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The association between critical life events, sociodemographic data and physical activity in the development of myocardial infarction in smokers and ex-smokers

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Open Journal of Preventive Medicine 2012年第3期2卷 403-409页

作者： Anna Schmidt Elke Driller melanie neumann Julia Jung Andrea Staratschek-Jox Christian Schneider Jürgen Wolf Holger Pfaff Department III for Internal Medicine University Hospital of Cologne Germany First Department of Internal Medicine Molecular Tumour Biology and Tumour Immunology & Centre for Integrated Oncology (CIO) University Hospital of Cologne Germany Gerhard Kienle Institute for Medical Theory Integrative and Anthroposophic Medicine Integrated Curriculum for Anthroposophic Medicine (ICURAM) Medical Department of the Private University of Witten/Herdecke Germany Institute for Medical Sociology Health Services Research and Rehabilitation Science (IMVR) Faculty of Human Science and Fac- ulty of Medicine University of Cologne Germany LIMES (Life and Medical Sciences Bonn) Genomics and Immunoregulation University of Bonn Germany

Background: Psychosocial factors attract interest in investigating the occurrence of cardiovascular disease. Design This study aimed to examine the impact of critical life events on the development of myocardial infarction in smokers and ex-smokers. We hypothesized that critical life events increase the risk of the disease. Methods: Data were taken from the Cologne Smoking Study (CoSmoS), a retrospective multicentre case-control study that examines which psychosocial factors may lead to a higher risk for smokers and ex-smokers of suffering from a myocardial infarction. Our sample consisted of n = 278 myocardial infarction participants and control participants. Both groups had a history of smoking. Logistic regression was used in the analysis. Results: The study results of the smoking and ex-smoking participants showed that sociodemographic data like gender and age have an effect on the development of myocardial infarction. Physical activity seems to offer protection aganist myocardial infarction. Final, the unexpected result that the experience of at least one critical life event seems to have a positive effect on health and so lowers the risk of myocardial infarction. Conclusions: Socio-demographic data and physical activity have an effect on the development of myocardial infarction. Participants with experience of critical life events appear to be strengthened after the events and possess adequate resources to protect their health.

关键词： Life Events Physical Activity Myocardial Infarction Smokers

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Prospects and limitations of soil amendment and irrigation techniques for the water-saving public urban greenery and ephemeral weed management in the sandy soils of the United Arab Emirates

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Journal of Arid Land 2024年第9期16卷 1288-1302页

作者： Ayesha ALAM Elke GABRIEL-neumann Department of Integrative Agriculture College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates ASPIRE Research Institute of Food Security in Drylands College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates

Public urban greenery greatly contributes to the residential and tourist value of cities in the Gulf Region,but due to the hyper-arid climatic conditions,the cost of irrigation and plant maintenance is very *** strategies to reduce the monetary and ecological costs involve the cultivation of native xerophytic plantations,and/or the use of soil improvers to increase water-and nutrient-holding capacity of the sandy *** soil improvers based on mineral,organic,or synthetic materials have entered the United Arab Emirates(UAE)market in recent years,but there is considerable uncertainty about how they should best be used in combination with ornamental plant stands involving xerophytic native *** present study investigated the effect of soil amendment and deep pipe irrigation on perennial ornamental plant stands involving native plants(Tephrosia appolinea(Gel.)Link in combination with Aerva javanica(Burm.f.)*** Schult.)and native-exotic plants(*** in combination with Ruelia simplex ***)either or not topsoil and subsoil amendment with bentonite and hydrophobic sand under the irrigation water supply of less than 50%of reference evapotranspiration(ET0).After one year of cultivation,*** and ***(native ***)produced high biomass and exhibited high water use efficiency(WUE)as compared with *** and ***(native ***)combination given that no significant differences were found under the soil amendment *** stands thrived under irrigation water supply far below what is usually supplied to exotic ornamental stands in public parks of the Al Ain City,the ***,subsoil amendment in combination with deep pipe irrigation reduced the occurrence of weeds and increased the overall plant rooting *** results suggest that subsoil amendment and irrigation up to 60-80 cm depth can potentially control ephemeral weed infestation,which is a great challenge in various plant production systems of the

