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MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

World Journal of Gastroenterology 2013年第20期19卷 3043-3051页

作者： Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur LC da Silva Isabel ca.Sca.etsky José Pedrazzoli Jr Marcelo L Ribeiro Unidade Integrada de Farmacologia e Gastroenterologia Universidade So FranciscoBragan a Paulista 12916-900SPBrazil Programa de Pós Gradua o em Genética.e Biologia Molecular State University of CampinasCampinas 13083-970SPBrazil Departamento de Clínica.Médica UNESPBotucatu 18618-970SPBrazil Departamento de Genética Universidade Federal do ParáBelém 68400-000PABrazil Departamento de Microbiologia Imunologia e ParasitologiaUniversidade Federal de So PauloSo Paulo 04021-001SPBrazil

AIM:To evaluate the association between Helicobacter pylori(***) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or ***-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric ca.cer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver *** analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistica. significa.ce for expression analysis was assessed using an unpaired Student's ***:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of *** infection *** MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with *** infection(P ca.cer patients,and the difference in the percentage of methylated samples between these patients and those from ***-infected chronic gastritis patients was statistica.ly significa.t(P ca.cer patients in comparison to samples from ***-infected adult chronic gastritis patients(P ca.cer sam

关键词： Helicobacter pylori Microsatellite instability Promoter methylation MLH1 MGMT Gastric ca.cer

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土耳其东部的潘卡利镍-铜硫化物矿化

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地质地球化学 1989年第2期17卷 9-15页

作者： M.N.ca.atay 李林林

潘卡利Ni-Cu矿化产于比特利斯地块由黑云母片麻岩、石英长石片麻岩、角闪岩和变花岗岩组成的变质地层中。这些岩石可能形成于前寒武纪并受到区域性角闪岩相变质作用和晚期碎裂作用的影响。也有遭受早期榴辉岩相变质作用的迹象。Ni-Cu矿... 详细信息

潘卡利Ni-Cu矿化产于比特利斯地块由黑云母片麻岩、石英长石片麻岩、角闪岩和变花岗岩组成的变质地层中。这些岩石可能形成于前寒武纪并受到区域性角闪岩相变质作用和晚期碎裂作用的影响。也有遭受早期榴辉岩相变质作用的迹象。Ni-Cu矿化呈块状硫化物透镜状矿体产出,这些矿体平行于不同层位的穿插叶理,呈线状排列分布。这些矿体长达3m,宽为2m。紧邻矿体的围岩一般为石英-长石片麻岩或较少为石英-长石片麻岩和角闪岩。矿石中含有由磁黄铁矿、镍黄铁矿和黄铜矿组成的共生矿物组合及As、Co的含量低表明,矿化为正岩浆成因。潘卡利矿床中尖晶石矿物的结构和化学性质以及矿石的Cu/(Cu+Ni)比值=0.29表明,该矿床与基性岩浆有成因联系。区内唯一的镁铁岩是角闪岩,以具拉斑玄武岩的化学成分为特征。但是,在任一角闪岩岩体中却无浸染状和网脉状矿石存在。提出了一个根据岩浆房中硫化物熔体与玄武岩岩浆相互分离而建立的模式。该熔体和玄武岩岩浆后来分别侵入到围岩中是造成角闪岩中缺乏浸染状和网脉状矿石的原因,并可用以解释矿体与角闪岩的地质背景相似性及所观测的二者的野外地质关系。这些矿石的构造和结构特点表明,它们遭受了区域性变质作用和对围岩也有影响的碎裂变形作用。笔者认为。

关键词：镍-铜矿化硫化物矿床成因

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Comparative Analysis of Four Stem Taper Models for Quercus glauca.in Mount Halla,Jeju Island,South Korea

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Journal of Mountain Science 2014年第2期11卷 442-448页

作者： LUMBRES Roscinto Ian ca.icosa LEE Young Jin CHOI Hyung Soon KIM Sung Yong JANG Mi Na ABINO Azyleah ca.izares SEO Yeon Ok KIM Chan Soo PARK Jung Hwan Department of Forest Resources Kongju National University College of Forestry- Benguet State University La Trinidad Benguet 2601 Philippines Warm Temperate and Subtropica. Forest Research Center Korea Forest Research Institute

This study was conducted to fit the diameter-height data of Quercusglauca.n Jeju Island, South Korea to the four commonly used stem taper equations andto evaluate the performance of the four stem taper models using four statistica. criteria： Fit index （FI）, root mean square error （RMSE）, bias （）,and absolute mean difference （AMD）. Results showed that the Kozak02stem taper equation provided the best FI（0.9847）, RMSE（1.5745）,（-0.0030 cm） and AMD （1.0990 cm） whileMax and Burkhart model had the poorest performance among the four stem taper models based on the four evaluation statistics （FI ： 0.9793,RMSE ： 1.8272, ： 0.3040 cm and AMD ： 1.3060 cm）. These stem taper equations ca. serve as a useful tool for forest managers in estimating the diameter outside bark at any given height, merchantable stem volumes and total stem volumesof the standing trees of Quercusglauca.n theGotjawal forests loca.ed in Mount Halla, Jeju Island, South Korea.

关键词： MountHalla Merchantable stem volume Diameter outside bark Kozak model Model evaluation

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Radiation protection for the interventional ca.diologist:Practica. approach and innovations

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World Journal of ca.diology 2022年第1期14卷 1-12页

作者： Alejandro Gutierrez-Barrios Dolores ca.adas-Pruaño Inmaculada Noval-Morillas Livia Gheorghe Rica.do Zayas-Rueda German ca.le-Perez Department of ca.diology Hospital Puerta del MarCadiz 11009Spain

Use of ionizing radiation during ca.diac ca.heterization interventions adversely impacts both the patients and medica. *** recent years,radiation dose in ca.diac ca.heterization interventions has become a topic of increasing interest in interventional ca.diology and there is a strong interest in reducing radiation exposure during the *** review presents the current status of radiation protection in the ca.diac ca.heterization laboratory and summarizes a practica. approach for radiation dose management for minimizing radiation *** review also presents recent innovations that have clinica. potential for reducing radiation during ca.diac interventions.

关键词： Radiation ca.diac ca.heterization Quality improvement ca.hlab Ionizing radiation

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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenoca.cinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha ca.ão Coimbra Marina Alessandra Pereira Leonardo ca.dili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric ca.cer(GC).However,PD-L1 ca. express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathologica. *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)ca.es with pN+were included(sample loss of 4 ca.es).Of the PD-L1+PT,54.2%(13/24 ca.es)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistica. difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric ca.cer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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论阿尼玛卿山神的来源及流变

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青海民族研究 2011年第4期22卷 71-76页

作者：才贝青海民族大学青海西宁810007

阿尼玛卿作为藏区颇负盛名的山神,其来源及流变是一个可供人类学解读的神话"记忆文本",从其名称与认同、起源神话、藏史记载及宗教文本等多方面可以解读阿尼玛卿富有层次的三个来源:本土、卫藏及印度来源,并可从中阐释其对传统的再造;... 详细信息

阿尼玛卿作为藏区颇负盛名的山神,其来源及流变是一个可供人类学解读的神话"记忆文本",从其名称与认同、起源神话、藏史记载及宗教文本等多方面可以解读阿尼玛卿富有层次的三个来源:本土、卫藏及印度来源,并可从中阐释其对传统的再造;通过大量的民族志材料,在有关"祖先"和"英雄"的记忆中可以考察阿尼玛卿流变的趋势:祖先→英雄→菩萨,在藏传佛教强大的文化情境中,阿尼玛卿作为十地菩萨已成为安多藏区最普遍的认同,正因为阿尼玛卿完成了从居士到十地菩萨的演变,其身份便超越世俗界限,成为广大信徒朝圣、皈依的佛教圣地,这一过程也体现了藏民族对于精神气质的选择。

关键词：阿尼玛卿山神来源流变

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地震复发模型中时间与震级的依赖性

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世界地震译丛 1989年第4期20卷 14-23页

作者： Corn.,ca.雷建成

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Stability of Time-Dependent Diffusion Semigroups and Kernels

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Acta Mathematica.Sinica.English Series 1999年第4期15卷 575-586页

作者： Weian ZhengDepartment of Mathematics,University of ca.ifornia,Irvine,ca.2612,U S ADepartment of Statistics,East China Normal University,Shanghai 200062,P.R.China E-mail:wzhengmath.uci.edu Department of Mathematics University of California Irvine USA Department of Statistics East China Normal University Shanghai P. R. China

The main result of this paper is that when the coefficients of the time-dependent divergence form operators are Hlder continuous in time with order not too much smaller than （1/2）,the distance of the semigroups of t... 详细信息

关键词： Time-dependent diffusion semigroups Stability Hlder continuous

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Prenatal and pubertal testosterone exposure imprint permanent modifica.ions in the prostate that predispose to the development of lesions in old Mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： Manoel F Bianca.di Ana PS Perez ca.sia RS ca.res Luiz R Falleiros Jr Rejane M Goes Patricia SL Vilamaior Diogenes R Freitas Jr Fernanda ca.Santos Sebastiao R Taboga Department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2Department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil Medica. School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphologica., biometrica., stereologica., Kariometric, immunohistochemica., and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemica.s gerbil prostate development testosterone

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APPLIca.IONS OF A HYBRID QUADRUPOLE-TOF MASS SPECTROM ETER

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质谱学报 1999年第Z1期 7-8页

作者： CHEN Ling, Tina Settineri (PE Biosystems, 850 Lincoln Centre Dr., Foster City, ca.94404 )

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