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Prognostic factors of breast cancer brain metastasis

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World Journal of Clinical Oncology 2024年第1期15卷 5-8页

作者： melek Yakar Durmuş Etiz Department of Radiation Oncology Osmangazi UniversityEskişehir 26040Turkey Department of Radiation Oncology Eskisehir Osmangazi University Faculty of MedicineEskişehir 26040Turkey

In this editorial we comment on the article by Chen et al published in the recent issue of the World Journal of Clinical *** metastasis is one of the most serious complications of breast cancer and causes high morbidity and *** metastases may involve the brain parenchyma and/or *** brain metastases develop in 10%-16%of newly recognized cases each year,and this rate increases to 30%in autopsy *** on the size of the metastatic foci,it may be accompanied by extensive vasogenic edema or may occur as small tumor *** brain metastases are a significant cause of morbidity and mortality,early diagnosis can have significant effects on survival and quality of *** risk of developing brain metastases emerges progressively due to various patient and tumor *** variability may be particularly important in the susceptibility and distribution of brain metastases because malignant blood must cross the brain barrier and move within the brain *** characteristics of the tumor,such as gene expression,may increase the risk of brain *** growth,tumor stage,tumor grade,growth receptor positivity,HER2 positivity,molecular subtype(such as triple negative status,luminal/nonluminal feature)increase the risk of developing breast cancer *** related to survival due to breast cancer brain metastasis include both tumor/patient characteristics and treatment characteristics,such as patient age,lung metastasis,surgery for brain metastasis,and HER2 *** cases with a high risk of developing brain metastasis can be identified with the help of clinical procedures and artificial intelligence,survival and quality of life can be increased with early diagnosis and *** the same time,it is important to predict the formation of this group in order to develop new treatment methods in cases with low survival expectancy with brain metastases.

关键词： Breast cancer Brain metastasis Prognosis Artificial intelligence Clinicopathological features

Circulating tumor cells as prognostic marker in pancreatic cancer

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World Journal of Clinical Oncology 2024年第2期15卷 165-168页

In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Clinical *** cancer is the fourth most common cause of cancer-related mortality and has the lowest survival rate among all solid *** causes 227000 deaths annually worldwide,and the 5-year survival rate is very low due to early metastasis,which is 4.6%.Cancer survival increases with better knowledge of risk factors and early and accurate *** tumor cells(CTCs)are tumor cells that intravasate from the primary tumor or metastasis foci into the peripheral blood circulation system spontan-eously or during surgical *** of CTC in blood is promising for early *** addition,studies have associated high CTC levels with a more advanced stage,and more intensive treatments should be considered in cases with high *** tumors that are considered radiologically resectable,it may be of critical importance in detecting occult metastases and preventing unnecessary surgeries.

关键词： Pancreatic cancer Circulating tumor cells Prognosis Biomarkers Overall survival

Detection of critical road roughness sections by trend analysis and investigation of driver speed interaction

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 515-532页

作者： Meltem SAPLIOGLU Ayse UNAL melek BOCEK Department of Civil Engineering Suleyman Demirel UniversityIsparta 32260Turkey Department of Civil Engineering Siirt UniversitySiirt 56100Turkey

Pavement roughness(IRI—International Roughness Index values)influence the stability of traffic movements both on intercity roads and urban *** study is to determine the exact locations of critical pavement roughness values that affect traffic motion stability and comfort in city centre highway *** data with 10 m intervals were collected on a 3140 m divided road containing three consecutive signalized intersections in the city centre *** data were analysed using the distance-dependent Mann-Kendall trend analysis method and checkerboard *** sections where roughness is important were determined at a 95%confidence *** results will show where future pavement improvements should be prioritized for municipalities and road maintenance engineers and will form a basis for the urban road management system.

关键词： trend analysis checkerboard model IRI driver speed

Crystal Structure, Vibrational Studies, Optical Properties and TG-DTA Investigations of a New Chlorocadmate Templated by 1-Methylimidazolium

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Chemical Research in Chinese Universities 2016年第2期32卷 253-260页

作者： melek HAJJI Taha GUERFEL Laboratory of Electrochemistry Materials and Environment Preparatory Institute for Engineering Studies Kairouan University 3100 Kairouan Tunisia

Chemical preparation, X-ray single crystal diffraction, thermal analysis, electrochemical measurements, IR, Raman and UV spectroscopic investigations of a novel organic-inorganic hybrid material（CaH7N2）CdCl3（H2O）（1） were described. 1-Methylimidazolium aquapentachlorocadmate（II） crystallized in the monoclinic system with P2 1/n space group. Its structure provided a new interesting example of infinite inorganic layers of [CdCl3（H2O）]n n- centered by （-101） planes. The [CdCl5（H2O）]- anions were interconnected by O-H...Cl hydrogen bonds. Acidic protons of the chloride group were transferred to the organic molecule, giving the singly-protonated cations. The ability of ions to form a spontaneous three-dimensional structure through O-H…Cl and N-H…Cl hydrogen bonds was fully utilized. These hydrogen bonds induced notable vibrational effects. IR and Raman spectra were reported and discussed on the basis of group theoretical analysis and on quantum chemical density theory（DFT） calculation. The molecular HOMO-LUMO compositions and their respective energy gaps were also drawn to explain the activity of our compound. The role of the intermolecular interaction in this crystal was analyzed. The optical study was also investigated by UV-Vis absorption spectrum. Thermal analysis reveals the hydrous character of the compound. Cyclic voltammetry was studied to evaluate the spectral and structural changes accompanying electron transfer.

