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IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα

Acta Pharmaceutica Sinica B 2022年第2期12卷 651-664,F0004页

作者： Juan liu Yuxin Zhuang Jianlin Wu Qiang Wu meixian liu Yue Zhao Zhongqiu liu Caiyan Wang Linlin Lu Yingjiao Meng Kawai Lei Xiaojuan Li Qibiao Wu Elaine Lai-Han Leung Zhengyang Guo Liang liu Ting Li State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao SAR 999078China International Institute for Translational Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China Guangdong Provincial Key Laboratory of New Drug Screening/Laboratory of Anti-inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease Macao University of Science and TechnologyMacao SAR 999078China Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Macao University of Science and TechnologyMacao SAR 999078China

Inhibitor of nuclear factor kappa-B kinase subunit beta(IKKβ)is one of important kinases in inflammation to phosphorylate inhibitor of nuclear factor kappa-B(IκBα)and then activate nuclear factor kappa-B(NF-κB).Inhibition of IKKβhas been a therapeutic strategy for inflammatory and autoimmune diseases.Here we report that IKKβis constitutively activated in healthy donors and healthy Ikkβ^(C46A)(cysteine 46 mutated to alanine)knock-in mice although they possess intensive IKKβ-IκBα-NF-κB signaling activation.These indicate that IKKβactivation probably plays homeostatic role instead of causing inflammation.Compared to IkkβWTlittermates,lipopolysaccharides(LPS)could induce high mortality rate in Ikkβ^(C46A) mice which is correlated to breaking the homeostasis by intensively activating p-IκBα-NF-κB signaling and inhibiting phosphorylation of 5’adenosine monophosphate-activated protein kinase(p-AMPK)expression.We then demonstrated that IKKβkinase domain(KD)phosphorylates AMPKa1 via interacting with residues Thr183,Ser184,and Thr388,while IKKβhelix-loop-helix motifs is essential to phosphorylate IκBαaccording to the previous reports.Kinase assay further demonstrated that IKKβsimultaneously catalyzes phosphorylation of AMPK and IκBαto mediate homeostasis.Accordingly,activation of AMPK rather than inhibition of IKKβcould substantially rescue LPS-induced mortality in Ikkβ^(C46A) mice by rebuilding the homeostasis.We conclude that IKKβactivates AMPK to restrict inflammation and IKKβmediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα.

关键词： IKKβ Homeostasis Kinase domain AMPK Inflammation IκBα Anti-inflammatory drug Phosphorylation

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A prospective cohort study of the presence of SARS-CoV-2 in clinical samples from multiple bodily sites:implications for transmission routes of COVID-19

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Journal of Bio-X Research 2022年第1期5卷 27-34页

作者： meixian liu Huimin Huang Xiqing Bian Zhiyuan Zheng Na Li Baoqing Sun Jian-Lin Wu State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyAvenida Wai LongTaipaMacao Special Administrative Region State Key Laboratory of Respiratory Disease National Clinical Center for Respiratory DiseasesGuangzhou Institute of Respiratory DiseasesFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Objective: The coronavirus disease 2019 (COVID-19) epidemic resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has still spread globally. The occurrence of the Delta variant, which is more infectious and spreads faster than earlier forms of the virus that causes COVID-19, makes infection prevention more challenging. Therefore, this study aimed to gain a comprehensive insight into the transmission routes of SARS-CoV-2 for curbing the propagation of SARS-CoV-2 in human populations.Methods: We studied a prospective cohort of 576 patients admitted consecutively to the First Affiliated Hospital of Guangzhou Medical University from January 21 to June 8, 2020. These patients were chosen based on their similar clinical phenotypes or imaging findings. There were 21 (3.6%) laboratory-confirmed COVID-19 patients (16 severe and 5 mild cases) and 555 non-COVID-19 patients. The antibody response and routes and duration of viral shedding were systematically evaluated in serial clinical specimens. Moreover, SARS-CoV-2 RNA was also detected in a mouth rinse, urine, and tear samples. This study was approved by the Medical Ethical Committee of The First Affiliated Hospital of Guangzhou Medical University (approval No. 2020-77).Results: SARS-CoV-2 mainly existed in sputum, nasal and throat swabs, and feces samples. Virus latency was longer in sputum and feces samples than in nasopharyngeal samples. IgG antibody response in respiratory samples was related to disease severity. Although droplets and aerosols are the major transmission routes for COVID-19, covert routes of transmission from asymptomatic patients, contaminated surfaces, and wastewater are also of interest.Conclusion: Our findings provide a solid foundation for developing prophylactic measures against SARS-CoV-2.

