related genes,a univariate Cox regression analysis and least absolute shrinkage and selection operator Cox regression analysis were carried *** on a median risk score,patients were divided into high-risk and low-risk categories.A nomogram was created to predict the 1-,2-,and 3-year overall survival(OS)of esophageal cancer patients using four platelet-related gene signatures,TNM stages,and pathological ***,the concordance index,receiver operating characteristic curve,and calibration curve were used to validate the *** The prognosis of esophageal cancer was associated to APOOL,EP300,PLA2G6,and VAMP7 according to univariate Cox regression analysis and least absolute shrinkage and selection operator regression *** with esophageal cancer at high risk had substantially shorter OS than those with cancer at low risk,according to a Kaplan-Meier analysis(P<0.05).TNM stage(hazard ratio:2.187,95%confidence interval:1.242-3.852,P=0.007)in both univariate and multivariate Cox regression and risk score were independently correlated with OS(hazard ratio:2.451,95%confidence interval:1.599-3.756,P<0.001).CONCLUSION A survival risk score model and independent prognostic variables for esophageal cancer have been developed using APOOL,EP300,PLA2G6,and *** for esophageal cancer might be predicted using the nomogram based on TNM stage,pathological type,and risk *** nomogram demonstrated strong predictive ability,as shown b

关键词： Esophageal cancer Platelet Gene signature Overall survival Nomogram

Optimizing surgical outcomes for elderly gallstone patients with a high body mass index using enhanced recovery after surgery protocol

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2191-2200页

作者： Yue-Xia Gu Xin-Yu Wang Yang Chen Jun-Xiu Shao Shen-Xian Ni Xiu-Mei Zhang Si-Yu Shao Yu Zhang Wen-Jing Hu Ying-Ying Ma meng-yao liu Hua Yu Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital School of Medicine Tongji UniversityShanghai 200434China Department of Nursing Shanghai Xuhui Central HospitalShanghai 200031China

BACKGROUND Rehabilitation of elderly patients with a high body mass index(BMI)after cholecystectomy carries risks and requires the adoption of effective perioperative management *** enhanced recovery after surgery(ERAS)protocol is a comprehensive treatment approach that facilitates early patient recovery and reduces postoperative *** To compare the effectiveness of traditional perioperative management methods with the ERAS protocol in elderly patients with gallbladder stones and a high *** This retrospective cohort study examined data from 198 elderly patients with a high BMI who underwent cholecystectomy at the Shanghai Fourth People's Hospital from August 2019 to August *** them,99 patients were managed using the traditional perioperative care approach(non-ERAS protocol),while the remaining 99 patients were managed using the ERAS *** indicator data were collected for patients preoperatively,intraoperatively,and postoperatively,and surgical outcomes were compared between the two *** The comparison results between the two groups of patients in terms of age,sex,BMI,underlying diseases,surgical type,and preoperative hospital stay showed no statistically significant ***,the ERAS group had a significantly shorter preoperative fasting time than the non-ERAS group(4.0±0.9 h vs 7.6±0.9 h).Regarding intraoperative indicators,there were no significant differences between the two groups of ***,in terms of postoperative recovery,the ERAS protocol group exhibited significant advantages over the non-ERAS group,including a shorter hospital stay,lower postoperative pain scores and postoperative hunger scores,and higher satisfaction *** readmission rate was lower in the ERAS protocol group than in the non-ERAS group(3.0%vs 8.1%),although the difference was not ***,there were significant differences between the two groups in terms of postoperative nausea and vomit

关键词： Enhanced recovery after surgery protocol Cholecystectomy Rehospitalization rate Postoperative nausea and vomiting Degree of abdominal distension Daily living ability

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui Chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi yao liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu Sha-Sha Cui Ting-Ting Li Xiao-meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

长链非编码RNA SNHG3对人乳腺癌细胞MCF-7增殖、迁移与侵袭的影响

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中国生物工程杂志 2019年第1期39卷 13-20页

作者：万群刘梦瑶夏菁苟理尧唐敏孙恃雷张彦重庆医科大学检验医学院临床检验诊断学教育部重点实验室重庆400016

目的:探讨长链非编码RNA SNHG3对人乳腺癌细胞MCF-7增殖、迁移与侵袭的影响。方法:构建SNHG3过表达质粒,实验分别设置阴性对照组(pcDNA-3. 1+)与SNHG3基因过表达组(pcDNA-3. 1+/SNHG3)。将MCF-7细胞转染对照组质粒和SNHG3过表达质粒,采... 详细信息

目的:探讨长链非编码RNA SNHG3对人乳腺癌细胞MCF-7增殖、迁移与侵袭的影响。方法:构建SNHG3过表达质粒,实验分别设置阴性对照组(pcDNA-3. 1+)与SNHG3基因过表达组(pcDNA-3. 1+/SNHG3)。将MCF-7细胞转染对照组质粒和SNHG3过表达质粒,采用实时定量PCR方法检测SNHG3 mRNA转录水平,Western blot检测MMP9及EMT相关蛋白质水平;集落形成实验检测MCF-7细胞增殖能力;划痕愈合实验检测MCF-7细胞横向迁移能力; Transwell小室实验检测MCF-7细胞纵向迁移能力及侵袭能力。结果:过表达SNHG3后,MCF-7细胞中SNHG3的mRNA水平显著增高(P <0. 001); MCF-7细胞的体外增殖能力明显增加(P <0. 01),迁移(P <0. 01)与侵袭能力(P <0. 001)也显著增强,实时定量PCR,Western blot结果显示SNHG3可激活EMT相关通路。结论:过表达SNHG3可能通过激活EMT通路促进乳腺癌MCF-7细胞的增殖,迁移与侵袭。

关键词：乳腺癌长链非编码RNA SNHG3 增殖迁移侵袭

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling liu Biao meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis