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Journal of Oceanology and Limnology 2024年第2期42卷 408-420页

作者： Zhe CHANG Lina SUN Tengfei LIU meng zhang Keda LIANG Junmin meng Jing WANG School of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Optical remote sensing has been widely used to study internal solitary waves(ISWs).Wind speed has an important effect on ISW imaging of optical remote sensing.The light and dark bands of ISWs cannot be observed by optical remote sensing when the wind is too strong.The relationship between the characteristics of ISWs bands in optical remote sensing images and the wind speed is still unclear.The influence of wind speeds on the characteristics of the ISWs bands is investigated based on the physical simulation experiments with the wind speeds of 1.6,3.1,3.5,3.8,and 3.9 m/s.The experimental results show that when the wind speed is 3.9 m/s,the ISWs bands cannot be observed in optical remote sensing images with the stratification of h_(1)∶h_(2)=7∶58,ρ_(1)∶ρ_(2)=1∶1.04.When the wind speeds are 3.1,3.5,and 3.8 m/s,which is lower than 3.9 m/s,the ISWs bands can be obtained in the simulated optical remote sensing image.The location of the band’s dark and light extremum and the band’s peak-to-peak spacing are almost not affected by wind speed.More-significant wind speeds can cause a greater gray difference of the light-dark bands.This provided a scientific basis for further understanding of ISW optical remote sensing imaging.

关键词： internal solitary wave(ISW) optical remote sensing wind speed characteristics of ISWs bands

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Ischemia-reperfusion injury:molecular mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 558-596页

作者： meng zhang Qian Liu Hui meng Hongxia Duan Xin Liu Jian Wu Fei Gao Shijun Wang Rubin Tan Jinxiang Yuan The Collaborative Innovation Center Jining Medical UniversityJiningShandong 272067China Clinical Medical College Jining Medical UniversityJiningShandong 272067China Second Clinical Medical College Jining Medical UniversityJiningShandong 272067China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Institute of Zoology Chinese Academy of SciencesBeijingChina Department of Physiology Basic medical schoolXuzhou Medical UniversityXuzhou 221004China

Ischemia-reperfusion(I/R)injury paradoxically occurs during reperfusion following ischemia,exacerbating the initial tissue damage.The limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic interventions.The Wnt signaling pathway exhibits extensive crosstalk with various other pathways,forming a network system of signaling pathways involved in I/R injury.This review article elucidates the underlying mechanisms involved in Wnt signaling,as well as the complex interplay between Wnt and other pathways,including Notch,phosphatidylinositol 3-kinase/protein kinase B,transforming growth factor-β,nuclear factor kappa,bone morphogenetic protein,N-methyl-D-aspartic acid receptor-Ca2+-Activin A,Hippo-Yes-associated protein,toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-β,and hepatocyte growth factor/mesenchymal-epithelial transition factor.In particular,we delve into their respective contributions to key pathological processes,including apoptosis,the inflammatory response,oxidative stress,extracellular matrix remodeling,angiogenesis,cell hypertrophy,fibrosis,ferroptosis,neurogenesis,and blood-brain barrier damage during I/R injury.Our comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery,while activation of the non-canonical Wnt pathways exacerbates injury.Moreover,we explore novel therapeutic approaches based on these mechanistic findings,incorporating evidence from animal experiments,current standards,and clinical trials.The objective of this review is to provide deeper insights into the roles of Wnt and its crosstalk signaling pathways in I/R-mediated processes and organ dysfunction,to facilitate the development of innovative therapeutic agents for I/R injury.

关键词： therapeutic reperfusion damage

Insulation Design Rule for a Spacer in SF_(6)/N_(2)-filled DC Gas Insulated Apparatus

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 727-735页

作者： Hongyang Zhou Guoming Ma meng zhang Cong Wang Youping Tu Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

