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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 79-96页

作者： Haoyu SUN Haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG Qing YU meiwen an Meiling WEN Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular function.This report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell culture.Microchannels and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like channels.Mechanical characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture applications.Compared to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube formation.Moreover,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

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Chinese Journal of Cancer Research 2024年第2期36卷 226-232页

作者： Jun Luo Mingxuan Zhu Long Zhao meiwen He Bei Li Yifan Liu Yuhan Sun Guoqing Lyu Zhanlong Shen Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China Department of Gastroenterological Surgery Laboratory of Surgical OncologyBeijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People's HospitalBeijing 100044China School of Medicine the Chinese University of Hong KongShenzhen 518172China

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin.

关键词： Colorectal cancer distal resection margin neoadjuvant therapy

Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

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Engineered Regeneration

Engineered Regeneration 2022年第1期3卷 53-58页

作者： Xiang Gao Meiling Wen Yang Liu Tian Hou meiwen an Institute of Biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyShanxi Key Laboratory of Material Strength&Structural ImpactTaiyuanShanxi030024China Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound site.The current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged regions.In our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via electrospinning.The electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable porosity.Moreover,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite scaffolds.These findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering.

关键词： Electrospun membranes Poly(L-lactide-co-caprolactone) Polyurethane Human skin fibroblasts Skin tissue engineering

DETERMINATION OF QUADRICEPS FORCES IN SQUAT AND ITS APPLICATION IN CONTACT PRESSURE ANALYSIS OF KNEE JOINT

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Acta Mechanica Solida Sinica 2012年第1期25卷 53-60页

作者： Yuan Guo Xushu Zhang meiwen an Weiyi Chen Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China

While the quadriceps muscles of human body are quite important to the daily ac-tivities of knee joints,the determination of quadriceps forces poses significant challenges since it cannot be measured in vivo.Here,a novel approach is presented to obtain the forces in squat through the combination of motion photography,force transducers measuring,multi-rigid-body theory and finite element analysis.Firstly,the geometrical and angular data of human for squat process were obtained through the analysis of photographed pictures for human squat with cam-era.At the same time,force transducers were used to measure the reaction forces from feet and to determine the center of gravity for identical squat process.Next,based on the multi-rigid-body dynamics,a mathematical model for human right leg and foot was established in order to determine the quadriceps torques under different squat angles.Then,so as to determine the quadriceps forces along with varied squat angles,a simplified three-dimensional finite element model was built,including tibia,fibula,patella,patella ligament and quadriceps tendon.Finally,the contact pressure of knee joint was analyzed for the squat with the established model of knee joint involving the obtained quadriceps forces from finite element analysis.And it showed that in the 0-90 degree squat process,the peak value of contact pressure of articular cartilages and menisci is increased with the increased squat angle.This study can be referenced for further un-derstanding of the biomechanical behaviors of knee,contact pressure effects of daily activities on knee,and is significantly instructive for sports rehabilitation.

关键词： quadriceps force force transducers motion analysis finite element analysis squat

静电纺纳米纤维表面形貌的制备及其生物医学应用

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复合材料学报 2024年第5期41卷 2236-2248页

作者：文美玲高翔刘阳安美文太原理工大学生物医学工程学院生物医学工程研究所材料强度与结构冲击山西省重点实验室太原030024 太原理工大学生物医学工程学院纳米生物材料与再生医学研究中心太原030024

通过模仿天然细胞外基质的成分和结构特性对材料表面形貌进行设计与调控,可获得新型仿生材料,并广泛应用于生物医学领域。其中,静电纺纳米纤维通过调控孔隙率、比表面积及微纳米结构等,可以模拟天然细胞外基质的结构,实现其生物功能。... 详细信息

通过模仿天然细胞外基质的成分和结构特性对材料表面形貌进行设计与调控,可获得新型仿生材料,并广泛应用于生物医学领域。其中,静电纺纳米纤维通过调控孔隙率、比表面积及微纳米结构等,可以模拟天然细胞外基质的结构,实现其生物功能。本文将提供不同表面形貌电纺纤维的概述。首先介绍静电纺丝的原理、设备和参数,然后讨论电纺纤维的4种表面形貌:纳米孔、串晶、沟槽和皱缩结构的制备原理、方法及在生物医学领域的应用,并对该领域相关研究和研究现状进行评价。

