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PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer

Journal of Genetics and Genomics 2021年第7期48卷 640-651页

作者： Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang meiting yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Medical Oncology The First Affiliated HospitaHengyang MedicalSchoolUniversity of South ChinaHengyangHunan 421001China School of Life Science and Technology Shanghai Tech UniversityShanghai 200120China CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to ***,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely *** comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to *** or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly ***,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with *** chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway *** findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment.

关键词： SCLC Heterogeneity Growth pattern Phenotype transition Drug resistance PI3K/Akt/mTOR pathway

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基于GWR模型的京津冀县域碳排放强度时空演变及影响因素分析

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湖南工业大学学报 2023年第5期37卷 68-77页

作者：韩聪张立新岳美亭青岛理工大学管理工程学院山东青岛266520

为探究京津冀各县域碳减排潜力,在计算2008—2017年165个县域碳排放强度的基础上,采用标准差椭圆、探索性空间数据分析及地理加权回归等空间统计工具进行定性分析与定量研究。研究发现:河北省平均碳排放强度明显高于北京、天津两地,研... 详细信息

为探究京津冀各县域碳减排潜力,在计算2008—2017年165个县域碳排放强度的基础上,采用标准差椭圆、探索性空间数据分析及地理加权回归等空间统计工具进行定性分析与定量研究。研究发现:河北省平均碳排放强度明显高于北京、天津两地,研究期间各区县碳排放强度下降明显,表明近年来的碳减排取得了良好成效。其次,分析重心-标准差椭圆发现碳排放强度重心始终位于保定市高阳县,重心逐渐向南迁移,标准差椭圆在空间上呈“东北-西南”分布格局。最后对碳排放强度影响因素进行了分析,发现人口密度、产业结构多元化、固定资产投资和财政收支在不同区域影响效果不同,但在多数地区可以有效降低碳排放强度。

关键词：京津冀县域碳排放强度空间格局地理加权回归

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Combining metal-organic frameworks(MOFs)and covalentorganic frameworks(COFs):Emerging opportunities for new materials and applications

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Nano Research 2022年第4期15卷 3514-3532页

作者： Zhixi Li Jun Guo yue Wan Yutian Qin meiting Zhao Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China School of Chemistry Tiangong UniversityTianjin 300387China

In the past decades,metal-organic frameworks(MOFs)and covalent organic frameworks(COFs)basically enjoy the coordination chemistry and covalent chemistry,respectively,and such uniqueness has become the major obstacle hampering their further scope diversity and application *** from the principle of organic retrosynthesis,combining coordination bond and covalent bond together offers additional opportunities for constructing novel MOFs,COFs and MOF@COF hybrids as well as confer on them superior performances in versatile application *** this review,we firstly classify and summarize the recently reported synthesis strategies based on the integration of metal-ligand coordination and dynamic covalent ***,the application performances of as-constructed MOFs,COFs as well as MOF@COF hybrids are discussed and highlighted in the fields of adsorption,separation,catalysis,biosensing,energy storage and so ***,our personal insights of the remaining challenges and further prospects are also provided,in order to trigger much more inspirations and endeavors for this hot research field.

关键词： metal-organic frameworks(MOFs) covalent organic frameworks(COFs) hybrids coordination chemistry covalent chemistry applications

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蛋黄壳结构FeF_(3)·0.33H_(2)O@N掺杂碳纳米笼正极材料的构筑及其电化学性能

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无机材料学报 2024年第3期39卷 299-305,I0003,I0004页

作者：程节周月罗薪涛高美婷骆思妃蔡丹敏吴雪垠朱立才袁中直华南师范大学化学学院广州510006

FeF_(3)·0.33H_(2)O具有理论容量和电压高的特点,但其导电性差、氧化还原反应过程中体积变化严重导致电化学循环性能不佳,应用受到限制。本研究采用多巴胺自组装包覆纳米立方Fe_(2)O_(3)颗粒,再经过碳化、HCl刻蚀和HF氟化的策略,合成了... 详细信息

FeF_(3)·0.33H_(2)O具有理论容量和电压高的特点,但其导电性差、氧化还原反应过程中体积变化严重导致电化学循环性能不佳,应用受到限制。本研究采用多巴胺自组装包覆纳米立方Fe_(2)O_(3)颗粒,再经过碳化、HCl刻蚀和HF氟化的策略,合成了由N掺杂石墨烯外壳和纳米立方FeF_(3)··0.33H_(2)O内核所构成的蛋黄壳结构复合材料FeF_(3)·0.33H_(2)O@CNBs,粒径约250 nm,碳壳厚度为30~40 nm。FeF_(3)·0.33H_(2)O@CNBs在0.2C(1C=237 mA·g^(-1))电流密度下充放电初始容量为208 mAh·g^(-1),循环50圈之后容量仍然有173 mAh·g^(-1),每圈容量衰减率仅为0.3%;而纯FeF_(3)·0.33H_(2)O初始容量只有112 mAh·g^(-1),循环50圈之后只有95 mAh·g^(-1)。FeF_(3)·0.33H_(2)O@CNBs的循环性能明显优于FeF_(3)·0.33H_(2)O,同时0.1C~1C充放电结果表明其倍率性能也明显优于FeF_(3)·0.33H_(2)O。这是因为该策略制备的N掺杂石墨烯外壳提供了良好的电子/离子输运性能,同时碳壳可缓冲和抑制内核FeF_(3)·0.33H_(2)O的体积变化,其空隙体积对电解液的储液保液性能缩短了离子迁移距离,提升了Li+迁移速率,从而得到了比文献报道更好的电化学性能。

