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Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia:Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1180-1191页

作者： Qian Zhou Meiling Le Yiyi Yang Wenjuan wang Yuqi Huang Quan wang Yijing Tian meiyan Jiang Yong Rao Hai-Bin Luo Yinuo Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Song Li’Academician Workstation of Hainan University(School of Pharmaceutical Sciences) Sanya 572000China

Vascular dementia(VaD)is the second commonest type of dementia which lacks of efficient treatments currently.Neuroinflammation as a prominent pathological feature of VaD,is highly involved in the development of VaD.In order to verify the therapeutic potential of PDE1 inhibitors against VaD,the anti-neuroinflammation,memory and cognitive improvement were evaluated in vitro and in vivo by a potent and selective PDE1 inhibitor 4a.Also,the mechanism of 4a in ameliorating neuroinflammation and VaD was systematically explored.Furthermore,to optimize the drug-like properties of 4a,especially for metabolic stability,15 derivatives were designed and synthesized.As a result,candidate 5f,with a potent IC50 value of 4.5 nmol/L against PDE1C,high selectivity over PDEs,and remarkable metabolic stability,efficiently ameliorated neuron degeneration,cognition and memory impairment in VaD mice model by suppressing NF-κB transcription regulation and activating cAMP/CREB axis.These results further identified PDE1 inhibition could serve as a new therapeutic strategy for treatment of VaD.

关键词： Vascular dementia Phosphodiesterase 1(PDE1) Neuroinflammation Structural-based drug design cAMP/CREB axis

Screening Rice Germplasm with Different Genetic Backgrounds for Cadmium Accumulation in Brown Rice in Cadmium-Polluted Soils

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Rice science 2023年第4期30卷 267-270页

作者： ZHANG Weixing GUAN meiyan wang Jie wang Yulei ZHANG Weigui LU Xinzhe XU Ping CHEN Mingxue ZHU Youwei Rice Product Quality Supervision and Inspection Center China National Rice Research InstituteHangzhou 310006China Zhejiang Main Station of Cultivated Land Quality and Fertilizer Management Agricultural and Rural Bureau of Zhejiang ProvinceHangzhou 310020China Zhejiang Institute of Geological Survey Hangzhou 311200China

To screen rice germplasm with different genetic backgrounds for cadmium(Cd)accumulation in brown rice from common cultivated rice,we monitored grain Cd concentrations and characterized their patterns of 54 main varieties planted at two sites[Fuyang(FY)and Changshan(CS)in Zhejiang Province,China]with both low and high Cd-polluted levels.We found most varieties got higher Cd levels than 0.2 mg/kg in the Cd-polluted soil with the normal agronomic management,which suggested high risk of Cd exposure from the two sites.High Cd accumulation pattern was found in hybrid rice,but it differed between subspecies.Moreover,varieties with the same female or male parent may have different Cd accumulation capacities,meaning that the environment factors should be considered to screen low-Cd-accumulation varieties.

关键词： planted soil cultivated

基于P2P的碳市场交易模型及电碳联合出清方法

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电力需求侧管理 2024年第3期26卷 95-100页

作者：曾慧王美艳李涛段丽娟孙开元夏天广东电网有限责任公司广州供电局广州510620 清华大学电机工程与应用电子技术系北京100084

围绕电力行业的低碳发展需求,针对目前电力市场和碳市场所存在未能协调运行的问题,设计一种电碳联合P2P交易机制,通过引入电力P2P交易,给予用户和发电商调动自身灵活性的空间,为火电企业提供碳减排服务的同时,促进新能源消纳,提高各参... 详细信息

围绕电力行业的低碳发展需求,针对目前电力市场和碳市场所存在未能协调运行的问题,设计一种电碳联合P2P交易机制,通过引入电力P2P交易,给予用户和发电商调动自身灵活性的空间,为火电企业提供碳减排服务的同时,促进新能源消纳,提高各参与主体的效益。同时,分析了传统电力市场以及在引入P2P交易和碳市场机制的交易模式下参与主体的效益变化情况。根据设计机制的需求,建立电碳联合市场出清模型,并通过设计算例进行模拟,分析该交易机制的可行性和有效性。

关键词： P2P 碳交易电力市场电碳联合

单孔无气腹腔镜手术与传统腹腔镜手术对妇科良性疾病患者血流动力学、凝血功能及并发症的影响

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广西医学 2024年第3期46卷 392-396页

作者：朱名颖王春玲阳敏蔡美燕邓文阳桂芬中国人民解放军联勤保障部队第九二四医院妇科广西桂林市541002

目的比较单孔无气腹腔镜手术与传统腹腔镜手术对妇科良性疾病患者血流动力学、凝血功能及并发症的影响。方法选取80例行腹腔镜手术治疗的妇科良性疾病患者,随机分为对照组与研究组,各40例。对照组采用传统腹腔镜手术治疗,研究组采用单... 详细信息

