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Non-operative successful management of a perforated small bowel diverticulum

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World Journal of Gastroenterology 2014年第48期20卷 18477-18479页

作者： melissa M Levack Maria Lucia Madariaga Haytham MA Kaafarani Division of Trauma Department of Surgery SurgicalCritical Care Massachusetts General Hospital Harvard MedicalSchool Boston MA 02114 United States

Jejunoileal diverticula are rare and generally asymptomatic. In the few cases of patients who develop complications such as diverticulitis, perforation, obstruction, and/or hemorrhage, conventional treatment consists of surgical resection. We describe a case of perforated jejunoileal diverticulum with localized abscess and highlight the merits of surgical vs medical management. The patient is a 77-year-old male who presented with sharp, constant abdominal pain just inferior to the umbilicus. Administration of intravenous antibiotics results in complete and long-term resolution of the patient’s symptoms. In this report, we establish a framework for safely treating perforated small bowel diverticulum without surgical exploration.

关键词： Jejunal diverticula Diverticulitis Small bowel perforation Antibiotics Abscess

Role of Schwann cells in the regeneration of penile and peripheral nerves

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Asian Journal of Andrology 2015年第5期17卷 776-782,I0008页

作者： Lin Wang melissa T Sanford Zhongcheng Xin Guiting Lin Tom F Lue Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA USA Andrology Center Department of Urology Peking University First Hospital Peking University Beijing China

Schwann cells （SCs） are the principal gila of the peripheral nervous system. The end point of SC development is the formation of myelinating and nonmyelinating cells which ensheath large and small diameter axons, respectively. They play an important role in axon regeneration after injury, including cavernous nerve injury that leads to erectile dysfunction （ED）. Despite improvement in radical prostatectomy surgical techniques, many patients still suffer from ED postoperatively as surgical trauma causes traction injuries and local inflammatory changes in the neuronal microenvironment of the autonomic fibers innervating the penis resulting in pathophysiological alterations in the end organ. The aim of this review is to summarize contemporary evidence regarding：（1） the origin and development of SCs in the peripheral and penile nerve system; （2） Wallerian degeneration and SC plastic change following peripheral and penile nerve injury; （3） how SCs promote peripheral and penile nerve regeneration by secreting neurotrophic factors; （4） and strategies targeting SCs to accelerate peripheral nerve regeneration. We searched PubMed for articles related to these topics in both animal models and human research and found numerous studies suggesting that SCs could be a novel target for treatment of nerve injury-induced ED.

关键词： erectile dysfunction growth factors prostatectomy

Interval estimation for minimal clinically important difference and its classification error via a bootstrap scheme

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Statistical Theory and Related Fields 2020年第2期4卷 135-145页

作者： Zehua Zhou Jiwei Zhao melissa Kluczynski Department of Biostatistics School of Public Health and Health ProfessionsState University of New York at BuffaloBuffaloNYUSA Department of Orthopaedics Jacobs School of Medicine and Biomedical SciencesState University of New York at BuffaloBuffaloNYUSA

With the improved knowledge on clinical relevance and more convenient access to the patientreported outcome data,clinical researchers prefer to adopt minimal clinically important difference(MCID)rather than statistical significance as a testing standard to examine the effectiveness of certain intervention or treatment in clinical trials.A practical method to determining the MCID is based on the diagnostic *** using this approach,the MCID can be formulated as the solution of a large margin classification ***,this method only produces the point estimation,hence lacks ways to evaluate its *** this paper,we introduce an m-out-of-n bootstrap approach which provides the interval estimations for MCID and its classification error,an associated accuracy measure for performance assessment.A variety of extensive simulation studies are implemented to show the advantages of our proposed *** of the chondral lesions and meniscus procedures(ChAMP)trial is our motivating example and is used to illustrate our method.

关键词： Minimal clinically important difference classification error confidence interval non-convex optimisation bootstrap m-out-of-n bootstrap

Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis

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Translational Neurodegeneration 2017年第1期6卷 29-36页

作者： Gary Leung melissa Tully Jonathan Tang Shengxi Wu Riyi Shi Department of Basic Medical Sciences College of Veterinary MedicinePurdue UniversityWest LafayetteIN 47907USA Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIN 47907USA MSTP program Indiana University School of MedicineIndianapolisINUSA Department of Neurobiology Fourth Military Medical UniversityXi’anChina

