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由出生时体重及成年后体重指数来预测女性患冠心病和卒中风险的纵向研究

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中华全科医师杂志 2006年第4期5卷 226-226页

作者： janet W Rich-Edwards Ken Kleinman Karin B Michels meir j stampfer joAnn E Manson Kathryn M Rexrode Eileen N Hibert Walter C Willett 不详

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。

关键词：出生时体重体重指数冠心病纵向研究女性预测成年卒中风险

由出生时体重及成年后体重指数来预测女性患冠心病和卒中风险的纵向研究

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英国医学杂志中文版 2005年第4期8卷 257-257页

作者： janet W Rich-Edwards Ken Kleinman Karin B Michels meir j stampfer joAnn E Manson Kathryn M Rexrode Eileen N Hibert Walter C Willett 杨斌

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。设计：纵向队列研究。背景与入选者：从1976年开始随访出生时为单胎、足月妊娠的66 111名女护士，于1... 详细信息

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。设计：纵向队列研究。背景与入选者：从1976年开始随访出生时为单胎、足月妊娠的66 111名女护士，于1992年记录了她们的体重。主要结果测定：冠心病事件(心肌梗死或心脏猝死)1504例及卒中1164例。结果：出生体重每超出(标准值)1000克，前瞻性分析得出的冠心病年龄校正风险比为0.77 (95%可信区间0.69 ～ 0.87)；所有卒中的风险比为0.89 (0.78 ～ 1.01)；综合前瞻性和回顾性分析发现，所有卒中的风险比为0.84 (0.76 ～ 0.93)，缺血性卒中为0.83 (0.71 ～ 0.96)，出血性卒中为0.86 (0.66 ～ 1.11)。若将巨大体重婴儿(>4536克)排除在外，则预测力更强。对于出生时体重低而成人后体重指数高的女性来说患冠心病的风险尤其高。在各级成人体重指数范围内，较低出生体重与卒中风险增加的关系是明显的，而在较重的女性并非特别显著。结论：对于出生时体重低的女性，成年时期较高的体重指数是罹患冠心病极强的风险因子。本组大样本队列研究资料显示，女性出生时的体重和成年期肥胖可预示冠心病事件而非卒中的发生。

关键词：出生体重成年体重指数疾病预测女性冠心病卒中

Characterizing cellular mechanical phenotypes with mechanonode-pore sensing

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Microsystems & Nanoengineering 2018年第1期4卷 438-449页

作者： junghyun Kim Sewoon Han Andy Lei Masaru Miyano jessica Bloom Vasudha Srivastava Martha R.stampfer Zev j.Gartner Mark A.LaBarge Lydia L.Sohn Department of Mechanical Engineering University of California at BerkeleyBerkeleyCA 94720-1740USA Department of Bioengineering University of California at BerkeleyBerkeleyCA 94720-1762USA Department of Population Sciences Beckman Research InstituteCity of HopeDuarteCA 91010USA Department of Pharmaceutical Chemistry University of CaliforniaSan FranciscoSan FranciscoCA 94143USA Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryCA 94720USA Graduate Program in Bioengineering University of CaliforniaBerkeleyand University of CaliforniaSan FranciscoBerkeleyCA 94720USA

The mechanical properties of cells change with their differentiation,chronological age,and malignant ***,these properties may be useful label-free biomarkers of various functional or clinically relevant cell ***,we demonstrate mechano-node-pore sensing(mechano-NPS),a multi-parametric single-cell-analysis method that utilizes a four-terminal measurement of the current across a microfluidic channel to quantify simultaneously cell diameter,resistance to compressive deformation,transverse deformation under constant strain,and recovery time after *** define a new parameter,the whole-cell deformability index(wCDI),which provides a quantitative mechanical metric of the resistance to compressive deformation that can be used to discriminate among different cell *** wCDI and the transverse deformation under constant strain show malignant MCF-7 and A549 cell lines are mechanically distinct from non-malignant,MCF-10A and BEAS-2B cell lines,and distinguishes between cells treated or untreated with cytoskeleton-perturbing small *** categorize cell recovery time,ΔT_(r),as instantaneous(ΔTr~0 ms),transient(ΔT_(r)≤40 ms),or prolonged(ΔT_(r)>40 ms),and show that the composition of recovery types,which is a consequence of changes in cytoskeletal organization,correlates with cellular *** the wCDI and cell-recovery time,mechano-NPS discriminates between sub-lineages of normal primary human mammary epithelial cells with accuracy comparable to flow cytometry,but without antibody ***-NPS identifies mechanical phenotypes that distinguishes lineage,chronological age,and stage of malignant progression in human epithelial cells.

关键词： microfluidics mechanical phenotyping node-pore sensing biosensors label-free

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维生素预防卒中干预试验的疗效分析

世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 52-53页

作者： Spence j.D. Chambless L.E. stampfer M.j. 郭中孟 Stroke Prevention and Atherosclerosis Research Centre 1400 Western Rd London Ont. N6G 2V2 Canada

