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Chinese consensus on the diagnosis and treatmen. of immunoglobulin light-chain cardiac amyloidosis

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Chinese Medical Journal 2024年第2期137卷 127-129页

作者： Kaini Shen Zhuang Tian Yajuan gao Yining Wang Li Huo Jian Li Yun Zhang Shuyang Zhang On behalf of Chinese Society of Rare Diseases and Rare Diseases Branch of China Research Hospital Association Departmen. of Hematology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Departmen. of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Departmen. of Clinical Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Departmen. of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Departmen. of Nuclear Medicine Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicineState Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Departmen. of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250012China Cardiovascular Disease Research Center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China 不详

Epidemiology of Amyloid Light-Chain Cardiac Amyloidosis(AL-CA)The annual incidence of amyloid light-chain(AL)amyloidosis is 3-5/million,and the incidence in men.is slightly higher than that in ***,70%of patients with ... 详细信息

关键词： amyloid cardiac diagnosis

羧基功能化微滤膜PSF-g-PMAA的制备及对三嗪类除草剂的截留去除性能

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高等学校化学学报 2023年第4期44卷 172-179页

作者：杜瑞奎高保娇门吉英中北大学材料科学与工程学院太原030051

使用过硫酸盐在胺基化的氯甲基化聚砜微滤膜表面形成—NH2/S2O82-氧化还原引发体系,将甲基丙烯酸(MAA)接枝聚合到聚砜微滤膜表面,得到羧基功能化PSF-g-PMAA微滤膜.采用等温吸附和渗透实验,考察了PSF-g-PMAA膜对三嗪类除草剂(扑草净、莠... 详细信息

使用过硫酸盐在胺基化的氯甲基化聚砜微滤膜表面形成—NH2/S2O82-氧化还原引发体系,将甲基丙烯酸(MAA)接枝聚合到聚砜微滤膜表面,得到羧基功能化PSF-g-PMAA微滤膜.采用等温吸附和渗透实验,考察了PSF-g-PMAA膜对三嗪类除草剂(扑草净、莠灭净、阿特拉津)的截留去除性能.结果表明,基于静电相互作用和氢键的协同吸附作用,PSF-g-PMAA膜对三嗪类除草剂显示出良好的去除效果,其中对莠灭津的最大吸附量达到0.18μmol/cm^(2)(41μg/cm^(2)).采用膜面积为1.77 cm^(2)的注射过滤器,PSF-g-PMAA膜对浓度为0.8 mg/L的三嗪类除草剂溶液的截留率接近100%(渗透液体积100 mL).

关键词：接枝微滤膜甲基丙烯酸三嗪类除草剂截留去除

Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease

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Chinese Medical Journal 2011年第11期124卷 1731-1734页

作者： gao Fei WANG Zan-xin men.Jian-long REN Jing WEI Min-xin Departmen. of Carcliovascular Surgery Department of Clinical LaboratoryTianjin Medical University General Hospital Tianjin 300052China

Background Aspirin is widely used in the secondary prevention of coronary artery diseases, including myocardial infarction, stroke, and vascular related deaths. However, the antiplatelet effect of aspirin appears to be variable and aspirin resistance （AR） is currently still controversial for Chinese patients. The aim of this study was to describe the prevalence of AR, and identify possible risk factors associated with a lack of response to aspirin treatmen.s in patients with unstable coronary artery disease.

关键词： aspirin," platelet aggregation," thromboxane genetic polymorphism

左束支区域起搏对比传统右心室起搏对双腔起搏器植入术后患者左心功能的影响

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中华心血管病杂志 2024年第2期52卷 180-184页

作者：刘飞李响蒋志丽罗伟高海首都医科大学附属北京安贞医院心内急诊冠脉病房北京100029

目的比较左束支区域起搏(LBBaP)与传统右心室起搏(RVP)对双腔起搏器植入术后患者左心功能的影响。方法本研究为回顾性队列研究。纳入2017年3月至2021年4月在首都医科大学北京安贞医院接受双腔起搏器植入术的患者,根据心室导线置入部位分... 详细信息

目的比较左束支区域起搏(LBBaP)与传统右心室起搏(RVP)对双腔起搏器植入术后患者左心功能的影响。方法本研究为回顾性队列研究。纳入2017年3月至2021年4月在首都医科大学北京安贞医院接受双腔起搏器植入术的患者,根据心室导线置入部位分为LBBaP组和RVP组。随访时间截至2022年3月,分别比较两组患者基线、随访期间的超声心动图检查结果、心电图测得的QRS宽度、起搏参数,并发症(心室电极穿孔、脱位、心包积液、三尖瓣穿孔等)发生率、发生时间。结果共纳入163例患者,年龄(68.3±13.5)岁,其中男性82例(50.3%)。LBBaP组80例,RVP组83例。LBBaP组患者的基线左心室舒张末期内径[(50.49±4.95)mm比(47.43±8.15)mm,P=0.01]、左心房内经[(33.14±5.94)mm比(30.18±3.92)mm,P=0.001]高于RVP组;随访时LBBaP组的左心房内径低于RVP组[(37.10±6.70)mm比(40.10±8.90)mm,P=0.016]。两组基线QRS宽度差异无统计学意义(P=0.490),LBBaP组术后QRS宽度小于RVP组[(110.69±24.01)ms比(139.65±29.85)ms,P0.05];LBBaP组患者术后并发症发生时间早于RVP组[中位时间:29.74(95CI%27.21~32.26)个月比46.17(95CI%42.48~49.86)个月,P=0.030]。结论LBBaP的起搏参数更稳定,对临床左心功能改善更明显,但阈值相对高于RVP,且并发症出现时间相对较早。

