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心内骨水泥栓塞1例

医学影像学杂志 2024年第9期34卷 179-180页

作者：张文婧孟蕾刘村山东第二医科大学医学影像学院山东潍坊261053 山东第一医科大学附属中心医院超声科山东济南250013

患者女,83岁。自述扭伤致胸、背部疼痛,活动受限一周余,于2020年6月28日入院检查。一般情况:神志清,精神可,强迫体位,查体合作,全身皮肤、黏膜无黄染,未触及肿大淋巴结。头颅无畸形,双侧瞳孔等大等圆,对光及调节反射正常存在。双侧胸廓... 详细信息

患者女,83岁。自述扭伤致胸、背部疼痛,活动受限一周余,于2020年6月28日入院检查。一般情况:神志清,精神可,强迫体位,查体合作,全身皮肤、黏膜无黄染,未触及肿大淋巴结。头颅无畸形,双侧瞳孔等大等圆,对光及调节反射正常存在。双侧胸廓对称无畸形,胸廓挤压试验阴性,未闻及干湿啰音,心前区无隆起,心界不大,各瓣膜听诊区未闻及杂音,腹部平软,无压痛反跳痛。专科检查:脊柱腰段生理弯曲存在,未见明显畸形,前屈后伸活动受限,四肢及躯干感觉无明显异常,四肢肌力、肌张力、肌容积正常,深、浅反射存在,病理反射阴性。DR、CT提示:T9椎体压缩性骨折(图1),胸、腰椎MRI:T9椎体新鲜压缩性骨折;腰椎退行性改变。

关键词：心内骨水泥栓塞超声心动图并发症

F-box and leucine-rich repeat 6 promotes gastric cancer progression via the promotion of epithelial-mesenchymal transition

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 490-503页

作者： lei meng Yu-Ting Hu A-Man Xu Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Immunology College of Basic MedicineAnhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND F-box and leucine-rich repeat 6(FBXL6)have reportedly been associated with several cancer ***,the role and mechanisms of FBXL6 in gastric cancer(GC)require further *** To investigate the effect of FBXL6 in GC tissues and cells and the underlying *** TCGA and GEO database analysis was performed to evaluate the expression of FBXL6 in GC tissues and adjacent normal *** transcription-quantitative polymerase chain reaction,immunofluorescence,and western blotting were used to detect the expression of FBXL6 in GC tissue and cell *** clone formation,5-ethynyl-2’-deoxyuridine(EdU)assays,CCK-8,transwell migration assay,and wound healing assays were performed to evaluate the malignant biological behavior in GC cell lines after transfection with FBXL6-shRNA and the overexpression of FBXL6 ***,in vivo tumor assays were performed to prove whether FBXL6 promoted cell proliferation in *** FBXL6 expression was upregulated more in tumor tissues than in adjacent normal tissues and positively associated with clinicopathological *** outcomes of CCK-8,clone formation,and Edu assays demonstrated that FBXL6 knockdown inhibited cell proliferation,whereas upregulation of FBXL6 promoted proliferation in GC ***,the transwell migration assay revealed that FBXL6 knockdown suppressed migration and invasion,whereas the overex pression of FBXL6 showed the opposite *** the subcutaneous tumor implantation assay,it was evident that the knockdown of FBXL6 inhibited GC graft tumor growth in *** blotting showed that the effects of FBXL6 on the expression of the proteins associated with the epithelial-mesenchymal transition-associated proteins in GC *** Silencing of FBXL6 inactivated the EMT pathway to suppress GC malignancy in ***6 can potentially be used for the diagnosis and targeted therapy of patients with GC.

