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A novel cascaded energy conversion system inducing efficient and precise cancer therapy

Bioactive Materials 2023年第2期20卷 663-676页

作者： Yong Kang Na Kong meitong ou Ying Wang Qicai Xiao Lin Mei Bing Liu Liqun Chen Xiaobin Zeng Xiaoyuan Ji Center Lab of Longhua Branch and Department of Infectious Disease Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020GuangdongChina Academy of Medical Engineering and Translational Medicine Medical CollegeTianjin UniversityTianjin300072China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityGuangzhou510275China Department of Disease Control and Prevention Rocket Force Characteristic Medical Center16 Xinjiekouwai StreetXicheng DistrictBeijing10088China

Cancer therapies based on energy conversion,such as photothermal therapy(PTT,light-to-thermal energy conversion)and photodynamic therapy(PDT,light-to-chemical energy conversion)have attracted extensive attention in preclinical research.However,the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied light prevent further advanced clinical practices.Here,we developed a thermoelectric therapy(TET)based on thermoelectric materials constructed p-n heterojunction(SrTiO_(3)/Cu_(2)Se nanoplates)on the principle of light-thermal-electricity-chemical energy conversion.Upon irradiation and natural cooling-induced the temperature gradient(35-45℃),a self-build-in electric field was constructed and thereby facilitated charges separation in bulk SrTiO_(3)and Cu_(2)Se.Importantly,the contact between SrTiO_(3)(n type)and Cu_(2)Se(p type)constructed another interfacial electric field,further guiding the separated charges to re-locate onto the surfaces of SrTiO_(3)and Cu_(2)Se.The formation of two electric fields minimized probability of charges recombination.Of note,high-performance superoxide radicals and hydroxyl radicals’generation from O_(2)and H_(2)O under catalyzation by separated electrons and holes,led to intracellular ROS burst and cancer cells apoptosis without apparent damage to surrounding tissues.Construction of bulk and interfacial electric fields in heterojunction for improving charges separation and transfer is also expected to provide a robust strategy for diverse applications.

关键词： Thermoelectric therapy Photothermal therapy Reactive oxygen species p-n heterojunction Energy conversion

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Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5107-5120页

作者： Yan Zhang Haiyun Zhang Faquan Zhao Zhengping Jiang Yuanlu Cui meitong ou Lin Mei Qiangsong Wang Tianjin Key Laboratory of Biomedical Materials Institute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China State Key Laboratory of Component-based Chinese Medicine Research Center of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China

Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke.The development of new approaches to simultaneously diminish oxidative stress and resist mitochondrial dysfunction is urgently needed.Inspired by the overproduced reactive oxygen species(ROS)at ischemic neuron mitochondria,multifunctional nanoparticles with ROS-responsiveness and mitochondrial-targeted(SPNPs)were engineered,achieving specific targeting delivery and controllable drug release at ischemic penumbra.Due to the nose-to-brain pathway.SPNPs which were encapsulated in a thermo-sensitive gel by intranasal administration were directly delivered to the ischemic penumbra bypassing the blood-brain barrier(BBB)and enhancing delivery efficiency.The potential of SPNPs for ischemic stroke treatment was systematically evaluated in vitro and in rat models of middle cerebral artery occlusion(MCAO).Results demonstrated the mitochondrialtargeted and protective effects of SPNPs on H2O2-induced oxidative damage in SH-SY5Y cells.In vivo distribution analyzed by fuorescence imaging proved the rapid and enhanced active targeting of SPNPs to the ischemic area in MCAO rats.SPNPs by intranasal administration exhibited superior therapeutic efficacy by alleviating oxidative stress,diminishing infammation,repairing mitochondrial function,and decreasing apoptosis.This strategy provided a multifunctional delivery system for the effective treatment of ischemic injury,which also implies a potential application prospect for other central nervous diseases.

