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Effect and Safety of herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang wang mei LI Qing-bo LI Shan-shan wang Shi-dong Dai Fang LIU Zhen-jie ZHAO Ling WEN jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun he Liu SONG Wei SUN Lu LUO Lu-lu he Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Phe reduction of TCSS-TS score at 12 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(Phe number of adverse events did not differ significantly between groups(P>0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

First-principles theory on electronic structure and floatability of spodumene

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Rare Metals 2014年第6期33卷 742-748页

作者： gui-chun he Hua-mei xiang Wei jiang Qian Kang jian-Hua Chen Faculty of Resource and Environmental Engineering Jiangxi University of Science and Technology College of Resources and Metallurgy Guangxi University

The band structure, density of states, Mulliken populations, and frontier orbital of spodumene crystal were calculated using the first-principles method based on the density functional theory（DFT） and further analyzed in detail. The calculation results reveal that the O in spodumene is the most active and easily links with H＋in the water, but the active Li is very low, so it is better to add activator to increase the concentrate grade and recovery rate of spodumene in the flotation process. Si–O bonds in spodumene crystal are mainly covalent, since the covalency of Al–O bonds is stronger than that of Li–O bonds,and minerals dissociate along the weakest Li–O bonds. In addition, the study of the frontier orbital indicates that both O and Si atoms have large contribution to the frontier orbital in the spodumene crystal. Oleate and dodecylamine are used as the collectors of spodumene. The results contribute to the understanding of crystal structures of spodumene, and can be used in guiding related practical applications.

关键词： Spodumene Electronic structure Floatability First-principles method Frontier orbital

Tea consumption and risk of stroke:a dose-response meta-analysis of prospective studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 652-662页

作者： Li SheN Liu-guang SONG Hong MA chun-na JIN jian-an wang mei-xiang xiang Department of Cardiology the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Cardiovascular Key Lab of Zhejiang Province the Second A3filiated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

Objective:To determine the association between tea consumption and the risk of stroke. Methods:We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates. Results:Fourteen studies, consisting of 513 804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81-0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69-0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82-1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57-1.16). Conclusions:Tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes.

关键词： Tea Stroke Prospective studies Dose-response meta-analysis

雌性斑马鱼暴露于环境剂量三唑磷对亲代生殖和氧化应激及子代胚胎发育的影响

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水生生物学报 2024年第2期48卷 185-192页

作者：汪和祥李瑞娇张建禄张春云王立新陈绪梁昊熊冬梅西北农林科技大学动物科技学院水产科学系杨凌712100 陕西省水产研究与技术推广总站西安710086 陕西省秦岭生态安全重点实验室陕西省动物研究所西安710032

三唑磷作为一种广泛使用的有机磷杀虫剂,该药物在自然水体中的残留可对非靶标生物产生潜在威胁,文章旨在探究三唑磷对斑马鱼的毒性效应。研究将3月龄雌性斑马鱼(Danio rerio)持续暴露于环境相关浓度的三唑磷(10μg/L)21d,然后与健康雄... 详细信息

三唑磷作为一种广泛使用的有机磷杀虫剂,该药物在自然水体中的残留可对非靶标生物产生潜在威胁,文章旨在探究三唑磷对斑马鱼的毒性效应。研究将3月龄雌性斑马鱼(Danio rerio)持续暴露于环境相关浓度的三唑磷(10μg/L)21d,然后与健康雄鱼自然受精产卵;通过测定雌鱼生殖力、亲代与子代的氧化应激及子代胚胎发育相关指标,评估三唑磷对亲代雌鱼及其子代的毒性效应。主要研究结果:亲代雌鱼经10μg/L三唑磷暴露后,产卵量显著提高(Phe)活性显著降低(Phe与SOD活性呈下降趋势但差异不显著,MDA含量显著增加(P<0.05),GPx与GST活性显著降低(P<0.05),CarE活性显著提高(P<0.05)。以上研究结果表明环境浓度三唑磷21d暴露可提高雌性斑马鱼的生殖力,诱导亲代及子代氧化应激反应,并对子代胚胎发育过程产生不良影响。