关键词： Gastric cancer F-box and leucine-rich repeat 6 Invasion Epithelial-mesenchymal transition Metastasis

“钢结构”课程中“教赛融合”教学模式探索——以鲁东大学为例

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教育教学论坛 2024年第17期 165-168页

作者：孟雷范庆来贾淑娟鲁东大学土木工程学院山东烟台264025

在新工科背景下,卓越工程师的培养更突出创新性和实践性,以满足社会人才需要。以鲁东大学为例,结合结构设计竞赛模式,对“钢结构”课程进行教学改革,对教赛融合的培养模式和评价体系进行探索,提出“三位一体”的培养模式和“六位一体”... 详细信息

在新工科背景下,卓越工程师的培养更突出创新性和实践性,以满足社会人才需要。以鲁东大学为例,结合结构设计竞赛模式,对“钢结构”课程进行教学改革,对教赛融合的培养模式和评价体系进行探索,提出“三位一体”的培养模式和“六位一体”的评价体系。根据课程体系,结合结构竞赛模式,建立了三个课程案例库。通过课程教学改革,形成高起点、高利用率、受益面广的学生自主学习、实践、创新的教学模式,加强培养学生的创新能力和实践能力,构建学生自主创新的拔尖创新人才培养模式,为竞赛输出优秀人才,培养具有综合素质的卓越工程师。

关键词：钢结构教赛融合 “三位一体”培养模式 “六位一体”评价

Effects of long-term amendment of organic manure and nitrogen fertilizer on nitrous oxide emission in a sandy loam soil

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Journal of Environmental Sciences 2007年第2期19卷 185-193页

作者： DING Wei-xin meng lei CAI Zu-cong HAN Feng-xiang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China College of Agriculture South China University of Tropical Agriculture Danzhou 571737 China Department of Plant and Soil Sciences Mississippi State University StarkviUe MS 39759 USA

To understand the effects of long-term amendment of organic manure and N fertilizer on N2O emission in the North China Plain, a laboratory incubation at different temperatures and soil moistures were carried out using soils treated with organic manure （OM）, half organic manure plus half fertilizer N （HOM）, fertilizer NPK （NPK）, fertilizer NP （NP）, fertilizer NK （NK）, fertilizer PK （NK） and control （CK） since 1989. Cumulative N2O emission in OM soil during the 17 d incubation period was slightly higher than in NPK soil under optimum nitrification conditions （25℃ and 60% water-filled pore space, WFPS）, but more than twice under the optimum denitrification conditions （35℃ and 90% WFPS）. N2O produced by denitrification was 2.1-2.3 times greater than that by nitrification in OM and HOM soils, but only 1.5 times greater in NPK and NP soils. These results implied that the long-term amendment of organic manure could significantly increase the N2O emission via denitrification in OM soil as compared to NPK soil. This is quite different from field measurement between OM soil and NPK soil. Substantial inhibition of the formation of anaerobic environment for denitrification in field might result in no marked difference in N2O emission between OM and NPK soils. This is due in part to more rapid oxygen diffusion in coarse textured soils than consumption by aerobic microbes until WFPS was 75% and to low easily decomposed organic C of organic manure. This finding suggested that addition of organic manure in the tested sandy loam might be a good management option since it seldom caused a burst of N2O emission but sequestered atmospheric C and maintained efficiently applied N in soil.

关键词： denitrification N fertilizer nitrification N2O emission organic manure

Polymer electrolytes reinforced by 2D fluorinated filler for all-solidstate Li-Fe-F conversion-type lithium metal batteries

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Nano Research 2023年第6期16卷 8469-8477页

