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Fundamental Research 2023年第4期3卷 602-610页

作者： Qiang Chen meifang liu Xiangdong liu Bo Li Yongping Chen Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Uniform poly-α-methylstyrene(PAMS)hollow core microcapsules(HCMs)are widely used as templates to fabricate glow discharge polymer(GDP)fuel capsules,which are fundamental devices for inertial confinement fusion(ICF)*** sphericity and surface finish uniformity of PAMS HCMs are critical for achieving highquality GDP fuel *** this work,millimeter-scale PAMS HCMs were fabricated by a microencapsulation *** sphericity and surface finish uniformity were concurrently improved using di-t-butyl peroxide(DTBP).The mechanisms of these effects were also experimentally and theoretically *** results show that DTBP distributes at the O-W2 interface of W1/O/W2 compound droplets,which resists the diffusion of molecules through the O-W2 interface *** resisted diffusion of H_(2)O molecules into the O phase eliminates PAMS HCM surface ***,the resistance of fluorobenzene(FB)molecules from diffusing from the O phase into the W2 phase can effectively extend the solidification of W1/O/W2 compound droplets and thus improve the spherical uniformity of the *** these improved PAMS HCMs,GDP fuel capsules meeting the stringent requirements for ICF engineering are prepared,and the quality of which is beyond the National Ignition Facility standard.

关键词： Inertial confinement fusion engineering Mass transfer regulation PAMS HCMs Spherical uniformity Surface finish

Research progress of MOF-based materials in the photocatalytic CO_(2)reduction

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Carbon Resources Conversion 2024年第1期7卷 103-121页

作者： Qian Su Qingjie Guo Haiquan Wang meifang liu Cheng Zuo College of Chemistry&Chemical and Environmental Engineering Weifang UniversityWeifangPeople’s Republic of China State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuanPeople’s Republic of China

Photocatalytic technology could utilize solar energy to reduce CO_(2)into high-value-added fossil fuels,providing promising solutions for global energy and environmental ***-organic frameworks(MOFs)are a class of crystalline porous solids with high porosity and flexible ***-based photocatalysts have excellent CO_(2)capture ability,photochemical and structural characteristics and have shown infinite development potential in CO_(2)***,in practical large-scale applications,MOF-based photocatalysts still have some urgent problems to be solved,such as high composite rate of photogenerated carriers,limited response range to visible spectrum,poor photocatalytic activity and weak reduction *** paper introduces series of MOF-based photocatalysts,including pure MOF materials,compounds,and derivatives,were reviewed based on recent *** was placed on the modification strategy of photocatalysts,the photocatalytic reaction’s key physical and chemical parameters,and the mechanism of synergistic improvement of chemical fuel *** and most importantly,the future development trends and prospects of MOF-based catalysts for photocatalytic CO_(2)reduction were discussed.

关键词： Photocatalysis Metal-organic frameworks Rational design CO_(2)reduction

Fabrication of solid CH-CD multilayer microspheres for inertial confinement fusion

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Matter and Radiation at Extremes 2021年第2期6卷 28-36页

作者： meifang liu Xing Ai Yiyang liu Qiang Chen Shuai Zhang Zhibing He Yawen Huang Qiang Yin Research Center of Laser Fusion China Academy of Engineering PhysicsMianyangChina State Key Laboratory of Envronment-Friendly Energy Materials Southwest University of Science and TechnologyMianyangChina

Deuterated polymer microspheres can be used as a neutron source in conjunction with lasers because thermonuclear fusion neutrons can be produced efficiently by collisions of the resulting energetic deuterium ions.A new type of solid deuterated polymer microsphere with a carbon hydrogen–carbon deuterium(CH-CD)multilayer has been designed for preparing the target for inertial confinement fusion(ICF)*** fabricate these solid CH-CD multilayer microspheres,CH beads are first fabricated by a microfluidic technique,and the CD coating layer is prepared by a plasma polymerization *** polystyrene(PS)and poly(α-methylstyrene)(PAMS)are used as the material sources for the CH *** effects of the PS and PAMS materials on the quality of the solid CH beads and the resulting CH-CD multilayer polymer microspheres are *** solid PS beads have better sphericity and a smoother surface,but large vacuoles are observed in solid PS-CD multilayer microspheres owing to the presence of residual fluorobenzene in the beads and a glass transition temperature of the solid PS beads that is lower than the temperature of plasma ***,solidPAMSbeads are more suitable as a mandrel for fabricating solid CH-CD multilayer polymer *** CH-CD multilayer microspheres with specified size have been successfully prepared by controlling the droplet size and the CD deposition rate and deposition *** with the design value,the diameter deviation of the inner CH beads and the thickness deviation of the CD layer can be controlled within 20μmand 2μm,***,an approach has been developed to fabricate solid CH-CD multilayer microspheres that meet the physical design requirements for ICF.