Background:It is increasingly clear that in addition to myelin disruption,axonal degeneration may also represent a key pathology in multiple sclerosis(MS).Hence,elucidating the mechanisms of axonal degeneration may not only enhance our understanding of the overall MS pathology,but also elucidate additional therapeutic *** objective of this study is assess the degree of axonal membrane disruption and its significance in motor deficits in EAE ***:Experimental Autoimmune Encephalomyelitis was induced in mice by subcutaneous injection of myelin oligodendrocyte glycoprotein/complete Freud’s adjuvant emulsion,followed by two intraperitoneal injections of pertussis *** assessment was performed using a 5-point *** Peroxidase Exclusion test was used to quantify the disruption of axonal *** glycol was prepared as a 30%(w/v)solution in phosphate buffered saline and injected ***:We have found evidence of axonal membrane disruption in EAE mice when symptoms peak and to a lesser degree,in the pre-symptomatic stage of EAE ***,polyethylene glycol(PEG),a known membrane fusogen,significantly reduces axonal membrane disruption in EAE *** PEG-mediated membrane repair was accompanied by significant amelioration of behavioral deficits,including a delay in the emergence of motor deficits,a delay of the emergence of peak symptom,and a reduction in the severity of peak ***:The current study is the first indication that axonal membrane disruption may be an important part of the pathology in EAE mice and may underlies behavioral *** study also presents the initial observation that PEG may be a therapeutic agent that can repair axolemma,arrest axonal degeneration and reduce motor deficits in EAE mice.

关键词： Multiple sclerosis EAE Axonal membrane damage Polyethylene glycol Acrolein Horseradish Peroxidase Membrane permeability Neurodegeneration

A Survey on Mixed Spin P-Fields

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Chinese Annals of Mathematics,Series B 2017年第4期38卷 869-882页

作者： Huai-Liang CHANG Jun LI Wei-Ping LI Chiu-Chu melissa LIU Department of Mathematics Hong Kong University of Science and Technology Hong Kong China. Shanghai Center for Mathematical Sciences Fudan University Shanghai 200433 China Department of Mathematics Stanford University Stanford CA 94305-2125 USA. Department of Mathematics Columbia University New York NY 10027 USA.

The mixed spin P-fields （MSP for short） theory sets up a geometric platform to relate Gromov-Witten invariants of the quintic three-fold and Fan-Jarvis-Ruan-Witten invariants of the quintic polynomial in five variables. It starts with Wittens vision and the P-fields treatment of GW invariants and FJRW invaxiants. Then it briefly discusses the master space technique and its application to the set-up of the MSP moduli. Some key results in MSP theory are explained and some examples are provided.

关键词： Mixed Spin P-fields GW invariants FJRW invariants P-fields Cosection localization

Thermoelectric Properties of p-Type PbSe Nanowires

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Nano Research 2009年第5期2卷 394-399页

作者： Wenjie Liang Oded Rabin Allon IHochbaum melissa Fardy Minjuan Zhang Peidong Yang Department of Chemistry University of CaliforniaBerkeleyCA 94720USA Materials Research Department Toyota Technical CenterToyota Motor Engineering&Manufacturing North America(TEMA)Inc.1555 Woodridge Ave.Ann ArborMI 48105USA Current Address:Institute of Physics Chinese Academy of SciencesBeijing 100080China Current Address:Department of Materials Science and Engineering and the Institute for Research in Electronics and Applied Physics University of MarylandCollege ParkMD 20742USA

The thermoelectric properties of individual solution-phase synthesized p-type PbSe nanowires have been *** nanowires showed near degenerately doped charge carrier *** to the bulk,the PbSe nanowires exhibited a similar Seebeck coefficient and a significant reduction in thermal conductivity in the temperature range 20 K to 300 *** annealing of the PbSe nanowires allowed their thermoelectric properties to be controllably tuned by increasing their carrier concentration or hole *** optimal annealing,single PbSe nanowires exhibited a thermoelectric figure of merit(ZT)of 0.12 at room temperature.

关键词： Nanowire thermoelectrics thermopower thermal conductivity lead chalcogenide

The effects of glycyrrhizic acid and glabridin in the regulation of CXCL5 inflammation gene on acceleration of wound healing

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 108-113页

作者： Hong Yung Yip melissa Su Wei Poh Yoke Yin Chia School of Biosciences Division of Medicine Pharmacy and Health Sciences Taylor's University

Objective: To evaluate the anti-inflammatory property of both glycyrrhizic acid(GA)and glabridin in reducing inflammation to accelerate wound regeneration on 3T3-L1 and NIH-3T3 fibroblast cell ***: Cell proliferation and viability assay(MTT assay), scratch wound healing assays,and quantitative real-time PCR were conducted to investigate the effects on cell proliferation,cell migration, and expression of CXC chemokine ligand 5 inflammation gene ***: Results showed that at a low concentration of 1 × 10^(-8)mol/L, glabridin down regulated cell proliferation in NIH-3T3 significantly, suggesting its involvement in ERK1/2 signaling pathway. GA and glabridin significantly accelerated cell migration through wound healing in both 3T3-L1 and NIH-3T3 and significantly down regulated the expression of CXC chemokine ligand 5 in 3T3-L1 at concentration 1 × 10^(-8)mol/L,indicating the possible involvement of nuclear factor-k B and cyclooxygenase 2 transcriptions ***: Both GA and glabridin can serve as potential treatment for chronic inflammatory disease, and glabridin as an oncogenic inhibitor due to its anti-proliferative property.

