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中华灾害救援医学 2015年第4期3卷 181-185页

作者：张宏伟 meir oren 彭心宇新疆维吾尔自治区石河子大学医学院第一附属医院普外科 832008 Hillel Yaffe Medical Center hadera38100

中国目前在公共安全的防控方面存在脆性一面,主要表现在防控体系建设不完善、日常管理缺陷、国家投入不足,以及公众意识薄弱等方面。笔者结合一些实际的公共安全案例,对比国内外的公共安全防控现状,对我国防控脆性进行了探讨。

关键词：公共安全事件脆性国际经验

以色列突发大规模伤亡事件应急体系对我国西部应急医疗体系建设的启示

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中华灾害救援医学 2014年第10期2卷 541-546页

作者：张宏伟王芳景曜 meir oren 彭心宇新疆石河子大学医学院第一附属医院普外科 832008 Hillel Yaffe Medical Center hadera38100

以色列突发大规模伤亡事件的应急体系,具有合理的组织构架、训练有素的团队成员、和谐的医护警配合、充足的应急物资储备、强大的通讯设施、丰富的实战及演练经验。针对中国西部(以青海省,新疆、西藏自治区为例)的应急医疗体系中存在的... 详细信息

以色列突发大规模伤亡事件的应急体系,具有合理的组织构架、训练有素的团队成员、和谐的医护警配合、充足的应急物资储备、强大的通讯设施、丰富的实战及演练经验。针对中国西部(以青海省,新疆、西藏自治区为例)的应急医疗体系中存在的问题,可借鉴以色列应急体系,构建区域特色的医疗卫生应急体系,进一步确保人民生命安全。

关键词：大规模伤亡事件应急体系西部地区以色列

Limnological instrumentation in the middle of the 19^(th) century:the first temperature and density profiles measured in the Dead Sea

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Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1496-1504页

作者： Aharon oren Department of Plant and Environmental Sciences Alexander Silberman Institute of Life SciencesHebrew University of Jerusalem

The first modem survey of the Dead Sea was performed by the Geological Survey of Israel in 1959-1960, and the report published remains the baseline study for our understanding of the physical and chemical properties of the lake. At the time the Dead Sea was a meromictic lake with a strong salinity gradient separating the deep waters （〉40 m depth） from the less saline surface waters. A few results of analyses of deeper water samples collected in the 1930s were reported, but overall we have very little information about the structure of the lake＇s water column before the 1959-1960 survey. However, it is little known that data on the physical and the chemical structure of the Dead Sea water column were obtained already in the middle of the 19~ century, and the information collected then is highly relevant for the reconstruction of the limnological properties of the lake in earlier times. The expedition of Lieutenant William Lynch （U.S. Navy） in 1848 reported the presence of a temperature minimum at a depth of-18 m, and also retrieved a water sample collected close to the bottom for chemical analysis. In 1864, the French Dead Sea exploration by the Duc de Luynes and his crew yielded detailed density and salinity profiles for a number of sampling stations. The results of these pioneering studies are discussed here, as well as the sampling equipment and measuring instruments used by the 1848 and the 1864 expeditions.

关键词： Dead Sea stratification research history sampling equipment self-registering thermometer

p53:not just a tumor suppressor

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Journal of Molecular Cell Biology 2019年第7期11卷 539-543页

作者： Moshe oren Department of Molecular Cell Biology Weizmann Institute of ScienceRehovot 76100Israel

Nowadays,p53 is like a Dreamliner airplane,riding the high skies of cancer research with dignity and *** do not have to be a card-bearing p53 researcher to know about p53,care about it,and respect ***,this was not always *** a matter of fact,in the first years of p53 research,from its discovery in the late 1970's to about the end of the 1980's,p53 was more like a kite:one moment high up in the air,the next moment being dragged on the ground.