关键词： method. multilayer beads

Recent progress in ICF target fabrication at RCLF

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Matter and Radiation at Extremes 2018年第3期3卷 135-144页

作者： Kai Du meifang liu Tao Wang Xiaoshan He Zongwei Wang Juan Zhang Research Center of Laser Fusion CAEPP.O.Box 919-987MianyangSichuan 621900China

Target is one of the essential parts in inertial confinement fusion(ICF)*** ensure the symmetry and hydrodynamic stability in the implosion,there are stringent specifications for the *** by the need to fabricate the target required by ICF experiments,a series of target fabrication techniques,including capsule fabrication techniques and the techniques of target characterization and assembly,are developed by the Research Center of Laser Fusion(RCLF),China Academy of Engineering Physics(CAEP).The capsule fabrication techniques for preparing polymer shells,glow discharge polymer(GDP)shells and hollow glass micro-sphere(HGM)are studied,and the techniques of target characterization and assembly are also investigated in this *** research about the target fabrication is also done to improve the quality of the *** on the development of target fabrication techniques,some kinds of target have been prepared and applied in the ICF experiments.

关键词： Capsule fabrication Target characterization and assembly Microencapsulation technique Depolymerizable mandrel technique White-light interferometry

The role of innate lymphoid cells in liver diseases

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The role of innate lymphoid cells in liver diseases

Effect of molecular weight on the quality of poly(alpha-methylstyrene) mandrel

第十届全国免疫学学术大会

作者： meifang liu Cai Zhang Institute of Immunopharmacology & Immunotherapy School of Pharmaceutical Sciences Shandong University

Innate lymphoid cells(ILCs)are a recently identified group of innate immune cells lacking antigen-specific receptors that can mediate immune responses and regulate tissue homeostasis and *** ILCs usually localize at mucosal surfaces and combat pathogens by rapidly releasing some kinds of *** the other hand,the uncontrolled activation of ILCs can lead to some damaging inflammation especially in gut,lung and ***,the physiological and pathogenic roles of ILCs in liver diseases are becoming more and more attention,especially the roles of the liver-resident *** liver resident ILCs are also termed as"liver-resident NK cells"based on their certain phenotypic ***1s produce type 1 cytokines with T-bet as signature *** are widely present in mucosal tissues and contribute to the pathology of ***,it has been reported that ILC1s contribute to the pathogenesis of chronic hepatitis ***2s produce type 2 cytokines,with GATA-3 as its signature ***-33 could induce ILC2s and modulates liver injury in viral ***-33-dependent ILC2s is also reported to mediate hepatic ***3s produces type 3 cytokines,with RORgt as its signature ***-22-producing ILC3s play a novel protective role in murine acute *** findings suggest the ILCs and their related molecules can be recognized as targets of diagnostic and therapeutic strategies for liver diseases.

关键词： Innate lymphoid cells liver diseases

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Matter and Radiation at Extremes 2017年第4期2卷 197-203页

作者： Xiuyun Shangguan Sufen Chen Shuang Ma meifang liu Changhuan Tang Yong Yi Zhanwen Zhang School of Material Science and Engineering Southwest University of Science and TechnologyMianyang621010China Research Center of Laser Fusion CAEPP.O.Box 919-987Mianyang621900China

Hollow poly(alpha-methylstyrene)(PAMS)shows application in inertial confinement fusion experiments as the degradable mandrels of glow plasma polymer ***,the molecular weight of PAMS has great influence on the quality of *** this work,this influence was systematically studied using several PAMS samples with different molecular *** PAMS shells with 900 mm inner diameter and different wall thickness,when the molecular weight of PAMS is in the range of 300e500 kg·mol^(-1),perfect sphericity and good wall thickness uniformity can be *** contrast,when increasing molecular weight to 800 kg·mol^(-1),the sphericity and the wall thickness uniformity become ***,compared with the wall uniformity,the sphericity of PAMS shells was much less sensitive to the molecular *** results also showed that the stability of W1/O compound droplets of PAMS shells were less affected by the molecular *** was revealed that the wall uniformity and the sphericity of the PAMS shells were associated with the diffusion rates of fluorobenzene(FB).

关键词： Poly(alpha-methylstyrene) Molecular weight Sphericity Wall thickness uniformity Diffusion rate

Investigation of spherical and concentric mechanism of compound droplets

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Matter and Radiation at Extremes 2016年第4期1卷 213-223页

作者： meifang liu Lin Su Jie Li Sufen Chen Yiyang liu Jing Li Bo Li Yongping Chen Zhanwen Zhang Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang621900China School of Energy and Power Engineering Yangzhou UniversityYangzhouJiangsu225127China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjingJiangsu210096China

Polymer shells with high sphericity and uniform wall thickness are always needed in the inertial confined fusion(ICF)*** by the need to control the shape of water-in-oil(W1/O)compound droplets,the effects of the density matching level,the interfacial tension and the rotation speed of the continuing fluid field on the sphericity and wall thickness uniformity of the resulting polymer shells were investigated and the spherical and concentric mechanisms were also *** centering of W1/O compound droplets,the location and movement of W1/O compound droplets in the external phase(W2)were significantly affected by the density matching level of the key stage and the rotation speed of the continuing fluid ***,by optimizing the density matching level and rotation speed,the batch yield of polystyrene(PS)shells with high sphericity and uniform wall thickness ***,the sphericity also increased by raising the oil/water(O/W2)interfacial tension,which drove a droplet to be *** experimental results show that the spherical driving force is from the interfacial tension affected by the two relative phases,while the concentric driving force,as a resultant force,is not only affected by the three phases,but also by the continuing fluid *** understanding of spherical and concentric mechanism can provide some guidance for preparing polymer shells with high sphericity and uniform wall thickness.

