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3D Photo-Fabrication for Tissue Engineering and Drug Delivery

Engineering 2015年第1期1卷 90-112页

作者： Rúben F.pereira Paulo j.Bártolo Centre for Rapid and Sustainable Product Development (CDRsp) Polytechnic Institute of Leiria Instituto de Investiga??o e Inova??o em Saúde (I3S) Universidade do Porto Instituto Nacional de Engenharia Biomédica (INEB) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar (ICBAS) Universidade do Porto School of Mechanical Aerospace and Civil EngineeringUniversity of Manchester Manchester Institute of Biotechnology University of Manchester

The most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix(ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photofabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.

关键词：三维结构照片制作组织工程传递药物生物活性分子生物活性化合物合成环境

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A HISTORIC AND EPOCH-MAKING EVENT

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Beijing Review 2022年第43期65卷 20-21页

作者： Carlos Miguel pereira 不详

There is no doubt that the 20th National Congress of the Communist Party of China (CPC) is a momentous and historic *** General Secretary of the CPC Central Committee Xi jinping pointed out,the past five years have been momentous,in which China achieved extraordinary results thanks to the persistence of its national rejuvenation strategy amid great and profound challenges.

关键词： doubt Communist profound

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Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

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Advances in Microbiology 2023年第1期13卷 1-23页

作者： Alessandra Gomes Mariscal Beatriz Fernanda Siqueira Matias Cíntia Batista de Almeida Nadir Cléia Alves de Santana Simone Matos de Campos Roseli de Souza Klaucia Rodrigues Vasconcelos Margareth Léa da Silva Maia Cristiane Coimbra de Paula Diniz pereira Leite júnior Faculdade EducareMT Cuiab&aacute Brazil Centro Universitá rio de Vá rzea Grande (UNIVAG) V&aacute rzea Grande Brazil Laborató rio Central de Saú de Pú blica do Estado de Mato Grosso (LACEN) Cuiab&aacute Brazil Instituto Ciê ncias Biomé dicas (ICB) Universidade de Sã o Paulo (USP) S&atilde o Paulo Brazil Laboratory Carlos Chagas Sabin Group Cuiab&aacute Brazil Instituto Adolfo Lutz Center of Parasitology and Micology Micology Nucleus S&atilde o Paulo Brazil Research Laboratory Medical School Universidade Federal de Mato Grosso (UFMT) Cuiab&aacute Brazil

Background: COVID-19 is a rapidly transmissible pneumonia-like illness caused by SARS-CoV-2 that out broke in China in 2019 and is currently circulating worldwide. In the current context of the SARS-CoV-2 pandemic, complications are observed in clinical settings for the treatment of severe COVID-19 disease in nosocomial settings, due to cases of fungal co-infections. Objective: To carry out a review on fungal infections associated with respiratory infections caused by COVID-19 (Sars-Cov-2) and their aggravation. Methodology: The purpose of this study is to inform the reader about the characteristics of SARS-CoV-2 and the main fungal species that are affecting patients undergoing treatment for severe COVID-19, provoking discussion of the importance of the proposed topic, in relation to co-infections by different fungal microorganisms. Result: 80 scientific studies were selected, resulting from patients with COVID-19 and most commonly observed in patients with a history of comorbidities such as diabetes mellitus, hypertension, kidney disease, severe liver disease, oncological diseases, obesity and with severe COVID-19. These data do not represent the total number of records of the disease in the world, but cases reported by researchers in their series, showing the overlapping of fungal co-infection through the compromised immune status due to the use of therapeutic drugs, dysregulation of the microbiota, age of patients and the severity itself of the severe inflammation caused by COVID-19. Conclusion: The immunosuppression caused by the infection of COVID-19 concomitant with its therapy through corticosteroid therapy and comorbidities of the patients made fungal infections more susceptible, and these interfere in the evolution of the case and in the treatment of COVID-19, being relevant to distinguish secondary infections to therapy and the best possible reconstitution of the clinical picture.