关键词： Dreamliner dignity ground

Motion of charged particles in bright squeezed vacuum

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Light(Science & Applications) 2024年第2期13卷 347-353页

作者： Matan Even Tzur oren Cohen Solid State Institute and Physics Department Technion-Israel Institute of TechnologyHaifa3200003Israel

The motion of laser-driven electrons quivers with an average energy termed pondermotive *** explore electron dynamics driven by bright squeezed vacuum(BSV),finding that BSV induces width oscillations,akin to electron quivering in laser light,with an equivalent ponderomotive *** identify closed and open trajectories of the electronic width that are associated with high harmonic generation and above-threshold ionization,respectively,similarly to trajectories of the electron position when its motion is driven by coherent *** the case of bound electrons,the width oscillations may lead to ionization with noisy sub-cycle *** results are foundational for strong-field and free-electron quantum optics,as they shed light on ionization,high harmonic generation,and nonlinear Compton scattering in BSV.

关键词： structure vacuum ionization

Immunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers

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Oncology Research 2024年第9期32卷 1389-1399页

作者： meir DJALDETTI Laboratory for Immunology and Hematology Research Rabin Medical CenterHasharon HospitalPetah-Tiqvathe Sackler School of MedicineTel-Aviv UniversityRamat Aviv69978Israel

Resveratrol(RSV),the primary polyphenol found in grapes,has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines,including IL-1β,IL-6,IL-1ra and TNFα.Considering the close association between chronic inflammation and cancer development,RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation,proliferation,neovascularization,and *** influences the generation of microtumor environment which is one of the key factors in cancer *** addition to immunomodulation,RSV inhibits cancer development by expressing anti-oxidant effects,causing cell cycle arrest,stimulating the function of certain enzymes,and activating cell signaling *** end outcome is one of the various forms of cell death,including apoptosis,pyroptosis,necroptosis,and more,as it has been observed in *** has been shown to act against cancer in practically every organ,while its effects on colon cancer have been documented more *** is remarkable that longer-term clinical studies that may have established the potential for this natural substance to serve as a therapeutic adjuvant to traditional anti-cancer medications were not prompted by the encouraging outcomes seen with cancer cells treated with non-toxic doses of *** current review aims to assess the recent findings about the immunological and anti-cancer characteristics of RSV,with a particular emphasis on cancers of the digestive tract,as a challenge for future clinical research that may contribute to the better prognosis of cancer.

关键词： Resveratrol(RSV) Chemoprevention Digestive tract cancers Immunity Cell death Polyphenols

Coupling concepts for simulation:A systematic and comprehensive view and advantages with declarative models

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International Journal of Modeling, Simulation, and Scientific Computing 2014年第2期5卷 158-174页

作者： Tuncer oren School of Electrical Engineering and Computer Science University of Ottawa Ottawa OntarioCanada

A brief review of the importance of simulation-based engineering and science(including social sciences)is followed by a historic perspective of model-based *** 2 is on declarative modeling of component systems as well as its advantages for self-documentation and for computer-aided checks and *** an example for declarative modeling,General System Theory(GEST)implementor is *** Sec.3,basic concepts for coupling of component models,and rules for computer-assisted coupling specification are *** 4 is devoted to possible computerized checks in couplings of declarative models such as:(1)automatic unit checking to avoid meaning-less input/output matching at the time of coupling specification,(2)automatic threshold checking to provide warnings and/or to avoid disasters,and(3)automatic unit conversion for convenience of using library *** 5 is about several layers of nested couplings for modeling systems of *** Sec.6,two types of variable couplings are discussed:(1)couplings with variable connections(to allow input/output relations of models to depend on time or state conditions)and(2)coupling with variable component models(to allow component(or coupled)models to be switched based on time or state conditions).Section 7 is on the use of multimodels as component models in *** 8 is on types of inputs and their use in couplings as well as on exter-nal inputs to simulation *** Sec.9,conclusions and future work for complex systems are ***,the values of simulation systems engineering as well as understanding and avoidance of misunderstanding in cognitive and emotive simulations are *** A is a list of almost 50 types of couplings and Appendix B lists over 50 terms related with couplings in modeling and *** show the richness of“input”concept which is important in specification of input/output relations of component models,Appendix C lists almost 150 types of inputs.I