关键词： native and exotic plant communities competitive strength soil improvers urban plantation subsoil amendment weed management

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Probe based confocal laser endomicroscopy of the pancreatobiliary system

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World Journal of Gastroenterology 2015年第44期21卷 12696-12708页

作者： Majid A Almadi Helmut neumann Division of Gastroenterology Department of Medicine King Saud University Medical City King Saud University Division of Gastroenterology The Mc Gill University Health Center Montreal General Hospital Mc Gill University Department of Medicine I University of Erlangen-Nuremberg

AIM:To review applications of confocal laser endomicroscopy(CLE) in pancreatobiliary lesions and studies that assessed training and interpretation of images. METHODS: A computerized literature search was performed using OVID MEDLINE, EMBASE, Cochrane library, and the ISI Web of Knowledge from 1980 to October 2014. We also searched abstracts from major meetings that included the Digestive Disease Week, Canadian Digestive Disease Week and the United European Gastroenterology Week using a combination of controlled vocabulary and text words related to p CLE, confocal, endomicroscopy, probe-based confocal laser endomicroscopy, and bile duct to identify reports of trials. In addition, recursive searches and crossreferencing was performed, and manual searches of articles identified after the initial search was also completed. We included fully published articles and those in abstract form. Given the relatively recent introduction of CLE we included randomized trials and cohort studies.R E S U LT S : In the evaluation of indeterminate pancreatobiliary strictures CLE with ERCP compared to ERCP alone can increase the detection of cancerous strictures with a sensitivity of(98% vs 45%) andhas a negative predictive value(97% vs 69%), but decreased the specificity(67% vs 100%) and the positive predictive value(71% vs 100%) when compared to index pathology. Modifications in the classification systems in indeterminate biliary strictures have increased the specificity of p CLE from 67% to 73%. In pancreatic cystic lesions there is a need to develop similar systems to interpret and characterize lesions based on CLE images obtained. The presence of superficial vascular network predicts serous cystadenomas accurately. Also training in acquiring and interpretation of images is feasible in those without any prior knowledge in CLE in a relatively simple manner and computer-aided diagnosis software is a promising innovation. CONCLUSION: The role of p CLE in the evaluation of pancreatobilia

关键词： Probe based confocal laser endomicroscopy Confocal

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Quo Vadis Influenza?

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China CDC weekly 2021年第49期3卷 1046-1048页

作者： Gabriele neumann Yoshihiro Kawaoka Influenza Research Institute University of Wisconsin-MadisonMadisonWIUSA Institute of Medical Science University of TokyoTokyoJapan Research Center for Global Viral Diseases National Center for Global Health and MedicineTokyoJapan.

The number of influenza virus detections declined tremendously after the emergence and worldwide spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);an effect most likely caused by non-pharmaceutical interventions to slow the spread of *** data suggest that influenza virus detection has slightly increased in parts of the world,perhaps owing to the relaxation of social distancing measures.

关键词： acute respiratory likely

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Colonic metastasis of Klatskin tumor:Case report and discussion of the current literature

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World Journal of Gastroenterology 2006年第33期12卷 5393-5395页

作者： M Schmeding U neumann P Neuhaus Department of Gen-eral and Transplantation Surgery Charité Campus Virchow Klini-kum Berlin Germany