关键词： Fungal Coinfections COVID-19 Coronavirus Systematic Review

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生物多样性热点地区内的群落预测:堆叠物种分布模型与森林清查数据对比

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journal of Plant Ecology 2023年第3期16卷 96-107页

作者： Victor pereira Zwiener Valéria Andressa Alves Laboratório de Ecologia e Biogeografia de plantas Departamento de BiodiversidadeSetor PalotinaUniversidade Federal do ParanáRua Pioneiro2153Jardim Dallas85950-000 PalotinaPRBrazil

鉴于当前气候变化和人类活动的影响,生物多样性的空间预测对其保护和修复至关重要。本文将不同堆叠物种分布模型(stacked species distribution models,S-SDMs)的预测结果与森林清查数据进行了比较,以评估这些S-SDMs模型能否捕获生物多... 详细信息

鉴于当前气候变化和人类活动的影响,生物多样性的空间预测对其保护和修复至关重要。本文将不同堆叠物种分布模型(stacked species distribution models,S-SDMs)的预测结果与森林清查数据进行了比较,以评估这些S-SDMs模型能否捕获生物多样性热点地区物种丰富度的新特性和地理分布及局部群落的组成。我们选取大西洋沿岸森林151处地点的1499个树种进行SDM模型构建,并利用4种模型堆叠方法重建植物群落。这43种方法分别为二进制SDM模型(bS-SDM)、由最小凸多边形裁剪得到的二进制SDM模型(bS-SDM-CROP)、受物种丰富度观测结果约束的堆叠SDM模型(cS-SDM)以及物种出现点的最小凸多边形(MCP)。我们从物种丰富度、组成、群落预测指标以及β多样性组分(物种嵌套和物种周转)等方面将各堆叠方法与局部群落进行对比。研究结果表明,所有S-SDM模型均捕获到了一般分布格局,其中bS-SDM-CROP模型最为简约。各堆叠模型预测得到的物种组成与局部群落的实际情况存在一定的差异,其中bS-SDM、bS-SDM-CROP和MCP模型呈现出嵌套格局,而物种周转在cS-SDM模型中最为显著。这些S-SDM模型在性能、遗漏率和记账错率方面的表现各不相同,对一些脆弱、濒危和极度濒危物种给出了错误预测。尽管与森林清查数据有差别,但这些S-SDM模型均捕获了与局部群落数据的部分差异,可以表征物种的潜在分布区。本研究的结论有助于S-SDM模型在粗尺度生物多样性整合与保护规划中的应用,但在生物高度多样性地区局部尺度上可能会得出错误的预测结果。

关键词：大西洋森林物种丰富度物种组成嵌套周转生态位建模

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Diet as an epigenetic factor in inflammatory bowel disease

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World journal of Gastroenterology 2023年第41期29卷 5618-5629页

作者： Karina Marangoni Gilson Dorneles Daniella Miranda da Silva Letícia pereira Pinto Carina Rossoni Sabrina Alves Fernandes Egas Moniz School of Health and Science Caparica-AlmadaPortugalCaparica 2820-062Portugal National Institute of Sciences and Technology-Theranostics and Nanobiotechnology Federal University of Uberlandia-MGBrazilUberlândia 38400-902Brazil Corporate Social Responsibility Hospital Moinhos de VentoPorto Alegre 90035-004Brazil Postgraduate Program in Gastroenterology Universidade Federal do Rio Grande do SulPorto Alegre 91540-000Brazil Department of Nutrition Uniasselvi-Group VitruSanta Catarina 89082-262Brazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Master in Physical Activity and Health Polytechnic Institute of BejaBeja 7800-000Portugal Degree in Nutrition Sciences Lusófona UniversityLisboa 1749-024Portugal

Inflammatory bowel disease(IBD)has as a main characteristic the exacerbation of the immune system against enterocytes,compromising the individual’s intestinal *** inflammatory cascade causes several nutritional deficiencies,which further compromise immunological functioning and,as a result,worsen the *** vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition,acting directly on the inflammatory process of IBD through the interaction of food,intestinal microbiota,and *** nutritional intervention for IBD has a crucial role in preventing and managing disease *** review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

关键词： Inflammatory bowel disease Epigenetics Nutrition Nutrigenetics

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Growth inhibitory effects of Phyllanthus niruri extracts in combination with cisplatin on cancer cell lines

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World journal of Gastroenterology 2012年第31期18卷 4162-4168页

作者： Raimundo Fernandes de Araújo júnior Luiz Alberto Lira Soares Cínthia Raquel da Costa Porto Ranniere Gurgel Furtado de Aquino Hugo Gon alo Guedes Pedro Ros Petrovick Tatiane pereira de Souza Aurigena Antunes de Araújo Gerlane Coelho Bernardo Guerra Department of Morphology/Postgraduate Program in Morphological Sciences Federal University of Rio Grande do NorteNatal 59072-970Rio Grande do NorteBrazil Postgraduate Program in Pharmaceutical Sciences Federal University of PernambucoRecife 50670-901PernambucoBrazil Postgraduate Program in Pharmaceutical Sciences Federal University of Rio Grande do NorteNatal 59012-570Rio Grande do NorteBrazil Department of Production and control of drugs Federal University of Rio Grande do SulPorto Alegre 90610-000Rio Grande do SulBrazil Department of Food and Drug Administration Federal University of AmazonasManaus 69077-000AmazonasBrazil Department of Biophysics and Pharmacology Federal University of Rio Grande do NorteNatal 59072-970Rio Grande do NorteBrazil

