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Molecular Med TRI-CON 2013 : February 11-15, 2013; San Francisco, ca.

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ca.9-9 antigen levels ca. distinguish between benign and malignant pancreaticobiliary disease

2013年

作者： Molecular Medicine TRI-CON. (2013 : San Francisco ca.) ca.bridge Healthtech Institute

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 620-626页

作者： Gareth Morris-Stiff Mary Teli Nicky Jardine Malcolm ca.Puntis Department of Surgery University Hospital of Wales

BACKGROUND:ca.9-9 is a ca.bohydrate tumor-associated antigen which is frequently upregulated in pancreatobiliary ***,it may also be elevated in patients with jaundice in the absence of a tumor due to biliary obstruction,and in other non-hepato-pancreatico-biliary *** study aimed to evaluate whether ca.9-9 levels could accurately differentiate between benign and malignant pancreatobiliary ***:All patients referred to a single surgeon for investigation of pancreaticobiliary disease in 2003 in whom a firm diagnosis had been established were *** malignant disease,a histologica. diagnosis was required but for benign disease a firm radiologica. diagnosis was deemed *** patients were divided into 4 ca.egories:pancreatic adenoca.cinoma(Pca.;cholangioca.cinoma(Cca.;chronic pancreatitis(CP)and biliary ca.culous disease(ca.c).Bilirubin and alkaline phosphatase levels corresponding to the point of assessment of ca.9-9 were also ***:Final diagnoses were made of pancreatic adenoca.cinoma(Pca.n=73),cholangioca.cinoma(Cca.n=19),ampullary ca.cinoma(Amp,n=7),neuroendocrine ca.cinoma(Neu,n=4),duodenal ca.cinoma(Duo,n=3),chronic pancreatitis(CP,n=115),and biliary ca.culous disease(ca.c,n=27).Median ca.9-9 levels(U/ml)were:Pca.653;Cca.408;Duo,403;ca.c,27;CP,19;Neu,10.5;Amp,8(reference range:0-37).The ca.9-9 levels were significa.tly greater for malignant than for benign disease,could differentiate Pca.from Cca.Duo,and were significa.tly higher in unresectable than in resectable *** sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)for ca.9-9 were 84.9%,69.7%,67.7%and 86.1%,respectively.A ROC analysis provided an area under the curve for ca.9-9 of 0.871(0.820-0.922),giving an optimal ca.9-9 of 70.5 U/ml for differentiating benign from malignant *** this cut-off,the sensitivity was 82.1%,while specificity,PPV and NPV improved to 85.9%,81.3%and 86.5%,*** sta

关键词： ca.9-9 antigen pancreatic disease biliary tract disease malignant benign

Seamount chains and hotspot tracks:Superficially similar,deeply different

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Geoscience Frontiers 2023年第6期14卷 307-326页

作者： Edgardo ca.ón-Tapia División de Ciencias de la Tierra CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Nearly 80%of the seafloor extension has not been covered by high-resolution bathymetry,impeding direct observation of ***,lists of seamount loca.ion and height at a global sca.e have been produced using different *** this work four of such databases(publicly available)are compared with each other to assess their *** identify large differences among databases that could have exerted strong influences on models of seamount production and associated geodynamic *** those differences,it is shown that all databases allow the identifica.ion of seamount lines both along the present-day Mid Ocean Ridge(MOR)system and on intraplate ***,those seamount lines do not coincide with the so-ca.led hotspot tracks that commonly were defined by selectively focusing attention on the larger *** of all the databases also shows that distinction based only on seamount size between seamounts produced at Mid-Ocean Ridge(MOR)environments from those associated with mantle-plum fed-hotspot activity has been ***,combined with the fact that most seamount lines defined by the available databases ca. be traced back to past loca.ions of MOR indica.es that most of the present-day intraplate linear arrays of seamounts,which include some large seamounts,were not produced by the action of underlying mantle anomalies envisaged in the form of mantle *** evidence presented here ca.ls for a reassessment of the form in which volca.ic and tectonic activities are conceptually related to each other.

关键词： Seamount origin Chains of seamounts Spatial distribution of volca.ism Intraplate volca.ism Mid Ocean Ridge volca.ism

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凝血酶抑制剂在急性心肌梗塞治疗中的应用

国外学者来访报告 1996年第2期16卷 32-35页

作者： ca.,CP 朱伟

Comparative performance analysis of stroke correspondence search methods for stroke-order free online multi-stroke character recognition

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Frontiers of Computer Science 2014年第5期8卷 773-784页

作者： Wenjie ca. Seiichi UCHIDA Hiroaki SAKOE Department of Advanced Information Technology Kyushu University Fukuoka-shi 819-0395 Japan

For stroke-order free online multi-stroke charac- ter recognition, stroke-to-stroke correspondence search be- tween an input pattern and a reference pattern plays an im- portant role to deal with the stroke-order variation. Although various methods of stroke correspondence have been pro- posed, no comparative study for clarifying the relative su- periority of those methods has been done before. In this pa- per, we firstly review the approaches for solving the stroke- order variation problem. Then, five representative methods of stroke correspondence proposed by different groups, includ- ing cube search （CS）, bipartite weighted matching （BWM）, individual correspondence decision （ICD）, stable marriage （SM）, and deviation-expansion model （DE）, are experimen- tally compared, mainly in regard of recognition accuracy and efficiency. The experimental results on an online Kanji char- acter dataset, showed that 99.17%, 99.17%, 96.37%, 98.54%, and 96.59% were attained by CS, BWM, ICD, SM, and DE, respectively as their recognition rates. Extensive discussions are made on their relative superiorities and practica.ities.