We report the case of a 65-year old male patient who initially presented with recurrent episodes of upper abdominal pain, lack of appetite and weight loss. Abdominal ultrasound indicated enlarged intrahepatic bile ducts, abdominal CT scan and ERC were performed and bile duct carcinoma （Klatskin Type Ⅲ b） was diagnosed. The tumor was located in the segments 2,3,4 and 1 with possible invasion of the left intrahepatic portal vein. Both the segments 2 and 3 of the liver were atrophic and displayed a cholestatic bile duct system. Preoperatively an intraductal stent was placed in the left bile duct using ERC to drain the left hepatic lobe. A specimen of the ascites present preoperatively displayed no malignant cells. After evaluation of the preoperatively obtained data left hepatic resection was planned. Following laparotomy we found local peritoneal carcinosis in the ligamentum hepatoduodenale with lymphatic nodules that tested positive for cholangiocellular carcinoma in online pathological examination. In the course of further exploration of the abdomen a solid tumor was detected in the sigmoid colon. Regarding the advanced stage of the neoplasm it was decided to cancel hemihepatectomy and perform sigmoid resection only in order to guarantee uncomplicated intestinal passage. The sigmoid colon was removed by a typical resection technique with end- to-end anastomosis. Histological examination of the resected sigmoid revealed transmural manifestation of a malignant neoplastic process with both a tubular and a solid growth pattern in conformity with metastasis of a Klatskin tumor. The mucosal layer showed no neoplastic alteration. Peritoneal carcinosis is a common phenomenon in the dissemination pattern of advancedstage Klatskin tumors, yet to our knowledge this is the first case of intramural colonic growth following peritoneal metastasis.

关键词： Klatskin Metastasis Tumor Bile duct

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New endoscopic approaches in IBD

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World Journal of Gastroenterology 2011年第1期17卷 63-68页

作者： Helmut neumann Markus F Neurath Jonas Mudter Department of Medicine I University of Erlangen-Nuremberg91054 ErlangenGermany

Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular *** review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD.

关键词： Endoscopy Inflammatory bowel disease Endomicroscopy Endocytoscopy Narrow band imaging Fujinon intelligent color enhancement i-Scan Spectroscopy Chromoendoscopy Ulcerative colitis Crohn's disease Fluorescence endoscopy

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Beyond white light endoscopy: The role of optical biopsy in inflammatory bowel disease

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World Journal of Gastroenterology 2013年第43期19卷 7544-7551页

作者： Julia Liu Aldona Dlugosz Helmut neumann Division of Gastroenterology the Centre of Excellence for Gastrointestinal Inflammation and Immunity ResearchUniversity ofAlbertaAlberta T6G 2X8Canada Division of Gastroenterology and Hepatology Department of MedicineKarolinska University HospitalKarolinska InstitutetSE-141 86 StockholmSweden Department of Medicine 1 Interdisciplinary EndoscopyUniversity of Erlangen-Nuremberg91054 ErlangenGermany

In this review,we will discuss the use of two optical biopsy modalities in inflammatory bowel disease(IBD).The two techniques reviewed here are confocal laser endomicroscopy and *** will describe the technical performance of the procedure,discuss the clinical indications for optical biopsy in IBD,and highlight active research areas with respect to the pathogenesis of *** indications for optical biopsies in IBD include assessment of mucosal inflammation,dysplasia detection and evaluation of cell shedding for disease *** application in the area of barrier dysfunction will also be discussed.

关键词： Optical biopsy Confocal endomicroscopy Endocytoscopy Dysplasia Mucosal inflammation Disease relapse Mucosal healing Barrier function

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Defining a mountain landscape characterized by grazing using actor perception, governmental strategy, and environmental monitoring data

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Journal of Mountain Science 2019年第7期16卷 1691-1701页

作者： Wiebke neumann Camilla SANDSTROM Lina HOLMGREN Goran ERICSSON Department of Wildlife Fish and Environmental StudiesSwedish University of Agricultural Science90183 Ume&Sweden Department of Political Sciences Ume&University90183 UmeaSweden

