检索结果-南通市图书馆

同方期刊数据库

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-ra.Jeon Changmin Shin Sun-Young Kwon Sojin Shin department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUNd The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic chara.teristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief litera.ure review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next genera.ion sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such ra.e tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next genera.ion sequencing Case report

A review on machinability of carbon fiber reinforced polymer(CFRP)and glass fiber reinforced polymer(GFRP)composite materials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

defence Technology（防务技术） 2018年第4期14卷 318-326页

作者： meltem Altin kara.as Hasan Gokkaya Abant_Izzet Baysal University Gerede Vocational SchoolMachinery and Metal Technology DepartmentBolu 14900Turkey kara.ük University Engineering FacultyMechanical Engineering Department78050 KarabükTurkey

Fiber reinforced polymer(FRP) composite materials are heterogeneous and anisotropic materials that do not exhibit plastic deformation. They have been used in a wide ra.ge of contempora.y applications particularly in space and aviation,automotive,maritime and manufacturing of sports equipment. Carbon fiber reinforced polymer(CFRP) and glass fiber reinforced polymer(GFRP) composite materials,among other fiber reinforced materials,have been increasingly replacing conventional materials with their excellent strength and low specific weight properties. Their manufactura.ility in varying combinations with customized strength properties,also their high fatigue,toughness and high tempera.ure wear and oxidation resistance capabilities render these materials an excellent choice in engineering *** the present review study,a litera.ure survey was conducted on the machinability properties and related approaches for CFRP and GFRP composite materials. As in the machining of all anisotropic and heterogeneous materials,failure mechanisms were also reported in the machining of CFRP and GFRP materials with both conventional and modern manufacturing methods and the results of these studies were obtained by use of variance analysis(ANOVA),artificial neura. networks(ANN) model,fuzzy inference system(FIS),harmony search(HS) algorithm,genetic algorithm(GA),Taguchi's optimization technique,multi-criteria optimization,analytical modeling,stress analysis,finite elements method(FEM),data analysis,and linear regression technique. Failure mechanisms and surface quality is discussed with the help of optical and scanning electron microscopy,and profilometry. ANOVA,GA,FEM,etc. are used to analyze and genera.e predictive models.

关键词： Composite materials Fiber reinforced polymer composite materials CFRP GFRP Machining Wear Surface damage

Effectiveness of menstruation hygiene skills tra.ning for adolescents with autism

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2023年第11期13卷 958-966页

作者： meltem ka.dıra. Büşra.Yılmaz Merve Azak Çiğdem Bilge department of Women Health and Gynecologic Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye department of Pediatric Nursing Istanbul University-CerrahpaşaFlorence Nightingale Faculty of NursingIstanbul 34381Türkiye department of Obstetrics and Women's Health Nursing Muğla SıtkıKoçman UniversityFaculty of Health SciencesMuğla 48000Türkiye

BACKGROUNd Adolescents with autism spectrum disorder(ASd)may encounter many difficulties with their menstrual *** challenges that adolescents with ASd may face include understanding physical changes,coping with symptoms,emotional sensitivity,communication,personal care,and *** To evaluate the effect of menstrual hygiene skills tra.ning given to adolescents with ASd on their menstrual hygiene *** The study was conducted with 15 adolescents diagnosed with ASd by the single group pre-test and post-test model in three special education centers in Tü*** were collected with the Adolescent and Parent Information Form and the Adolescent-Specific Menstrual Hygiene Skill Registra.ion *** While the mean age of adolescents was 16.06±0.88 years,the mean age of individuals responsible for adolescent care was 43.66±5.56 *** 60.0%of the adolescents noticed the onset of bleeding before tra.ning,this ra.e was 93.3%after *** Adolescent-Specific Menstrual Hygiene Skill Registra.ion Form showed a statistically significant increase in the application steps after the *** difference between the menstrual hygiene skill scores of adolescents CONCLUSION The menstrual hygiene skills tra.ning given to adolescents with ASd was beneficial in increasing their menstrual hygiene *** individuals must take responsibility during menstruation and independently manage their continuous care activities.

