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Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring

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Maternal-Fetal Medicine 2023年第1期5卷 31-35页

作者： Meihua Zhang Munan Ma Jinping Wang Yijun Wang Xinrui Yang Songtao Fu Maternity Department Taiyuan Maternal and Child Health HospitalTaiyuanShanxi 030001China Department of Biochemistry&Molecular Biology Shanxi Medical UniversityTaiyuanShanxi 030001China Birth Defects and Regenerative Medicine Laboratory Department of Biochemistry&Molecular BiologyShanxi Medical UniversityTaiyuanShanxi 030001China Biomedicine and Health Graduate Education Innovation Center TaiyuanShanxi 030001China

The effects of gestational diabetes mellitus (GDM) on offspring include macrosomia, hypoglycemia, respiratory distress syndrome, cardiovascular disease, neural and mental injury, etc. The effects of GDM on the health status of offspring are sustained although pregnancy has ended. It has been proposed that fetal reprogramming causes long-term consequences to metabolic health in offspring. An intrauterine high-glucose environment may lead to changes in the multi-differentiation proficiency of intracorporal stem cells, showing decreased proliferation and osteogenic ability, increased adipogenic ability, accelerated apoptosis, and occurrence of premature failure. This environment also reduces the mobilization of bone marrow stem cells, whereas it increases that of medullary cells. This results in pro-inflammatory conditions and sustained inflammation in the body, thereby increasing the risk of obesity, cardiovascular and neurological disorders, and metabolic abnormalities. Stem cells derived from the amniotic membrane, umbilical cord, or placenta may be a reliable predictor of the long-term effects of GDM on offspring. The levels of blood glucose during pregnancy should be effectively controlled to reduce harm to the neonate.

关键词： Diabetes gestational Growth and development Offspring Stem cells

Proving Mutual Authentication Property of RCIA Protocol in RFID Based on Logic of Events

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Chinese Journal of Electronics 2022年第1期31卷 79-88页

作者： ZHONG Xiaomei XIAO meihua zhang Tong YANG Ke LUO Yunxian School of Software East China Jiaotong University

The increasing commercialization and massive deployment of radio frequency identification(RFID) systems has raised many security related issues which in return evokes the need of security protocols. Logic of events theory(Lo ET) is a formal method for constructing and reasoning about distributed systems and protocols that involve concepts of security. We propose fresh ciphertext and ciphertext release lemmas to extend Lo ET for analyzing and proving the security of authentication protocols that use symmetric key cryptography more than just digital signature. Based on the extended Lo ET we formally analyze and prove the authentication property of RCIA protocol, which provides mutual authentication between Tag and Reader in RFID system.Our proof approach based on extended Lo ET could be applied to the design and analysis of such ultralightweight RFID mutual authentication protocols.

关键词： RFID Ultralightweight mutual authentication protocol RCIA protocol Logic of events Theorem proving

Three New Species of Diploderma Hallowell, 1861 (Reptilia: Squamata: Agamidae) from the Shaluli Mountains in Western Sichuan, China

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Asian Herpetological Research 2022年第4期13卷 205-223页

作者： Bo CAI Meihua Zhang Jing LI Simeng DU Feng XIE Mian HOU Huaming ZHOU Jianping JIANG CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu 610041SichuanChina Ganzi Institute of Forestry Research Kangding 626001SichuanChina College of Continuing(Online)Education Sichuan Normal UniversityChengdu 610068SichuanChina University of the Chinese Academy of Sciences Beijing 100049China Mangkang Biodiversity and Ecological Station Tibet Ecological Safety Monitor NetworkChangdu 854500TibetChina

In recent years,taxonomic research of the genus Diploderma has made great progress,but there are still areas lacking relevant investigations.During 2020-2021,we carried out survey of reptile diversity in and around the Shaluli Mountains and collected some specimens of Diploderma.Of which,based on systematics inferred from mitochondrial ND2 gene sequence and morphological data,three new species were recognized:Diploderma daochengense sp.***.from the Shuiluo River and Muli River valleys in southeastern Daocheng County,D.xinlongense sp.***.from the upper-middle valleys of the Yalong River in Xinlong County,and D.kangdingense sp.***.from the Yalong River middle valley and Liqiu River valley.Specifically,these three new species formed three monophyletic lineages with strongly supported and nested into the subclade I of the Bayesian and Maximum Likelihood trees.The uncorrected mean genetic distance between these new species and their closely related species was 4.3%(D.xinlongense sp.***.vs.D.panchi),3.4%(D.daochengense sp.***.vs.D.yulongense)and 5.5%(D.kangdingense sp.***.vs.D.bowoense),higher than many pairs of species of Diploderma.With respect to the morphology,D.daochengense sp.***.can be easily diagnosed from D.yulongense byhaving smoothupper edge of the dorsolateral stripes,cyan or dark olive green to yellow gular spots inbothsexes and light yelloworwhite ventrolateral body in males;D.xinlongense sp.***.can be easily diagnosed from D.panchi by having cyan gular spot in both sexes;D.kangdingense sp.***.can be easily diagnosed from D.bowoense by having more T4S 20-25(average 23),more F4S 16-20(average 17)and yellow to light yellow ventrolateral body,yellow gular spot present in males.To date,the number of species of the genus Diploderma has increased to 40,of which 37 species have been known in China.

