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Time-Varying Channel Estimation Based on Air-Ground Channel Modelling and Modulated Learning Networks

Chinese Journal of Electronics 2022年第3期31卷 430-441页

作者： LIU Chunhui wang meilin DONG Zanliang wang Pei Institute of Unmanned System Beihang University School of Electronic and Information Engineering Beihang University

To improve the time-varying channel estimation accuracy of orthogonal frequency division multiplexing air-ground datalink in complex environment, this paper proposes a time-varying air-ground channel estimation algorithm based on the modulated learning networks,termed as MB-Chan Est-TV. The algorithm integrates the modulated convolutional neural networks(MCNN) with the bidirectional long short term memory(Bi-LSTM),where the MCNN subnetworks accomplish channel interpolation in frequency domain and compress the network model while the Bi-LSTM subnetworks achieve channel prediction in time domain. Considering the unique characteristics of airframe shadowing for unmanned aircraft systems, we propose to combine the classical 2-ray channel model with the tapped delay line model and present a more realistic channel impulse response samples generation approach, whose code and dataset have been made publicly available. We demonstrate the effectiveness of our proposed approach on the generated dataset, where experimental results indicate that the MB-Chan Est-TV model outperforms existing state-of-the-art methods with a lower estimation error and better bit error ratio performance under different signal to noise ratio *** also analyze the effect of roll angle of the aircraft and the duration percentage of the airframe shadow on the channel estimation.

关键词： OFDM modulation channel prediction realistic channel impulse response samples generation approach modulated learning networks Bi-LSTM subnetworks telecommunication computing air-ground datalink wireless channels 2-ray channel model convolutional neural nets interpolation time-varying channels MB-ChanEst-TV model air-ground channel modelling frequency domain error statistics recurrent neural nets channel estimation modulated convolutional neural networks bidirectional long short term memory learning (artificial intelligence) time-varying air-ground channel estimation algorithm network model channel interpolation MCNN tapped delay line model lower estimation error time-varying channel estimation accuracy

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Flavonoids of Rosa rugosa *** tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells

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Food Science and Human Wellness 2022年第2期11卷 374-382页

作者： Zhiguo Zhang meilin wang Shu Xing Chen Zhang School of Food Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Chemistry and Pharmaceutical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Science The Hong Kong University of Science and TechnologyHong KongChina

Rosa rugosa *** recognized as both medicine and edible in *** article investigated the antitumor activity of rose ***-extracted rose flavonoids(RFW)and ethanol-extracted rose flavonoids(RFE)were achieved by extracting with distilled water and 70%ethanol,*** effects of the two extracts on proliferation inhibition,apoptosis inducement and metastasis prevention of human HepG2 hepatocellular carcinoma cell lines were tested,via optical/fluorescence microscopy,MTT detection,Transwell assay,flow cytometry and Western blot,*** results indicated that rose flavonoids at low concentration(10-40μg/mL)had a better inhibitory effect on migration and invasion of HepG2 cells in a dose-dependent manner,while rose flavonoids at high concentration(80-160μg/mL)could induce apoptosis of HepG2 cells by up-regulating the expression of pro-apoptotic proteins p53 and Bax,and down-regulating the expression of anti-apoptotic proteins Bcl-2,leading to the functioning of caspase-3 and *** effect of RFE at the same concentration was significantly better than that of ***,this study found that rose flavonoids had a certain inhibitory effect on proliferation and metastasis of human liver cancer cells HepG2,indicating the application of rose flavonoids in preventing and treating of liver cancer.

关键词： Rose flavonoids Tumor metastasis Apoptosis Human liver cancer

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Differences in breaking behavior of rice leaves under microwave and naturally drying processes

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International Journal of Agricultural and Biological Engineering 2022年第1期15卷 89-100,F0002页

作者： meilin wang Zhong Tang Ben Zhang Yu Li Key Laboratory of Modern Agricultural Equipment and Technology Ministry of EducationJiangsu UniversityZhenjiang 212013JiangsuChina

In order to fight for good farming time or harvest in bad weather,combine harvester will produce more broken leaves when threshing high moisture content rice,which will seriously hinder the grain cleaning *** this study,the breaking behavior of rice leaves under different microwave drying time and drying power was ***,based on the appearance of freshly rice leaves undergoing microwave drying,the changing property of moisture content,weightlessness rate and temperature rise of rice leaves were tested and ***,the tensile breaking force of freshly rice leaves under different microwave drying time and drying power was tested and compared with the tensile breaking force of naturally dried ***,the optimal microwaves parameters of rice leaves after drying which could result in greater breaking force than the natural drying state were *** result showed that microwave drying method will reduce the moisture content of rice leaves and change the microstructure,which would affect the tensile-breaking property of rice *** maximum tensile breaking force of rice leaves appeared at microwave dried power 70 W for 5-8 min and at microwave dried power 210 W for 3-4 *** tensile breaking property of rice leaves at microwave dried power 350 W for 6-8 min were the weakest,which was lower than that of fresh rice ***,the optimal microwave drying parameters of rice leaves will provide a basis for the application of microwave technology in the threshing process.

