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Gangrenous cholecystitis: A silent but potential fatal disease in patients with diabetic neuropathy. A case report

World Journal of Clinical Cases 2018年第15期6卷 1007-1011页

作者： melorin mehrzad Charles C Jehle Lauren O Roussel Raman mehrzad Department of Plastic and Reconstructive Surgery Rhode Island Hospital Brown University

Gangrenous cholecystitis(GC) is a severe and potentially deadly complication of acute cholecystitis. We present a 83-year-old gentleman with a past medical history of type 2 diabetes mellitus with significant associated neuropathy, presenting to a community hospital in a major metropolitan area with 10 days nausea and vomiting and a benign abdominal exam. While the patient was admitted for hyperglycemia, he was subsequently found to have severe GC requiring urgent surgical intervention.

关键词： Gangrenous cholecystitis Diabetes mellitus Hyperglycemia Complications Case report

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Safety,efficiency and cost effectiveness of Bivalirudin:A systematic review

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World Journal of Cardiology 2017年第9期9卷 761-772页

作者： melorin mehrzad Rasikh Tuktamyshov Raman mehrzad Department of Internal Medicine Yale New Haven HospitalYale School of medicineNew HavenCT 06510United States

AIM To review the early and more recent studies of Bivalirudin, to assess the safety, effectiveness, and cost benefits of this *** Literature search of MEDLINE and Pub Med databases from 1990 to 2017 using keywords as "bivalirubin" and "angiomax", combined with the words "safety", "effectiveness", "efficiency", "side effects", "toxicity", "adverse effect", and "adverse drug reaction".RESULTS A total of 66 publications were reviewed. The changes in clinical practice and differences in clinical protocols make it difficult to do direct comparisons of studies among each other. However, most trials showed decreased bleeding complications with bivalirudin, although ischemic complications and mortality were mostly comparable, with some favor towards *** Bivalirudin and heparin are both acceptable options according to current ACA/AHA guidelines. Authors conclude however, that that due to bivalirudin safer bleeding profile, it should be the preferred medication for anticoagulation.

关键词： Efficiency Cost effectiveness Bivalirudin Safety

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