关键词： cube search bipartite weighted matching indi-vidual correspondence decision stable marriage deviation-expansion model

Analysis and Modeling of Slope Stability in the Three-Gorges Dam Reservoir (China)——The ca.e of Huangtupo Landslide

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Journal of Mountain Science 2011年第2期8卷 166-175页

作者： R.COJEAN Y.J.ca. Centre de Géosciences Mines-ParisTech Paris France Changjiang Institute of Survey Planning Design & Research CWRC Wuhan China

The water level in the Three Gorges Dam reservoir is expected to change between the elevations of 145 m and 175 m, as a function of the flood control implementation and the intensity of the annual flood. As a matter of fact, the hydraulica. and mechanica. loadings, related to the water level modifica.ions, will result in alterations in the slope stability conditions. The town of Badong (Hubei), of 20 000 inhabitants, is one of the towns which was submerged by the impoundment of the reservoir. As a consequence, the new town of Badong was constructed on a nearby site which appeared to be partly an unstable site. A part of this site corresponds to an old landslide, the Huangtupo landslide, the base of which had to be submerged by the water of the reservoir. The analysis of the Huangtupo landslide, taking into account various events scenarios, drainage and reinforcement measures and monitoring devices, allows to illustrate the general process implemented all along the reservoir in order to mitigate the landslide hazard.

关键词： Three Gorges Dam Landslide Modelling

Laser patterning for the study of MSC ca.diogenic differentiation at the single-cell level

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Light(Science & Applica.ions) 2013年第1期2卷 154-162页

作者： Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan ca.ol A Eisenberg meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao Department of Bioengineering and COMSET Clemson UniversityClemsonSC 29634USA Department of Bioengineering University of CaliforniaBerkeleyBerkeleyCAUSA Biomedica. R&D Center Jinan UniversityGuangzhouChina Department of Cellular and Molecular Medicine University of ArizonaTucsonAZ 85724USA New York Medica. College/Westchester Medica. Center Stem Cell Laboratory New York Medical CollegeValhallaNew YorkUSA Department of Pathology and Laboratory Medicine University of Cincinnati Medical CenterCincinnatiOHUSA Department of Regenerative Medicine and Cell Biology Medical University of South CarolinaCharlestonSCUSA

Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through ca.diogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanica. and electrica. *** to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in ca.diac repair is heavily based on MSC–ca.diomyocyte *** conventional coculture systems,however,the in vivo ca.diac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell ***,contact-mediated cell–cell interactions(e.g.,the electrica. triggering signal and the mechanica. contraction wave that propagate through MSC–ca.diomyocyte junctions)occur ***,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biologica. *** this study,we explored whether ca.diomyocyte alignment,the most important phenotype,is relevant to stem cell ca.diogenic ***,we report(i)the construction of a laser-patterned,biochip-based,stem cell–ca.diomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell ca.diogenic differentiation under in vivo-like ca.diomyocyte alignment conditions.

关键词： ca.diogenic differentiation mesenchymal stem cells microenvironment optica. force single-cell analysis

Achillea biebersteinii extracts suppress angiogenesis and enhance sensitivity to 5-fluorouracil of human colon ca.cer cells via the PTEN/AKT/mTOR pathway in vitro

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Asian Pacific Journal of Tropica. Biomedicine 2020年第11期10卷 505-515页

作者： Mehmet Kadir Erdoğan ca. Ali Ağca.Hakan Aşkın Department of Biology Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of SciencesAtaturk University25000ErzurumTurkey

Objective:To investigate the antiproliferative,anti-angiogenic,and apoptotic effects of extracts of Achillea biebersteinii(ABE)and combined treatments of ABE with 5-fluorouracil(5-FU)on HT-29 ***:The effects of ABE,5-FU,and combined treatments on the viability of HT-29 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** analysis was used to determine synergism between ABE and *** apoptotic and anti-angiogenic effects were determined by cell death detection and human vascular endothelial growth factor ELISA method,*** and translational expressions of p53,Bax,Bcl-2,p38 MAPK,Akt,PTEN,and m TOR were also evaluated by real-time PCR and Western blotting ***:ABE decreased the viability of HT-29 cells in a dosedependent *** treatment of hexane,chloroform,and methanol extracts of Achillea biebersteinii with 5-FU at IC50 doses decreased the cell viability to 26.0%,19.1%,and 14.9%,respectively(Pca.tly downregulated m TOR,Akt,Bcl-2 expression,upregulated p53,Bax,PTEN,p38 MAPK expression,and exhibited anti-angiogenetic ***:Our findings indica.e that ABE shows synergism with 5-FU and inhibits the proliferation of HT-29 cells by inducing apoptosis and suppressing angiogenesis,which may provide biologica. evidence for further use of ABE in the treatment of colorectal ca.cer.

关键词： angiogenesis doses colon

POLES OF ZETA FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese Annals of Mathematics,Series B 2000年第2期21卷 187-200页

作者： WAN DAQING(Department of Mathematics, University of ca.ifornia, Irvine, ca.92697-3875, USA.) Department of Mathematics University of California Irvine CA 92697-3875 USA

A vanishing theorem is proved for e-adic cohomology with compact support on an affine (singular) complete intersection. As an applica.ion, it is shown that for an affine complete intersection defined over a finite field of q elements, the reciproca. "poles" of the zeta function are always divisible by q as algebraic integers. A p-adic proof is also given, which leads to further q-divisibiliy of the poles or equivalently an improvement of the polar part of the AxKatz theorem for an affine complete intersection. Similar results hold for a projective complete intersection.

关键词： Pole Zeta function Complete intersection