AIM:To investigate the cytotoxic effects of spray-dried extracts of Phyllanthus niruri in combination with cisplatin on two cancer cell ***:Colorectal carcinoma(HT29) and human hepatocellular carcinoma(HepG2) cells were treated with spray-dried extracts of Phyllanthus niruri(SDEPN) either alone or in combination with cisplatin at different concentrations(0.5 mg/mL and 1 mg/mL) for 4 h and 24 *** verify and quantify cancer cells treated with these products as well as identify the cell cycle stage and cell viability,we stained the cells with propidium iodide and assessed them by flow *** percentage of cells in different cell cycle phases was quantified and data were expressed as *** differences between groups were determined using analysis of variance and Bonferroni's test,as indicated.A value of P 0.05) and HepG2(5.07 ± 0.3 vs 15.9 ± 1.04,P 0.05) and HepG2(14.56 ± 1.6 vs 35.67 ± 3.94,P < 0.001) cells when compared to control cells for 24 *** cell lines were killed by cisplatin in a dose-dependent manner compared to control cells(HepG2 cells for 4 h:10.78 ± 1.58 vs 53.89 ± 1.53,P < 0.001;24 h:8.9 ± 1.43 vs 62.78 ± 1.87,P < 0.001 and HT29 cells for 4 h:9.52 ± 0.913 vs 49.86 ± 2.89,P < 0.001;24 h:11.78 ± 1.05 vs 53.34 ± 2.65,P < 0.001).In HT29 cells,pretreatment with SDEPN and subsequent treatment with cis-platin resulted in a greater number of cells being killed(12.78 ± 1.01 vs 93.76 ± 1.6,P < 0.001).HepG2 cells showed significant cell killing with treatment with SDEPN when combined with cisplatin(12.87 ± 2.78 vs 78.8 ± 3.02,P < 0.001).CONCLUSION:SDEPN is selectively toxic against two cancer cell ***,SDEPN in combinati

关键词：肿瘤细胞株提取物生长抑制作用顺铂珍珠 HepG2细胞细胞毒作用喷雾干燥

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Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco jairo Soares pereira Antonio Viana da Silva Filho josé Wellington Batista Lopes josé Carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(july 2018-july 2019). Measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. Only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and Maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

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Behavior of wood basic density according to environmental variables

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journal of Forestry Research 2022年第2期33卷 497-505页

作者： Gabriel Marcos Vieira Oliveira joséMárcio de Mello Carlos Rogério de Mello joséRoberto Soares Scolforo Eder pereira Miguel Thiago Campos Monteiro Brazil Institute of Agricultural and Forestry Defense of Espírito Santo(IDAF) Av.Lourival Lugon Moulinnº300CentroJerônimo MonteiroES CEP:29.550-000Brazil Department of Forestry Sciences Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Engineering Department Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Forestry Engineering Department Faculdade de TecnologiaUniversity of Brasilia-UnBCampus Universitário Darcy RibeiroCaixa Postal 4357Asa Norte-BrasíliaDF CEP:70910-900Brazil Department of Forestry Engineering and Technology Universidade Federal do Paraná-UFPRAv.Pref.Lothário Meissner632Jardim BotânicoCuritibaPR CEP:80.210-170Brazil

The relationships between climate conditions and wood density in tropical forests are still poorly *** quantify spatial dependence of wood density in the state of Minas Gerais(MG,Brazil),map spatial distribution of density,and correlate density with climate variables,we extracted data from the Forest Inventory of Minas Gerais for 1988 trees scaled throughout the territory and measured wood density of discs removed from the *** variables were extracted from the database of the Ecological-Economic Zoning of Minas *** spatial analysis,tree densities were measured at 44 georeferenced sampling *** data were subjected to exploratory analysis,variography,cross-validation,model selection,and ordinary *** relationships between wood density and environmental variables were calculated using dispersion matrices,linear correlation,and *** density proved to be highly spatially dependent,reaching a correlation of 96%,and was highly continuous over a distance of 228 *** distribution of wood density followed a continuous gradient of 514-659 kg m^(−3),enabling corre-lation with environment *** was correlated with mean annual precipitation(−0.57),temperature(0.63),and evapotranspiration(0.83).Geostatistical methods proved useful in predicting wood density in native tropical forests with different climate *** results confirmed the sensitivity of wood density to climate change,which could affect future carbon stock in forests.

