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Experience with Miniaturized Cardiopulmonary Bypass in Cardiac Surgery: A Prospective Comparison of the NovoSCI Ready System to Off-Pump and Conventional Coronary Artery Bypass Grafting

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World Journal of Cardiovascular Surgery 2014年第12期4卷 232-238页

作者： Dominic Emerson Debbie Baldwin Miguel Pinales Michael Greenberg melissa mattes Gregory Trachiotis Veterans Affairs Medical Center Washington DC USA Georgetown University Hospital Washington DC USA The George Washington University Hospital Washington DC USA

The major source of morbidity following cardiopulmonary bypass (CPB) is the systemic inflammatory response (SIRS response) which leads to multiple derangements in different organ systems. To combat this, miniaturized cardiopulmonary bypass circuits (MCPBC) have been created to lessen the inflammatory response to CPB. Here we examine early outcomes following coronary artery bypass grafting (CABG) using a MCPBC system compared to conventional bypass techniques at a single institution. Methods: 60 consecutive patients undergoing elective CABG were prospectively enrolled. Nine patients underwent coronary artery bypass grafting (CABG) with conventional CPB (cCABG), 33 underwent off-pump CABG (OPCAB), and the remaining 18 patients underwent CABG with a MCPBC system. Demographics and outcomes were compared between groups and statistical analyses applied. Results: No significant difference was observed in mortality between groups, with only one death reported in total. Morbidity was also low, totaling only 6.7%, with none occurring in the MCPBC group. The MCPBC group required less PRBC and total blood product transfusion than the cCABG and OPCABG groups (p = 0.05), but changes in PLT and Hct over time were not different between groups. Conclusions: The MCPBC system was shown to be comparable to conventional bypass and OPCABG in terms of postoperative complications and mortality. Furthermore, the MCPBC system had the advantage of a decreased transfusion requirement. Based on our preliminary observations, this mini-cardiopulmonary bypass circuit provides a safe alternative to conventional bypass techniques.

关键词： Miniaturized Circuits Coronary Artery Bypass Graft Outcomes

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Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination

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Neural Regeneration Research 2024年第3期19卷 493-494页

作者： melissa Schepers Tim Vanmierlo Department of Neuroscience Biomedical Research InstituteFaculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology School for Mental Health and NeuroscienceMaastricht UniversityMaastrichtNetherlands University MS Center(UMSC)Hasselt-Pelt HasseltBelgium

In neurodegenerative and classically demyelinating disorders such as multiple sclerosis(MS),spinal cord injury(SCI),stroke,and Charcot-Marie-Tooth disease,glial functioning is compromised and nervous tissue integrity is ***,primary neurodegenerative disorders such as Alzheimer’s disease,amyotrophic lateral sclerosis(ALS),and Parkinson’s disease(PD)are increasingly linked to impaired oligodendroglia functioning upon *** to the destructive micro-environment created by nervous tissue damage,the progressive cellular loss in these disorders,and the amitotic nature of neurons,spontaneous endogenous repair process are limited in ***,there is a medical need for efficient therapeutic strategies capable of supporting neuro-reparative processes to occur,likely supported by improved oligodendroglia cell functioning.

关键词： impaired inflammation Marie

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Odor cues rather than personality affect tadpole deposition in a neotropical poison frog

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Current Zoology 2024年第3期70卷 332-342页

作者： melissa Peignier Max Ringler Eva Ringler Division of Behavioural Ecology Institute of Ecology and EvolutionUniversity of BernCH-3032 HinterkappelenSwitzerland Messerli Research Institute University of Veterinary Medicine Vienna1210 ViennaAustria Department of Behavioral and Cognitive Biology University of Vienna1030 ViennaAustria Department of Evolutionary Biology University of Vienna1030 ViennaAustria lnstitute of Electronic Music and Acoustics University of Music and Performing Arts Graz8010 GrazAustria

Animals constantly need to evaluate available external and internal information to make appropriate ***,assessing,and acting on relevant cues in contexts such as mate choice,intra-sexual competition,and parental care is particularly important for optimizing individual reproductive *** factors can infuence decision-making,such as external environmental cues and the animal’s own internal state,yet,we have limited knowledge on how animals integrate available ***,we used an entire island population(57 males,53 females,and 1,109 tadpoles)of the neotropical brilliant-thighed poison frog Allobates femoralis to investigate how 2 factors(olfactory cues and personality traits)infuence the ability of males to fnd and use new resources for tadpole *** experimentally manipulated the location of tadpole deposition sites and their associated olfactory cues,and repeatedly measured exploration and boldness in adult *** further reconstructed tadpole deposition choices via inferred parent–offspring relationships of adult frogs and tadpoles deposited in our experimental pools using molecular parentage *** found that the discovery and use of new rearing sites were heavily infuenced by olfactory cues;however,we did not fnd an effect of the measured behavioral traits on resource discovery and *** conclude that in highly dynamic environments such as tropical rainforests,reliable external cues likely take priority over personality traits,helping individuals to discover and make use of reproductive resources.

