检索结果-南通市图书馆

中国学校卫生 2019年第1期40卷 51-54页

作者：李春玫王健黄情文小桐 melissa Deadmond Gabriela Vieyra 戴新平袁兆康杨维南昌大学公共卫生学院/江西省预防医学重点实验室江西330006 美国内华达大学婺源县疾病预防控制中心

目的了解江西省南昌市和婺源县高中生各类健康危险行为的流行现状,为有针对性地预防青少年危险行为的发生提供参考依据。方法采取多阶段分层随机整群抽样的方法,抽取南昌市5所中学高一、高二年级10个班级的高中生;采用整群抽样的方法,... 详细信息

目的了解江西省南昌市和婺源县高中生各类健康危险行为的流行现状,为有针对性地预防青少年危险行为的发生提供参考依据。方法采取多阶段分层随机整群抽样的方法,抽取南昌市5所中学高一、高二年级10个班级的高中生;采用整群抽样的方法,抽取婺源县1所中学全体高一、高二学生作为研究对象,分别描述2个地区的高中生健康危险行为流行现状,并进行比较。结果在造成高中生伤害的行为中,过去12个月中骑自行车的时候从不或很少戴头盔(婺源县56.6%,南昌58.6%)、乘坐别人开的车的时候从不或很少系安全带(婺源县48.7%,南昌39.7%)、边发信息边骑车(婺源县13.5%,南昌9.4%)和打架(婺源县10.2%,南昌10.0%)的报告率较高。婺源县高中生有35.2%曾经吸烟,51.5%曾经饮酒,4.0%发生过性行为,32.7%认为自己微胖或超重,49.1%准备减肥,南昌市高中生大部分健康危险行为报告率高于婺源县。不同性别、不同类型学校学生多数健康危险行为报告率差异有统计学意义(P值均<0.05)。结论南昌市高中生多数健康危险行为报告率高于婺源县。应采取有针对性的措施引导学生树立健康的行为习惯,以有效减少健康危险行为的发生。

关键词：危险行为健康教育创伤和损伤吸烟饮酒学生

A convenient approach to facilitate monitoring Gaucher disease progression and therapeutic response

在线全文

学校读者我要写书评

暂无评论

A convenient approach to facilitate monitoring Gaucher disea...

Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five european centres

第21届全国色谱学术报告会及仪器展览会

作者： Wujuan Zhang melissa Oehrle Carlos e.Prada Ida Schwartz Somchai Chutipongtanate Duangrurdee Wattanasirichaigoon Venette Inskeep Mei Dai Dao Pan Ying Sun Kenneth DR Setchell Department of Pathology and Laboratory Medicine Cincinnati Children's Hospital Medical Center Division of Human Genetics Cincinnati Children's Hospital Medical Center Bucaramanga ColombiaGenetics DepartmentUFRGS Department of Pediatrics Faculty of Medicine Ramathibodi HospitalMahidol University Division of experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center

＜正＞BACKGROUND:Gaucher disease （GD） is caused by mutations on GBA1 gene leading to deficiency in acidβ-glucosidase （GCase） function and subsequent accumulation of its substrates, glucosylceramide （GlcC）and glucosylsphingosine（GlcS）.GlcS in plasma has been proposed as a highly sensitive and specific biomarker for diagnosis of GD and for monitoring disease progression and response to therapy. The method was also capable of resolving the isomeric pair, glucosylsphingosine and galactosylsphingosine, the latter

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第39期25卷 5991-6005页

作者： melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara Department of Medical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Analytics and Development The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Pathology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Medical Oncology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom UCL Cancer Institute University College LondonLondon WC1E 6AGUnited Kingdom Department of Histopathology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom Department of Gastroenterology and Medical Oncology Edouard Herriot HospitalHospices Civils de LyonLyon 69003France Department of Gastroenterology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom Department of Cellular Pathology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom Department of Hepatology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom Department of Surgical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Division of Cancer Sciences University of ManchesterManchester M13 9PLUnited Kingdom

BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNeN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic *** is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be *** To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of *** Consecutive patients with a histologically proven diagnosis of MiNeN were identified at 5 european *** data were retrospectively collected from medical *** samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of *** responses to systemic treatment were assessed according to the Response evaluation Criteria in Solid Tumours ***-Meier analysis was applied to estimate survival *** between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).ReSULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 ***:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases *** distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine ***-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of *** was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal *** localised cases,median recurre

关键词： Mixed neuroendocrine non-neuroendocrine neoplasm 2017 World Health Organisation classification Mixed adeno-neuroendocrine carcinoma Gastro-enteropancreatic tract Digestive system Neuroendocrine neoplasms Survival outcomes

expressing Food through Art: evidence for a Nutrient-Specific effect on Mood

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2013年第2期3卷 163-167页

作者： Gregory J. Privitera Brianne K. Moshaty Frank C. Marzullo melissa L. Misenheimer Department of Psychology Saint Bonaventure University St. Bonaventure USA

Background: Brain imaging studies show evidence of selective brain reward responses to high calorie foods. Behavioral studies extend this research by showing that such foods can enhance emotions, even for sweet-tasting low calorie foods (i.e., fruits). In the present study, we tested the hypothesis that participants will show more positive emotional change when drawing pictures of foods that are high fat or taste sweet compared to bitter-tasting foods—as a possible behavioral intervention for enhancing mood. Method: Participants were randomly assigned to one of four art groups: high fat-high sugar (HFHS;stimulus food: cupcakes), high fat-low sugar (HFLS;stimulus food: pizza), low fat-high sugar (LFHS;stimulus food: strawberries), or low fat-low sugar (LFLS;stimulus food: peppers). Participants used three colors (red, green, black) in their art, were required to use all three colors, and told that the colors they use must reflect actual colors that are natural for the food depicted. Participants drew images of a stimulus food and prepost measures of mood and arousal were recorded. Results: Consistent with the hypothesis, the results show that drawing pictures of high fat foods (cupcakes, pizzas) and a food that tastes sweet (strawberries) results in greater increases in mood compared to drawing a bitter-tasting food (peppers). Changes in mood were independent of BMI, daily sugar intake, daily fat intake, arousal, and hunger. Conclusion: These results extend a growing body of biobehavioral research on the positive impact of food images on mood by showing that this impact can be applied to enhance mood when expressing food images through art.

关键词： Art Sugar Fat Mood enhancement Arousal

Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSeRM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

用Agilent 7000 GC/MS/MS分析豆奶中的八种植物雌激素

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

食品安全导刊 2010年第7期 36-38页

作者： Imma Ferrer e.Michael Thurman melissa Churley Harry Prest Phil Stremple Phil Wylie Jerry Zweigenbaum 科罗多拉大学环境质谱中心安捷伦科技公司

植物雌激素是来源于植物．分子结构和雌激素相似，在体肉有雌激素样作用的一组非类固醇多酚化合物．分为异黄酮．类黄酮类、木酚素类和coumestans，主要存在于大豆．三叶草、紫花苜蓿、黄豆，豌豆等豆科植物中。与合成激素不同，天然植... 详细信息

植物雌激素是来源于植物．分子结构和雌激素相似，在体肉有雌激素样作用的一组非类固醇多酚化合物．分为异黄酮．类黄酮类、木酚素类和coumestans，主要存在于大豆．三叶草、紫花苜蓿、黄豆，豌豆等豆科植物中。与合成激素不同，天然植物雌激素没有副作用。但是随着合成激素和动物雌激素在废水中的排放．植物雌激素也被认为会干扰鱼的内分泌。