关键词： Wound healing Glycyrrhizic acid Glabridin CXCL5 Inflammation Cell proliferation Cell migration

Synchronous colorectal cancer: Clinical, pathological and molecular implications

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World Journal of Gastroenterology 2014年第22期20卷 6815-6820页

作者： Alfred King-Yin Lam Sally Sze-Yan Chan melissa Leung Cancer Molecular Pathology Griffith Health InstituteGriffith UniversityGold Coast QLD 4222QueenslandAustralia

Synchronous colorectal carcinoma refers to more than one primary colorectal carcinoma detected in a single patient at initial presentation. A literature review has shown that the prevalence of the disease is approximately 3.5% of all colorectal carcinomas. This disease has a male to female ratio of 1.8:1. The mean age at presentation of patients with synchronous colorectal cancer is in the early half of the seventh decade. Patients with inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), hereditary non-polyposis colorectal cancer, familial adenomatous polyposis and serrated polyps/hyperplastic polyposis are known to have a higher risk of synchronous colorectal carcinoma. These predisposing factors account for slightly more than 10% of synchronous colorectal carcinomas. Synchronous colorectal carcinoma is more common in the right colon when compared to solitary colorectal cancer. On pathological examination, some synchronous colorectal carcinomas are mucinous adenocarcinomas. They are usually associated with adenomas and metachronous colorectal carcinomas. Most of the patients with synchronous colorectal cancer have two carcinomas but up to six have been reported in one patient. Patients with synchronous colorectal carcinoma have a higher proportion of microsatellite instability cancer than patients with a solitary colorectal carcinoma. Also, limited data have revealed that in many synchronous colorectal carcinomas, carcinomas in the same patient have different patterns of microsatellite instability status, p53 mutation and K-ras mutation. Overall, the prognosis of patients with synchronous colorectal carcinoma is not significantly different from that in patients with solitary colorectal carcinoma, although a marginally better prognosis has been reported in patients with synchronous colorectal carcinoma in some series. A different management approach and long-term clinical follow-up are recommended for some patients with synchronous colorect

关键词： Synchronous carcinoma Colorectal carcinoma Prevalence Microsatellite instability Review

Effectiveness of modified pedestrian crossing signs in an urban area

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第1期9卷 21-32页

作者： Stephen A.Arhin Adam Gatiba melissa Anderson Babin Manandhar Melkamsew Ribbisso Ebenezer Acheampong Transportation Research Center Howard UniversityWashington DC 20059USA

The District of Columbia currently uses the standard pedestrian warning signs and diagonal arrow plaques at a substantial number of uncontrolled crosswalks within the ***, the widespread use of these measures appears to be ineffective in curbing the incidence of pedestrian involved crashes or pedestrian-vehicle conflicts. To compensate for the perceived lack of effectiveness of the standard pedestrian warning sign the District Department of Transportation developed a new side-of-street crossing sign to improve driver compliance based on pedestrian right-of-way *** study was aimed at determining the effectiveness(defined as the proportion of drivers approaching a crosswalk who stop or yield the right of way to a pedestrian in the crosswalk) of the experimental side-of-street pedestrian crossing sign compared to the standard sign, with and without rectangular rapid flashing beacons. Effectiveness of the side-of-street pedestrian sign and standard sign were observed at a total of 32 locations in the District over a one-year period using the “control” and “experimental” comparison approach. Video data for each location was obtained from March 2018 through February 2019 during typical weekdays for the morning and afternoon peak periods. The results of the study showed that the experimental signs with RRFBs provided higher driver compliance rates(yielding to pedestrians) compared to the standard signs for both the morning and afternoon peak periods. However, the differences in compliance rates for the experimental and standard signs were not statistically significant at a 95% confidence *** evaluation of the signs is recommended using the “before” and “after” approach in addition to an assessment of crash statistics at the selected locations.

关键词： Transportation engineering Pedestrian signs Crosswalk Compliance Driver yielding behavior District of Columbia