关键词：心脏起搏器左束支区域起搏右心室起搏左心室功能

Experimen.al Study of the Gas Triggered Switch's Breakdown by Optical Measuremen.

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Chinese Physics C 2008年第Z1期32卷 310-312页

作者：门涛高景明刘列文建春国防科技大学光电科学与工程学院长沙410073

In this paper the main technical data of the high speed camera(HSFC-PRO),components of gas triggered switch and the primary experimen.al results of the breakdown of gas triggered switch using high speed camera are *** photographs totaling in 24 nanoseconds in single trigger mode manifest that the breakdown consists of two phases,which are the breakdowns of the trigger electrode with positive and negative electrode successively. This phenomen.n is consist with the electric field distribution simulation result with the help of the software ANSYS. Eight photographs in double trigger mode prove that the breakdown time of the gas triggered switch is above 10.5 *** elemen.ary results show that high speed camera is a very efficient apparatus to study the discharge *** optical measuring technique is helpful to profoundly study the breakdown of high voltage switch. More studies and experimen.s would be continued in future.

关键词： high voltage triggered switch discharge spark high speed camera synchronized trigger

淫羊藿制剂相关肝损伤临床特征及潜在风险因素分析

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中国实验方剂学杂志 2024年第6期30卷 205-210页

作者：赵永康刘雨旸石伟高寒李珍柏兆方宋海波高源王伽伯肖小河成都中医药大学药学院成都611137 首都医科大学中医药学院北京100069 中国人民解放军总医院第五医学中心北京100039 福建中医药大学药学院福州350122 河南中医药大学药学院郑州453000 国家食品药品监督管理局药品评价中心北京100022

目的:对淫羊藿制剂相关肝损伤的临床特征及用药合理性进行分析,探讨其肝损伤可能的风险因素,以期为淫羊藿临床安全应用提供参考。方法:对2012—2016年淫羊藿制剂相关肝损伤病例进行回顾性分析。结果:含淫羊藿制剂用药相关的肝损伤报告... 详细信息

目的:对淫羊藿制剂相关肝损伤的临床特征及用药合理性进行分析,探讨其肝损伤可能的风险因素,以期为淫羊藿临床安全应用提供参考。方法:对2012—2016年淫羊藿制剂相关肝损伤病例进行回顾性分析。结果:含淫羊藿制剂用药相关的肝损伤报告数量和严重病例占比均呈升高趋势,提示淫羊藿相关制剂致肝损伤现象客观存在;淫羊藿制剂相关肝损伤病例女性多于男性,发病年龄跨度在15~91岁,中位数发病年龄为60岁(男、女性中位数发病年龄分别为59、60岁);淫羊藿制剂单独服药到发生肝损伤的时间跨度为1~386 d,中位数为38 d;淫羊藿制剂联合西药用药到肝损伤发生的时间跨度为1~794 d,中位数为34 d;淫羊藿相关致肝损伤制剂多由具有免疫促进作用的补益肝肾中药组成,提示机体免疫应激可能是淫羊藿制剂单用或联用导致肝损伤的成因机制;淫羊藿制剂致肝损伤没有“时-毒”和“量-毒”趋势;进一步探索其风险因素,发现患者存在超剂量用药、重复用药、多药联用等不合理用药方式,也可能是致淫羊藿相关肝损伤的重要风险因素之一。结论:淫羊藿制剂存在一定的肝损伤风险,在临床诊疗中应重点加强关注;免疫应激可能是淫羊藿制剂导致肝损伤的成因机制,在临床用药中因警惕与西药联合用药及不合理用药带来肝损伤风险。

关键词：淫羊藿制剂药物不良反应临床特征不合理用药风险因素

1990-2019年中国老年人肺结核疾病负担变化趋势

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疾病监测 2024年第2期39卷 189-194页

作者：高颖刘玉荣沈玉祯王媛天津医科大学天津300041 天津市滨海新区疾病预防控制中心天津300450

目的分析1990—2019年中国老年人肺结核疾病负担现状和趋势,探索老年人肺结核防治策略。方法利用2019年全球疾病负担数据,选取1990—2019年我国65~89岁老年人群肺结核的发病率、死亡率、伤残调整寿命年(DALY)、伤残损失寿命年(YLD)、过... 详细信息

