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GTSE1在肿瘤发生发展中作用的研究进展

国际遗传学杂志 2022年第3期45卷 195-200页

作者：温美艳周岚云南省肿瘤医院昆明医科大学第三附属医院临床营养科昆明

G2和S期表达-1(G2 and S phase-expressed-1, GTSE1)是一种微管定位蛋白, 在S和G2期特异性表达, 具有稳定微管、调控细胞周期、参与有丝分裂等作用。GTSE1在肺癌、胃癌、乳腺癌等多种肿瘤组织及细胞中异常高表达, 揭示其与肿瘤发生发展... 详细信息

G2和S期表达-1(G2 and S phase-expressed-1, GTSE1)是一种微管定位蛋白, 在S和G2期特异性表达, 具有稳定微管、调控细胞周期、参与有丝分裂等作用。GTSE1在肺癌、胃癌、乳腺癌等多种肿瘤组织及细胞中异常高表达, 揭示其与肿瘤发生发展密切相关。GTSE1通过与EB1相互作用、抑制微管解聚酶(mitotic centromere-associated kinesin, MCAK)活性、调控AKT及EMT等多个信号途径。同时, GTSE1影响P53、稳定P21蛋白功能, 促进肿瘤细胞迁移、侵袭和增殖, 进而促进肿瘤转移。此外, GTSE1还参与多种肿瘤化学药物治疗及放射治疗抵抗作用, 影响肿瘤预后, 与肿瘤临床特征及不良预后具有显著相关性。本文将对GTSE1如何参与肿瘤发生发展, 以及其对肿瘤治疗及预后的影响等方面作一综述。

关键词： G2和S期表达-1 肿瘤预后治疗抵抗

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粉煤灰-膨润土阻隔墙控制地下水中镉污染

环境工程学报 2019年第3期13卷 652-663页

作者：黄琴琴刘国文梅燕叶长文刘晏辉曾燚成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 成都理工大学国家环境保护水土污染协同控制与联合修复重点实验室成都610059

为了探究以固体废弃物粉煤灰和吸附性强的膨润土为材料制备的阻隔墙对镉污染的控制效果,采用微观表征、渗透实验、吸附实验、穿透实验、单轴抗压实验和侵蚀实验研究阻隔墙的性能。结果表明:阻隔墙材料的最佳质量配比为粉煤灰∶膨润土=5... 详细信息

为了探究以固体废弃物粉煤灰和吸附性强的膨润土为材料制备的阻隔墙对镉污染的控制效果,采用微观表征、渗透实验、吸附实验、穿透实验、单轴抗压实验和侵蚀实验研究阻隔墙的性能。结果表明:阻隔墙材料的最佳质量配比为粉煤灰∶膨润土=5∶1,水泥质量占整个体系的5%;所得阻隔墙的渗透系数为1.11×10-8m·s^(-1);最大抗压强度291.97 kPa;复合材料最大吸附率为98.38%。同时发现,固化体系中膨润土填充在粉煤灰球体的空隙处和表面,粉煤灰和膨润土都与水泥产生了水化产物和胶结物,Cd^(2+)附着在阻隔材料表面;阻隔墙吸附的系统符合准一级动力学模型和Freundlich方程;系统的总吸附速率受液膜扩散与颗粒扩散同时影响;阻隔墙对Cd^(2+)作用以物理吸附为主;墙体的抗碱腐蚀性比抗酸腐蚀性、耐有机污染物腐蚀性强。该研究可为将阻隔墙技术应用于地下水污染场地提供理论依据。

关键词：镉污染防治阻隔墙粉煤灰资源化改性增强膨润土重金属物理吸附

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Advances in Research of Epidemic Lung Preventive Mixture

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Medicinal Plant 2023年第4期14卷 106-108页

作者： meiyan QIU Bing QING wen ZHONG Jiangcun WEI Guangxi International Zhuang Medicine Hospital Nanning 530201China

This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a m... 详细信息

关键词： Epidemic Lung Preventive Mixture Preparation process Quality standard Cinnamomi Ramulus(Guizhi) Atractylodis Rhizoma(Cangzhu).