作者： meng lei Xiaoxue Wu Yangyang Liu Keyi Chen Jiulin Hu Chilin Li State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The polyethylene oxide(PEO)based solid-state batteries are considered as promising candidates for the next-generation Li metal batteries with high energy density and ***,the low Li-ion conductivity and high-voltage endurability hinder the further applications of PEO-based *** overcome these issues,herein two-dimensional(2D)CeF_(3)nanoplates with maximally exposed[001]crystal faces are introduced into the PEO matrix to expand the electrochemical window and improve Liion conduction and *** optimized crystal shape and crystal face anisotropy of CeF_(3)nanoplate filler reduce the crystallinity of composite solid polymer electrolyte(CSPE)via its Lewis acid-base interaction with ether oxygen of *** Liaffinity[100]and Li-repellent[001]crystal faces of CeF_(3)nanoplates synergistically realize the dissociation of lithium bis(trifluoromethanesulfonyl)imide(LiTFSI),fast Li-adsorption/desorption,and Li+*** optimized CSPE-0.1CeF_(3)membrane enables the achievement of Li metal batteries with high endurability and stability,from the kinetically favorable Li/Li symmetric cells with long-term cycling over 8000 *** highly reversible Li/LiFePO_(4) cells exhibit a capacity retention of 109.2 mAh·g^(−1)after 1000 cycles at 1 C,corresponding to a low capacity fading rate of 0.026%per *** conversion-type allsolid-state Li/CSPE-0.1CeF_(3)/FeF_(3)cells show a high reversible capacity of 201.9 mAh·g^(−1)after long-term 600 cycles and of 231.1 mAh·g^(−1)at an ultra-high rate of 5 C.

关键词： Polymer electrolytes 2D fluoride filler solid-state batteries Li-Fe-F conversion cathodes Li metal anodes

槐角提取物对雌激素缺乏性骨质疏松小鼠牙槽骨骨量的影响

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上海口腔医学 2024年第3期33卷 255-259页

作者：林惠高云飞卫超王梦蕾马旭辉上海交通大学医学院附属儿童医院口腔科上海200062 上海市第八人民医院口腔科上海200030 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011

目的:探讨槐角提取物对雌激素缺乏性骨质疏松小鼠牙槽骨骨量的影响。方法:6周龄雌性未孕野生型C57BL/6J小鼠,随机分为假手术组、卵巢切除(ovariectomy,OVX)组和OVX+槐角提取物组。OVX组和OVX+槐角提取物组小鼠摘除双侧卵巢,按照每次150 ... 详细信息

目的:探讨槐角提取物对雌激素缺乏性骨质疏松小鼠牙槽骨骨量的影响。方法:6周龄雌性未孕野生型C57BL/6J小鼠,随机分为假手术组、卵巢切除(ovariectomy,OVX)组和OVX+槐角提取物组。OVX组和OVX+槐角提取物组小鼠摘除双侧卵巢,按照每次150 mg/kg剂量槐角提取物对OVX+槐角提取物组小鼠进行灌胃处理,每周3次,连续给药4周,其余2组小鼠同期给予等体积生理盐水灌胃。每周测量体重3次,4周后以micro-CT检测小鼠牙槽骨骨微参数。采用GraphPad Prism 9软件对数据进行处理分析。结果:与假手术组相比,OVX组小鼠牙槽骨术后1个月骨小梁相关参数显著下降(P0.05);但骨小梁面积体积比(bone volume fraction,BV/TV)和骨小梁宽度(trabecular thickness,***)尚未完全恢复到假手术组水平(P<0.05)。结论:槐角提取物能有效增加雌激素缺乏而减小的牙槽骨骨量,可作为治疗绝经性牙槽骨骨质疏松症的潜在药物之一。

关键词：槐角提取物卵巢切除牙槽骨骨质疏松

Environmental risk assessment of industrial byproduct gypsum utilized for flling abandoned mines

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International Journal of Coal Science & Technology 2022年第4期9卷 214-225页

作者： XueHong Du Xiangdong Li Qiyan Feng lei meng Yue Sun School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China The National and Local Joint Engineering Laboratory of Internet Application Technology On Mine China University of Mining and TechnologyXuzhou 221008Jiangsu ProvinceChina IoT Perception Mine Research Center China University of Mining and TechnologyXuzhou 221008Jiangsu ProvinceChina Jiangsu Vocational Institute of Architectural Technology No.26 Xueyuan RoadXuzhou 221433China