关键词： animal personality Anura decision-making parental care tadpole transport

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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma melissa MTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

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Trust in ESG reporting:The intelligent Veri-Green solution for incentivized verification

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Blockchain(Research and Applications) 2024年第2期5卷 126-139页

作者： Liyuan Liu Zhiguo Ma Yiyun Zhou melissa Fan Meng Han Saint Joseph’s University 5600 City AvePhiladelphia19131PAUSA Zhejiang University 866 Yuhangtang RdHangzhou310027ZhejiangChina National Board of Medical Examiners 3750 Market StreetPhiladelphia19104PAUSA

In today’s corporate environment,Environmental,Social,and Governance(ESG)reports crucially reflect an orga-nization’s commitment to sustainability,environmental preservation,and social *** corporations share these detailed reports,the responsibility to validate and assure adherence to respected ESG benchmarks critically lies with third-party assurance ***,the essential verification process often encoun-ters challenges related to authenticity,credibility,and fairness,underscoring the need for a new *** selection of verifiers is a crucial aspect of this process,as their expertise and impartiality directly impact the validity and trustworthiness of the ***,“Veri-Green,”an innovative blockchain-based in-centive mechanism,has been introduced to improve the ESG data verification *** potential risks in verification systems,such as reputational damage due to oversight or inadvertent approval of inaccurate data,and data security risks involving the management of sensitive organizational information,the verifier se-lection process needs to be thoroughly considered and *** the utilization of advanced machine learning algorithms,potential verification candidates are precisely identified,followed by the deployment of the Vickrey Clarke Groves(VCG)auction *** approach ensures the strategic selection of verifiers and cultivates an ecosystem marked by truthfulness,rationality,and computational efficiency throughout the ESG data verification *** this framework,verifiers are not only encouraged but also properly incentivized,developing a more transparent and equitable verification process,thereby driving the ESG agenda towards a future defined by genuine,impactful corporate responsibility and sustainability.

关键词： Incentive mechanism ESG Artificial intelligence Truthfulness

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Understanding the Recovery of the Intervertebral Disc:A Comprehensive Review of In Vivo and In Vitro Studies

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Journal of Bionic Engineering 2024年第4期21卷 1919-1948页

作者： Faten Feki Fahmi Zaïri Abderrahman Tamoud melissa Moulart Rym Taktak Nader Haddar Fahed Zaïri Sfax University ENISMaterials Engineering and Environment Laboratory3038SfaxTunisia University of Lille IMT Nord EuropeJUNIAUniversity of ArtoisULR 4515-LGCgELaboratoire de Génie Civil et geo-Environnement59000LilleFrance PrediTwins Lab 59000LilleFrance Japet Medical Device 59000LilleFrance Sfax University ENISLaboratory of Advanced Materials3038SfaxTunisia Ramsay Générale de Santé Hôpital PrivéLe Bois59000LilleFrance

Within the consistent daily rhythm of human life,intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces,leading to significant morphological changes(in terms of volume,area,and height)as well as biomechanical alterations,including an increase in disc stiffness and a decrease in intradiscal ***,the discs demonstrate an ability to regain their original morphological and biomechanical characteristics after a period of nocturnal *** preservation of normal disc function is critically dependent on this recovery phase,which serves to forestall premature disc *** phenomenon of disc recovery has been extensively documented through numerous in vivo studies employing advanced clinical techniques such as Magnetic Resonance Imaging(MRI),stadiometry,and intradiscal pressure ***,the findings from in vitro studies present a more complex picture,with reports varying between full recovery and only partial recuperation of the disc ***,research focusing on degenerated discs in vitro has shed light on the quantifiable impact of degeneration on the disc ability to *** dynamics within the disc are considered a primary factor in recovery,yet the disc intricate multiscale structure and its viscoelastic properties also play key *** elements interact in complex ways to influence the recovery mechanism,particularly in relation to the overall health of the *** objective of this review is to collate,analyze,and critically evaluate the existing body of in vivo and in vitro research on this topic,providing a comprehensive understanding of disc recovery *** understanding offers a blueprint for future advancements in medical treatments and bionic engineering solutions designed to mimic,support,and enhance the natural recovery processes of intervertebral discs.

