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World Journal of Gastroenterology 2014年第22期20卷 6774-6785页

作者： Marco scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza melania scarpa Andromachi Kotsafti Imerio Angriman Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS)35128 PadovaItaly Department of Molecular Medicine University of Padova35128 PadovaItaly Department of Surgery Gastroenterology and OncologyUniversity of Padova35128 PadovaItaly

Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic ***-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal *** fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite *** of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory ***,p53 is frequently mutated in the early stages of UC-associated *** is an independentrisk factor for forthcoming carcinogenesis in *** cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis.

关键词： Colorectal cancer Ulcerative colitis Carcinogenesis Immune surveillance

Therapeutic strategies for pediatric non-alcoholic fatty liver disease: A challenge for health care providers

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World Journal of Gastroenterology 2007年第18期13卷 2639-2641页

作者： Valerio Nobili melania Manco Liver Unit Bambino Gesù Children's Hospital and Research Institute Rome Italy

Non-alcoholic steato-hepatitis (NASH) is related to insulin resistance and, thus, frequently occurs as part of the metabolic changes that accompany obesity, diabetes and hyperlipidemia. In childhood, the overwhelming boost of obesity and its co-morbidities have lead to the extraordinarily increased prevalence of NASH. Establishing effective therapeutic strategies to treat the disease represents the challenge for hepatologists and gastroenterologists in the next decade. Therapeutic approaches have aimed at treating associated conditions (obesity, insulin resistance, hyperlipemia, etc ) or reducing liver oxidative damage (vitamin E).

关键词： Insulin resistance Non-alcoholic fatty liverdisease Non alcoholic steato-Hepatitis Vitamin E, Diet Thiazolidinediones

Single cell whole-genome sequencing of brain cells:age-and cell-type specific mutational profiles

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3544-3545页

作者： melania Capasso N.Ahmad Aziz Immune Regulation German Center for Neurodegenerative Diseases(DZNE)BonnGermany Population and Clinical Neuroepidemiology German Center for Neurodegenerative Diseases(DZNE)BonnGermany Department of Neurology Faculty of MedicineUniversity of BonnBonnGermany

In a recent study published in Cell,Ganz et *** new light on the mutational landscape of brain cells,particularly neurons and oligodendrocytes(OLs).1 Utilizing a combination of optimized single-cell whole-genome sequencing with single-nucleus chromatin accessibility and gene expression analysis,they profiled somatic mutations in 86 OLs from 13 neurotypical individuals,spanning in age from infants to *** investigated were 56,derived from 19(including 12 overlapping)individuals(Fig.1).

关键词： landscape cytes

Enhancing bioelectricity generation in microbial fuel cells and biophotovoltaics using nanomaterials

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Nano Research 2019年第9期12卷 2184-2199页

作者： Mohammed Mouhib Alessandra Antonucci melania Reggente Amirmostafa Amirjani Alice J. Gillen Ardemis A.Boghossian Laboratory of NanoBiotechnology (LNB) Institute of Chemical Sciences and Engineering (ISIC)Ecole Polytechnique Federate de Lausanne (EPFL)Lausanne CH-1015Switzerland Department of Mining and Metallurgical Engin eering Amirkabir University of Technology (Tehran Polytechnic) Tehran ***Iran

Microbial fuel cells and biophotovoltaics represent promising technologies for green bioelectricity ***,these devices suffer from low durability and efficiency that stem from their reliance on living organisms to act as *** limitations can be overcome with augmented capabilities enabled by *** review presents an overview of the different nanomaterials used to enhance bioelectricity generation through improved light harvesting,extracellular electron transfer,and anode *** implementation of nanomaterials in whole-cell energy devices holds promise in developing bioelectrical devices that are suitable for industry.

关键词： biophotovoltaics extracellular electron transfer microbial fuel cell bioelectricity energy

Quasi noise-free digital holography

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Light(Science & Applications) 2016年第1期5卷 506-517页

作者： Vittorio Bianco Pasquale Memmolo melania Paturzo Andrea Finizio Bahram Javidi Pietro Ferraro Institute of Applied Sciences and Intelligent Systems''E.Caianiello'' Italian National Research Council(ISASI-CNR)Via Campi Flegrei 3480078Pozzuoli(Napoli)Italy ECE Department University of ConnecticutU-157StorrsConnecticut06269USA

One of the main drawbacks of Digital Holography(DH)is the coherent nature of the light source,which severely corrupts the quality of holographic *** numerous techniques to reduce noise in DH have provided good results,holographic noise suppression remains a challenging *** propose a novel framework that combines the concepts of encoding multiple uncorrelated digital holograms,block grouping and collaborative filtering to achieve quasi noise-free DH *** optimized joint action of these different image-denoising methods permits the removal of up to 98%of the noise while preserving the image *** resulting quality of the hologram reconstructions is comparable to the quality achievable with non-coherent techniques and far beyond the current state of art in *** validation is provided for both singlewavelength and multi-wavelength DH,and a comparison with the most used holographic denoising methods is performed.