关键词：植物雌激素 GC/MS/MS 豆奶多酚化合物激素样作用分子结构类黄酮类紫花苜蓿

在线全文

学校读者我要写书评

暂无评论

由案例构建理论的机会与挑战

管理世界 2010年第4期26卷 125-130页

作者：凯瑟琳.M.埃森哈特梅丽莎.e.格瑞布纳张丽华何威斯坦福大学得克萨斯大学奥斯汀分校中国人民大学劳动人事学院美国印地安那州立大学

《美国管理学会学报》（AMJ）近年来在各主要学刊中率先垂范，相继着力推出各种以充分利用丰富的实证数据见长的另类研究方法。在该刊“主编特荐”系列中，学者们充分翔实地介绍了这方面的若干题目，诸如质性研究（Gephart，2004），扎... 详细信息

《美国管理学会学报》（AMJ）近年来在各主要学刊中率先垂范，相继着力推出各种以充分利用丰富的实证数据见长的另类研究方法。在该刊“主编特荐”系列中，学者们充分翔实地介绍了这方面的若干题目，诸如质性研究（Gephart，2004），扎根理论（Suddaby，2006），数据丰富性的价值（Weick，2007）和单案例的说服力（Siggelkow，2007），等等。本文将着重探讨由案例构建理论的相关策略，尤其是多案例的理论构建。

关键词：案例率先垂范质性研究扎根理论丰富性说服力

利用红外相机技术分析秦岭有蹄类动物活动节律的季节性差异

在线全文

学校读者我要写书评

暂无评论

生物多样性 2014年第6期22卷 737-745页

作者：贾晓东刘雪华杨兴中武鹏峰 melissa Songer 蔡琼何祥博朱云西北大学生命科学学院西安710069 清华大学环境学院北京100084 沈阳师范大学化学与生命科学学院沈阳110034 Conservation ecology Center Smithsonian Conservation Biology Institute 陕西观音山自然保护区陕西佛坪723400 陕西佛坪自然保护区陕西佛坪723400

2009年8月至2013年4月期间,在陕西观音山自然保护区,利用18台红外相机收集到羚牛(Budorcas taxicolor)、川西斑羚(Naemorhedus griseus)、中华鬣羚(Capricornis milneedwardsii)、毛冠鹿(elaphodus cephalophus)、小麂(Muntiacus reevesi)、林麝(Moschus berezovskii)6种有蹄类动物的照片数据,通过相对丰富度指数分析了它们的活动规律及季节性差异。结果表明:(1)6种有蹄类动物在研究区域总丰富度达到了58.71%,其中羚牛的相对丰富度是28.02%,川西斑羚13.24%,毛冠鹿10.08%,中华鬣羚4.21%,小麂2.26%,林麝0.90%。(2)6种有蹄类动物的月相对丰富度反映了其年活动格局,其中羚牛、川西斑羚、毛冠鹿、中华鬣羚、小麂表现出一致性,即夏季活动最为频繁,秋季减弱,冬季达到活动低谷,春季逐渐回升;而林麝则在冬季活动最为频繁,夏季最弱。(3)日时间段相对丰富度反映了动物全年的日活动规律,其中川西斑羚和羚牛相似,主要以白天活动为主;毛冠鹿、小麂、林麝具有明显的晨昏活动习性;中华鬣羚活动高峰出现在02:00–06:00和20:00–22:00,以夜间活动为主。(4)分析不同季节6种有蹄类动物日活动规律,羚牛在春季出现一定的差异,活动高峰出现在16:00–20:00;川西斑羚、毛冠鹿、中华鬣羚在冬季表现出一定的差异,活动高峰相对延迟或者提前;小麂春季表现出差异,活动主要集中在00:00–10:00和18:00–20:00;林麝由于数据相对较少,在4个季节表现出不同的活动规律。(5)夜行性分析得到中华鬣羚具有较强的夜间活动能力,夜间相对丰富度达到了65.81%。这些研究结果有助于监测有蹄类动物种群的变化,为保护区有效保护管理提供了数据支持。

关键词：相机陷阱有蹄类活动节律季节性差异