关键词： Intervertebral disc Recovery In vivo vs.in vitro studies Degeneration Viscoelastic effects Fluid dynamics

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A lead role for a“secondary”axonal injury response

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Neural Regeneration Research 2025年第2期20卷 469-470页

作者： melissa A.Rudy Trent A.Watkins Division of Neuroimmunology and Glial Biology Department of NeurologyUniversity of California at San FranciscoSan FranciscoCAUSA Development Disease Modelsand Therapeutics Graduate ProgramBaylor College of MedicineHoustonTXUSA

Stress signaling following axon injury stimulates a transcriptional program for regeneration that might be exploited to promote central nervous system ***,this stress response drives neuronal apoptosis in non-regenerative *** duality presents a quandary for the development of therapeutic interventions:manipulating stress signaling to enhance recovery of damaged neurons risks accelerating neurodegeneration or restricting regenerative *** dichotomy is well illustrated by the fates of retinal ganglion cells(RGCs)following optic nerve *** this central nervous system injury model,disruption of a stress-activated MAP kinase(MAPK)cascade blocks the extensive apoptosis of RGCs that occurs in wild-type mice(Watkins et al.,2013;Welsbie et al.,2017).

关键词： injury axonal stress

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Should we perform decompressive laparotomy during severe acute pancreatitis with intra-abdominal hypertension below 25 mmHg:Only the gut knows

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1470-1473页

作者： Thibault Vieille melissa Crotet Celia Turco Paul Monasterolo Hadrien Winiszewski Gael Piton Medical Intensive Care Unit Besancon University HospitalBesancon 25000France Intensive Care Unit Vesoul HospitalVesoul 70000France Department of Digestive Surgical Oncology-Liver Transplantation Unit Besancon University HospitalBesancon 25000France Inserm UMRS-938 Centre de Recherche Saint-Antoine(CRSA)Sorbonne UniversitéParis 10041NY212France Intensive Care Unit Nord Franche Comte HospitalTrevenans 90400France

We suggest that during severe acute pancreatitis(SAP)with intra-abdominal hypertension,practitioners should consider decompressive laparotomy,even with intra-abdominal pressure(IAP)below 25 ***,in this setting,non-occlusive mesenteric ischemia(NOMI)may occur even with IAP below this cutoff and lead to transmural necrosis if abdominal perfusion pressure is not promptly *** report our experience of 18 critically ill patients with SAP having undergone decompressive laparotomy of which one third had NOMI while IAP was mostly below 25 mmHg.

关键词： Acute pancreatitis Abdominal compartment syndrome Decompressive laparotomy Mesenteric ischemia Intra-abdominal pressure Abdominal perfusion pressure

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

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Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li Jing Lyu Bei Qiu Ying-Hao Li Ruth Foley Ri-Jian Song melissa Johnson Qiang Geng Wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

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Injury and illness in short-course triathletes:A systematic review

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Journal of Sport and Health Science 2024年第2期13卷 172-185页

作者： Sara A.Guevara melissa L.Crunkhorn Michael Drew Gordon Waddington Julien D.Périard Naroa Etxebarria Liam A.Toohey Paula Charlton University of Canberra Research Institute for Sport and Exercise(UCRISE) BruceACT 2617Australia New South Wales Institute of Sport SydneyNSW 2127Australia Queensland Academy of Sport BrisbaneQLD 4111Australia Triathlon Australia Gold CoastQLD 4227Australia Australian Institute of Sport BruceACT 2617Australia

Background:Determining the incidence and prevalence of injury and illness in short-course triathletes would improve understanding of their etiologies and therefore assist in the development and implementation of prevention *** study synthesizes the existing evidence on the incidence and prevalence of injury and illness and summarizes reported injury or illness etiology and risk factors affecting short-course ***:This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** reporting health problems(injury and illness)in triathletes(all sexes,ages,and experience levels)training and/or competing in short-course distances were *** electronic databases(Cochrane Central Register of Controlled Trials,MEDLINE,Embase,APA PsychINFO,Web of Science Core Collection,and SPORTDiscus)were *** of bias was independently assessed by 2 reviewers using the Newcastle-Ottawa Quality Assessment *** authors independently completed data ***:The search yielded 7998 studies,with 42 studies eligible for ***-three studies investigated injuries,24 studies investigated illnesses,and 5 studies investigated both injuries and *** injury incidence rate ranged 15.7-24.3 per 1000 athlete exposures,and the illness incidence rate ranged 1.8-13.1 per 1000 athlete *** and illness prevalence ranged between 2%-15%and 6%-84%,*** injuries reported occurred during running(45%-92%),and the most frequently reported illnesses affected the gastrointestinal(7%-70%),cardiovascular(14%-59%),and respiratory systems(5%-60%).Conclusion:The most frequently reported health problems in short-course triathletes were:overuse and lower limb injuries associated with running;gastrointestinal illnesses and altered cardiac function,primarily attributable to environmental factors;and respiratory illness mostly caused by infection.

关键词： Athlete illnesses Athletic injuries Epidemiology Triathlon

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