关键词： Compound droplet stability Compound droplet deformation Sphericity Wall thickness uniformity Interfacial tension Density matching

γδT cells suppress murine liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells

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γδT cells suppress murine liver fibrosis via strong cytoly...

Progress and challenges in the fabrication of DPS shells for ICF

第十三届全国免疫学学术大会

作者： meifang liu Yi Yuan Yuan Hu Zhigang Tian Cai Zhang Institute of Immunopharmacology and Immunotherapy School of Pharmaceutical SciencesShandong University Institute of Immunology School of Life SciencesUniversity of Science and Technology of China

Liver fibrosis is the excessive accumulation of extracellular matrix proteins, resulting from maladaptive wound healing responses to chronic liver injury. γδT cells are important in chronic liver injury pathogenesis and subsequent liver fibrosis;however, their role and underlying mechanisms are not fully understood. In the present study, we examined whether γδT cells contribute to liver fibrosis regression by inhibiting the activated hepatic stellate cells(HSCs). Using a carbon tetrachloride(CCl4)-induced murine model of liver fibrosis in wild-type(WT) and γδT cell deficient(TCRδ-/-) mice, we demonstrated that γδT cells protected against liver fibrosis. γδT cells significantly accumulated and co-localized with activated HSCs in the periportal region and fibrotic septa of liver during liver fibrosis. γδT cells from fibrotic livers exhibited strong cytotoxicity against activated HSCs. Chronic liver inflammation promoted hepatic γδT cells to express natural killer cell p46-related protein(NKp46), which contribute to the direct killing of activated HSCs by γδT cells. Moreover, we identified that an interferon(IFN)γ-producing γδT cell subset(γδT1) cells exhibited stronger cytotoxicity against activated HSCs than the interleukin(IL)-17-producing subset(γδT17) cells upon chronic liver injury. By contrast, γδT cells promoted the anti-fibrotic ability of conventional natural killer(cNK) cells and liver-resident NK(lrNK) cells by enhancing their cytotoxicity against activated HSCs. The cell crosstalk between γδT and NK cells depended partly on co-stimulatory receptor 4-1 BB(CD137) engagement. Conclusion: Our data confirmed the protective effects of γδT cells, especially the γδT1 subset, by directly killing activated HSCs and increasing NK cell-mediated cytotoxicity against activated HSCs in CCl4-induced liver fibrosis.

关键词： chronic liver injury extracellular matrix NKp46 IFN-γ CD137

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Matter and Radiation at Extremes 2019年第1期4卷 24-31页

作者： meifang liu Yawen Huang Sufen Chen Dawei Pan Miao Chen Qiaomei Chu Yiyang liu Qiang Yin Zhanwen Zhang Research Center of Laser Fusion China Academy of Engineering PhysicsMianyangChina School of Material Science and Engineering Southwest University of Science and TechnologyMianyangChina

To improve the quality of deuterated polystyrene(DPS)shells,the synthesis and purification of DPS as well as the fabrication of DPS shells are *** molecular weight and molecular weight distribution,measured by GPC-MALLS,are about 350 kg mol^(-1) and less than 2.0,*** results of TG and GC-MS indicate that the residual solvent is almost completely *** shells with;300 mm–2500 mmdiameter and;10 mm–100mmwall thickness are successfully prepared by a microfluidic *** monodispersity of the diameter ismuchbetter than that of the wall thickness in a batch *** vacuoles can be suppressed by both reducing hydrophilic residues in DPS and adding some salts into the outer water phase(W2).The defects appearing during the drying process decrease by heat treatment,ethanol exchange,and lowered drying *** results presented in this work not only provide guidelines for the preparation of DPS shells of better quality,but also indicate challenges for the future.

关键词： shells DPS removed

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生物学类实验仪器设备资源共享研究

实验技术与管理 2018年第1期35卷 281-282,289页

作者：刘梅芳中南民族大学实验教学与实验室管理中心湖北武汉430074

探索将仪器设备分散管理的模式转变为集中管理新模式的方法,寻求推进实验模块化教学、优化配置教学与科研实验室、构建仪器设备共享平台等措施,以此促进实验仪器设备合理有效利用,为高校实验室建设与管理提供借鉴。

关键词：生物学实验仪器设备资源共享