关键词： coherent noise reduction digital holography image reconstruction techniques multiplex holography noise in imaging systems speckle

Endowing a plain fluidic chip with micro-optics: a holographic microscope slide

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Light(Science & Applications) 2017年第1期6卷 528-539页

作者： Vittorio Bianco Biagio Mandracchia Valentina Marchesano Vito Pagliarulo Federico Olivieri Sara Coppola melania Paturzo Pietro Ferraro Institute of Applied Sciences and Intelligent Systems-Italian National Research Council(ISASI-CNR) Via Campi Flegrei 34PozzuoliNapoli 80078Italy Universitàdegli Studi di Napoli‘Federico II’ P.le Tecchio 80Napoli 80100Italy

Lab-on-a-Chip(LoC)devices are extremely promising in that they enable diagnostic functions at the *** this scope,an important goal is to design imaging schemes that can be used out of the *** this paper,we introduce and test a pocket holographic slide that allows digital holography microscopy to be performed without an interferometer ***,a commercial off-the-shelf plastic chip is engineered and functionalized with this *** microfluidic chip is endowed with micro-optics,that is,a diffraction grating and polymeric lenses,to build an interferometer directly on the chip,avoiding the need for a reference arm and external bulky optical *** to the single-beam scheme,the system is completely integrated and robust against vibrations,sharing the useful features of any common path ***,it becomes possible to bring holographic functionalities out of the lab,moving complexity from the external optical apparatus to the chip ***-free imaging and quantitative phase contrast mapping of live samples are demonstrated,along with flexible refocusing ***,a liquid volume can be analyzed in one single shot with no need for mechanical scanning systems.

关键词： diffraction gratings digital holography Lab-on-a-Chip micro-optics optical devices polymer printing

Natural sediment at a dam and its inorganic materials as adsorbents of praseodymium(Pr(Ⅲ))

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International Journal of Sediment Research 2023年第4期38卷 566-575页

作者： melania Jiménez-Reyes Jaime Jiménez-Becerril Marcos Solache-Ríos Perla Tatiana Almazán-Sánchez Departamento de Química Instituto Nacional de Investigaciones Nucleares Carretera México-Toluca S/N CONACy T-Instituto Nacional de Investigaciones Nucleares

The sediment deposited behind a dam(DS) and its inorganic materials(IM-DS) were characterized and used for the removal of praseodymium(Pr) from aqueous solutions. Quartz, albite, and kaolinite were found in the sediment by X-ray diffraction. Kinetic data fit well to a pseudo second-order model, the equilibrium time for DS and IM-DS was 2 h and 3 min, respectively, and the adsorption capacity was higher for Pr/DS(qe= 4.91 mg/g) than for Pr/IM-DS(qe= 3.01 mg/g) in these conditions. Pr/DS and Pr/IM-DS data isotherms were in agreement with the Langmuir-Freundlich model and the maximum adsorption capacities were 4.95 and 4.01 mg/g, respectively. Both processes are exothermic(enthalpy change, ΔH0=-22.8 and-21.8 k J/mol for DS and IM-DS, respectively), the increase of the randomness is small, and the feasibility and spontaneity are low. Praseodymium was desorbed by ethylenediaminetetraacetic acid disodium(EDTA-Na2), sodium chloride, nitric, citric, and humic acids solutions, and one hundred percent of praseodymium was desorbed by the EDTA-Na2solution. The Pr2(EDTA)3(praseodymium ethylenediaminetetraacetate) complex was completely desorbed from both materials(DS and IM-DS). Distribution coefficients(KD) depend upon praseodymium concentration,temperature, p H, and the kind of adsorbent. Chemical reactions of praseodymium with kaolinite and iron minerals could explain the adsorption.