关键词： Biomass Climate variables Geostatistics Hardwood Forest inventory Minas Gerais

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Cationic antimicrobial protein of Mr 37 kDa:a multifunctional inflammatory protein

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Chinese Medical journal 2001年第1期114卷 9-13页

作者： H.Anne pereira Department of Pathology University of Oklahoma Health Sciences CenterOklahoma 73190USA

investigate the role of cationic antimicrobial protein of Mr 37?kDa (CAP37) a neutrophil derived inflammatory mediator on endothelial cell function Data sources Endothelial cells used in this study were obtained from human lung microvessels and rat aorta The latter was a kind gift of Dr Paula Grammas The mono mac 6 cell line used in this study was the generous gift of Dr H W Loms Ziegler Heitbrock Study selection and data extraction Endothelial cell proteins kinase C activity was determined by measuring calcium and phospholipid dependent phosphorylation of histone Endothelial cell migration was determined using Costar TM Transwell apparatus Cell surface expression of adhesion molecules, ICAM 1 and PECAM 1 was determined using flow cytometry RT PCR was used to amplify the CAP37 from endothelial cells treated with LPS Results We demonstrated that CAP37 which was originally identified as having potent antimicrobial activity and chemotactic activity for monocytes was capable of modulating endothelial cell functions CAP37 activated endothelial cell protein kinase C in a dose and time dependent fashion Importantly CAP37 increased the adhesive properties of the endothelium for monocytes CAP37 upregulated the well known adhesion molecules, ICAM 1 and PECAM 1 in a dose and time dependent manner In addition, CAP37 promoted endothelial cell migration Further investigations indicated that CAP37 was induced in endothelial cells in response to pro inflammatory cytokines such as tumor necrosis factor α and interleukin 1α as well as inflammatory mediators such as lipopolysaccharide Unstimulated endothelial cells did not constitutively express CAP37 The cDNA sequence of endothelial CAP37 was determined and found to be highly homologous to the sequence obtained for neutrophil derived CAP37 Conclusions Our studies strongly suggest that CAP37 plays a pivotal role in monocyte endothelial interactions and the transmigration of monocytes from the vasculature into extravascular

关键词： cationic antimicrobial protein Mr 37 kDa inflammatory mediator function

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Risk Factors Associated with Acinetobacter baumannii Infections in Patients in an Intensive Care Unit of a Public Hospital in Paraná

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Advances in Infectious Diseases 2022年第1期12卷 90-105页

作者： Mirian Carla Bortolamedi da Silva Maria Helena Brandeleiro Werlang Valdir Spada júnior Guilherme Welter Wendt Ana Paula Vieira Franciele Ani Caovilla Follador Léia Carolina Lucio Cleide Viviane Busanello Martins Kérley Braga pereira Bento Casaril Paulo Cezar Nunes Fortes Lirane Elize Defante Ferreto Post-Graduante Program Health Sciences University of Wester Paraná (UNIOESTE) Francisco Beltr&#227 o Brazil State of the Health of Paraná (SESA-PR) Francisco Beltr&#227 o Brazil

To identify risk factors for A. baumannii infection in patients hospitalized in an Intensive Care Unit (ICU) of a tertiary public hospital in Paraná, Brazil, a retrospective paired case-control study (ratio 1:2) was conducted from january 2018 to December 2020. Patients in the case group were hospitalized in the ICU with A. baumanni (n = 68 cases) and were compared with patients in the control group, without infection by A. baumannii (n = 136). Both were matched by age (±10 years), sex, and ICU stay (±5 days). Conditional multiple logistic regression was used to determine statistically significant risk factors based on the results of bivariate analyses. Mortality was higher in infected (cases) than in non-infected patients (51.5% vs. 39.7%). The incidence and bacterial resistance increased annually. At bivariate analysis, cases had longer hospital stays (median 35 vs. 22 days, p A. baumannii and antimicrobial resistance. There is need for surveillance, and constant evaluation of control actions. Risk factors were colonization, previous hospitalization, and hospitalization time. This is essential for the decision-making of professionals and optimization of prevention, control, and therapeutic management actions.

关键词： Acinetobacter baumannii Risk-Factors Infection Intensive Care

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