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延平区2006～2009年碘缺乏病监测状况分析

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现代预防医学 2011年第19期38卷 4012-4013页

作者：郑秋英福建省南平市延平区疾病预防控制中心

[目的]掌握延平区碘缺乏病状况,为延平区实现消除碘缺乏病提供依据。[方法]按《福建省碘缺乏病监测实施细则(试行)》(闽卫疾控[2008]40号)规定进行监测。[结果]延平区8～10岁儿童甲状腺肿大率为0.25%,尿碘中位数197.9μg/L;居民碘盐合格... 详细信息

[目的]掌握延平区碘缺乏病状况,为延平区实现消除碘缺乏病提供依据。[方法]按《福建省碘缺乏病监测实施细则(试行)》(闽卫疾控[2008]40号)规定进行监测。[结果]延平区8～10岁儿童甲状腺肿大率为0.25%,尿碘中位数197.9μg/L;居民碘盐合格率97.57%。[结论]各项防治指标已达到消除碘缺乏病目标县级考核标准。

关键词：碘缺乏病监测碘盐监测 8~10岁儿童居民

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安乐死与临终关怀的和谐统一

中国卫生事业管理 2011年第3期28卷 204-206页

作者：孟晶秋南京中医药大学经贸管理学院江苏南京210005

安乐死与临终关怀是两个不同的概念,二者既是对立又是统一的。文章通过对我国安乐死与临终关怀的分析指出,应积极推出安乐死方面的法律法规,同时高度重视并积极推进临终关怀制度,使二者和谐统一,使社会更加和谐。

关键词：安乐死临终关怀统一和谐

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持留态结核分枝杆菌的研究进展

中华结核和呼吸杂志 2010年第3期33卷 212-213页

作者：李强高孟秋北京市结核病胸部肿瘤研究所结核科 101149

结核病的易复发性和耐药结核病的流行是结核病控制面临的两大难题。持留态MTB对药物处于耐受状态，这是导致结核病病程迁延和复发的重要原因，而结核病病程迁延又增加了耐药MTB产生的机会。现就持留态MTB的研究进展进行综述。

关键词：结核分枝杆菌结核病控制耐药结核病病程迁延 MTB 复发性

Origin and molecular specification of oligodendrocytes in the spinal cord

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Origin and molecular specification of oligodendrocytes in th...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： meng-Sheng qiu College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou,China

＜正＞Myelin is critical for the rapid conduction of action potentials in the vertebrate nervous *** oligodendrocyte is the cell type responsible for producing myelin and ensheathing axons in central nervous system （CNS）.During early neural development,oligodendrocyte progenitor cells（OPCs） can be produced from a small number of neuroepithelial cells in both dorsal and ventral spinal cords,and both subpopulations of oligodendrocytes can contribute to axonal myelination during development and remyelination after *** of their embryonic origins,the development of OPCs appear to be regulated by the same set of regulatory *** Olig2 is essential for the initial specification of OPC cells,the terminal differentiation of OPCs is controlled by the Sox10 and Nkx2.2 transcription *** recent studies revealed a stage-dependent regulation of oligodendrocyte differentiation by Nkx2.2 homeodomain transcription *** myelination process is highly regulated by a number of extrinsic and intrinsic mechanisms during normal development of the oligodendrocyte *** several key factors have been identified to be critical for axonal myelination in the peripheral nervous system,the molecular control of CNS myelination has remained a *** this talk,I will present evidence that nectin-like cell adhesion molecules（Necl） and receptor molecules may participate in early CNS myelination and possibly in myelin regenerative process as well.

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来源： cnki会议评论

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神经干细胞在治疗脑缺血性疾病中的应用

上海交通大学学报（医学版） 2011年第2期31卷 238-242页

作者：周秋梦仲骏上海交通大学医学院附属新华医院神经外科上海200092

由于中枢神经系统对于缺血、缺氧等外界因素十分敏感,脑缺血性疾病的治疗一直是临床上的难题。大量研究表明,神经干细胞在中枢神经系统损伤后有再生和分化的潜能,脑组织神经元可能并不属于终末分化细胞,这为临床治疗脑缺血性疾病带来希... 详细信息

由于中枢神经系统对于缺血、缺氧等外界因素十分敏感,脑缺血性疾病的治疗一直是临床上的难题。大量研究表明,神经干细胞在中枢神经系统损伤后有再生和分化的潜能,脑组织神经元可能并不属于终末分化细胞,这为临床治疗脑缺血性疾病带来希望。文章就神经干细胞在治疗脑缺血性疾病中的应用作一综述。

关键词：神经干细胞脑缺血生长因子脊髓电刺激脑血流量

Diagnostic Value of Cerebrospinal Fluid *** for Tuberculousis Meningitis in China

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Biomedical and Environmental Sciences 2017年第9期30卷 681-684页

作者： LI Xue Lian XIE Na WANG Song Wang WU Qian Hong MA Yan SHU Wei CHEN Hong Mei ZHANG Li Qun WU Xiao Guang MA Li Ping CHE Nan Ying GAO meng qiu Beijing Chest Hospital Capital Medical UniversityBeijing 101149China Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149China Administration Office Clinical Center on Tuberculosis ControlChinese Center for Disease Control and PreventionBeijing 101149China Public Health Monitor and Information Service Center Chinese Center for Disease Control and PreventionBeijing 102206China Department of Tuberculosis Prevention and Treatment HosDital of Shanxi Province.Xian 7101130.Shanxi China

The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐*** test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐*** test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value（PPV）, and negative predictive value（NPV）. A receiver operating characteristic（ROC） curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐*** test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients（54.2%） of the 96 enrolled patients. The area under the curve（AUC） was 0.910, and the sensitivities of CSF T‐*** for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐*** test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.