关键词： Praseodymium Sediment Adsorption process parameters Desorption

Strategies for reducing speckle noise in digital holography

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Light(Science & Applications) 2018年第1期7卷 613-628页

作者： Vittorio Bianco Pasquale Memmolo Marco Leo Silvio Montresor Cosimo Distante melania Paturzo Pascal Picart Bahram Javidi Pietro Ferraro CNR-ISASI Istituto di Scienze Applicate e Sistemi Intelligenti“E.Caianiello” via Campi Flegrei 3480078 Pozzuoli(NA)Italy Universitédu Maine CNRS UMR 6613LAUMAvenue Olivier Messiaen72085 Le Mans Cedex 9France Electrical and Computer Engineering Department University of ConnecticutU-4157StorrsCT 06269USA

Digital holography(DH)has emerged as one of the most effective coherent imaging *** technological developments of digital sensors and optical elements have made DH the primary approach in several research fields,from quantitative phase imaging to optical metrology and 3D display technologies,to name a *** many other digital imaging techniques,DH must cope with the issue of speckle artifacts,due to the coherent nature of the required light *** the complexity of the recently proposed de-speckling methods,many have not yet attained the required level of *** is,a universal denoising strategy for completely suppressing holographic noise has not yet been *** the removal of speckle noise from holographic images represents a bottleneck for the entire optics and photonics scientific *** review article provides a broad discussion about the noise issue in DH,with the aim of covering the best-performing noise reduction approaches that have been proposed so *** comparisons among these approaches will be presented.

关键词： speckle holographic coherent

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

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Nano Research 2024年第2期17卷 875-881页

作者： Rossella Labarile Danilo Vona Maria Varsalona Matteo Grattieri melania Reggente Roberto Comparelli Gianluca M.Farinola Fabian Fischer Ardemis A.Boghossian Massimo Trotta Istituto per i Processi Chimico Fisici Consiglio Nazionale delle RicercheBari 70126Italy Dipartimento di Chimica Universitàdegli Studi di BariBari 70126Italy Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Institute of Life Technologies HES-SO Valais-Wallis1950 SionSwitzerland Institute for Renewable Energy HES-SO Valais-Wallis1950 SionSwitzerland

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial *** devices are limited by the poorly conductive interface between phototrophs and synthetic materials that inhibit charge *** study focuses on overcoming this bottleneck through the metabolically-driven encapsulation of photosynthetic cells with a bio-inspired conductive *** of the purple non sulfur bacterium Rhodobacter sphaeroides were coated with a polydopamine(PDA)nanoparticle layer via the self-polymerization of dopamine under anaerobic *** treated cells show preserved light absorption of the photosynthetic pigments in the presence of dopamine concentrations ranging between 0.05–3.5 *** thickness and nanoparticle formation of the membrane-associated PDA matrix were further shown to vary with the dopamine concentrations in this *** to uncoated cells,the encapsulated cells show up to a 20-fold enhancement in transient photocurrent measurements under mediatorless *** biologically synthesized PDA can thus act as a matrix for electronically coupling the light-harvesting metabolisms of cells with conductive surfaces.

关键词： bioelectronics photosynthetic bacteria purple bacteria electron transfer polydopamine biophotovoltaics

Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： melania Reggente Charlotte Roullier Mohammed Mouhib Patricia Brandl Hanxuan Wang Stefano Tacconi Francesco Mura Luciana Dini Rossella Labarile Massimo Trotta Fabian Fischer Ardemis A.Boghossian Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Biology and Biotechnology Charles Darwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale delle Ricerche–Istituto per i Processi Chimico Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy to *** bottleneck in these technologies is the limited electron transfer between the microbe and the electrode *** study focuses on enhancing this transfer by engineering a polydopamine(PDA)coating on the outer membrane of the photosynthetic microbe Synechocystis *** coating provides a conductive nanoparticle shell to increase electrode adhesion and improve microbial charge extraction.A combination of scanning electron microscopy(SEM),transmission electron microscopy(TEM),UV–Vis absorption,and Raman spectroscopy measurements were used to characterize the nanoparticle shell under various synthesis *** cell viability and activity were further assessed through oxygen evolution,growth curve,and confocal fluorescence microscopy *** results show sustained cell growth and detectable PDA surface coverage under slightly alkaline conditions(pH 7.5)and at low initial dopamine(DA)concentrations(1 mM).The exoelectrogenicity of the cells prepared under these conditions was also characterized through cyclic voltammetry(CV)and chronoamperometry(CA).The measurements show a three-fold enhancement in the photocurrent at an applied bias of 0.3 V(***/AgCl[3 M KCl])compared to non-coated *** study thus lays the framework for engineering the next generation of living photovoltaics with improved performances using biosynthetic electrodes.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polydopamine adherence