关键词： COVID-19 environment multiple bodily sites SARS-CoV-2 transmission route

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Hysteresis in sap flow and its controlling mechanisms for a deciduous broad-leaved tree species in a humid karst region

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Science China Earth Sciences 2019年第11期62卷 1744-1755页

作者： Rongfei ZHANG Xianli XU meixian liu Yaohua ZHANG Chaohao XU Ruzhou YI Wei LUO Chris SOULSBY Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Huanjiang Observation and Research Station for Karst Ecosystem Chinese Academy of SciencesHuanjiang 547100China University of Chinese Academy of Sciences Beijing 100049China Northern Rivers Institute School of GeosciencesUniversity of AberdeenAberdeen AB243UFScotlandUK

The critical zone(CZ) represents the intersection of the biosphere with the atmosphere, hydrosphere and lithosphere.Understanding the hydrological processes and human impact factors on the CZ is fundamental to sustainable water resources management for agroforestry. Transpiration(T) is an important component of terrestrial evapotranspiration(ET), and understanding the time lag(TL) between vegetation transpiration and meteorological factors can improve our knowledge of the mechanisms of vegetation adaptability to a changing environment. However, the controlling factors on the TL remain poorly understood. Therefore, the objective of this study is identifying the temporal dynamics of key controlling factors on the TL, using a typical deciduous broad-leaved tree species(Zenia insigins Chun) of CZ in subtropical humid karst regions. This species is used as an example to explore the characteristics of the TL between SF(sap flow) and hydro-meteorological forcing. Sap flow in these 6 trees was monitored using the thermal dissipation probes(TDP). Results showed that:(1) the peak of diurnal sap flow generally lagged behind PAR but preceded Ta(air temperature), RH(relative humidity) and VPD(vapor pressure deficit), with the mean TL of-67.4 min(PAR), 90.5 min(Ta), 91.6 min(RH) and 92.9 min(VPD), respectively;(2) TL had no significant relationships with the daily mean meteorological factors and soil moisture, but was highly(R^2>0.66) correlated to CRs(changing rates of meteorological factors) in the morning;(3) At seasonal scale, the sap flow rate and TL both were controlled by the seasonality of precipitation and temperature. Overall, the seasonality of the TL was caused by plants' high water loss and strongly active physiological response in hot seasons, leading to close stomata earlier than in cold seasons;(4) The reason why CRs proposed can explain the TL better than mean values of metrological factors is that the CRs considered the distribution and change processes of metrological factors in the daytime. This study may b

关键词： Eco-hydrology Soil hydrology Landscape ecology Earth's critical zone

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亚热带典型森林下垫面大气层结变化规律及其对潜在蒸散发估算的影响

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地理科学 2024年第2期44卷 359-367页

作者：郭宝刘梅先杜虎林凯荣罗威涂新军中山大学土木工程学院广东广州510275 中国科学院亚热带农业生态研究所湖南长沙410125

为评估忽略大气稳定性对潜在蒸散发(Potential Evapotranspiration,PET)估算的影响,本文以亚热带森林下垫面为例,结合涡动相关观测及莫宁-奥布霍夫相似原理,探讨了冠层上方大气层结变化规律,比较了基于中性假设和考虑大气稳定性影响的PE... 详细信息

为评估忽略大气稳定性对潜在蒸散发(Potential Evapotranspiration,PET)估算的影响,本文以亚热带森林下垫面为例,结合涡动相关观测及莫宁-奥布霍夫相似原理,探讨了冠层上方大气层结变化规律,比较了基于中性假设和考虑大气稳定性影响的PET之间的差异。结果表明:①中性、稳定和不稳定3种大气层结具有明显的日内与季节变化特征,不稳定层结在中午居多,稳定层结在早晨和傍晚居多,而中性层结在昼间均有分布;同时,春夏两季的不稳定层结高频时段较长,而秋冬两季相对较短;总体上,观测期内不稳定、中性和稳定3种层结平均占比分别为41.4%、34.7%与24.0%。②基于中性假设的空气动力学阻力估算方法在一定程度上高估了空气动力学阻力,导致PET存在低估现象(RMSE=25.82 W/m^(2)),且误差偏离随着PET增大而愈加明显。③在当地条件下当量空气动力学阻力r_(a)与风速呈显著的指数关系(r_(a)=7.83u^(-2.92)+32.66,R^(2)=0.50,P<0.05,N=394),基于该关系估算的PET相对于中性假设而言具有更高的精度(R^(2)提高了3.26%,RMSE降低了19.83%)。

关键词：大气稳定度潜在蒸散发空气动力学阻力莫宁-奥布霍夫相似原理涡度相关

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以竹代塑产品在包装领域应用现状

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包装工程 2024年第11期45卷 22-33页

作者：刘美仙程峥毛凯韵肖乃玉刘义存张雪琴钟乐仲芸芸仲恺农业工程学院轻工食品学院广州510225 仲恺农业工程学院园艺园林学院广州510225 广东省食品绿色包装工程技术研究中心广州510225 岭南特色食品绿色加工与智能制造重点实验室广州510225