关键词： Chlorocadmate(II) X-Ray diffraction Thermal analysis(TG-DTA) Vibrational study Density functional theory calculation Cyclic voltammetry

Comprehensive chemical characterization of PM_(2.5) in the large East Mediterranean-Middle East city of Beirut,Lebanon

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Journal of Environmental Sciences 2023年第11期133卷 118-137页

作者： Nansi Fakhri Marc Fadel Fatma Ozturk melek Keles Minas Iakovides Michael Pikridas Charbel Abdallah Cyril Karam Jean Sciare Patrick L.Hayes Charbel Afif EMMA Research Group Centre d’Analyses et de RechercheFaculty of SciencesUniversitéSaint-JosephBeirutLebanon Department of Chemistry Faculty of SciencesUniversitéde MontréalMontréalQuébecCanada Environmental Engineering Department Faculty of EngineeringBolu Abant Izzet Baysal UniversityBoluTurkey Climate and Atmosphere Research Center(CARE-C) The Cyprus InstituteNicosiaCyprus

The chemical composition of PM_(2.5) at two sites in Lebanon,a country in the East Mediterranean-Middle East region,is investigated in the spring and summer *** average PM_(2.5) concentrations were of(29±16)μg/m 3 for Beirut urban site and(32±14)μg/m 3 for Beirut suburban *** study showed that the geographic location of the East Mediterranean region,such as its proximity to the Mediterranean Sea and the dust storm intrusion are a significant contributor to the high PM levels from natural sources,which cannot be mitigated,rendering the PM_(2.5) WHO annual Air Quality guideline unattainable due to high natural background,which also applies to the entire Middle East *** and Eastern Europe are the dominant origin of air masses throughout our sampling days,suggesting the long-range transport as an important potential contributor to the high observed concentrations of V,Ni,and sulfate in this region most probably in other East Mediterranean countries than Lebanon *** local sources determined through the chemical speciation including organics are road transport,resuspension of dust and diesel private generators.A health risk assessment of airborne metals was performed and the carcinogenic risk for all the metals exceeded by 42(adults)and 14(children)times the acceptable risk level(10^(-6))at both *** was the predominant carcinogenic metal,emphasizing the need to replace energy production with cleaner energy on a regional level and highlighting the severe impact of air pollution on the health of inhabitants in this region’s main cities.

关键词： Chemical composition PM_(2.5) Eastern Mediterranean Middle East Organic aerosols Health risk assessment

Geochemistry and Petrogenesis of Intracontinental Basaltic Volcanism on the Northwest Arabian Plate,Gaziantep Basin,Southeast Anatolia,Turkey

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Acta Geologica Sinica(English Edition) 2018年第2期92卷 519-535页

作者： Sevcan KURUM Abdurrahman BOLUCU melek URAL Department of Geological Engineering University of Ftrat23110 ElazigTurkey Institute of Science and Technology University of Ftrat23110 Elaztg Turkey

Volcanism along the northwest boundary of the Arabian Plate found in the Gaziantep Basin, southeast Turkey, is of Miocene age and is of alkaline and calc-alkaline basic composition. The rare earth element data for both compositional series indicates spinel-peridotite source areas. The rare earth and trace elements of the alkaline lavas originate from a highly primitive and slightiy contaminated asthenospheric mantle; those of the calc-alkaline lavas originate from a highly heterogeneous, asthenospheric, and lithospheric mantle source. Partial melting and magmatic differentiation processes played a role in the formation of the petrological features of these volcanics. These rocks form two groups on the basis of their 87Sr[S6Sr and 143Nd/lI4Nd isotopic compositions in addition to their classifications based on their chemical compositions （alkaline and calc-alkaline）. These isotopic differences indicate a dissimilar parental magma. Therefore, high Nd isotope samples imply a previously formed and highly primitive mantle whereas low Nd isotope samples may indicate comparable partial melting of an enriched heterogeneous shallow mantle. Other isotopic changes that do not conform to the chemical features of these lavas are partly related to the various tectonic events of the region, such as the Dead Sea Fault System and the Bitlis Suture Zone.