关键词： rice harvesting rice leaves microwave drying moisture content breaking force

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Ni_(4)-thiacalix[4]arene sandwiched Mo_8 polyoxometalate bimetallic nanoclusters for electrocatalytic glucose oxidation

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Chinese Chemical Letters 2023年第3期34卷 477-480页

作者： meilin wang Yinjuan Guo Guiyan Zhao Baokuan Chen Yanfeng Bi School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun 113001China

Available online two new Ni_(8)Mo_(8) bimetallic coordination clusters,[Ni_(4)(TC4A)]_(2)[(Mo_5~VMo_(3)~ⅥO_(24))(PO_(4))](+Solvent)(Ni_(8)PMo_(8),H_(4)TC4A=p-tert-butylthiacalix[4]arene) and[Ni_(4)(TC4A)]_(2)[(Mo_5~VMo_(3)~ⅥO_(24))(OH)(CO_(3))](+Solvent)(Ni_(8)Mo_(8)),were synthesized by solvothermal method and structurally characterized by single-crystal X-ray diffraction,powder X-ray diffraction,FT-IR spectroscopy,and TGA experiments,*** usage of H_(3)PMo_(12)O_(40) as source for Ni_(8)PMo_(8) resulted a sandwich like structure built from two Ni_(4)-thiacalix[4]arene units and a Mo_(8) polyoxometalate with inner spaces of PO_(4)^(3-).Ni_(8)Mo_(8) with the similar structure to that of Ni_(8)PMo_(8) is from H_(2)MoO_(4) starting reagent with OH^(-)and CO_(3)^(2-)anions encapsulated in the *** two clusters can be directly loaded on carbon paper and utilized as working electrodes which showed distinguishable performances for glucose detection and *** work provides a better understanding of the structure-property relationships in using substituted polyoxometalates for electrochemical applications and is helpful for building calixarene-based or polyoxometalatebased functional materials.

关键词： Thiacalixarene Substituted polyoxometalates Bimetallic nanocluster Crystal structure Glucose oxidation

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Structure design and rice threshing performance of the variable-speed inertial pulley for simulating artificial threshing

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 33-40页

作者： Tiantian Jing Zhong Tang Shuaihua Hao Cheng Shen Ting wang meilin wang School of Agricultural Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Hangzhou 310058China College of Engineering China Agricultural UniversityBeijing 100083China Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Jiangsu World Agriculture Machinery Co. Ltd(WORLD A/M)Zhenjiang 212311JiangsuChina

Due to the small models and compact structures,small harvesters have also caused problems such as poor threshing separation performance and large loss *** order to solve unstable cleaning effects of small harvesters when they facing different working conditions,this study selected rice plants in hilly areas for the *** breaking force of different parts of mature rice was tested,which revealed the fracture mechanism of each part under the combined *** threshing method was used to simulate artificial plate bin and design three kinds of non-circular pulley variable speed transmission threshing *** the help of transient inertia force,threshing force was *** paper tested the harvesting performance of the variable speed threshing device with the help of the harvest performance *** show when facing the small rice planting area,the T/2 variable speed threshing device has better cleaning performance,and also the harvest loss rate of T/4 variable speed threshing device is the *** with the constant speed threshing device,the impurity content rate of the variable speed threshing device is increased by 0.64%to 8.76%;the loss rate is reduced by 0.45%to 1.79%,which provides a basis for the optimization design of small combine harvester in hilly areas.

关键词： small harvesters fracture mechanism transient inertia force non-circular pulley

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Biological functions and potential implications of circular RNAs

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The Journal of Biomedical Research 2023年第2期37卷 89-99页

作者： Lan Ma Haiyan Chu meilin wang Zhengdong Zhang Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China.

Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges,interacting with proteins, modulating the expression of related genes and translating into peptides or *** have also been used as biomarkers for a number of diseases, which could improve clinical *** review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.