目的分析1990—2019年中国老年人肺结核疾病负担现状和趋势,探索老年人肺结核防治策略。方法利用2019年全球疾病负担数据,选取1990—2019年我国65~89岁老年人群肺结核的发病率、死亡率、伤残调整寿命年(DALY)、伤残损失寿命年(YLD)、过早死亡损失寿命年(YLL)等数据,评估中国老年人群在不同时期、不同性别及不同年龄组的肺结核疾病负担情况,并与全球不同地区的结果进行对比。结果1990—2019年中国老年人肺结核的发病人数从19.63万例增加到20.45万例,增长率为4.18%,死亡人数从6.73万例减少到2.11万例,减少68.65%。年龄别发病率、死亡率以及粗发病率和死亡率均呈现下降趋势;总体年龄别标化的YLD率、YLL率及DALY率呈下降趋势(平均年度变化百分比分别为–2.83%、–7.42%、–6.64%,均P<0.05);各指标性别、年龄组构成中,75~79岁年龄组DALY率最大,85~89岁年龄组发病率及死亡率最高,男性疾病负担重于女性;老年人肺结核的年龄别标化发病率、死亡率及DALY率在各级社会发展指数(SDI)国家中处于中等水平,但与高SDI地区相比负担仍较重。结论1990—2019年中国老年人的肺结核疾病负担有所下降,但老年人群肺结核的疾病负担仍较重,男性≥75岁老年群体为重点关注对象,应采取针对性的防治措施。

关键词：老年人肺结核疾病负担变化趋势

The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children

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Neuroscience Bulletin 2022年第6期38卷 607-621页

作者： Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei men.Shuping Tan Jia-Hong gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao National Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Bejing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBejing 100875China Center for MRI Research Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Beijing City Key Laboratory for Medical Physics and Engineering Institute of Heavy lon PhysicsSchool of PhysicsPeking UniversityBeijing 100871China MeGovern Institute for Brain Research Peking UniversityBeijing 100871China Psychiatry Research Center Bejing HuiLongGuan HospitalPeking UniversityBejing 100096China Division of Molecular Neuroimaging Institute of Neuroscience and Medicine-2Research Center Julich52425 JilichGermany Institute of Biomedical Engineering and Instrumen.ation School of AutomationHangzhou Dianzi UniversityHangzhou 310018China Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China

School-age children are in a specific developmen. stage corresponding to juvenility,when the white matter of the brain experiences ongoing ***-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in *** the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference *** tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial ***,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain ***,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 *** an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific *** with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult *** similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial *** forward,the SACT template could contribute to future studies of white matter developmen. in both healthy and clinical *** SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283).

关键词： School-age children Diffusion-weighted MRI Diffusion tensor template Spatial normalization

Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

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Frontiers of Medicine 2019年第6期13卷 690-704页

作者： Yuqin men.Xiujuan Li Hailong Tu Aizhen Zhang Xiaolong Fu Zhishuo Wang Yecheng Jin Congzhe Hou Tingting Zhang Sen Zhang Yichen Zhou Boqin Li Jianfeng Li Xiaoyang Sun Haibo Wang Jiangang gao School of Life Science Shandong UniversityJinan 250100China Rizhao Polytechnic Rizhao 276826China The Second Hospital of Shandong University Jinan 250033China Electron Microscopy Laboratory Shandong Institute of OtolaryngologyJinan 250022China Laboratory of Electron Microscopy Jinan WEI-YA Biotech CompanyJinan 250100China Departmen. of Otolaryngology-Head and Neck Surgery Provincial Hospital Affiliated to Shandong UniversityJinan 250021China

Tprn encodes the taperin protein,which is concentrated in the tapered region of hair cell stereocilia in the inner *** humans,TPRN mutations cause autosomal recessive nonsyndromic deafness(DFNB79)by an unknown *** determine the role of Tprn in hearing,we generated Tprn-null mice by clustered regularly interspaced short palindromic repeat/Cas9 genome-editing technology from a CBA/CaJ *** observed significant hearing loss and progressive degeneration of stereocilia in the outer hair cells of Tprn-null mice starting from postnatal day *** electron microscopy images of stereociliary bundles in the mutant mice showed some stereociliary rootlets with curved *** central cores of the stereociliary rootlets possessed hollow structures with surrounding loose peripheral dense ***,a protein expressed at stereocilia tapering,was abnormally dispersed along the stereocilia shafts in Tprn-null *** expression levels of radixin andβ-actin significantly *** propose that Tprn is critical to the retention of the integrity of the stereociliary *** of Tprn in Tprn-null mice caused the disruption of the stereociliary rootlet,which resulted in damage to stereociliary bundles and hearing *** generated Tprn-null mice are ideal models of human hereditary deafness DFNB79.

关键词： TPRN stereocilia stereociliary rootlet actin filamen. CRISPR/Cas9 hearing