关键词： Autism Adolescent Menstruation Hygiene Tra.ning

detection of critical road roughness sections by trend analysis and investigation of driver speed intera.tion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structura. and Civil Engineering 2022年第4期16卷 515-532页

作者： meltem SAPLIOGLU Ayse UNAL Melek BOCEK department of Civil Engineering Suleyman Demirel UniversityIsparta 32260Turkey department of Civil Engineering Siirt UniversitySiirt 56100Turkey

Pavement roughness(IRI—International Roughness Index values)influence the stability of tra.fic movements both on intercity roads and urban *** study is to determine the exact locations of critical pavement roughness values that affect tra.fic motion stability and comfort in city centre highway *** data with 10 m intervals were collected on a 3140 m divided road containing three consecutive signalized intersections in the city centre *** data were analysed using the distance-dependent Mann-Kendall trend analysis method and checkerboard *** sections where roughness is important were determined at a 95%confidence *** results will show where future pavement improvements should be prioritized for municipalities and road maintenance engineers and will form a basis for the urban road management system.

关键词： trend analysis checkerboard model IRI driver speed

Targeting molecular pathways for the treatment of inherited retinal degenera.ion

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Research 2020年第10期15卷 1784-1791页

作者： meltem Kutluer Li Huang Valeria Marigo department of Life Sciences University of Modena and Reggio Emilia

Inherited retinal degenera.ion is a major cause of incura.le blindness chara.terized by loss of retinal photoreceptor *** retinal degenera.ion is chara.terized by high genetic and phenotypic heterogeneity with severa. genes mutated in patients affected by these genetic *** high genetic heterogeneity of these diseases hampers the development of effective thera.eutic interventions for the cure of a large cohort of *** cell demise mechanisms can be envisioned as targets to treat patients regardless the specific *** of these targets is the increase of intra.ellular calcium ions,that has been detected in severa. murine models of inherited retinal ***,neurotrophic factors that favor the efflux of calcium ions to concentra.ions below toxic levels have been identified as promising molecules that should be evaluated as new treatments for retinal ***,we discuss thera.eutic options for inherited retinal degenera.ion and we will focus on neuroprotective approaches,such as the neuroprotective activity of the Pigment epithelium-derived *** chara.terization of specific targets for neuroprotection opens new perspectives together with many questions that require deep analyses to take advantage of this knowledge and develop new thera.eutic *** believe that minimizing cell demise by neuroprotection may represent a promising treatment stra.egy for retinal degenera.ion.

关键词： achromatopsia calcium calpains calpastatin congenital stationary night blindness Leber’s congenital amaurosis retinitis pigmentosa stargardt disease

Biochemical dissection of STAT3 signaling in amyotrophic latera. sclerosis

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic latera. sclerosis(ALS)is a progressive neurodegenera.ive disease chara.terized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the avera.e time from the onset of symptoms to the need for respira.ory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a ra.e of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overa.l.

关键词： STAT3 dissection sclerosis

在线全文

学校读者我要写书评

暂无评论

氟化钙样物质的合成和检测的体外研究

中华口腔医学杂志 1995年第4期30卷 222-224页

作者：郑睿 ra.,Z.L. 北京医科大学口腔医学院材料研究室

牙釉质经氟化物处理后，表面生成“氟化钙样”的物质（“ＣａＦ＿２－ｌｉｋｅ”ｍａｔｅｒｉａｌｓ）。这种物质为量极少，且采集技术也有困难，故很难利用其作为防龋机理研究的样本。为获取代替牙面的氟化钙样物质，本研究采用化学合... 详细信息

牙釉质经氟化物处理后，表面生成“氟化钙样”的物质（“ＣａＦ＿２－ｌｉｋｅ”ｍａｔｅｒｉａｌｓ）。这种物质为量极少，且采集技术也有困难，故很难利用其作为防龋机理研究的样本。为获取代替牙面的氟化钙样物质，本研究采用化学合成的方法，制备了不同磷含量的氟化钙样物质，并分析、测定了这种物质在醋酸钾缓冲液中的溶解性能。对氟化钙样物质中磷与溶解性能的关系，作了定量的分析，并在其成分、溶解性、晶形结构等方面与纯氟化钙进行了比较。结果表明，用化学方法合成的氟化钙样物质，可以反应对牙面上氟化钙样物质的研究。本研究还验证了磷能使氟化钙样物质的结晶形态从立方晶形转变为微小的球滴状，溶解性随着磷含量的增加而加大。该实验是对氟防龋机理研究的一种方法。

关键词：氟化钙类龋齿磷牙釉质

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the centra. event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors ra.her than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,ra.her than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé ra.iro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from centra. nervous system(CNS)tra.ma depends not only on axon regenera.ion or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** severa. studies have successfully promoted long-distance axonal regenera.ion in distinct CNS injury models,none of them have resulted in a viable thera.eutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new stra.egies to promote functional restora.ion in tra.matic CNS disorders.

关键词： viable injury instru