关键词：锂离子电池电极材料氟化铁蛋黄壳结构

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Two-dimensional metal-organic framework nanosheet composites:Preparations and applications

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Chinese Chemical Letters 2022年第2期33卷 693-702页

作者： Yutian Qin yue Wan Jun Guo meiting Zhao School of Chemistry Tiangong UniversityTianjin 300387China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China

As emerging two-dimensional materials, metal-organic framework(MOF) nanosheet composites possess many unique physical and chemical properties, thus being expected to be widely applied in gas separation and adsorption, energy conversion and storage, heterogeneous catalysis, sensing as well as biomedicine. In this review, we first introduce the methods for integrating MOF nanosheets with other materials to prepare multifunctional composites. Next, the applications of MOF nanosheet composites in versatile fields are summarized and discussed. We hope this review will be instructive for researchers in the aspects of designs, preparations and applications of MOF nanosheet composites.

关键词： Metal-organic framework 2D nanosheet Composite Energy conversion Catalysis Separation Biomedicine

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SNHG10低表达与卵巢癌预后和耐药的相关性研究

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广西医科大学学报 2024年第2期41卷 193-203页

作者：施丽州陈小英于玥蔡美婷刘夏尹富强广西医科大学生命科学研究院南宁530021 广西医科大学转化医学研究中心“长寿与老年相关疾病”教育部重点实验室、神经科学研究所“广西脑科学研究”重点实验室南宁530021

目的:探讨长链非编码小核仁RNA宿主基因10(SNHG10)与卵巢癌细胞增殖、耐药及预后的关系。方法:通过开放大数据(库)筛选88例正常卵巢组织和426例卵巢癌组织中差异表达SNHGs,分析其与卵巢癌患者预后的相关性,并通过受试者工作特征(ROC)曲... 详细信息

目的:探讨长链非编码小核仁RNA宿主基因10(SNHG10)与卵巢癌细胞增殖、耐药及预后的关系。方法:通过开放大数据(库)筛选88例正常卵巢组织和426例卵巢癌组织中差异表达SNHGs,分析其与卵巢癌患者预后的相关性,并通过受试者工作特征(ROC)曲线评估SNHGs预警卵巢癌紫杉醇和铂类药物耐药的价值。采用实时荧光定量PCR(RT-qPCR)检测SNHG10在卵巢癌紫杉醇/卡铂耐药细胞(SKOV3-R/SKOV3-CBP)及其亲本细胞(SKOV3)中的相对表达水平。通过慢病毒感染在卵巢癌亲本细胞SKOV3中构建过表达SNHG10的细胞株,分为对照组(S-eGFP组)和过表达组(S-SNHG10组)。采用CCK-8、平板克隆形成实验评估细胞增殖能力;通过Cell Titer-Glo发光活细胞检测法评估细胞对紫杉醇的敏感性。结果:SNHG10在卵巢癌组织显著低表达(P0.6,P<0.05)。与S-eGFP组相比,S-SNHG10组细胞的增殖能力下降,对紫杉醇的敏感性增强(P<0.001)。结论:过表达SNHG10显著抑制卵巢癌细胞增殖并提高卵巢癌细胞对紫杉醇的敏感性。

关键词：小核仁RNA宿主基因10 卵巢癌预后耐药

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Dynamically modulated synthesis of hollow metal-organic frameworks for selective hydrogenation reactions

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Nano Research 2023年第8期16卷 11334-11341页

作者： Liyun Xiao Chuanqi Cheng Zhixi Li Chaoyang Zheng Jing Du Meina Song yue Wan Shaopeng Li Guo Jun meiting Zhao Department of Chemistry Institute of Molecular Aggregation ScienceTianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityTianjin 300072China Institute of New Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300072China State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China

Hollow metal-organic frameworks(MOFs)have attracted increasing attention in the field of catalysis in recent years due to their unique cavity structure with fast mass-diffusion rates and easily accessible active ***,we report the use of dynamic modulators,which are formed by the in-situ imine condensation reaction of 4-aminobenzoic acid and 4-formylbenzoic acid,to regulate the growth of MOFs to synthesize well-defined hollow thioether functionalized UiO-67(denoted as H-UiO-67-S)single *** supporting Pd nanoparticles,the designed catalysts Pd@H-UiO-67-S show excellent conversion(>99.9%),selectivity(>99.9%),and stability(10 cycles)in the selective hydrogenation of nitrobenzenes with other reducible *** functional theory calculations and the experimental results reveal that Pd nanoparticles not only selectively adsorb the nitro-groups on nitrobenzene,but also restrict the adsorption of the aniline product,due to the interaction of thioether with Pd in the confined pores of H-UiO-67-S,finally result in a significant increase in selectivity of nitro-hydrogenation.