关键词： Ganzi taxonomy Hengduan Mountains Mountain Dragons RGBcolormodel

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

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Neural Regeneration Research 2024年第9期19卷 2041-2049页

作者： Zhihua Wang Wu Zhou Zhixiong zhang Lulu zhang meihua Li Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Postdoctoral Innovation Practice Base The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Nephrology Nanchang People’s Hospital Affiliated to Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models.Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.Metformin is a classic drug used to treat type 2 diabetes that can inhibit ferroptosis.Previous studies have shown that,when used to treat cardiovascular and digestive system diseases,metformin can also upregulate heme oxygenase-1 expression.Therefore,we hypothesized that heme oxygenase-1 plays a significant role in mediating the beneficial effects of metformin on neuronal ferroptosis after spinal cord injury.To test this,we first performed a bioinformatics analysis based on the GEO database and found that heme oxygenase-1 was upregulated in the lesion of rats with spinal cord injury.Next,we confirmed this finding in a rat model of T9 spinal cord compression injury that exhibited spinal cord nerve cell ferroptosis.Continuous intraperitoneal injection of metformin for 14 days was found to both upregulate heme oxygenase-1 expression and reduce neuronal ferroptosis in rats with spinal cord injury.Subsequently,we used a lentivirus vector to knock down heme oxygenase-1 expression in the spinal cord,and found that this significantly reduced the effect of metformin on ferroptosis after spinal cord injury.Taken together,these findings suggest that metformin inhibits neuronal ferroptosis after spinal cord injury,and that this effect is partially dependent on upregulation of heme oxygenase-1.

关键词： acyl-CoA synthetase long-chain family member 4 ferroptosis glutathione peroxidase 4 heme oxygenase-1 inflammation iron lipid peroxidation metformin neuroprotection spinal cord injury

A New Species of Genus Microhyla(Amphibia： Anura： Microhylidae) from Zhejiang Province, China

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Asian Herpetological Research 2018年第3期9卷 135-148页

作者： Meihua Zhang Liang FEI Changyuan YE Yufan WANG Bin Wang Jianping JIANG CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China University of Chinese Academy of Sciences Beijing 100049 China Zhejiang Forest Resource Monitoring Center Hangzhou 310020 China

We described a new species, Microhyla beilunensis sp. nov., from Zhejiang Province of China. Phylogenetic analyses based on the mitochondrial 12 S, 16 S and CO1 gene sequences suggested that the new taxon was distinctly separated from its congeners and closed to M. mixtura and M. okinavensis. Morphologically, the new species could be identified from its congeners except M. mixtura by several characters：（1） rudimentary webs on toe base;（2） absence of disks and dorsal median longitudinal grooves on finger tips;（3） presence of disks and dorsal median longitudinal grooves on toe tips. As well, the new species could be identified from topotype M. mixtura by the combination of characters：（1） apart from the stripes, bar-shaped and oval-shaped patterns, the rounded spots present on the dorsum of body and legs;（2） the outer metacarpal tubercles prominently larger than the inner one;（3） of males, the ratios of HW, IND, UEW and LAW to SVL of the new species were significantly larger than those of M. mixtura（P 〈 0.01）, and the ratios of SL, IOD, LAHL, HLL, TL, TFL and FL to SVL of the new species were significantly less than those of M. mixtura（P 〈 0.05）.

关键词： Microhyla morphological comparison new species phylogenetic analysis taxonomy Zhejiang

PKC-SWI6 signaling regulates asexual development,cell wall integrity,stress response,and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora

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Science China(Life Sciences) 2022年第12期65卷 2455-2471页

作者： meihua Xie Ni Ma Na Bai Le Yang Xuewei Yang Ke-Qin zhang Jinkui Yang State Key Laboratory for Conservation and Uilization of Bio-Resources Key Laboratory for Microbial Resources of the Ministry of EducationSchool of Life SciencesYumman UniversityKunming 650091China School of Resource Emvironment and ChemistryChuciong Normal UniversityChnuciong 675000China Yunnan Center for Disease Control and Prevention Kunming 650022China

Predatory fungi possess intricate signal transduction systems that regulate their development and support successful infection of the host.Herein,we characterized three components of the cell wall integrity-controlling pathway,namely protein kinase C(Ao PKC),SLT2-MAPK(Ao SLT2),and SWI6(Ao SWI6),in a representative nematode-trapping fungus Arthrobotrys oligospora,using gene disruption and multi-omics approaches.The phenotypic traits(such as mycelia development,conidiation,stress response,and trap morphogenesis) and metabolic profiles of ΔAopkc and ΔAoswi6 mutants were similar but differed from those of the ΔAoslt2 mutants.Transcriptomic analysis indicated that the genes differentially expressed in the absence of Aoswi6 were involved in DNA replication,repair,and recombination during trap formation.Moreover,the yeast two-hybrid assay showed that Ao PKC interacted with Ao SWI6,suggesting that in A.oligospora,PKC can directly regulate SWI6,bypassing the SLT2signaling cascade.Conclusively,our findings deepen our understanding of the regulatory mechanism of asexual development and lifestyle switching in nematode-trapping fungi.