TLC Identification and Extraction Process of Rubiasin-1-methyl Ether from Yao Medicine Chuanlianzhu

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Medicinal Plant 2024年第3期15卷 35-38页

作者： Jingrong LU Jiangcun WEI Xiumei MA Bing QING meiyan QIU wen ZHONG Guangxi International Zhuang Medicine Hospital Nanning 530201China

[Objectives]To establish a thin-layer chromatography(TLC)method for the determination of rubiadin-1-methyl ether in Yao Medicine Chuanlianzhu(Damnacanthus giganteus).[Methods]A silica gel G thin-layer plate was adopted for *** ether(60-90℃)-chloroform-methanol-water(7:15:3:1)was used as the developing solvent and inspected under ultraviolet lamp(365 nm).The content was determined by Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm),mobile phase:acetonitrile-0.2%phosphoric acid gradient elution,detection wavelength 277 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The spots of 10 Chuanlianzhu samples from different origins showed the same color at the same position as the control,and the spots were clear and *** injection volume of rubiadin-1-methyl ether showed a good linear relationship in the range of 2.90-145μg(R=0.9996).The average recovery rate of rubiadin-1-methyl ether in the low,medium and high dose groups of Yao Medicine Chuanlianzhu was 98.72%,and RSD=1.78%.[Conclusions]This method can effectively identify Yao Medicine Chuanlianzhu medicinal materials and accurately determine the content of rubiadin-1-methyl ether in the medicinal *** provides a scientific basis for the development and utilization of Yao Medicine Chuanlianzhu medicinal resources.

关键词： Chuanlianzhu Thin-layer chromatography (TLC) Extraction process Rubiadin-1-methyl ether Content determination

Extraction Process of Zhuang Medicine Fumigation Lotion

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Medicinal Plant 2023年第5期14卷 29-31,41页

作者： Jiangcun WEI meiyan QIU Bing QING Xianyi SHI Yinghong HUANG Xian PENG wen ZHONG Guangxi International Zhuang Medical Hospital Nanning 530201China

[Objectives]To establish the extraction process and quality standard method of Zhuang medicine fumigation lotion.[Methods]The orthogonal design method was employed to optimize the water extraction process with the amount of water added,decocting time and extraction times as factors,and syringin content and dry extract yield as *** content of syringin was determined by high performance liquid chromatography.[Results]The best water extraction process was:soaking in water for 1 h,decocting twice,added 10 times the amount of water each time,decocting for 1 *** average content of syringin in 3 batches was 0.98 mg/g,and the average dry extract yield was 26.07%.[Conclusions]The project adopts water extraction method to prepare Zhuang medicine fumigation lotion,which has the characteristics of high efficiency and suitable for large-scale *** quality control method is reliable,rapid and accurate,and can effectively control the quality of the lotion.

关键词： Zhuang medicine fumigation lotion Extraction process Content determination

Anti-inflammatory Effect of Polysaccharide from Embelia parviflora *** Rheumatoid Arthritis in Rats

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Medicinal Plant 2024年第3期15卷 41-44页

作者： Jiangcun WEI Yong CHEN Xiumei MA meiyan QIU Bing QING Leimin JIANG wen ZHONG Zujie QIN Guangxi International Zhuang Medicine Hospital Nanning 530201China Guangxi University of Chinese Medicine Nanning 530200China

[Objectives]To investigate the anti-inflammatory effect of Embelia parviflora *** on rheumatoid arthritis(RA)in rats.[Methods]RA rat model was induced by type II *** successful modeling,the rats were divided into model group,positive group,low,medium and high dose of *** *** groups,and normal control *** mass,toe volume and arthritis index were measured,and thymus index and spleen index were *** levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin serum and synovial tissue of ankle joint were detected by ELISA.[Results]Compared with the normal control group,the pathological changes such as synovial hyperplasia and unclear layer were observed in the model group,the body mass was decreased(P0.05).[Conclusions]*** *** can reduce the body's inflammatory response and improve RA,which may be related to the inhibition of the activation of inflammatory cytokines IL-1β,IL-6 and TNF-α.

