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Methodological exploration on the construction of a traditional Chinese medicine nursing expert consensus based on evidence--taking stroke as an example

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 128-134页

作者： Xuejing Li Ke Peng meiqi meng Liu Han Dan Yang Junqiang Zhao Yufang Hao School of Nursing Beijing University of Chinese MedicineBeijing102488China Beijing University of Chinese Medicine Collaborating Center of Joanna Briggs Institute Beijing102488China Beijing University of Chinese Medicine Best Practice Spotlight Organization Beijing102488China Department of Nursing Beijing University of Chinese Medicine Third Affiliated HospitalBeijing100029China School of Nursing University of OttawaOttawaOntarioK1N 6N5Canada Center for Research on Health and Nursing University of OttawaOttawaOntarioK1N 6N5Canada

Objective: To explore the methodology of the evidence-based expert consensus formulation process of traditional Chinese medicine(TCM) nursing taking stroke as an ***: First, preliminary and comprehensive presentation of all stroke-related symptoms and corresponding TCM nursing techniques involved were revealed through bibliometric analysis. Then, selection of stroke symptoms and TCM nursing techniques for inclusion in the consensus was performed using an expert consultation method. Next, we determined the search strategy for a precise evidence search;conducted an evaluation of evidence quality and the grade of the evidence;and completed evidence extraction, evidence analysis, and evidence synthesis based on the included symptoms and TCM nursing techniques. The Delphi method was then applied to determine the strength of each recommendation and the choice of nursing care points by referring to the Grading of Recommendations, Assessment, Development, and Evaluations grid. Finally, we conducted an external expert validation of the Delphi results to form an expert consensus ***: Through the bibliometric analysis, 22 stroke symptoms and 18 TCM nursing techniques were identified in the literature. Then, after expert consultation, 22 symptoms and 111 pairs of symptoms combined with TCM nursing techniques were selected for the evidence search. Evidence integration yielded 10 stroke symptoms corresponding to 29 bodies of evidence;these 10 symptoms were retained through the Delphi consultation, and recommendation strength results for 26 recommendations were obtained. A total of 9 symptoms were further retained for expert external validation to form 24 recommendations, with a recommendation process score range of 7.64-9.99 points and a more scientific and standardized recommendation-formation ***: Owing to the current limited conditions of evidence-based resources for TCM nursing, the present consensus-building process represents only a

关键词： Traditional Chinese medicine nursing Evidence Stroke Hemiplegia Expert consensus Delphi method

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Role of ACLY in the development of gastric cancer under hyperglycemic conditions

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Quantitative Biology 2024年第1期12卷 100-116页

作者： Keran Sun Jingyuan Ning Keqi Jia Xiaoqing Fan Hongru Li Jize Ma meiqi meng Cuiqing Ma Lin Wei Department of Immunology Immunology Department of Hebei Medical UniversityShijiazhuangChina Department of Pathology Pathology Department of the Fourth Hospital of Hebei Medical UniversityShijiazhuangChina

To investigate the impact of hyperglycemia on the prognosis of patients with gastric cancer and identify key molecules associated with high glucose levels in gastric cancer development,RNA sequencing data and clinical features of gastric cancer patients were obtained from The Cancer Genome Atlas(TCGA)*** glucose-related genes strongly associated with gastric cancer were identified using weighted gene co-expression network and differential analyses.A gastric cancer prognosis signature was constructed based on these genes and patients were categorized into high-and low-risk *** immune statuses of the two patient groups were *** citrate lyase(ACLY),a gene significantly related to the prognosis,was found to be upregulated upon high-glucose *** and molecular analyses confirmed high ACLY expression in gastric cancer tissues and *** Set Enrichment Analysis(GSEA)revealed the involvement of ACLY in cell cycle and DNA replication *** of ACLY affected the proliferation and migration of gastric cancer cells induced by high glucose *** findings suggest that ACLY,as a high glucose-related gene,plays a critical role in gastric cancer progression.

关键词： ACLY gastric cancer high glucose immune microenvironment

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老年人久坐行为干预策略的范围综述

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中华护理杂志 2024年第8期59卷 1012-1020页

作者：张小艳李学靖杨丹孟美琪郝玉芳北京医院血管外科/国家老年医学中心/中国医学科学院老年医学研究院北京市100730 北京中医药大学护理学院

目的通过范围综述明确现有老年人久坐行为干预策略的特征、有效性及干预策略中所使用的行为改变技术。方法以Arksey和O’Malley提出的范围综述方法框架为指导,检索PubMed、Embase、PsycINFO、Cochrane Library、CINAHL、久坐行为研究数... 详细信息

