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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 41-42页

作者： melichar b. UrminskáH. KohlováT. 赵秀敏 Dept. of Oncology and R adiotherapy Charles Univ. Med.Sch. Teach. Hosp. Hradec Králové Czech Republ ic

b.ckground. b.ain represents a rare site of metastasis in patients with epithe lial ovarian carcinoma (EOC).Case report. We ob.erved a case of multiple b.ain m etastases in an EOC patient after complete response of a pelvic recurrence to pl atinum/paclitaxel chemotherapy. Complete response of b.ain metastases was ob.erv ed after whole b.ain radiotherapy and sub.equent chemotherapy b. comb.nation of cisplatin and gemcitab.ne. Three sub.equent recurrences of b.ain metastases were controlled b. re-treatment b. the comb.nation of 5-fluorouracil, cisplatin an d gemcitab.ne. Methods. b.cause of limited information on the outcome of EOC b.a in metastases in reported case series, a pooled analysis of the pub.ished report s in patients with EOC b.ain metastases was performed. Data were extracted from 46 reports that contained sufficient details on 189 individual patients. The sur vival was analyzed b. the Kaplan-Meier method. Univariate and multivariate anal yses were performed b. the log-rank test and Cox method, respectively. Results. The most favorab.e outcome was ob.erved in patients treated b. surgery comb.ned with radiotherapy and/or chemotherapy. The survival was significantly b.tter in reports describ.ng only one or two cases, in patients diagnosed after 1992, in patients who received therapy in addition to symptomatic treatment, in patients treated b. radiotherapy, chemotherapy and surgery, in patients without extracran ial metastases and with single b.ain metastases. On multivariate analysis, the a b.ence of extracranial metastases, treatment b. chemotherapy, surgery and radiot herapy were independent positive predictors of survival. Conclusions. EOC b.ain metastases are responsive to chemotherapy. An aggressive multidisciplinary thera peutic approach including chemotherapy may lead to prolonged survival.

关键词：卵巢上皮癌脑转移文献回顾合并分析联合化疗患者存活率紫杉醇化疗联合放疗尿嘧啶转移部位

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Different clinical presentations of metachronous pulmonary metastases after resection of pancreatic ductal adenocarcinoma: Retrospective study and review of the literature

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World Journal of Gastroenterology 2017年第35期23卷 6420-6428页

作者： Martin Lovecek Pavel Skalicky Josef Chudacek Marek Szkorupa Hana Sveb.sova Radmila Lemstrova Jiri Ehrmann b.huslav melichar Tharani Yogeswara Dusan Klos Radek Vrb. Roman Havlik b.atrice Mohelnikova-Duchonova Department of Surgery I University Hospital Olomouc and Faculty of Medicine and DentistryPalacky University Department of Oncology University Hospital Olomouc and Faculty of Medicine and DentistryPalacky University Department of Molecular Pathology Faculty of Medicine and DentistryPalacky University OlomoucUniversity Hospital Olomouc Institute of Molecular and Translational Medicine Faculty of Medicine and DentistryPalacky University Department of Oncology Faculty of Medicine and DentistryPalacky University OlomoucUniversity Hospital Olomouc Department of Surgery I Faculty of Medicine and DentistryPalacky University

AIM To analyze pancreatic cancer patients who developed metachronous pulmonary metastases(MPM) as a first site of recurrence after the curative-intent *** One-hundred-fifty-nine consecutive pancreatic ductal adenocarcinoma(PDAC) patients who underwent radical pancreatic surgery b.tween 2006 and 2013 were included in this retrospective analysis. The clinical data including age, sex, grade, primary tumor location, p TNM stage, lymph node infiltration, microangioinvasion, perineural invasion, lymphovascular invasion, the therapy administered, and follow-up were all ob.ained from medical records. Further analysis covered only patients with metachronous metastases. Clinical and histopathological data(age, sex, grade, primary tumor location, p TNM stage, lymph node infiltration, microangioinvasion, perineural invasion, lymphovascular invasion, the therapy administered and follow-up) of patients with metachronous non-pulmonary metastases and patients with metachronous pulmonary metastases were statistically assessed. Disease-free survival(DFS) from pancreas resection until metastases onset and overall survival(OS) were calculated. Wilcoxon test, χ~2 test and survival functions computed b. the KaplanMeier method were used. Statistical significance was evaluated b. the log-rank test using SPSS. A P-value of less than 0.05 was considered statistically *** Metachronous pulmonary metastases were ob.erved in 20(16.9%) and were operab.e in 3(2.5%) of PDAC patients after a prior curative-intent surgery. Patients with isolated pulmonary metastases(oligometastases and multiple metastases) had estimated prior DFS and OS of 35.4 and 81.4 mo, respectively, and those with metachronous pulmonary metastases accompanied b. other metastases had prior DFS and OS of 17.3 and 23.4 mo, respectively. Patients with non-pulmonary metastases had prior DFS and OS of 9.4 and 15.8 mo, respectively. Different clinical scenarios according to the presentation of MPM were ob.er

关键词： Pancreatic cancer Pulmonary metastases Metachronous metastases Surgical resection Overall survival Chemotherapy

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