目的比较单孔无气腹腔镜手术与传统腹腔镜手术对妇科良性疾病患者血流动力学、凝血功能及并发症的影响。方法选取80例行腹腔镜手术治疗的妇科良性疾病患者,随机分为对照组与研究组,各40例。对照组采用传统腹腔镜手术治疗,研究组采用单孔无气腹腔镜手术治疗。比较两组手术指标(手术时间、术中出血量、术后肛门排气时间及术后6 h、24 h疼痛程度)、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及D-二聚体水平]、血流动力学指标[平均动脉压(MAP)、心率、气道峰压、呼气末二氧化碳分压(PetCO_(2))],以及并发症发生情况。结果与对照组比较,研究组手术时间、术后肛门排气时间更短,术中出血量更少,术后6 h、24 h疼痛评分更低(P<0.05);术中30 min、术毕时,研究组PT、APTT、TT及D-二聚体水平低于对照组(P<0.05);术中60 min、术毕时,研究组MAP、心率、气道峰压及PetCO_(2)低于对照组(P<0.05);研究组并发症总发生率低于对照组(P<0.05)。结论相较于传统腹腔镜手术,单孔无气腹腔镜手术在妇科良性疾病的治疗中更具优势,可减少术中出血量,减轻患者疼痛程度,对凝血功能、血流动力学影响更小,并发症发生率更低。

关键词：妇科良性疾病单孔无气腹腔镜手术腹腔镜手术血流动力学凝血功能并发症

Effects of frozen storage on texture,chemical quality indices and sensory properties of crisp Nile tilapia fillets

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Aquaculture and Fisheries 2023年第6期8卷 626-633页

作者： Xi Xie Xiaoqian Zhai meiyan Chen Qingqing Li Yao Huang Lijuan Zhao Qin wang Li Lin College of Light Industry and Food Zhongkai University of Agriculture and EngineeringGuangzhou510225China Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl BreedingCollege of Animal Science TechnologyZhongkai University of Agriculture and EngineeringGuangzhou510225China

Crisp Nile tilapia(Oreochromis niloticus)is a kind of valuable fish product with high muscle firmness and crispiness texture.However,with the change of physicochemical in crisp Nile tilapia,the frozen storage parameters and quality would be different comparing to normal Nile tilapia.Thus,the aim of this study was to analyze the changes in texture,chemical quality indices and volatile compounds of Nile tilapia fillets during frozen storage.The remaining storage time of the crisp Nile tilapia fillets could be estimated within 120 days.During frozen storage,fillets resulted in softer started at 90-day,and 36.75%,45.74%,48.81%and 20.37%reduction of hardness,springiness,gumminess and chewiness were observed at 120-day.Thiobarbituric acid reactive substances(TBARS)for frozen samples showed similar with fresh fillets within 60 days,while the TBARS was 1.97 folds higher than fresh one at 120-day.Low-field nuclear magnetic resonance(LF-NMR)indicated that the water loss of Nile tilapia fillets was significant changed at 120-day,which reduced more than 12.5%water out of weight.The volatile compound analysis showed that more free fatty acid will be detected at 120-day comparing to the fresh fillets.The combined results demonstrated that the crisp Nile tilapia fillets had the best quality before 60 days frozen storage then loss of some quality properties in longer freezing.Thus,these results identified the ideal storage strategy for the preservation of crisp Nile tilapia without affecting sensory appeal and commercial value.

关键词： Crisp Nile tilapia Frozen storage Texture Quality Shelf life

Recent advances in small incision lenticule extraction(SMILE)-derived refractive lenticule preservation and clinical reuse

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再生工程(英文)

再生工程(英文) 2023年第2期4卷 103-121页

作者： Xiaojun Hu Ruoyan Wei Chang Liu Yunzhe wang Danjuan Yang Ling Sun Fei Xia Shengtao Liu meiyan Li Xingtao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory of Myopia NHC Key Laboratory of Myopia(Fudan University)Chinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care China

Small incision lenticule extraction(SMILE)has become one of the mainstream refractive surgeries in recent years,with satisfactory efficacy,safety,and predictability.SMILE-derived refractive lenticule,the byproduct of the surgery,holds great potential in clinical practice given its easy access and good biocompatibility.Numerous studies have been published to describe its applications in refractive correction,corneal ectasia diseases,and corneal defects.The feasibility and safety were validated in both animal models and clinical studies.Moreover,the preservation method is also crucial for its further promotion and application.Novel techniques are also evaluated and applied in lenticule preservation.We covered the recent advances in the preservation of corneal stromal lenticules and their clinical reuse in this review.