Background and Purpose -The Vitamin Intervention for Stroke Prevention trial (VISP) intention-to-treat analysis did not show efficacy of combined vitamin therapy for recurrent vascular events in patients with nondisabling stroke. Reasons for lack of efficacy may have included folate fortification of grain products, inclusion of the recommended daily intake for B12 in the lowdose arm, treatment with parenteral B12 in patients with low B12 levels in both study arms, a dose of B12 too low for patients with malabsorption, supplementation with nonstudy vitamins, and failure of patients with significant renal impairment to respond to vitamin therapy. We conducted an efficacy analysis limited to patients most likely to benefit from the treatment, based on hypotheses arising from evidence developed since VISP was initiated. The criteria for this subgroup were defined before any data analysis. Methods -For this analysis, we excluded patients with low and very high B12 levels at baseline ( 637 pmol/L, representing the 25th and 95th percentiles), to exclude those likely to have B12 malabsorption or to be taking B12 supplements outside the study and patients with significant renal impairment (glomerular filtration rate justed P=0.049; adjusted for age, sex, blood pressure, smoking, and B12 level P=0.056). In Kaplan-Meier survival analysis comparing 4 groups, patients with a baseline B12 level at the median or higher randomized to high-dose vitamin had the best overall outcome, and those with B12 less than the median assigned to low-dose vitamin had the wo rst (P=0.02 for combined stroke, death, and coronary events; P=0.03 for stroke a nd coronary events). Concl

关键词：干预试验联合终点吸收不良高半胱氨酸血症百分位数亚组肾功能损害缺血性卒中处方量生存分

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生活方式干预对脂肪储存库动员的影响

中华高血压杂志 2017年第12期25卷 1199-1199页

作者： Gepner Y Shelef I Schwarzfuchs D Zelicha H Tene L Yas-kolka meir A Tsaban G Cohen N Bril N Rein M Serfaty D Kenigsbuch S Komy O Wolak A Chassidim Y Golan R Avni-Hassid H Bilitzky A Sarusi B Goshen E Shemesh E Henkin Y Stumvoll M Blüher M Thiery j Ceglarek U Ru-dich A stampfer Mj Shai I 黄洁叶鹏

该研究的目的是评估不同的生活方式干预能否对身体的脂质储存部位产生不同的影响。方法：研究者在278名腹型肥胖（209名，占75％）或脂质代谢紊乱的成年人中进行了一项为期18个月的随机对照研究，提供午餐并对用餐情况进行监督。

关键词：生活方式干预储存脂质代谢紊乱脂肪随机对照研究腹型肥胖成年人

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叶酸摄入与女性高血压发病危险间关系

心血管病学进展 2006年第2期27卷 246-246页

作者： Forman jp Rimm EB stampfer M j 袁志敏（摘译）刘运德（校）不详四川省第五人民医院成都市第三人民医院

众所周知，叶酸通过增加内皮细胞一氧化氮合成，或降低血浆半胱氨酸水平，后者可引发内皮细胞损伤，而对血压调控有裨益。实验表明，补充叶酸能改善内皮功能。然而有关叶酸摄入与高血压发病危险间关系尚不清楚。2项小样本试验表明，大... 详细信息

众所周知，叶酸通过增加内皮细胞一氧化氮合成，或降低血浆半胱氨酸水平，后者可引发内皮细胞损伤，而对血压调控有裨益。实验表明，补充叶酸能改善内皮功能。然而有关叶酸摄入与高血压发病危险间关系尚不清楚。2项小样本试验表明，大剂量叶酸摄入有助于降低血压。本文就大剂量叶酸摄入与女性高血压发病风险间关系进行长程调查分析。

关键词：发病危险高血压叶酸摄入女性内皮细胞损伤一氧化氮合成半胱氨酸血压调控内皮功能

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长期摄入咖啡因与女性高血压患病风险

世界核心医学期刊文摘(心脏病学分册) 2006年第4期 20-20页

作者： Winkelmayer W. C. stampfer M. j. Willett W. C. Curhan G. C. 任付先 Division of Pharmacoepidemiology and Pharmacoeconomics Renal Division Brigham and Women's Hospital 1620 Tremont St BostonMA 02120 United States Dr.

Context: Caffeine acutely increases blood pressure, but the association between habitual consumption of caffeinated beverages and incident hypertension is uncertain. Objective: To examine the association between caffeine intake and incident hypertension in women. Design, Setting, and Participants: Prospective cohort study conducted in the Nurses'Health Studies(NHSs)I and II of 155 594 US women free from physician-diagnosed hypertension followed up over 12 years(1990-1991 to 2002-2003 questionnaires). Caffeine intake and possible confounders were as certained from regularly administered questionnaires. We also tested the associations with types of caffeinated beverages. Main Outcome Measure: Incident physician-diagnosed hypertension. Results: During follow-up, 19 541 incident cases of physician-diagnosed hypertension were reported in NHS I and 13 536 in NHS II. In both cohorts, no linear association between caffeine consumption and risk of incident hypertension was observed after multivariate adjustment(NHS I, P for trend=.29; NHS II, P for trend=.53). Using categorical analysis, an inverse U-shaped association between caffeine consumption and incident hypertension was found. Compared with participants in the lowest quintile of caffeine consumption, those in the third quintile had a 13%and 12%increased risk of hypertension, respectively(95%confidence interval in NHS I, 8%-18%; in NHS II, 6%-18%). Whe n studying individual classes of caffeinated beverages, habitual coffee consumption was not associated with increased risk of hypertension. By contrast, consumption of cola beverages was associated with an increased risk of hypertension, independent of whether it was sugared or diet cola(P for trend< .001). Conclusion: No linear association between caffeine consumption and incident hypertension was *** though habitual coffee consumption was not associated with an increased risk of hypertension, consumption of sugared or diet cola was associated with it. Further re

关键词：高血压饮料患病风险咖啡因嘌呤生物碱女性