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考虑发动机推力受限和动特性的有限时间收敛制导律

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系统工程与电子技术 2017年第9期39卷 2068-2074页

作者：段美君周荻哈尔滨工业大学控制科学与工程系黑龙江哈尔滨150001

针对发动机推力受限和动态延迟的制导问题,设计了一种具有鲁棒性的非奇异滑模制导律,并证明了有限时间收敛条件。首先,基于平面弹-目相对运动学关系,建立了考虑发动机一阶动态延迟的弹-目相对运动数学模型。其次,基于有限时间理论,证明... 详细信息

针对发动机推力受限和动态延迟的制导问题,设计了一种具有鲁棒性的非奇异滑模制导律,并证明了有限时间收敛条件。首先,基于平面弹-目相对运动学关系,建立了考虑发动机一阶动态延迟的弹-目相对运动数学模型。其次,基于有限时间理论,证明了推力受限下制导律有限时间收敛条件及其性质;并推广到动态延迟情况下,设计了非奇异滑模制导律;最后,用边界层函数代替符号函数去除抖振。仿真结果表明了制导律具有更高的制导精度并对高速目标机动具有鲁棒性,验证了有限时间收敛条件和性质。

关键词：制导律有限时间控制推力受限发动机动态非奇异终端滑模

基于有限时间理论的临近空间拦截器末制导律PWPF调节器研究

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航空学报 2018年第1期39卷 268-277页

作者：段美君周荻程大林哈尔滨工业大学航天学院哈尔滨150001 北京宇航系统工程研究所北京100076

针对拦截临近空间高速机动目标,基于有限时间理论,设计了有限时间收敛末制导律和脉冲宽度脉冲频率(PWPF)调节器。首先,介绍了加入PWPF调节器的末制导数学模型及工作原理;其次,设计了有限时间收敛制导律,应用有限时间理论证明了收敛条件... 详细信息

针对拦截临近空间高速机动目标,基于有限时间理论,设计了有限时间收敛末制导律和脉冲宽度脉冲频率(PWPF)调节器。首先,介绍了加入PWPF调节器的末制导数学模型及工作原理;其次,设计了有限时间收敛制导律,应用有限时间理论证明了收敛条件和性质,并推广到推力受限条件下;最后,考虑视线(LOS)角速率快速收敛和发动机最小工作时间要求,设计了PWPF调节器参数。仿真结果表明,视线角速率在制导结束前的有限时间收敛至零,对目标机动具有鲁棒性,具有较高的制导精度,避免了发动机频繁开启,节省了燃料。

关键词：临近空间末制导律有限时间收敛推力受限 PWPF调节器

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基于共享学习策略的微分进化算法

工程科学与技术 2019年第1期51卷 205-212页

作者：段美军杨红雨刘洪陈俊逸刘宇四川大学视觉合成图形图像技术国防重点学科实验室四川成都610065 四川大学计算机学院四川成都610065

针对传统微分进化算法易发生早熟收敛问题,提出基于共享学习策略的微分进化算法(SLDE),引入共享个体和共享学习因子。共享个体覆盖整个种群,较优个体可引导算法朝希望方向进化,较差个体则能维持种群的多样性,向共享个体学习可避免丢失... 详细信息

针对传统微分进化算法易发生早熟收敛问题,提出基于共享学习策略的微分进化算法(SLDE),引入共享个体和共享学习因子。共享个体覆盖整个种群,较优个体可引导算法朝希望方向进化,较差个体则能维持种群的多样性,向共享个体学习可避免丢失个体信息,实现整个种群间的信息交换,有助于算法跳出局部最优解,提高算法的局部开采和全局勘探能力。同时,算法充分利用个体的进化信息,根据个体适应值到最优适应值的距离自适应地调整共享学习因子,以弥补随机个体对进化带来的随机性和盲目性,增强算法的搜索能力。采用22个不同特性的Benchmark测试函数对算法进行性能测试,与7种改进DE算法进行性能对比,实验结果表明,SLDE具有较强的跳出局部最优解能力,能显著减少进化代数,大幅地提高算法的收敛精度、收敛速度和稳定性,SLDE的全局优化性能整体上远优于其他改进DE算法。

关键词：微分进化共享学习共享个体共享学习因子自适应

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen duan Lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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多拦截弹分离过程姿态控制方法

导弹与航天运载技术 2013年第6期 15-19页

作者：段美君周荻王亚辉王锦涛哈尔滨工业大学控制科学与工程系中国人民解放军63883部队陆航部军事代表局

多拦截弹分离过程在栅格舵展开前姿态控制系统是静不稳定且无控的,导致姿态角发散,针对此规律,提出一种基于反步法(BS)设计的非线性姿态控制律,可以保证姿态角快速收敛。将其应用到多拦截弹分离过程,仿真结果表明该控制方法能有效解决... 详细信息

多拦截弹分离过程在栅格舵展开前姿态控制系统是静不稳定且无控的,导致姿态角发散,针对此规律,提出一种基于反步法(BS)设计的非线性姿态控制律,可以保证姿态角快速收敛。将其应用到多拦截弹分离过程,仿真结果表明该控制方法能有效解决栅格舵展开前姿态不稳定的影响。通过与古典控制方法比较,显示其具有更优良的控制品质和更优越的分离性能指标。

关键词：多拦截弹分离姿态控制反步法栅格舵

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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星形AB共聚物和A均聚物的共组装模拟研究

原子与分子物理学报 2025年第5期42卷 90-94页

作者：段润宇新疆大学物理科学与技术学院乌鲁木齐830017

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系... 详细信息

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系中聚集体的共组装形貌.预测了一些有趣的结构,比如,具有较厚壳层的核-壳-补丁结构、具有壳层的且中心凹陷的圆盘状结构以及不规则椭球的多室结构.本文还发现对于具有较长A嵌段的星形链,增大A均聚物在聚集体中的浓度能够消除聚集体内B嵌段形成的核;对于具有较短A嵌段的星形链,少量的A均聚物能够诱导聚集体共组装成具有长条状核的多室纳米粒子.

关键词：耗散粒子动力学星形二嵌段共聚物共组装纳米粒子