关键词： petrography geochemistry isotopes basaltic volcanism Arabian Plate Turkey

Faculty of health sciences students’knowledge and attitudes toward coronavirus disease 2019 during the first wave of the pandemic:A cross-sectional survey

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Journal of Integrative Nursing 2022年第3期4卷 151-156页

作者： melek Ertürk YAVUZ Bahar CandaşALTINBAŞ Didem SARIMEHMET Ayla GÜRSOY CanselÖZEL Department of Surgical Nursing Faculty of Health SciencesArtvinÇoruh UniversityArtvinTurkey Department of Surgical Nursing Faculty of Health SciencesKaradeniz Technical UniversityTrabzonTurkey Department of Medical Services and Techniques Vocational School of Health SciencesKaradeniz Technical UniversityTrabzonTurkey Department of Surgical Nursing Faculty of Health SciencesAntalya Bilim UniversityAntalyaTurkey Neonatal Intensive Care Unit ElazığMedikalpark HospitalElazığTurkey

Objective:The study aimed to determine the faculty of the health sciences students’knowledge and attitudes regarding the coronavirus disease 2019(COVID-19)*** and Methods:This cross-sectional survey was completed with 317 undergraduate students of one health sciences faculty in *** data were collected between March 1,2020,and March 15,2020,by face-to-face interviews using a questionnaire created by the ***,percentage,mean,standard deviation,and Pearson Chi-square test were used to evaluate the ***:In this study,a high proportion of students answered questions about COVID-19 *** 55.8%of the students took partial precautions against COVID-19 to protect themselves against COVID-19 and“frequent washing of hands”was the most common *** determined that the main reasons for not taking any precautions against COVID-19 were“low number of cases in Turkey”and“getting irritated by the mask.”About 98.4%of the participants were entirely/partially following the news on COVID-19,with social media being the most commonly used *** students took more protective measures than male *** 1st-year students had more positive thoughts about vaccination compared to those in the other ***:Although the knowledge of the students about COVID-19 was good in the first wave of the pandemic,more than half of the students stated that they partially complied with the protective measures.

关键词： Attitude COVID-19 knowledge pandemic student

Commentary on COVID-19-induced liver injury in various age and risk groups

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World Journal of Virology 2023年第1期12卷 44-52页

作者： ÖnerÖzdemir Hacer Efnan melek Arsoy Department of Pediatrics Sakarya UniversityMedical FacultySakarya 54100Türkiye

Towards the end of 2019,a new type of coronavirus,severe acute respiratory syndrome,emerged in the city of Wuhan in China's Hubei *** first occurrence was described as a case of *** disease 2019(COVID-19)can progress primarily with symptoms varying from a mild upper respiratory tract infection to severe pneumonia,acute respiratory distress syndrome,and *** the mechanisms of action of this virus,which can affect all systems including gastrointestinal,is vital for predicting the progression of the disease and managing its *** is important to demonstrate the mechanisms of action of COVID-19 in patients without a previously known chronic or systemic *** there is still no specific treatment for the virus,various algorithms have been *** a result of the applied algorithms,the response to the treatment was satisfactory in some patients,while unexpected side effects occurred in some *** helps to clarify whether the unwanted effects that occur are due to the effect of the disease or the side effects of the drugs used in the *** is currently increasing interest in COVID-19 interaction with liver ***,we would like to discuss the details of liver injury/dysfunction in the current literature.

关键词： COVID-19 Liver injury SARS-CoV-2

Application of Response Surface Methodology for Optimization of Cadmium Ion Removal from an Aqueous Solution by Eggshell Powder

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Chemical Research in Chinese Universities 2018年第2期34卷 302-310页

作者： SABAH Hajji THOURAYA Turki melek Hajji NADIA Mzoughi Natural Water Treatment Laboratory Water Researches and Technologies Centre of Borj Cedria(CERTE) Technopark of Borj Cedria Soliman 8020 Tunisia Faculty of Science of Bizerte University of Carthage Jarzouna-Bizerte 7000 Tunisia Research Unit: Electrochemistry Materials and Environment Preparatory Institute forEngineering Studies of Kairouan University of Kairouan Kairouan 3100 Tunisia High Institute of Environmental Sciences and Technologies of Borj Cedria Environmental Sciences and Technologies Laboratory University of Carthage Hammam Lif 2050 Tunisia

The removal of cadmium（Cd） from synthetic solutions by batch adsorption process was performed using eggshell powder, which is mainly composed of calcite（CaCO3）. In order to optimize the adsorption process, a re- sponse surface methodology（RSM） based on Central Composite Design（CCD） was applied. Developed model for Cd removal yields（R, %） response was statistically validated by variance analysis（ANOVA） which showed a high de- termination coefficient value（R2=0.9889）. According to Minitab software, the optimal conditions were found at tem- perature of 44℃, eggshell adsorbent dose of 2.98 g, initial Cd concentration of 36.74 mg/L and initial pH of 7. Under these conditions, the Cd removal yield was 98.76%. The deviation value of 1.24% confirms the validity of the model for the adsorption process optimization. The adsorption isotherm has been described by a Freundlich model. In addition, the predominant sorption mechanisms are the chemisorptions or precipitation（non-reversible） and ion ex- change（reversible）.

关键词： Response surface methodology Cadmium Eggshell Sorption Desorpfion Freundlich model