关键词：静电纺丝纤维材料表面形貌生物医学应用组织工程

初产妇阴道试产结局影响因素分析及预测模型构建

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中国妇产科临床杂志 2024年第2期25卷 145-149页

作者：陈美文葛莉娜中国医科大学附属盛京医院妇产科沈阳110004

目的探讨影响初产妇阴道试产结局的影响因素,并根据影响因素构建初产妇阴道试产预测模型。方法按1∶1选取同期经阴道试产,试产结局为异常分娩(包括阴道手术助产和中转剖宫产)和正常分娩足月单胎初产妇的临床资料共626例进行回顾性病例... 详细信息

目的探讨影响初产妇阴道试产结局的影响因素,并根据影响因素构建初产妇阴道试产预测模型。方法按1∶1选取同期经阴道试产,试产结局为异常分娩(包括阴道手术助产和中转剖宫产)和正常分娩足月单胎初产妇的临床资料共626例进行回顾性病例对照研究。对可能影响试产结局的相关因素进行单因素分析,将有统计学意义的变量进行logistic回归分析,根据回归结果构建预测模型。结果多因素logistic回归分析显示,胎膜早破、分娩镇痛、临产前体质指数、宫高、脐带绕颈、胎儿头围、胎儿腹围为异常分娩发生的独立危险因素(OR>1,P<0.05),孕妇身高和宫颈Bishop评分为异常分娩的独立保护性因素(OR<1,P<0.05)。依据偏回归系数构建模型方程,ROC曲线下面积为0.839(95%CI:0.8018~0.8754),模型通过Homer-Lemeshow检验,有较好的区分度和校准度(χ^(2)=0.212,P=0.121)。结论影响初产妇异常分娩发生的因素较多,根据独立影响因素构建的预测模型对初产妇异常分娩的发生有一定预测能力,可对孕妇进行产前评估。

关键词：初产妇试产结局危险因素预测模型

基于网络用户评价数据+的旅游风景道路网布局研究

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地理与地理信息科学 2024年第1期40卷 18-25页

作者：陈美雯高悦尔程璟华侨大学建筑学院福建厦门361021 华侨大学统计学院福建厦门361021

为充分考虑游客的实际出行需求并提高旅游风景道路网布局的合理性,该文基于网络用户评价数据和旅游服务质量等级数据,提出一种旅游风景道路网布局方法,即通过K-means++和随机森林算法对旅游节点各指标进行客观赋权,计算节点重要度及节... 详细信息

为充分考虑游客的实际出行需求并提高旅游风景道路网布局的合理性,该文基于网络用户评价数据和旅游服务质量等级数据,提出一种旅游风景道路网布局方法,即通过K-means++和随机森林算法对旅游节点各指标进行客观赋权,计算节点重要度及节点间的路线重要度,并结合现状路网条件,制定区域性“快进+慢游”的旅游风景道路网布局方案。以G228福建段沿线区域为例,对旅游风景道路网布局方法的合理性进行验证,结果表明:该方法可有效划分旅游节点层次并优化区域性旅游风景道路网布局方案,最终构建出G228福建段沿线区域“两级四类”的区域性旅游风景道路网布局方案。研究结果对区域性旅游风景道路网的构建及旅游资源开发具有借鉴意义。

关键词：旅游风景道节点重要度网络点评数据路网规划

客户ESG表现对供应商绿色创新溢出效应分析

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大连理工大学学报（社会科学版） 2024年第3期45卷 49-60页

作者：孙雅妮吴锡皓卜美文海南大学国际商学院海南海口570228 扬州大学商学院江苏扬州225127 西南财经大学会计学院四川成都611130

基于2009~2020年中国A股上市公司数据,构建客户和供应商一一配对样本,考察客户ESG表现对供应商绿色创新的影响及其作用机理。研究发现,客户ESG表现通过供应商的“环保意识趋同”效应和“绿色资源汲取”效应而促使供应商积极进行绿色创新... 详细信息