目的介绍不同种类竹材包装的生产加工方式及其应用,并对以竹代塑产品在包装领域的发展进行展望,以期为以竹代塑产业发展提供借鉴和参考。方法总结不同以竹代塑产品生产工艺和性能的特点,分析原竹包装和经过化学改性竹包装技术在包装领... 详细信息

目的介绍不同种类竹材包装的生产加工方式及其应用,并对以竹代塑产品在包装领域的发展进行展望,以期为以竹代塑产业发展提供借鉴和参考。方法总结不同以竹代塑产品生产工艺和性能的特点,分析原竹包装和经过化学改性竹包装技术在包装领域的应用现状和存在问题。结果可以在竹包装材料加工过程中添加功能助剂,或者对竹基材进行物理或化学改性,以及生产设备的机械化和智能化延伸,提升以竹代塑产品的品质和货架期。结论以竹代塑产品的广泛应用势必会推动以竹代塑产业的可持续高质量发展,为提高竹包装品质和内装产品安全性提供了借鉴和参考。

关键词：竹材以竹代塑包装发展趋势

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Controllable Generation of Reactive Oxygen Species on Cyano-Group-Modified Carbon Nitride for Selective Epoxidation of Styrene

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The Innovation 2021年第1期2卷 82-90页

作者： Hao Tan Peng Kong Riguang Zhang Mengting Gao meixian liu Xianmo Gu Weifeng liu Zhanfeng Zheng State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province Institute of Coal Chemical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

The controlled generation of reactive oxygen species(ROS)to selectively epoxidize styrene is a grand challenge.Herein,cyano-group-modified carbon nitrides(CNCY_(x) and CN-T_(y))are prepared,and the catalysts show better performance in regulating ROS and producing styrene oxide than the cyano-free sample.The in situ diffuse reflectance infrared and density functional theory calculation results reveal that the cyano group acts as the adsorption and activation site of oxygen.X-ray photoelectron spectroscopy and NMR spectrum results confirm that the cyano group bonds with the intact heptazine ring.This unique structure could inhibit H_(2)O_(2) and,OH formation,resulting in high selectivity of styrene oxide.Furthermore,high catalytic activity is still achieved when the system scales up to 2.7 L with 100 g styrene under solar light irradiation.The strategy of cyano group modification gives a new insight into regulating spatial configuration for tuning the utilization of oxygen-active species and shows potential applications in industry.

关键词： epoxidation cyano modification carbon nitride ROS steric hindrance

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“三全育人”视域下“大土木”专业本科生导师制的探索与实践

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科教文汇 2024年第12期 18-22页

作者：龙通情林凯荣刘梅先张春蕾中山大学土木工程学院广东珠海519082

“三全育人”是新时代高等教育思想的重要变革。在“大土木”专业人才培养过程中,以本科生导师制为依托,践行“三全育人”理念,探索建立完善的全员育人机制、开展丰富的全过程育人实践以及拓展多维度的全方位育人空间,有利于形成专任教... 详细信息

“三全育人”是新时代高等教育思想的重要变革。在“大土木”专业人才培养过程中,以本科生导师制为依托,践行“三全育人”理念,探索建立完善的全员育人机制、开展丰富的全过程育人实践以及拓展多维度的全方位育人空间,有利于形成专任教师、管理人员、思政队伍育人合力,发挥导师制育人功能,与大类本科专业宽口径课程设置方案形成互补,落实个性化的人才培养目标,激发学生的学习力,提升学生的思想力和实践创新能力,对提升本科人才培养质量具有重要意义。

关键词：三全育人本科生导师制大土木

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以竹代塑现状及发展趋势

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造纸科学与技术 2024年第3期43卷 25-31页

作者：程峥毛凯韵刘美仙肖乃玉钟乐张雪琴王红蕾刘义存仲恺农业工程学院轻工食品学院广东广州510225 仲恺农业工程学院广东省食品绿色包装工程技术研究中心广东广州510225 仲恺农业工程学院广东省岭南特色食品科学与技术重点实验室广东广州510225 仲恺农业工程学院岭南特色食品绿色加工与智能制造重点实验室广东广州510225 仲恺农业工程学院园艺园林学院广东广州510225

综述了以竹代塑的现状及发展趋势。在全球限塑的背景下,以竹代塑作为一项绿色、环保、可持续发展的项目,有利于推进碳达峰、碳中和,推动绿色低碳高质量发展。首先介绍了以竹代塑的定义和塑料的危害,接着介绍了竹材的现状、我国竹材的优... 详细信息