In response to the basic policy of green and low-carbon circular development to solve resource,environmental and ecological problems,gypsum is considered to be a flling material for mine *** explore the potential risks of gypsum to the groundwater environment due to the backflling of abandoned mines,a sequential batch leaching experiment was carried out in this paper,which used three types of industrial waste gypsum,namely,phosphorus gypsum(PG),titanium gypsum(TG)and fue gas desulfurization gypsum(FGDG).COMSOL Multiphysics 5.4 software was used to simulate and solve the migration process of the leached metal elements in the mine foor when these three gypsum types were used as flling materials to observe the concentration distributions and difusion distances of the metal elements from these three gypsum types in the mine *** results show that(1)during repeated contact of the three types of industrial waste gypsum with the leaching medium,the pH levels changed,and the changes in pH afected the leaching patterns for the heavy metal elements in the gypsum.(2)Based on the concentrations of the metal elements that were leached from the three types of gypsum,it can be determined that these three types of gypsum are not classifed as hazardous solid wastes,but they cannot be ruled out with regard to their risk to the groundwater environment when they are used as mine flling materials.(3)When the three types of gypsum are used as flling materials,the concentration distributions of the metal elements and their migration distances all exhibit signifcant changes over *** concentration distributions,difusion rates and migration distances of the metal elements from the diferent gypsum types are afected by their initial concentrations in the *** maximum migration distances of Zn in the foor from the PG,FGDG and TG are 8.2,8.1 and 7.5 m,respectively.

关键词： Industrial solid waste gypsum Coal mine back-flling Leaching of metal elements Patterns of migration

Species-specific and generalized allometric biomass models for eight Fagaceae species in the understory of evergreen broadleaved forests in subtropical China

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Journal of Forestry Research 2024年第4期35卷 156-170页

作者： Shengwang meng Qianyanzhou Ecological Research Station Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101People’s Republic of China

Quantifying the biomass of saplings in the regeneration component is critical for understanding biogeochemical processes of forest ***,accurate allometric equations have yet to be developed in sufficient *** develop species-specific and generalized allometric equations,154 saplings of eight Fagaceae tree species in subtropical China’s evergreen broadleaved forests were *** dendrometric variables,root collar diameter(d),height(h),and crown area(ca)were applied in the model by the weighted nonlinear seemingly unrelated regression *** only d as an input variable,the species-specific and generalized allometric equations estimated the aboveground biomass reasonably,with R _(adj)^(2) values generally>*** h and/or ca improved the fitting of some biomass components to a certain *** equations showed a relatively large coefficient of variation but comparable bias to species-specific *** in the absence of species-specific equations at a given location are generalized equations for mixed species *** developed regression equations can be used to accurately calculate the aboveground biomass of understory Fagaceae regeneration trees in China’s subtropical evergreen broadleaved forests.

关键词： Allometry Aboveground biomass Additivity Regeneration Subtropical China

At FH16, an Arabidopsis Type II Formin, Binds and Bundles both Microflaments and Microtubules, and Preferentially Binds to Microtubules

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Journal of Integrative Plant Biology 2013年第11期55卷 1002-1015页

作者： Jiaojiao Wang Yi Zhang Jing Wu lei meng Haiyun Ren The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University

Formins are well-known regulators that participate in the organization of the actin cytoskeleton in organisms. The Arabidopsis thaliana L. genome encodes 21 formins, which can be divided into two distinct subfamilies. However, type II formins have to date been less well characterized. Here, we cloned a type II formin, AtFH16, and characterized its biochemical activities on actin and microtubule dynamics. The results show that the FH1 FH2 structure of AtFH16 cannot nucleate actin polymerization efficiently, but can bind and bundle microfilaments. AtFH16 FHIFH2 is also able to bind and bundle microtubules, and preferentially binds microtubules over microfilaments in vitro, in addition, AtFH16 FHIFH2 co-localizes with microtubules in onion epidermal cells, indicating a higher binding affinity of AtFH16 FHIFH2 for microtubules rather than microfilaments in vivo. In conclusion, AtFH16 is able to interact with both microfilaments and microtubules, suggesting that AtFH16 probably functions as a bifunctional protein, and may thus participate in plant cellular processes.

关键词： Actin filament Arabidopsis cytoskeleton formin microtubule.