In multi-functional mountainous landscapes worldwide,conservation of natural values is a major ***,pro-active policies can be a way *** Environmental Quality Objectives(EQO)to solve environmental problems for future generations,however,often wrestle with being too visionary and lacking specificity,which complicates their *** EQO“A Magnificent Mountain Landscape”that has been adopted by the Swedish Parliament in 1999 to preserve the pristine mountain environment in Sweden,experiences all these *** aid its implementation,we studied the conditions and processes needed to define,to evaluate,and to preserve its goals across the Swedish mountain chain,using one of its milestone targets(a landscape characterized by grazing)as a study *** qualitative and quantitative methods,we analyzed three types of data:1)referral responses to the governmental strategy document,2)interviews with relevant actors,and 3)environmental monitoring data(reindeer position data).Nationally,our results suggest a need for geographical differentiation to match regional/local ***,difference in both perception and definition of the milestone target among the actors hinders the formulation,monitoring,and evaluation of a common *** to a culture-nature divide,we found that a“within as a user”and“from the outside as an observer”perspective influenced suggested ***,we found a need for better defining whether the goal is maintaining current conditions or restoring previous *** result supports the use of animal position data as a decision support tool to monitor and to aid evaluation of the *** the number of actors involved and conflicts of interests present,we suggest the application of a structured decision process to accomplish agreements on a common ***,environmental monitoring data can aid a“landscape assessment step”as a natural part in the decision process to target landscape management acti

关键词： Milestone target Structured decision process Reindeer herding Herbivory Environmental Conservation strategy Sweden

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Advanced gastrointestinal endoscopic imaging forinflammatory bowel diseases

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World Journal of Gastroenterology 2016年第3期22卷 1246-1259页

作者： Gian Eugenio Tontini Timo Rath Helmut neumann Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San Donato20097 San Donato MilaneseItaly Department of Medicine 1 Division of GastroenterologyUniversity Hospital Erlangen91054 ErlangenGermany

Gastrointestinal luminal endoscopy is of paramount importance for diagnosis, monitoring and dysplasia surveillance in patients with both, Crohn's disease and ulcerative colitis. Moreover, with the recent recognition that mucosal healing is directly linked to the clinical outcome of patients with inflammatory bowel disorders, a growing demand exists for the precise, timely and detailed endoscopic assessment of superficial mucosal layer. Further, the novel field of molecular imaging has tremendously expanded the clinical utility and applications of modern endoscopy, now encompassing not only diagnosis, surveillance, and treatment but also the prediction of individual therapeutic responses. Within this review, we describe how novel endoscopic approaches and advanced endoscopic imaging methods such as high definition and high magnification endoscopy, dye-based and dye-less chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and molecular imaging now allow for the precise and ultrastructural assessment of mucosal inflammation and describe the potential of these techniques for dysplasia detection.

关键词： Ulcerative colitis Crohn's disease Advancedendoscopic imaging Chromoendoscopy Mucosal healing Colitis associated cancer Confocal laser endomicroscopy Endocytoscopy Molecular imaging

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Continuous size fractionation of magnetic nanoparticles by using simulated moving bed chromatography

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1346-1355页

作者： Carsten-Rene Arlt Dominik Brekel Stefan neumann David Rafaja Matthias Franzreb Institute of Functional Interfaces Karlsruhe Institute of Technology76344Eggenstein-LeopoldshafenKarlsruheGermany Institute of Materials Science TU Bergakademie Freiberg09599FreibergGermany

The size fractionation of magnetic nanoparticles is a technical problem,which until today can only be solved with great ***,there is an important demand for nanoparticles with sharp size distributions,for example for medical technology or sensor *** magnetic chromatography,we show a promising method for fractionation of magnetic nanoparticles with respect to their size and/or magnetic *** was achieved by passing magnetic nanoparticles through a packed bed of fine steel spheres with which they interact magnetically because single domain ferro-/ferrimagnetic nanoparticles show a spontaneous *** the strength of this interaction is related to particle size,the principle is suitable for size *** concept was transferred into a continuous process in this work using a so-called simulated moving bed *** a suspension of magnetic nanoparticles within a size range from 20 to 120 nm,the process showed a separation sharpness of up to 0.52 with recovery rates of 100%.The continuous feed stream of magnetic nanoparticles could be fractionated with a space-time-yield of up to 5 mg/(L∙min).Due to the easy scalability of continuous chromatography,the process is a promising approach for the efficient fractionation of industrially relevant amounts of magnetic nanoparticles.

关键词： magnetic chromatography simulated moving bed chromatography magnetic nanoparticles size fractionation

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