目的通过范围综述明确现有老年人久坐行为干预策略的特征、有效性及干预策略中所使用的行为改变技术。方法以Arksey和O’Malley提出的范围综述方法框架为指导,检索PubMed、Embase、PsycINFO、Cochrane Library、CINAHL、久坐行为研究数据库,收集老年人久坐行为干预策略相关文献,检索时间从建库至2022年9月20日。2名研究者独立筛选文献和提取资料,采用描述性分析和社会网络分析对文献进行汇总。结果共纳入31项独立研究,发表于2011年—2022年。其中,干预策略多以社会认知理论为基础,久坐行为干预策略均针对个人心理和行为层面。干预内容主要包括目标和计划、反馈和监测、自然后果、社会支持、重复和替代等。久坐行为干预策略社会网络中,度中心性排名靠前的行为改变技术包括目标设定(行为)、行为自我监控、行动计划、健康后果的信息、行为反馈等。干预策略可减少23~151 min/d的久坐时间。结论应重视老年人久坐行为,并基于现有久坐行为干预策略的特征、有效性和行为改变技术,开发适用于本土情境的老年人久坐行为干预策略。

关键词：老年人久坐行为干预策略行为改变技术范围综述

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渥太华决策支持框架内涵及其临床应用的范围综述

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中华护理杂志 2022年第6期57卷 756-762页

作者：李学靖赵俊强张小艳韩柳孟美琪彭可麦秋露郝玉芳北京中医药大学护理学院北京市102488 渥太华大学护理学院北京中医药大学第三附属医院老年科

目的全面检索国内外渥太华决策支持框架相关研究,明确其核心要素及其子要素的具体内涵,了解其临床应用所覆盖的研究领域,分析其在研究中的具体作用,以期为今后医患共同决策相关研究的实施和推广提供参考。方法采用Arksey and O’Malley... 详细信息

目的全面检索国内外渥太华决策支持框架相关研究,明确其核心要素及其子要素的具体内涵,了解其临床应用所覆盖的研究领域,分析其在研究中的具体作用,以期为今后医患共同决策相关研究的实施和推广提供参考。方法采用Arksey and O’Malley范围综述的方法,系统检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Cochrane Library、CINAHL、Embase、Web of Science,并根据纳入、排除标准筛选文献,由2名研究者独立提取渥太华决策支持框架核心要素及其构念、应用领域、应用方法相关资料,采用描述性分析及主题分析法对提取结果进行整理。结果共纳入143篇文献,渥太华决策支持框架在既往研究中共有3类概念描述,与渥太华决策辅助框架的3个版本相对应,框架覆盖研究领域较广,主要有癌症、骨科疾病、心血管疾病等,框架在研究中体现的指导作用主要有7类,国内外研究存在明显差异。结论国内护理研究者应重视对渥太华决策支持框架理论的解读,并在其指导下启动患者决策现状和需求的调查研究以及患者决策辅助工具的构建和实施研究。

关键词：实施科学渥太华决策支持框架范围综述护理研究医患共同决策

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao meng Qingbin meng Hongwen Jing Bo meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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实施科学视角下最佳证据实施情境测量工具的研究进展

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中国护理管理 2021年第11期21卷 1683-1688页

作者：张小艳王君鑫杨丹李学靖孟美琪郝玉芳北京中医药大学中医学院北京市102448 北京中医药大学护理学院北京市102448

情境是导致证据实施结果存在差异的核心因素,对证据、实施过程和实施者/采纳者影响广泛。介绍了情境相关概念,综述情境测量工具的研制过程、适用对象、测量内容、评分方法、信度、效度及应用现状,旨在为我国学者进行实施性研究的情境评... 详细信息

情境是导致证据实施结果存在差异的核心因素,对证据、实施过程和实施者/采纳者影响广泛。介绍了情境相关概念,综述情境测量工具的研制过程、适用对象、测量内容、评分方法、信度、效度及应用现状,旨在为我国学者进行实施性研究的情境评估提供参考。

关键词：最佳证据实施科学情境工具综述

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Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： meng Zheng Lei Zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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现实主义综述用于复杂护理干预评估的范围综述

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护理学杂志 2023年第16期38卷 119-124页

作者：孟美琪李学靖张小艳杨丹尹依依张静渊郝玉芳北京中医药大学护理学院北京102488

目的探讨现实主义综述评估复杂护理干预的现状,为引入该方法提供参考。方法采用范围综述方法,系统检索国内外数据库中护理领域的现实主义综述,检索时限为建库至2022年3月,由2名研究者独立筛选、提取资料,采用描述性分析及主题分析法对... 详细信息

目的探讨现实主义综述评估复杂护理干预的现状,为引入该方法提供参考。方法采用范围综述方法,系统检索国内外数据库中护理领域的现实主义综述,检索时限为建库至2022年3月,由2名研究者独立筛选、提取资料,采用描述性分析及主题分析法对提取结果进行整理。结果共纳入47篇文献,其中35篇发表于近5年。研究主题以社区/公共卫生护理和老年护理居多。构建初始项目理论、检索和筛选证据、评价证据、资料提取、综合与分析5个关键步骤中对核心过程项目理论构建与完善的报告不充分。结论现实主义综述可揭示复杂护理干预发挥作用的机制,国内需借鉴国外的应用经验并加以规范与完善,为发展我国护理理论和实践研究提供新思路。

关键词：现实主义综述现实主义整合复杂护理干预护理理论护理研究范围综述

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A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun Cui Ziquan Yan Weiping Hu Qingchun meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

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