关键词： Small incision lenticule extraction Refractive lenticule Preservation Clinical reuse

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含硒结晶盐富硒实验研究

盐科学与化工 2024年第3期53卷 22-25页

作者：吕洪亮张永和张美燕毛旭林王雪枫和布克赛尔蒙古自治县宏达盐业有限责任公司新疆塔城834400 新疆煤炭清洁转化与化工过程重点实验室新疆大学化工学院新疆乌鲁木齐830017

硒对人体健康有着积极促进作用,天然盐湖产出的含硒盐硒含量达不到富硒盐标准,采用浸润法在80℃下含硒盐中分批加入浓缩含硒卤水并不断搅拌,在100℃下干燥,可明显减少团块的出现。含硒卤水加入量为10mL/100g时硒含量可达到富硒标准以上。

关键词：硒氯化钠含硒卤水

A SMOOTHING TRUST REGION METHOD FOR NCPS BASED ON THE SMOOTHING GENERALIZED FISCHER-BURMEISTER FUNCTION

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Journal of Computational Mathematics 2011年第3期29卷 261-286页

作者： Xuebin wang Changfeng Ma meiyan Li School of Mathematics and Computer Science Fujian Normal University Fuzhou 350007 China School of Mathematics and Computing Science Guilin University of Electronic Technology Guilin 5~100~ China

Based on a reformulation of the complementarity problem as a system of nonsmooth equations by using the generMized Fischer-Burmeister function, a smoothing trust re- gion Mgorithm with line search is proposed for solving general （not necessarily monotone） nonlinear complementarity problems. Global convergence and, under a nonsingularity assumption, local Q-superlinear/Q-quadratic convergence of the algorithm are established. In particular, it is proved that a unit step size is always accepted after a finite number of iterations. Numerical results also confirm the good theoretical properties of our approach.

关键词： Nonlinear complementarity problem Smoothing method Trust region method Global convergence Local superlinear convergence.

Cenozoic tectonic and geomorphic evolution of the Longxi region in northeastern Tibetan Plateau interpreted from detrital zircon

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Science China Earth Sciences 2017年第2期60卷 256-267页

作者： wang ZhiXiang LIANG meiyan SUN YuQi DAI GaoWen State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Wuhan 430074 China Laboratory of Critical Zone Evolution School of Earth Sciences China University ofGeosciences Wuhan 430074 China Department of Regional Planning and Geoinformatical Technology School of Public Administration China University of Geoscienees Wuhan 430074 China Laboratory of Geographical Environment and National Park School of Public Administration China University of Geoscience Wuhan 430074. China

The Longxi region contains different kinds of Cenozoic sediments,including eolian deposits,reworked loess,fluvial and lacustrine deposits.The provenance evolution of these sediments is of great significance in exploring the uplift,tectonic deformation and associated with geomorphic evolution of the Northeastern Tibetan Plateau.In this paper,we used the single-grain zircon provenance analysis to constrain the provenances for the Paleogene alluvial conglomerates and for the Neogene fluvial-lacustrine sediments,and compared them with results from the loess deposits since the Miocene.The results show that:(1)the Paleogene alluvial conglomerates contain a large number of detrital zircons ranging from 560 to 1100 Ma that were derived from the Yangzi Block.However,the sediments of early Miocene have much fewer zircons of this age span,which are characterized by an abundance of zircon ages in the ranges of 200-360 Ma.This indicates that the Paleogene alluvial conglomerates mainly come from the middle and/or southern West Qinling,and the early Miocene sediments are primarily from the northern West Qinling;(2)Late Neogene fluvial sediments(11.5 Ma onward)in Tianshui-Qinan region are dominated by zircon ages of 3 80-450 Ma.This zircon population is similar to that of the exposed intrusive rocks of southern part of the Liupan Mountains,implying that the southern part of Liupan Mountains probably had already uplifted by 11.5 Ma;(3)Late Miocene lacustrine sediments in Tianshui region have a zircon age spectra that is remarkably different from coeval fluvial deposits,but is similar to the zircon age distributions of the Miocene loess in Qinan region,late Miocene-Pliocene Hipparion red clay and Quaternary loess.This indicates that fine particles within these Miocene lacustrine sediments in Tianshui region may be dominated by aeolian materials.This study reveals that provenance changes of Cenozoic sediments in Tianshui-Qinan region and its geomorphic evolution are closely related to the multi-stage uplift of the Northeastern Tibe

关键词：碎屑锆石地貌演化新生代东北地区南部地区东北部地区构造演化陇西