关键词： hollow structure metal-organic frameworks(MOFs) dynamically modulated synthesis selective hydrogenation nitrobenzene

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Advanced photocatalysts based on metal nanoparticle/metalorganic framework composites

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Nano Research 2021年第7期14卷 2037-2052页

作者： Jun Guo yue Wan Yanfei Zhu meiting Zhao Zhiyong Tang Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Photocatalysis,via conversion of light into valuable chemicals,is an economic and effective way to utilize inexhaustible solar energy for the sustainable development of our human *** at killing two birds with one stone,metal nanoparticle(MNP)/metal-organic framework(MOF)composites via integration of the individual advantages of MNP and MOF have been becoming a versatile ***,owing to the synergist effect between each component,MNP/MOF composite photocatalysts usually show greatly promoted catalytic activity,selectivity and long-term *** this review,first of all,the widely adopted synthesis strategies of MNP/MOF composite are introduced comprehensively,and then their recent advances in photocatalysis including photocatalytic hydrogen production,carbon dioxide reduction,organic transformation reactions and photodegradation of pollutants are summarized and ***,challenges and perspectives among MNP/MOF based photocatalysis are also proposed and discussed for advancing further development in this hot research field.

关键词： metal nanoparticles metal-organic frameworks composite photocatalysis

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Synthesis of MoX2 (X =Se or S) monolayers with high-concentration 1T'phase on 4H/fcc-Au nanorods for hydrogen evolution

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Nano Research 2019年第6期12卷 1301-1305页

作者： Zhengqing Liu Xiao Zhang yue Gong Qipeng Lu Zhicheng Zhang Hongfei Cheng Qinglang Ma Junze Chen meiting Zhao Bo Chen Ye Chen Xue-Jun Wu Pengfei Yin Lin Gu Yaping Du Hua Zhang School of Materials Science and Engineering & National Institute for Advanced Materials Nankai UniversityTianjin 300350China Center for Programmable Materials School of Materials Science and EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100190China

Controlled synthesis of transition metal dichalcogenide (TMD) monolayers with unusual crystal phases has attracted increasing attention due to their promising applications in ***,the facile and large-scale preparation of TMD monolayers with high-concentration unusual crystal phase still remains a ***,we report the synthesis of MoX2 (X =Se or S) monolayers with high-concentration semimetallic 1T'phase by using the 4H/face-centered cubic (fcc)-Au nanorod as template to form the 4H/fcc-Au@MoX2 *** concentrations of 1T'phase in the prepared MoSe2 and MoS2 monolayers are up to 86% and 81%,*** a proof-of-concept application,the obtained Au@MoS2 nanocomposite is used for the electrocatalytic hydrogen evolution reaction (HER) in acid medium,exhibiting excellent performance with a low overpotential of 178 mV at the current density of 10 mNcm^2,a small Tafel slope of 43.3 mV/dec,and excellent HER *** work paves a way for direct synthesis of TMD monolayers with high-concentration of unusual crystal phase for the electrocatalytic application.

关键词： MoS2 monolayers semimetallic 1T'phase 4H/face-centered cubic (fcc)-Au nanorods hydrogen evolution

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二维金属有机框架纳米片的合成及在超电容和电催化领域的应用

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高等学校化学学报 2021年第2期42卷 575-594页

作者：万月宋美娜赵美廷天津大学分子聚集态科学研究院化学系天津市分子光电科学重点实验室天津300072

二维金属有机框架(2D MOF)纳米片具有丰富且易暴露的表面活性位点、高度有序的孔结构以及多样且可调的化学成分,在电化学能量存储与转化中有利于降低反应电位,提高扩散速率和反应速率.关于2DMOF应用于电化学存储与转化的研究已有大量报... 详细信息

二维金属有机框架(2D MOF)纳米片具有丰富且易暴露的表面活性位点、高度有序的孔结构以及多样且可调的化学成分,在电化学能量存储与转化中有利于降低反应电位,提高扩散速率和反应速率.关于2DMOF应用于电化学存储与转化的研究已有大量报道.本文综合评述了近几年2D MOF的合成进展及其在超电容(SC)、析氧反应(OER)、析氢反应(HER)、氧还原反应(ORR)和二氧化碳还原反应(CRR)的应用,并对2D MOF作为电催化材料的研究现状和发展前景进行了总结与展望.

关键词：金属有机框架二维纳米材料电化学存储与转化

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