A recurring challenge of a DC SF_(6)/N_(2)-filled GIS/GIL apparatus is the charge accumulation at DC stress.The conventional design rules and knowledge of AC spacers may not be applicable for this new type of apparatus.A novel design rule is proposed considering the effect of accumulated charge on the threshold of electric field strength being resistant to the superposed voltage.A surface charge accumulation simulation model is introduced,and the key parameters in the simulation model are measured.In addition,an experimental platform for a 100 kV spacer flashover test is established.Spacer flashover tests under superimposed voltage with opposing polarities are carried out,and the withstanding voltage of the spacer is obtained.Finally,based on the proposed model,the threshold of the surface electric field strength(tangential component)on the DC spacer in SF_(6)/N_(2) mixed gases is discussed.For a reliable insulation design of a DC GIS/GIL apparatus filled with 0.7 MPa SF_(6)/N_(2),the threshold of surface electric field strength on the DC spacer is 12 kV/mm.The insulation design rule can be referenced in the design of a high-voltage DC SF_(6)/N_(2)-filled GIS/GIL apparatus.

关键词： Charge accumulation DC spacer flashover voltage SF_(6)/N_(2) threshold of surface electric field strength

Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

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Neural Regeneration Research 2024年第11期19卷 2488-2498页

作者： Yuanyuan Ding Yu Sun Hongyan Wang Hongqin Zhao Ruihua Yin meng zhang Xudong Pan Xiaoyan Zhu Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Qingdao Cadre Health Care Service Center The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE^(-/-)mice.However,little is known about the role of lnc_000048 in classically activated macrophage(M1)polarization.In this study,we established THP-1-derived testing state macrophages(M0),M1 macrophages,and alternately activated macrophages(M2).Real-time fluorescence quantitative PCR was used to verify the expression of marker genes and the expression of lnc_000048 in macrophages.Flow cytometry was used to detect phenotypic proteins(CD11b,CD38,CD80).We generated cell lines with lentivirus-mediated upregulation or downregulation of lnc_000048.Flow cytometry,western blot,and real-time fluorescence quantitative PCR results showed that down-regulation of lnc_000048 reduced M1 macrophage polarization and the inflammation response,while over-expression of lnc_000048 led to the opposite effect.Western blot results indicated that lnc_000048 enhanced the activation of the STAT1 pathway and mediated the M1 macrophage polarization.Moreover,catRAPID prediction,RNA-pull down,and mass spectrometry were used to identify and screen the protein kinase RNA-activated(PKR),then catRAPID and RPIseq were used to predict the binding ability of lnc_000048 to PKR.Immunofluorescence(IF)-RNA fluorescence in situ hybridization(FISH)double labeling was performed to verify the subcellular colocalization of lnc_000048 and PKR in the cytoplasm of M1 macrophage.We speculate that lnc_000048 may form stem-loop structure-specific binding and activate PKR by inducing its phosphorylation,leading to activation of STAT1 phosphorylation and thereby enhancing STAT1 pathway-mediated polarization of THP-1 macrophages to M1 and inflammatory factor expression.Taken together,these results reveal that the lnc_000048/PKR/STAT1 axis plays a crucial role in the polarization of M1 macrophages and may be a novel therapeutic target for atherosclerosis alleviation in stroke.

关键词： atherosclerosis inflammation lnc_000048 lncRNA macrophage polarization protein kinase RNA-activated(PKR) STAT1

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LncRNA-CCAT5-mediated crosstalk between Wnt/β-Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity

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Cancer Communications 2024年第1期44卷 76-100页

作者： Chenchen Liu Aiwen Shen Junquan Song Lei Cheng meng zhang Yanong Wang Xiaowen Liu Department of Gastric Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Nephrology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pulmonary Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China