关键词： Arthrobotrys oligospora conidiation stress response trap formation differential expression analysis metabolic profile pathogenicity

K_(2)S_(2)O_(8)-mediated acylarylation of unactivated alkenes via acyl radical addition/C–H annulation cascade of N-allyl-indoles with silver cocatalysis

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Organic Chemistry Frontiers 2022年第1期9卷 32-38页

作者： Jitan zhang Manyi Wu Hu Ju Haitao Yang Baiyang Qian Ke Ding Jiaping Wu meihua Xie Key Laboratory of Functional Molecular Solids(Ministry of Education) Anhui Key Laboratory of Molecular Based MaterialsCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China.

A silver-catalyzed,K_(2)S_(2)O_(8)-mediated protocol to access regioselective acylarylation of unactivated alkenes was developed.The reaction between N-allyl-indoles andα-oxocarboxylic acids proceeded smoothly and involved an acyl radical addition/C–H cyclization cascade.The protocol showed a broad substrate scope and good tolerance of functional groups.The reaction proceeded with both internal and terminal alkenes to furnish many functional pyrrolo[1,2-a]indoles bearing the ketone carbonyl group,and this feature also provides the potential to construct structurally complex N-containing heterocycles.

关键词： silver allyl radical

Regioselective Synthesis of Aurone Derivatives via PBu_(3)-Catalyzed Cyclization of 2-Alkynoylphenols

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中国化学:英文版 2014年第12期32卷 1233-1237页

作者： Changqing Liu Zhannan zhang Jitan zhang Xing Liu meihua Xie Key Laboratory of Functional Molecular Solids(Ministry of Education) Anhui Key Laboratory of MolecularBased MaterialsCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhuAnhui 241000China Department of Chemistry Bengbu Medical CollegeBengbuAnhui 233030China

Aurone derivatives were synthesized in good to high yields by PBu_(3)-catalyzed intramolecular 5-exo cyclization of 2-alkynoylphenols.The reaction proceeds in high regioselectivity without forming 6-endo cyclization p... 详细信息

关键词： 2-alkynoylphenol PBu_(3) intramolecular cyclization aurone

Tuning redox activity through delithiation induced protective layer and Fe-O coordination for Li-rich cathode with improved voltage and cycle performance

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Journal of Energy Chemistry 2022年第8期31卷 266-276,I0008页

作者： Kanghui Hu Li Ren Weifeng Fan Bing zhang meihua Zuo Yanhui zhang Genpin Lv Huiyuan Xu Wei Xiang Xiaodong Guo College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina Yibin Libode New Materials Co. Ltd.Yibin 644200SichuanChina Shaoguan HEC Technology R&D Co. Ltd.Ruyuan 512000GuangdongChina Yibin Tianyuan Grp Co. Ltd.Yibin 644200SichuanChina School of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina

Li-rich layered transition metal oxides are one of the most promising cathode materials for their high energy density.However,the cathodes usually suffer from severe potential dropping and capacity fading during cycling,which are associated with the surface oxygen release and accompanied by cation densification and structural collapse.Herein,an integrative approach of simultaneous constructing uniform 3d Fe-ion doping in the transition metal layer and Li-rich Li_(5)FeO_(4) shell to grab the oxygen and prevent interfacial side reactions is proposed.The introduction of Fe induces higher redox potential and stronger 3 d Fe-O_(2)p covalent bond,triggering reversible anionic redox via a reductive coupling mechanism.And the delithiated product of Li-rich Li_(5)FeO_(4) not only acts as a protective layer alleviating the side reactions but also enhances the surface kinetic property.With the benefit of promoted reversibility of oxygen redox and enhanced surface stability,the cathode exhibits high reversible capacity and superior cycle performance.Density function theory calculation indicates that the O_(2)p non-bonding state in the cathode incorporated with Fe sits at a lower energy band,resulting in higher energy storage voltage and improved oxygen stability.Consequently,the modified cathode exhibits a discharge specific capacity of 307 m A h g^(-1)(1 C=250 m A g^(-1)),coulombic efficiency of 82.09%in the initial cycle at 0.1 C and 88.34%capacity retention after 100 cycles at 1 C.The work illustrates a strategy that could simultaneously enhance oxygen redox reversibility and interface stability by constructing lattice bond coordination and delithiation induced protective layer to develop Li-rich materials with high reversible capacity and long lifespan.

关键词： Li-rich cathode Lattice oxygen evolution Tuning redox activity Interface modification