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World Journal of Gastroenterology 2011年第10期17卷 1332-1335页

作者： menachem moshkowitz Noya Horowitz Zamir Halpern Erwin Santo Department of Gastroenterology Tel-Aviv Sourasky Medical Center and the Sackler Faculty of MedicineTel-Aviv University

AIM： To evaluate the prevalence and sociodemographics of gastroesophageal reflux disease （GERD） symptoms and to identify treatment patterns among GERD patients. METHODS： A telephone survey of a representative sample of the adult Israeli population was conducted. The questionnaire included detailed sociodemographics, history of GERD symptoms and the various treatments used. RESULTS： The survey included 2027 subjects. Twice weekly, once weekly and monthly GEP, D symptoms were reported by 8.4%, 12.5% and 21.5% of subjects, respectively. There was no difference in prevalence between men and woman; however, GERD symptoms were significantly more prevalent within the older age group and lower socioeconomic status. Among those reporting weekly symptoms, a quarter did not use any kind of therapy and another quarter used various traditional remedies （e.g. soda, milk, almonds, etc.）. Antacids were used by 35.1%, H2 blockers by 13.2% and PPIs by 17.5%. CONCLUSION： We found that 12.5% of the adult Israeli population experience weekly GERD symptoms. GERD prevalence and sociodemographics are similar to those described in other Western countries, and treatment is still suboptimal.

关键词： Gastroesophageal reflux disease Prevalence Sociodemographics

Incidence of colorectal neoplasms among male pilots

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World Journal of Gastroenterology 2014年第27期20卷 9116-9120页

作者： menachem moshkowitz Ohad Toledano Lior Galazan Aharon Hallak Nadir Arber Erwin Santo Integrated Cancer Prevention Center and Department of Gastroenterology Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel-Aviv University

AIM: To assess the prevalence of colorectal neoplasms (adenomas, advanced adenomas and colorectal cancers) among Israeli military and commercial airline pilots.

关键词： Colorectal cancer Adenomatous polyps Colon neoplasms Hyperplastic polyps

prevalence of colorectal neoplasms in young, average risk individuals: A turning tide between East and West

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World Journal of Gastroenterology 2016年第32期22卷 7365-7372页

作者： Ari Leshno menachem moshkowitz Maayan David Lior Galazan Alfred I Neugut Nadir Arber Erwin Santo Integrated Cancer Prevention Center Tel-Aviv Sourasky Medical Center Tel-Aviv University Department of Gastroenterology Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine Tel-Aviv University Department of Epidemiology Mailman School of Public Health Columbia University Herbert Irving Comprehensive Cancer Center Columbia University Department of Medicine College of Physicians and Surgeons Columbia University

AIM To determine the prevalence of colorectal neoplasia in average risk persons 40-59 years of age in Israel and to compare the results with other populations. METHODS We reviewed the results of asymptomatic average-risk subjects, aged 40 to 59 years, undergoing their first screening colonoscopy between April 1994 and January 2014. The detection rates of adenoma, advanced adenoma(AA) and colorectal cancer(CRC) were determined in the 40's and 50's age groups by gender. The prevalence of lesions was compared between age groups. After meticulous review of the literature, these results were compared to published studies addressing the prevalence of colorectal neoplasia in similar patient groups, in a variety of geographical *** We included first screening colonoscopy results of 1750 individuals. The prevalence of adenomas, AA and CRC was 8.3%, 1.0% and 0.2% in the 40-49 age group and 13.7%, 2.4% and 0.2% in the 50-59 age group, respectively. Age-dependent differences in adenoma and AA rates were significant only among men(p < 0.005). Literature review disclosed 17 relevant studies. As expected, in both Asian and Western populations, the risks for overall adenoma and advanced adenoma was significantly higher in the 50's age group as compared to the 40's age group in a similar fashion. The result of the current study were similar to previous studies on Western populations. A substantially higher rate of adenoma, was observed in studies conducted among Asian populations in both age *** The higher rate of colorectal neoplasia in Asian populations requires further investigation and reconsideration as to the starting age of screening in that population.

关键词： Colonoscopy Adenoma Colorectal cancer Average risk Young Asian Western

Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients

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World Journal of Gastrointestinal Pathophysiology 2012年第3期3卷 80-84页

作者： menachem moshkowitz Noya Horowitz Anat Beit-Or Zamir Halpern Erwin Santo Department of Gastroenterology Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine Tel-Aviv UniversityTel-Aviv 64239 Maccabi Health Services Tel-Aviv 64239 Israel

AIM: To verify whether there is a gender difference in the 13C-urea breath test results in a large cohort. METHODS: The test results of dyspeptic patients referred for 13C-urea breath testing between January and December, 2007 were evaluated. Testing was carried out at the health insurance organization branches and evaluated at a central laboratory in Israel. RESULTS: Of a total of 28 746 test results, 18 122 (63.04%) were from females and 10 624 (36.95%) from males. Overall, 10 188 (35.4%) results [expressed as delta over baseline (DOB)] were positive (DOB 13C > 5), 18,326 (63.7%) were negative (DOB 13C < 3.5) and 232 (0.8%) were borderline (DOB 13C 3.5-5). There was a significant difference between the total positive rate among females and males (34.8% vs 37.2%, respectively, P = 0.0003). The mean test value was increased by approximately 10 units for females compared to males (P < 0.01) and this difference was consistent for all age groups (i.e., between 10-80 years of age, P < 0.01). CONCLUSION: More females were referred to 13C-urea breath testing. More males had positive results. The mean test values were significantly higher among females of all age groups, possibly representing an increased bacterial load among females and suggesting gender-associated differences in Helicobacter pylori host interactions.

关键词： Helicobacter pylori Urea breath test Gender Dyspepsia

视频胶囊内镜诊断小肠肿瘤在胃肠道息肉综合征患者中应用的初步经验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 35-35页

作者： Barkay O. moshkowitz M. Fireman Z. N. Arber 尹勇 Department of Cancer Prevention Tel-Aviv Sourasky Medical Center 6 Weizmann St 64239 Tel-Aviv IsraelDr.

Background: Small-bowel tumors frequently occur in familial adenomatous polyposis and other GI polyposis syndromes. These tumors are difficult to detect with conventional techniques. Our aim was to assess the utility of videocapsule endoscopy in the detection of small-bowel tumors in this setting. Methods: We examined 19 familial adenomatous polyposis patients and 3 patients with either Peutz-Jeghers syndrome, hyperplastic polyposis, or Cowden disease. Observations: Prevalence of small-bowel polyps on videocapsule endoscopy was 59% in all patients, 52.6% in familial adenomatous polyposis patients, and 75% in a subgroup of familial adenomatous polyposis patients with exon 15 mutations. Videocapsule endoscopy was safe and well tolerated in all patients. Conclusions: Videocapsule endoscopy has a high yield in detecting small-bowel tumors in patients with GI polyposis syndromes. It may be especially indicated in familial adenomatous polyposis patients with the aggressive phenotype of the disease, e.g., mutations in exon 15.

关键词：胃肠道息肉小肠肿瘤胶囊内镜息肉病初步经验性腺瘤内分泌肿瘤增生性息肉错构瘤肠息肉