关键词： Declarative modeling coupling nested coupling variable coupling time-varying coupling types of model couplings multi-models in coupling endogenous inputs types of inputs

Bacteremia and “Endotipsitis” following transjugular intrahepatic portosystemic shunting

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World Journal of Hepatology 2011年第5期3卷 131-137页

作者： Mizrahi meir Roemi Lilach Shouval Daniel Adar Tomer Korem Maya Moses Alon Bloom Alan Shibolet oren Liver Unit Division of MedicineHadassah-Hebrew University Medical CenterJerusalem 91120 Israel Department of Clinical Microbiology and Infectious Diseases Hadassah-Hebrew University Medical CenterJerusalem 91120 Israel Interventional Radiology Unit Department of RadiologyHadassah-Hebrew University Medical CenterJerusalem 91120 Israel

AIM: To identify all cases of bacteremia and suspected endotipsitis after Transjugular intrahepatic portosystemic shunting (TIPS) at our institution and to determine risk factors for their occurrence. METHODS: We retrospectively reviewed records of all patients who underwent TIPS in our institution between 1996 and 2009. Data included: indications for TIPS, underlying liver disease, demographics, positive blood cultures after TIPS, microbiological characteristics, treat- ment and outcome. RESULTS: 49 men and 47 women were included with a mean age of 55.8 years (range 15-84). Indications for TIPS included variceal bleeding, refractory ascites,hydrothorax and hepatorenal syndrome. Positive blood cultures after TIPS were found in 39/96 (40%) patients at various time intervals following the procedure. Seven patients had persistent bacteremia fitting the definition of endotipsitis. Staphylococcus species grew in 66% of the positive cultures, Candida and enterococci species in 15% each of the isolates, and 3% cultures grew other species. Multi-variate regression analysis identified 4 variables: hypothyroidism, HCV, prophylactic use of an- tibiotics and the procedure duration as independent risk factors for positive blood cultures following TIPS (P < 0.0006, 0.005, 0.001, 0.0003, respectively). Prophylactic use of antibiotics before the procedure was associated with a decreased risk for bacteremia, preventing mainly early infections, occurring within 120 d of the procedure. CONCLUSION: Bacteremia is common following TIPS. Risk factors associated with bacteremia include failure to use prophylactic antibiotics, hypothyroidism, HCV and a long procedure. Our results strongly support the use of prophylaxis as a means to decrease early post TIPS infections.

关键词： Tips Bacteremia Ascites Bleeding Liver Insufficiency

Modulators affecting the immune dialogue between human immune and colon cancer cells

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World Journal of Gastrointestinal Oncology 2014年第5期6卷 129-138页

作者： meir Djaldetti Hanna Bessler The Laboratory for Immunology and Hematology Research Rabin Medical Center Hasharon Hospital The Sackler School of Medicine Tel-Aviv University

The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells lea

关键词： Cytokines Immune dialogue Colon cancer Peripheral blood mononuclear cells Cross-talk

Simulation of Cyber-Physical Systems of Systems： Some Research Areas-Computational Understanding, Awareness, and Wisdom

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系统仿真学报 2018年第2期30卷 363-385页

作者： Tuncer oren School of Electrical Engineering and Computer Science University of Ottawa Ottawa ON Canada

After a brief emphasis about the interconnected world, including Cyber-Physical Systems of Systems, the increasing importance of the decision-making by autonomous, quasi-autonomous, and autonomic systems is emphasised. Promising roles of computational understanding, computational awareness, and computational wisdom for better autonomous decision-making are outlined. The contributions of simulation-based approaches are listed.

关键词： cyber-Physical Systems of Systems decision-making by autonomous andautonomic systems computational understanding computational awareness computational wisdom simulation-based knowledge processing