基于2009~2020年中国A股上市公司数据,构建客户和供应商一一配对样本,考察客户ESG表现对供应商绿色创新的影响及其作用机理。研究发现,客户ESG表现通过供应商的“环保意识趋同”效应和“绿色资源汲取”效应而促使供应商积极进行绿色创新,并显著提升了其绿色创新水平。异质性检验发现,当客户与供应商关系越稳定、彼此间信任程度越高以及客户议价能力越强时,客户ESG表现对供应商绿色创新的促进效果越为明显。此外,发现只有当客户“言行一致”时,才能真正促进供应商绿色创新水平的提升。文章从客户正向溢出视角延展了绿色创新的驱动因素研究,也为供应链企业如何实现绿色协同发展、提升可持续竞争优势提供了重要启示。

关键词：供应链 ESG表现溢出效应绿色创新

Circumferential variation in mechanical characteristics of porcine descending aorta

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BIOCELL 2018年第1期42卷 25-34页

作者： LINGFENG CHEN ZHIPENG GAO BAIMEI LIU YING LV meiwen an JILING FENG Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength&Structural Impact College of MechanicsTaiyuan University of TechnologyTaiyuan 030024China National Demonstration Center for Experimental Mechanics Education(Taiyuan university of Technology) Taiyuan 030024China School of engineering Faculty of Science and EngineeringManchester Metropolitan UniversityUK

Arterial characterization of healthy descending thoracic aorta(DTA)is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilation,rupture,and dissection when aneurysm occurs.Few studies have shown the inhomogeneity of DTA along the aorta tree considering changes in circumferential direction.The present study aims to clarify the circumferential regional characterization of DTA.Porcine DTA tissues were tested according to region and orientation using uniaxial tension.For axial test,results show that the difference in circumferential direction was mainly in collagen fiber modulus,where the anterior collagen fiber modulus was significantly lower than the posterior quadrant.For circumferential test,the difference in circumferential direction was mainly in the recruitment parameter,where the circumferential stiffness is significantly higher in the posterior region at physiological maximum stress.The proximal posterior quadrant and left quadrant showed significantly lower axial collagen fiber stiffness than the right and anterior quadrants,which may be a factor in aneurysm development.Furthermore,the constitutive parameters for similar detailed regions can be used by biomedical engineers to investigate improved therapies and thoroughly understand the initial stage of aneurysm development.The regional collagen fiber modulus can help improve our understanding of the mechanisms of arterial dilation and aortic dissection.

关键词： Thoracic aortic aneurysm Strain-energy function uniaxial test elastic modulus elastin collagen

Nonlinear free vibration of spinning cylindrical shells with arbitrary boundary conditions

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Applied Mathematics and Mechanics(English Edition) 2022年第8期43卷 1203-1218页

作者： Qingdong CHAI Yanqing WANG meiwen TENG Key Laboratory of Structural Dynamics of Liaoning Province College of SciencesNortheastern UniversityShenyang110819China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China

The aim of the present study is to investigate the nonlinear free vibration of spinning cylindrical shells under spinning and arbitrary boundary conditions.Artificial springs are used to simulate arbitrary boundary conditions.Sanders’shell theory is employed,and von Kármán nonlinear terms are considered in the theoretical modeling.By using Chebyshev polynomials as admissible functions,motion equations are derived with the Ritz method.Then,a direct iteration method is used to obtain the nonlinear vibration frequencies.The effects of the circumferential wave number,the boundary spring stiffness,and the spinning speed on the nonlinear vibration characteristics of the shells are highlighted.It is found that there exist sensitive intervals for the boundary spring stiffness,which makes the variation of the nonlinear frequency ratio more evident.The decline of the frequency ratio caused by the spinning speed is more significant for the higher vibration amplitude and the smaller boundary spring stiffness.

关键词： spinning cylindrical shell nonlinear free vibration arbitrary boundary condition Chebyshev polynomial Sanders’shell theory