综述了以竹代塑的现状及发展趋势。在全球限塑的背景下,以竹代塑作为一项绿色、环保、可持续发展的项目,有利于推进碳达峰、碳中和,推动绿色低碳高质量发展。首先介绍了以竹代塑的定义和塑料的危害,接着介绍了竹材的现状、我国竹材的优势、竹材的特性和开发背景,然后介绍了以竹代塑的发展现状和以竹代塑在包装工程中的应用,最后通过以竹代塑的指导思想和基本原则展望了以竹代塑的发展趋势和在发展新质生产力方面的美好前景。

关键词：以竹代塑包装环保竹材

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基于MIKE的滨海城市内涝模拟及深隧工程排涝效果评估

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人民珠江 2024年第5期45卷 123-131页

作者：谈荫涂新军余红刚林凯荣刘梅先马克中山大学水资源与环境研究中心广东广州510275 广东省华南地区水安全调控工程技术研究中心广东广州510275 南方海洋科学与工程广东省实验室广东珠海519000

在暴雨及风暴潮等极端气象水文条件潮位影响下,快速城市化的滨海地区内涝问题日益凸显。以粤港澳大湾区深圳市西部为研究区,耦合一维河道洪水模型及管网排水模型和二维地表漫流模型,模拟极端降水和典型风暴潮条件下城市内涝淹没过程,开... 详细信息

在暴雨及风暴潮等极端气象水文条件潮位影响下,快速城市化的滨海地区内涝问题日益凸显。以粤港澳大湾区深圳市西部为研究区,耦合一维河道洪水模型及管网排水模型和二维地表漫流模型,模拟极端降水和典型风暴潮条件下城市内涝淹没过程,开展内涝风险分级,评估深隧工程排涝效果。结果表明:MIKE多模型工具相结合能够较好地模拟城市内涝形成过程及淹没特征,引入概率矩阵法能够更清晰地揭示内涝风险等级之间的变化。极端气象水文条件下的滨海城市内涝淹没呈现快涨缓退特征,设计50年和100年一遇2 h极端降水下的内涝风险区面积分别为4.24、5.04 km^(2),其中1级到4级风险区范围的相对比例分别约为0.9:37.5:28.5:33.0和4.0:33.7:26.8:35.5,考虑深隧工程排涝的淹没范围分别减少了17.0%和13.4%、内涝风险区面积分别减少了28.8%和30.2%、典型易涝点的淹没持续时间缩短了60.0%~80.8%。大部分地区的内涝风险等级显著下降,深隧工程改善排涝效果明显。

关键词：内涝模拟多模型耦合概率矩阵法极端降水深隧工程粤港澳大湾区

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Effects of Rice-Wheat Rotation and Afforestation on Microbial Biomass Carbon in Coastal Salt-Affected Soils of Eastern China

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Pedosphere 2017年第5期27卷 938-948页

作者： JIN Wenhui YANG Jingsong YAO Rongjiang YU Shipeng liu meixian XIE Wenping State Key Laboratory of Soil and Sustainable Agriculture Nanjing Institute of Soil Science Chinese Academy of Sciences

Rice-wheat rotation and poplar afforestation are two typical land use types in the coastal reclaimed flatlands of eastern China.This study investigated two rice-wheat rotation lands(one reclaimed from 1995 to 2004 and cultivated since 2005, RW1, and the other reclaimed from 1975 to 1995 and cultivated since 1996, RW2) and a poplar woodland(reclaimed from 1995 to 2004 and planted in2004, PW1) to determine the effects of land use types and years of cultivation on soil microbial biomass and mineralizable carbon(C) in this coastal salt-affected region. The results showed that the soil in PW1 remained highly salinized, whereas desalinization was observed in RW1. The total organic C(TOC) in the top soil of PW1 and RW1 did not show significant differences, whereas at a soil depth of 20–30 cm, the TOC of RW1 was approximately 40%–67% higher than that of PW1. The TOC of 0–30-cm soil in RW2 was approximately 37% higher than that in RW1. Microbial biomass C(MBC) and mineralizable C(MNC) exhibited the trend of RW2 > RW1 > PW1. Sufficient nutrition with more abundant C substrates resulted in higher MBC and MNC, and soil respiration rates were negatively correlated with C/N in RW1 and RW2. Nutrient deficiency and high salinity played key roles in limiting MBC in PW1. These suggested that rice-wheat rotation was more beneficial than poplar afforestation for C accumulation and microbial biomass growth in the coastal salt-affected soils.

关键词：土壤微生物生物量碳滨海盐渍土稻麦轮作中国东部盐渍化造林土地利用类型再生栽培

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