Background:Although the constitutively activated Wnt/β-catenin signaling pathway plays vital roles in gastric cancer(GC)progression,few Wnt inhibitors are approved for clinical use.Additionally,the clinical significance of long non-coding RNAs(lncRNAs)in GC intraperitoneal dissemination(IPD)remains elusive.Here,we investigated the function and therapeutic potential of Wnt-transactivated lncRNA,colon cancer-associated transcript 5(CCAT5),in GC metastasis.Methods:LncRNA-sequencing assay was performed to document abun-dance changes of lncRNAs induced by Wnt family member 3A(Wnt3a)and degradation-resistantβ-catenin(S33Y mutated)in ascites-derived GC cells with low Wnt activity.Luciferase reporter,Chromatin immunoprecipitation(ChIP)-re-ChIP assays were performed to determine how CCAT5 was tran-scribed.The clinical significance of CCAT5 was examined in 2 cohorts of GC patients.The biological function of CCAT5 was investigated through gain-and loss-of-function studies.The molecular mechanism was explored through RNA-sequencing,mass spectrometry,and CRISPR/Cas9-knocknout system.The therapeutic potential of CCAT5 was examined through RNAi-based cell xenograft model and patient-derived xenograft(PDX)model of IPD.Results:WeidentifiedanovelWnt-regulatedlncRNA,CCAT5,whichwastrans-activated by theβ-catenin/transcription factor 3(TCF3)complex.CCAT5 was significantly upregulated in GC and predicted poor prognosis.Functional studies confirmed the promotive role of CCAT5 in GC growth and metastasis.Mechanis-tically,CCAT5 bound to the C-end domain of signal transducer and activator of transcription 3(STAT3)and blocks Src homology 2 domain-containing protein tyrosine phosphatase 1(SHP-1)-mediated STAT3 Y705 dephosphorylation,leading to STAT3 nuclear entry and transactivation,thus accelerating GC progression.Furthermore,we demonstrated that both Wnt3a andβ-catenin acted as activa-tor of STAT3 signaling pathway,and the interplay between CCAT5 and STAT3 was functionally essential for Wnt-drived STAT3 signaling and tumor evolu-tion.Fina

关键词： CCAT5 gastric cancer intraperitoneal dissemination STAT3 Wnt/β-catenin

An analysis of TinyML@ICCAD for implementing AI on low-power microprocessor

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Science China(Information Sciences) 2024年第4期67卷 343-344页

作者： Guoqing LI Jingwei zhang meng zhang Tuo LI Tinghuan CHEN Jun YANG Shandong Yunhai Guochuang Cloud Computing Equipment Industry Innovation Co. Ltd. School of Integrated Circuits Southeast University Shandong Inspur Artificial Intelligence Research Institute Co. Ltd. School of Science and Engineering The Chinese University of Hong Kong

Tiny machine learning(ML) is an important application area of artificial intelligence(AI), which focuses on deploying AI on small hardware platforms with constrained resources [1, 2]. The high-level TinyML contests at high-level conferences promote the development of TinyML areas, such as DAC-SDC [3] and TinyML@ICCAD [4].

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Fire-retardant, anti-dripping, biodegradable and biobased polyurethane elastomers enabled by hydrogen-bonding with cellulose nanocrystals

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Nano Research 2024年第3期17卷 2186-2194页

作者： Yijiao Xue Tianchen zhang Hong Peng Zhewen Ma meng zhang Mark Lynch Toan Dinh Zhezhe Zhou Yonghong Zhou Pingan Song Institute of Chemical Industry of Forest Products Chinese Academy of Forestry(CAF)Nanjing 210042China School of Chemical Engineering The University of QueenslandBrisbaneQld 4072Australia Department of Polymer Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Agriculture and Environmental Science University of Southern QueenslandToowoombaQld 4300Australia Centre for Future Materials University of Southern QueenslandToowoombaQld 4300Australia

Thermoplastic polyurethane(PU)elastomers have attracted significant attention because of their many important industrial applications.However,the creation of fire-retardant and anti-dripping PU elastomers has remained a grant challenge due to the lack of crosslinking and weak interchain interactions.Herein,we report a mechanically robust,biodegradable,fire-retardant,and anti-dripping biobased PU elastomer with excellent biodegradability using an abietic acid-based compound as hard segments and polycaprolactone diol(PCL)as soft segments,followed by physically crosslinking with cellulose nanocrystals(CNC)through dynamic hydrogen-bonding.The resultant elastomer shows the balanced mechanical and fire-retardant properties,e.g.,a tensile strength and break strain of 9.1 MPa and 560%,a self-extinguishing ability(V-0 rating in UL-94 testing),and an anti-dripping behavior.Moreover,the as-developed PU can be completely degraded in 1.0 wt.%lipase solution at 37℃ in 60 days,arising from the catalytic and wicking effect of CNC on PU chains.This work provides an innovative and versatile strategy for constructing robust,fire-retardant,anti-dripping,and biodegradable PU elastomers,which hold great promise for practical applications in electronic and automobile sectors.