关键词： circular RNAs biogenesis mechanisms database biomarkers

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Bladder cancer epidemiology and genetic susceptibility

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The Journal of Biomedical Research 2013年第3期27卷 170-178页

作者： Haiyan Chu meilin wang Zhengdong Zhang Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationSchool of Public HealthNanjing Medical University

Bladder cancer is the most common malignancy of the urinary system. The incidence of bladder cancer of men is higher than that of women （approximately 4：1）. Here, we summarize the bladder cancer-related risk factors, in- cluding environmental and genetic factors. In recent years, although the mortality rate induced by bladder cancer has been stable or decreased gradually, the public health effect may be pronounced. The well-established risk fac- tors for bladder cancer are cigarette smoking and occupational exposure. Genetic factors also play important roles in the susceptibility to bladder cancer. A recent study demonstrated that hereditary non-polyposis colorectal cancer is associated with increased risk of bladder cancer. Since 2008, genome-wide association study （GWAS） has been used to identify the susceptibility loci for bladder cancer. Further gene-gene or gene-environment interaction stud- ies need to be conducted to provide more information for the etiology of bladder cancer.

关键词： bladder cancer molecular epidemiology risk factors genetic susceptibility

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Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer

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The Journal of Biomedical Research 2013年第3期27卷 179-192页

作者： meilin wang Haiyan Chu Zhengdong Zhang Qingyi Wei Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationSchool of Public HealthNanjing Medical University Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Department of Epidemiology the University of Texas M. D. Anderson Cancer Center

Although tobacco and alcohol consumption are two common risk factors of head and neck cancer （HNC）, other specific etiologic causes, such as viral infection and genetic susceptibility factors, remain to be understood. Hu- man DNA is often damaged by numerous endogenous and exogenous mutagens or carcinogens, and genetic vari- ants in interaction with environmental exposure to these agents may explain interindividual differences in HNC risk. Single nucleotide polymorphisms （SNPs） in genes involved in the DNA damage-repair response are reported to be risk factors for various cancer types, including HNC. Here, we reviewed epidemiological studies that have assessed the associations between HNC risk and SNPs in DNA repair genes involved in base-excision repair, nucleotide-excision repair, mismatch repair, double-strand break repair and direct reversion repair pathways. We found, however, that only a few SNPs in DNA repair genes were found to be associated with significantly in- creased or decreased risk of HNC, and, in most cases, the effects were moderate, depending upon locus-locus in- teractions among the risk SNPs in the pathways. We believe that, in the presence of exposure, additional pathway- based analyses of DNA repair genes derived from genome-wide association studies （GWASs） in HNC are needed.

关键词： DNA repair molecular epidemiology head and neck cancer genetic variation genome-wide asso-ciation study

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Comparative research on karyotype in three species of Arcidae

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Acta Oceanologica Sinica 1996年第4期15卷 529-538页

作者： Zheng Jiasheng wang meilin Guo Danhong Xu Ximind and Gao Qinglan Marine Life College Ocean University of Qingdao Qingdao 266003 China

By air-dry method, the karyotype from gill cell in three clams of Bivalvia Pterimorphia Arcidae,Tegillarca granosa,Scapharca subcrenata and ***,was studied. Their chromosome number (2n ) andfundamenod number (W) are equal to each other. But their karyotype is different. In T. granosa, it is 2n = 38,28m+ 10sml In ***2n = 38, 14m + 22sm+ 2st, In *** 2n = 38, 12m+ 20sm+ 6st. *** has no subtelocentric (st) chromosome, *** has one Pair and S. then has three paris of *** centric (m) and submiddle centric chromosome are major type in karyotype of three species of Arcida; thelengths of chromosomes from the largest to the smallest changed gradually. The absolute length of the maximum chromosome in all three species do not exceed 5 μm and the minimum cluomonsome is about 2 μm. Inversion pericentricperhaps plays an important role in the evolution of chromosome. Hybridization among the three species of Arcidae ispossible.

关键词： T. granosa S. subcrenata S, broughtonii chromosome karyotype

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Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS

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The Journal of Biomedical Research 2024年第1期38卷 37-50页

作者： Sumeng wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng meilin wang Dongying Gu Lingxiang Liu Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China.

The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is *** address this gap,we conducted a study aiming to investigate this association and identify relevant *** analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune ***,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)*** employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune *** findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal ***,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA *** conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets.

关键词： trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis

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