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Incidence, mortality, and risk factors of immunotherapy-associated hepatotoxicity: A nationwide hospitalization analysis

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Liver Research 2021年第1期5卷 28-32页

作者： Simcha Weissman Saad Saleem Sachit Sharma menashe krupka Faisal Inayat Muhammad Aziz James H.Tabibian Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJUSA Department of Medicine Sunrise Hospital and Medical CenterLas VegasNVUSA Department of Medicine University of Toledo Medical CenterToledoOHUSA Department of Medicine Westchester Medical CenterValhallaNYUSA Department of Medicine Allama Iqbal Medical CollegeLahorePakistan Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOHUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA David Geffen School of Medicine at UCLA Los AngelesCAUSA

Background and aims Anti-neoplastic immunotherapy has revolutionized cancer management;however,its safety profile with respect to liver-related injury remains largely ***,we analyzed a United States national database to determine the incidence,mortality,and predictors of hepatotoxicity in the setting of anti-neoplastic *** This was a nationwide retrospective study of hospital encounters from 2011 to 2014 using the National Inpatient Sample(NIS)*** utilized the International Classification of Diseases,Ninth Revision(ICD-9)coding system to identify all adult patients who underwent anti-neoplastic immunotherapy during *** primary outcome was the incidence of hepatotoxicity during the same *** outcomes included in-hospital mortality as well as socioeconomic and ethno-racial predictors of *** were performed using IBM SPSS Statistics *** The sample included 3002 patients who underwent inpatient anti-neoplastic *** incidence of hepatotoxicity was 10.1%,which was significantly higher as compared to a matched inpatient population(adjusted odds ratio(aOR)4.93,95%confidence interval(CI):3.80–6.40,P=0.001).No significant mortality difference was seen in those that developed hepatotoxicity compared to those who did not(aOR 0.47,95%CI:0.03–8.03,P=0.612).Age under 60(aOR 1.56,95%CI:1.23–1.78,P=0.050)and white race(aOR 1.85,95%CI:1.35–2.04,P<0.010)were independent risk factors for developing immunotherapy-associated *** In this large,nationwide database analysis,we found that anti-neoplastic immunotherapy was associated with a nearly five-fold risk of in-hospital hepatotoxicity as compared to a matched inpatient population,though without an associated mortality ***,younger age and white race were identified as predictors of immunotherapy-associated *** vigilance and prospective investigation of the

关键词： Hepatotoxicity Tumor immunotherapy Liver enzymes Outcomes Risk factors Mortality

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Propofol sedation in routine endoscopy:A case series comparing target controlled infusion vs manually controlled bolus concept

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 11-17页

作者： Riad Sarraj Lorenz Theiler Nima Vakilzadeh Niklas krupka Reiner Wiest Department of Visceral Surgery and Medicine Inselspital University HospitalBern 3010Switzerland Clinic for Anesthesia PerioperativeEmergency&Intensive Care MedicineKantonsspital AarauAarau 5001Switzerland Department of Nephrology and Hypertension University Hospital LausanneLausanne 1011Switzerland

BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or *** To assess safety and performance of propofol TCI sedation in comparison with nurse-administered *** Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with *** were matched for age and endoscopic *** recorded time of sedation and endoscopy,dosage of medication and adverse *** There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both *** differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse *** This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of *** may translate into less adverse ***,further and randomized trials need to confirm this trend.

关键词： Sedation Endoscopy Propofol Target controlled infusion Non-anaesthesiologist propofol sedation Adverse event

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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Radioisotope production using lasers:From basic science to applications

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Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.L.Andreoli M.Huault H.Larreur D.Singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.La Cognata S.Palmerini T.Carriere M.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal M.krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

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Investigation of the tribological performance of ionic liquids in non-conformal EHL contacts under electric field activation

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Friction 2020年第5期8卷 982-994页

作者： Michal MICHALEC Petr SVOBODA Ivan krupka Martin HARTL Aleksandar VENCL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Central European Institute of Technology Brno University of TechnologyBrno 61200Czech Republic Faculty of Mechanical Engineering University of BelgradeBelgrade 11120Serbia South Ural State University Chelyabinsk 454080Russia

Real-time external alteration of the internal properties of lubricants is highly desirable in all mechanical systems. However, fabricating a suitable and effective smart lubricant is a long-lasting experimental process. In this study, the film thickness and frictional response of ionic liquid-lubricated non-conformal contacts to an electric field excitation under elastohydrodynamic conditions were examined. Film thickness was evaluated using a "ball-on-disc" optical tribometer with an electric circuit. Friction tests were carried on a mini traction machine (MTM) tribometer with a "ball-on-disc" rotation module and an electric circuit for contact area excitation. The results demonstrate that there is a difference in the behaviour of the ionic liquid during electric field excitation at the evaluated film thicknesses. The results of evaluated film thicknesses demonstrate that there is a difference in the behaviour of the ionic liquid during electric field excitation. Therefore, the ionic liquids could be a new basis for the smart lubrication of mechanical components. Moreover, the proposed experimental approach can be used to identify electrosensitive fluids.