关键词： Polysaccharide from Embelia parviflora Wall. Rheumatoid arthritis (RA) Anti-inflammatory effect

伊拉克HF油田Mishrif组厚壳蛤滩相储层沉积与早期成岩特征

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中国石油大学学报（自然科学版） 2016年第5期40卷 1-9页

作者：伏美燕赵丽敏段天向周文刘磊成都理工大学油气藏地质及开发工程国家重点实验室四川成都610059 成都理工大学能源学院四川成都610059 中国石油勘探开发研究院北京100083

通过岩心观察、薄片鉴定、同位素和微量元素分析,研究伊拉克HF油田Mishrif组富厚壳蛤层MB2-MC1层的沉积微相和早期成岩特征。结果表明,Mishrif组MB2-MC1层发育在开阔台地-台地边缘相。富厚壳蛤层中发育2期厚壳蛤滩以及2套含厚壳蛤风暴... 详细信息

通过岩心观察、薄片鉴定、同位素和微量元素分析,研究伊拉克HF油田Mishrif组富厚壳蛤层MB2-MC1层的沉积微相和早期成岩特征。结果表明,Mishrif组MB2-MC1层发育在开阔台地-台地边缘相。富厚壳蛤层中发育2期厚壳蛤滩以及2套含厚壳蛤风暴层。厚壳蛤滩沉积在台地边缘,Sr/Ba比值为5.74,高于2套开阔台地沉积的风暴层。厚壳蛤滩的发育特征有别于厚壳蛤礁,无原地生长特点,同沉积破碎严重,以厚壳蛤砾屑灰岩、厚壳蛤颗粒灰岩和泥粒灰岩为主要岩相,与开阔台地潮下浅滩交互沉积。同生期厚壳蛤滩相的暴露导致早期大气淡水淋滤作用较强,而胶结作用较弱,形成以粒间孔、粒间溶孔、溶洞、溶缝为主的储集空间。

关键词： HF油田白垩系厚壳蛤台缘滩储层沉积成岩特征

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TLC Identification of Yao Medicine Pileostegia tomentellal and Extraction Technology and Content Determination of Umbelliferone

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Medicinal Plant 2024年第2期15卷 15-17,20页

作者： Jiangcun WEI Xiumei MA meiyan QIU Bing QING Jingrong LU Hong LEI Xiaodong HUANG wen ZHONG Guangxi International Zhuang Medical Hospital Nanning 530201China Guangxi University of Chinese Medicine Nanning 530200China

[Objectives]To establish a TLC and content determination method of Pileostegia tomentellal,with umbelliferone as the indicator component.[Methods]TLC identification was performed by silica gel G thin layer plate with n-hexane-ethyl acetate(4:3)as the developing agent,and the plate was examined by UV lamp(365 nm).The umbelliferone content was determined by HPLC:Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm);mobile phase acetonitrile-0.2%phosphoric acid gradient elution;detection wavelength 320 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The chromatogram of *** showed the same color spot in the same position as that of reference medicinal material,and the spot was clear with good *** showed a good linear relationship when the injection volume was 2.63-131.27μg/mL(R^(2)=0.9997).The average recovery of umbelliferone in the low,middle and high adding groups of *** was 99.57%and the RSD was 2.15%.[Conclusions]The method can effectively identify Yao medicine *** and accurately determine the content of umbelliferone in medicinal materials,which will provide a scientific basis for the development and utilization of medicinal resources of Yao medicine ***.

关键词： Pileostegia tomentellal TLC identification Extraction technology Umbelliferone Content determination

Research Overview of Zhuang Medicine Fumigation Lotions

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Medicinal Plant 2024年第1期15卷 35-37页

作者： Bing QING Jiangcun WEI Fangmei LI Xianyi SHI Li LONG Xian PENG meiyan QIU wen ZHONG Zujie QIN Guangxi International Zhuang Medical Hospital Nanning 530201China

At present,there is little research on the application of Zhuang medicine fumigation lotions in skin diseases,and there is no research on related preparation processes and quality *** this paper,the characteristics of its formulation and the research progress in skin diseases are reviewed,in order to deepen the understanding of Zhuang medicine fumigation lotions and provide a more detailed theoretical basis for its clinical research,development and application.

关键词： Zhuang medicine fumigation lotions Ilicis Rotundae Cortex Eiliae Herba Polygoni Perfoliati Herba Rhei Radix Et Rhizoma