关键词： Ischemic stroke Inflammation Mitochondrial targeted Multifunctional nanocarriers Nose-to-brain pathway Oxidative stress Puerarin ROs-Responsiveness

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基于合成数据集的多目标识别与6-DoF位姿估计

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华南理工大学学报（自然科学版） 2024年第4期52卷 42-50页

作者：胡广华欧美彤李振东华南理工大学机械与汽车工程学院广东广州510640

多目标识别及六自由度(6-DoF)位姿估计是实现物料无序堆放状态下机器人自动分拣的关键。近年来,基于深度神经网络的方法在目标识别及位姿估计领域受到广泛关注,但此类方法依赖大量训练样本,而样本的采集及标注费时费力,限制了其实用性... 详细信息

多目标识别及六自由度(6-DoF)位姿估计是实现物料无序堆放状态下机器人自动分拣的关键。近年来,基于深度神经网络的方法在目标识别及位姿估计领域受到广泛关注,但此类方法依赖大量训练样本,而样本的采集及标注费时费力,限制了其实用性。其次,当成像条件差、目标相互遮挡时,现有位姿估计方法无法保证结果的可靠性,进而导致抓取失败。为此,文中提出了一种基于合成数据样本的目标识别、分割及位姿估计方法。首先,以目标对象的3维(3D)几何模型为基础,利用3D图形编程工具生成虚拟场景的多视角RGB-D合成图像,并对生成的RGB图像及深度图像分别进行风格迁移和噪声增强,从而提高合成数据的真实感,以适应真实场景的检测需要;接着,利用合成数据集训练YOLOv7-mask实例分割模型,运用真实数据进行测试,结果验证了该方法的有效性;然后,以分割结果为基础,基于ES6D目标位姿估计模型,提出了一种在线姿态评估方法,以自动滤除严重失真的估计结果;最后,采用基于主动视觉的位姿估计校正策略,引导机械臂运动到新的视角重新检测,以解决因遮挡而导致位姿估计偏差的问题。在自行搭建的6自由度工业机器人视觉分拣系统上进行了实验,结果表明,文中提出的方法能较好地适应复杂环境下工件的识别与6-DoF姿态估计要求。

关键词：目标识别位置测量 6-DoF位姿估计机器人自动分拣 RGB-D图像

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Biodegradable calcium sulfide-based nanomodulators for H_(2)S-boosted Ca^(2+)-involved synergistic cascade cancer therapy

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4472-4485页

作者： Chuchu Lin Chenyi Huang Zhaoqing Shi meitong ou Shengjie Sun Mian Yu Ting Chen Yunfei Yi Xiaoyuan Ji Feng Lv Meiying Wu Lin Mei School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Academy of Medical Engineering and Translational Medicine Medical CollegeTianjin UniversityTianjin 300072China

Hydrogen sulfide(H_(2)S)is the most recently discovered gasotransmitter molecule that activates multiple intracellular signaling pathways and exerts concentration-dependent antitumor effect by interfering with mitochondrial respiration and inhibiting cellular ATP generation.Inspired by the fact that H_(2)S can also serve as a promoter for intracellular Ca^(2+)influx,tumor-specific nanomodulators(I-CaS@PP)have been constructed by encapsulating calcium sulfide(CaS)and indocyanine green(ICG)into methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PLGA-PEG).I-CaS@PP can achieve tumor-specific biodegradability with high biocompatibility and pH-responsive H_(2)S release.The released H_(2)S can effectively suppress the catalase(CAT)activity and synergize with released Ca^(2+)to facilitate abnormal Ca^(2+)retention in cells,thus leading to mitochondria destruction and amplification of oxidative stress.Mitochondrial dysfunction further contributes to blocking ATP synthesis and downregulating heat shock proteins(HSPs)expression,which is beneficial to overcome the heat endurance of tumor cells and strengthen ICG-induced photothermal performance.Such a H_(2)S-boosted Ca^(2+)-involved tumor-specific therapy exhibits highly effective tumor inhibition effect with almost complete elimination within 14-day treatment,indicating the great prospect of CaS-based nanomodulators as antitumor therapeutics.

关键词： Calcium sulfide Hydrogen sulfide Calcium overload Oxidative stress Photothermal therapy Biodegradability Controllable release Nanomodulators

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