关键词： friction thin film lubrication electro-rheological fluid smart fluid lubrication

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Lubricant flow in thin-film elastohydrodynamic contact under extreme conditions

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Friction 2016年第4期4卷 380-390页

作者： P.SPERKA I.krupka M.HARTL Faculty of Mechanical Engineering Brno University of Technology Technicka 2896/2 Brno 61669 Czech Republic

To further extend knowledge about fluid film friction in elastohydrodynamic contact, it is important to examine how lubricant flows. In this paper, several film thickness results obtained by interferometry technique for different kinds of experiments were analyzed and discussed based on lubricant flow continuity. Results of two steady-state and two transient experiments are presented. Possible speed profiles that can explain observed film thickness distributions were suggested. It is shown that major part of present experiments can be explained by a single speed profile known as a plug flow. This finding is in contradiction to usual linear speed profile predicted by Reynolds equation.

关键词： fluid film friction speed profile flow rate continuity lubricant rheology plug flow

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Running-in friction of hip joint replacements can be significantly reduced:The effect of surface-textured acetabular cup

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Friction 2020年第6期8卷 1137-1152页

作者： David NECAS Hatsuhiko USAMI Tatsuya NIIMI Yoshinori SAWAE Ivan krupka Martin HARTL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Kanefusa Corporation Nagoya 480-0192Japan Faculty of Engineering Kyushu UniversityFukuoka 819-0395Japan

Hip joint replacements represent the most effective way of treatment for patients suffering from joint *** the rapid improvement of implant materials over the last few decades,limited longevity associated with wear-related complications persists as the main ***,improved tribological perfor-mance is required in order to extend the service life of *** effect of surface texturing of ultra-high molecular weight polyethylene(UHMWPE)acetabular cup was investigated in the present *** tilling method was utilized for manufacturing the dimples with controlled diameter and depths on the contact surface of the *** experiments with four commercial femoral components and two model lubricants were *** main attention was paid to a coefficient of friction considering the differences between the original and the dimpled *** showed remarkable lowering of friction,in *** on the simulated human synovial fluid,friction was reduced by 40%(alumina ceramic),38.8%(zirconia toughened ceramic),25.5%(metal),and 9.9%(oxinium).In addition,the dimples helped to keep the friction stable without *** conclude,the paper brings a new insight into frictional behaviour of the hip replacements during running-in phase which is essential for overall implant *** is believed that proper surface texturing may rapidly improve the life quality of millions of patients and may lead to considerable financial savings.

关键词： hip joint replacement friction texturing dimple longevity

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Calculated Lattice Energies of Energetic Materials in a Prediction of their Heats of Fusion and Sublimation

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含能材料 2002年第1期10卷 27-33页

作者： Svatopluk Zeman, Miloslav krupka (Department of Theory and Technology of Explosives,University of Pardubice CZ 532 10 Pardubice, Czech Republic) Department of Theory and Technology of Explosives University of Pardubice CZ-532 10 Pardubice Czech Republic

The paper specifies an unambiguous basic relationship between the published results of ab initio calculations of lattice energies, E L,and heats of sublimation, ΔH s,of individual energetic materials. In this relationship,the ΔH s value has been replaced by heats of fusion, ΔH m,tr . Thereby its unambiguity has been lost,and the similarity of details of molecular structure begins to be of decisive importance. The resulting partial relationships,together with the basic relationship,have been used for prediction of ΔH s,and ΔH m,tr values of technically attractive polynitro compounds.

关键词：计算晶格能量预测熔解热升华热 DSC 硝基混合物分子结构

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Optical Absorption Measurement Using Thermal Waves

Optical Absorption Measurement Using Thermal Waves

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1996年中国青年学者物理学讨论会

作者： Rene krupka L.D.Favro R.L.Thomas On leave from Institut fuer Strahlwerkzeuge Universitaet Stuttgart Germany. Institute for Manufacturing Research Wayne State University DetroitMI 48202 Institute for Manufacturing Research Wayne State University DetroitMI 48202

＜正＞A novel photothermal technique,referred to as surface thermal lensing（STL）,is developed as an ultrasensitive tool for measuring weak absorption in thin film *** with the various conventional photothermal methods,STL drasmatically reduces the experimental complexity but retains the advantages of being sensitive,accurate and non-contact,and capable of in-situ monitoring of optical absorption down to the sub-ppm *** technique is also demonstrated to have micron-size spatial resolution when applied for photothermal imaging of localized absorptive defects.

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Contactless Magnetoresistance in Large Area Epitaxial Graphene Grown on SiC Substrates

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材料科学与工程（中英文A版） 2012年第7期2卷 489-493页

作者： Tymoteusz Ciuk Jerzy krupka Cezariusz Jastrzebski Jaroslaw Judek Wlodek Strupinski Serkan Butun Ekmel Ozbay Mariusz Zdrojek Institute of Microelectronics and Optoelectronics Warsaw University of Technology Koszykowa 75 00-662 Warsaw Poland Faculty of Physics Warsaw University of Technology Koszykowa 75 00-662 Warsaw Poland Institute of Electronic Materials Technology Wolczynska 1335 01-919 Warsaw Poland Department of Physics Department of Electrical and Electronics Engineering Nanotechnology Research Center BilkentUniversity Bilkent 06800 Ankara Turkey

The present contactless measurements of magnetoresistance of large area graphene films grown by chemical vapor deposition method on semi-insulating SiC substrates. For this purpose we propose microwave technique using single post dielectric resonator operating at frequency about 13.5 GHz. Comparison of microwave measurements with classic van der Pauw method shows good agreement and proves usefulness of contactless technique in magnetoresistance studies. Experiments have been performed at 4.2 K in magnetic fields up to 7 T. Significant differences in graphene magnetoresistance depending on the orientation and crystal structure of SiC substrates have been observed.

关键词：非接触式 SiC 石墨衬底面积化学气相沉积方法磁电阻效应生长

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