关键词： polyurethane elastomers cellulose nanocrystals fire retardancy anti-dripping biodegradation

PSRDP:A Parallel Processing Method for Pulsar Baseband Data

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Research in Astronomy and Astrophysics 2024年第1期24卷 300-310页

作者： Ya-Zhou zhang Hai-Long zhang Jie Wang Xin-Chen Ye Shuang-Qiang Wang Xu Du Han Wu Ting zhang Shao-Cong Guo meng zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

To address the problem of real-time processing of ultra-wide bandwidth pulsar baseband data,we designed and implemented a pulsar baseband data processing algorithm(PSRDP)based on GPU parallel computing technology.PSRDP can perform operations such as baseband data unpacking,channel separation,coherent dedispersion,Stokes detection,phase and folding period prediction,and folding integration in GPU clusters.We tested the algorithm using the J0437-4715 pulsar baseband data generated by the CASPSR and Medusa backends of the Parkes,and the J0332+5434 pulsar baseband data generated by the self-developed backend of the Nan Shan Radio Telescope.We obtained the pulse profiles of each baseband data.Through experimental analysis,we have found that the pulse profiles generated by the PSRDP algorithm in this paper are essentially consistent with the processing results of Digital Signal Processing Software for Pulsar Astronomy(DSPSR),which verified the effectiveness of the PSRDP algorithm.Furthermore,using the same baseband data,we compared the processing speed of PSRDP with DSPSR,and the results showed that PSRDP was not slower than DSPSR in terms of speed.The theoretical and technical experience gained from the PSRDP algorithm research in this article lays a technical foundation for the real-time processing of QTT(Qi Tai radio Telescope)ultra-wide bandwidth pulsar baseband data.

关键词： (stars:)pulsars:general methods:data analysis techniques:miscellaneous

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Biomass-based materials for advanced supercapacitor:principles,progress,and perspectives

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Aggregate 2024年第1期5卷 95-114页

作者： Yaxuan Wang Ting Xu Kun Liu meng zhang Xu-Min Cai Chuanling Si State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin Key Laboratory of Pulp and PaperTianjin University of Science and TechnologyTianjinChina Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjingChina

Supercapacitors exhibit considerable potential as energy storage devices due to their high power density,fast charging and discharging abilities,long cycle life,and ecofriendliness.With the increasing environmental concerns associated with synthetic compounds,the use of environment friendly biopolymers to replace conventional petroleum-based materials has been widely studied.Biomass-based materials are biodegradable,renewable,environment friendly and non-toxic.The unique hierarchical nanostructure,excellent mechanical properties and hydrophilicity allow them to be used to create functional conductive materials with precisely controlled structures and different properties.In this review,the latest development of biomass-based supercapacitor materials is reviewed and discussed.This paper describes the physical and chemical properties of various biopolymers and their impact on supercapacitors,as well as the classification and basic principles of supercapacitors.Then,a comprehensive discussion is presented on the utilization of biomass-based materials in supercapacitors and their recent applications across a range of supercapacitor devices.Finally,an overview of the future prospects and challenges pertaining to the utilization of biomass-based materials in supercapacitors is provided.

关键词： biomass electrodes electrolyte energy storage supercapacitor

Ethnopharmacology, chemical composition and functions of Cymbopogon citratus

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Chinese Herbal Medicines 2024年第3期16卷 358-374页

作者： Xiqin Du meng zhang Shuping Wang Jingyang Li Jingze zhang Dailin Liu Tianjin University of Traditional Chinese Medicine Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd. Characteristic Medical Center of Chinese People's Armed Police Force Department of Pharmacy Logistics College of Chinese People's Armed Police Force

Cymbopogon citratus in the gramineous family,also known as lemongrass(LG),is a perennial herb.LG,a drug and food homologous medicine,has a widely recorded medicinal value and food applications.To date,158 LG compounds have been reported,including terpenoids,flavonoids,phenolic acids.Pharmacological and clinical studies have indicated that LG has antibacterial,neuroprotective,hypoglycemic,hypotensive,anti-inflammatory,and anti-tumor effects.This article reviews LG in ethnopharmacology,chemical composition,pharmacology,food,medicine,and daily chemical applications to provide a basis for the subsequent development of food and medicine.

关键词： chemical composition Cymbopogon citratus (DC.) Stapf drug and food homologous medicine ethnopharmacology lemongrass medicine and food applications