关键词： T‐SPOT TB Tuberculous meningitis Cerebrospinal fluid Diagnosis

结肠癌奥沙利铂耐药细胞系的建立及其生物学特性的研究(英文)

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Chinese Journal of Cancer 2010年第7期29卷 661-667页

作者：刘桢邱萌唐秋琳 Department of Medical Oncology West China HospitalSichuan University The Laboratory of Signal Transduction & Molecular Targeting Therapy State Key Laboratory of BiotherapyWest China HospitalSichuan University

Background and Objective:Chemotherapy is the main treatment for colon cancer,while multidrugresistance is the main reason for chemotherapy failure and tumor *** study was to establish two oxaliplatinresistant colon cancer cell lines and evaluate their biological *** hods:Oxaliplatin-resistant colon cancer cell lines SW620/L-OHP and lovo/L-OHP were established in vitro by continuous exposure to oxaliplatin(L-OHP) of low and gradually increased *** curve,cross-resistance and resistance index of the oxaliplatin-resistant cell lines to various anti-cancer agents were determined by CCK8 *** expressions of P-glycoprotein(P-gp),multidrugresistance protein 1(MRP1) and MRP2 were detected by Western *** cycle distribution as well as the expression of CD133 and CD44 were measured by flow *** s:It took 10 months to establish the SW620/L-OHP and LoVo/L-OHP cell lines with stable resistance to ***-resistance to 5-fluorouracil,etoposide,cisplatin,vincristine and epirubicin but not to paclitaxel was *** doubling time,higher proportion of cells in G0/G1 phase and lower proportion in G2/M phase were observed in the two oxaliplatin-resistant cell lines compared with their parental cell *** expression of MRP2 in the oxaliplatin-resistant cells was up-regulated,while those of P-gp and MRP1 had no significant ***133 was overexpressed while CD44 level remained unchanged in SW620/L-OHP and LoVo/L-OHP ***:SW620/L-OHP and LoVo/L-OHP cell lines show a typical and stably resistant phenotype and may be used as research models.

关键词：奥沙利铂生物学特性细胞株结肠癌 CD44 流式细胞仪气象部门生长曲线

人工原子间耦合:超构表面调控电磁波的新自由度

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中国光学 2021年第4期14卷 717-735页

作者：林婧李琦邱孟何琼周磊复旦大学物理学系表面物理国家重点实验室上海200438

近年来,纳米光学体系中共振体间耦合引起了人们的广泛关注。相对于单一光子共振结构体系,由多个光子共振体组成的复杂耦合体系有着更大的调控自由度和更令人着迷的现象。然而,相比人们在实验方面取得的进步,对于耦合问题的理论描述仍远... 详细信息

近年来,纳米光学体系中共振体间耦合引起了人们的广泛关注。相对于单一光子共振结构体系,由多个光子共振体组成的复杂耦合体系有着更大的调控自由度和更令人着迷的现象。然而,相比人们在实验方面取得的进步,对于耦合问题的理论描述仍远未令人满意。本文从少体问题到周期性超构表面,从光子封闭体系到开放体系,系统介绍了多种处理共振体间耦合的理论工具,以及如何利用这些工具设计具有特定电磁波调控功能的新型超构表面。本文将着重展示本研究团队近些年在这一领域的研究进展,为相关领域研究人员提供指引与参考。

关键词：超构表面超构材料人工原子耦合紧束缚近似理论角度色散开放体系

Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 564-569页

作者： Hui Cao, Jia Xu, Hua Liu, Fang-Bin meng, Jiang-Feng qiu and Zhi-Yong Wu Department of Surgery, Renji Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200127, China Department of Surgery Renji Hospital College of Medicine Shanghai Jiaotong University Shanghai 200127 China. xujia201800@***

BACKGROUND : The importance of nitric oxide (NO) in the pathogenesis of portal hypertension (PHT) has been extensively studied, but whether or not prostacyclin (PGI2) plays a role in formation and development of hyperdynamic circutatory state in PHT has not been verified. The present study was undertaken to investigate the possible interaction between prostacyclin (PGI2) and nitric oxide (NO) in the hyperdynamic circulatory state of rats with chronic portal hypertension (PHT), by measuring the hemodynamic changes and expression of cyclooxygenase (COX) mRNA in vessels and small intestine after administration of Nω- nitro-L-arginine (L-NNA) or indomethacin (INDO) either in the short-term (7 days) or long-term (15 days). METHODS: Ninety-seven male Sprague-Dawley rats were divided into three groups: intrahepatic portal hypertension (IHPH) induced by injection of CCl4, prehepatic portal hypertension (PHPH) induced by partial stenosis of the portal vein, and sham-operated controls (SO). Animals of each group received L-NNA or INDO either for 7 or 15 days, with saline as control. Splanchnic hemodynamics was measured by the radioactive microsphere technique. The concentration of NO in serum was determined as the nitrate; nitrite ratio (NO2-/NO3-, μmol/L) by a colorometric method, and that of PGI2 was measured by specific radioimmunoassay for its stable hydrolysis product 6-keto-PGF1α (pg/ml). The reverse transcription- polymerase chain reaction measured the levels of COX-1 mRNA in the superior mesenteric artery, thoracic aorta, and small intestine of these ***: Compared with SO rats, COX-1 mRNA expression and the concentrations of plasma 6-keto- PGF1α and serum NO2-/NO3- were enhanced in both IHPH and PHPH rats; splanchnic vascular resistance (SVR) decreased, but portal venous inflow (PVI) markedly increased (P<0.05). Seven or 15 days of L-NNA treatment reduced COX-1 mRNA expression in these vessels and the small intestine, concomitant with a significant decrease i

关键词： portal hypertension hyperhemodynamics prostacyclin cyclooxygenase nitric oxide