关键词：三唑磷胚胎发育氧化应激解毒酶斑马鱼

维普期刊数据库博看期刊

Association between SNP rs1800875,serum chymase and immunoglobulin E levels in patients with coronary heart disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 660-667页

作者： chun-na JIN Hong MA Yan LIN jian-an wang mei-xiang XIAN Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective:The gene for mast cell chymase (CMA1) is an ideal candidate for investigating the genetic predisposition to coronary heart disease (CHD),as activated mast cells have been found to be present in a greater proportion in the shoulder region of atheroma than in normal coronary *** studies have indicated that CMA1 promoter polymorphism rs1800875 may be involved in regulating immunoglobulin E (IgE) levels in patients with eczema,and it is associated with the progression of immunoglobulin A ***:The association between single nucleotide polymorphism (SNP) rs1800875,serum chymase,and serum IgE levels was examined in 175 CHD subjects and 95 non-CHD ***:Statistical analysis indicated no significant difference in allele frequency between CHD and ***,a significant association was found between CMA1 genotypes and total IgE levels in CHD ***,crossover analysis revealed that,in GG homozygotes,CHD risk was nearly six times higher in those with IgE (U/ml) level natural logarithm conversion),while no association was found with chymase ***:Polymorphism rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects,but not with chymase level in both *** GG homozygotes,high IgE level is a protective factor against coronary disease.

关键词： Coronary heart disease CMA 1 Serum immunoglobulin E (IgE) Serum chymase

NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu Chen-gui Lu Fa-Tai Mai Yuan mei Hao Qiu xiang-Ming Sun Xiao-Xing Tang Hu-Lin wang Qian-Ming wang Le Xiao Mu-Yun Xiao jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley national Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

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5种虎红平板凝集检测试剂盒应用效果评价

动物医学进展 2024年第6期45卷 136-139页

作者：刘平张毅刘俐君董春霞卢美侯建石代钰徐全刚孙向东王幼明中国动物卫生与流行病学中心山东青岛266032 遵义医科大学公共卫生学院贵州遵义563000 四川达州市动物疫病预防控制中心四川达州635000 重庆市动物疫病预防控制中心重庆401123

为评价常见市售虎红平板凝集试验(RBT)试剂盒的试验特性,选取基层动物疫病预防控制机构常用的5种试剂盒,以布鲁氏菌竞争酶联免疫吸附试验(cELISA)结果为相对金标准,分别对60份阳性、50份阴性布鲁氏菌病羊血清进行检测。结果显示,5种RBT... 详细信息

为评价常见市售虎红平板凝集试验(RBT)试剂盒的试验特性,选取基层动物疫病预防控制机构常用的5种试剂盒,以布鲁氏菌竞争酶联免疫吸附试验(cELISA)结果为相对金标准,分别对60份阳性、50份阴性布鲁氏菌病羊血清进行检测。结果显示,5种RBT试剂检测结果敏感性为70%~91.67%,特异性为94%~100%,符合率为81.82%~92.73%,与布鲁氏菌cELISA检测方法的Kappa值介于0.64~0.86。其中有2种RBT试剂检测结果与cELISA检测结果无统计学差异。研究结果为基层动物疫病预防控制机构选择适合的筛检试剂建立了参考方法,为进一步提高布鲁氏菌流行情况估计和布鲁氏菌病疫病净化效果评估等工作的准确性提供了可靠的技术支持。

关键词：布鲁氏菌病虎红平板凝集评价

Purified terephthalic acid wastewater biodegradation and toxicity

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Journal of Environmental Sciences 2005年第5期17卷 876-880页

作者： ZHANG Xu-xiang WAN Yu-qiu CheNG Shu-pei SUN Shi-lei ZHU Cheng-jun LI Wei-xin ZHANG Xiao-chun wang gui-lin LU jian-hua LUO xiang GU Ji-dong The State Key Laboratory of Pollution Control and Resource Reuse School of Environment Nanjing University Nanjing 210093 China Yangtze Petrochemical Corporation Nanjing 210048 China Department of Ecology and Biodiversity The University of Hong Kong SAR China

The biodegradation and toxicity of the purified terephthalic acid（PTA） processing wastewater was researched at NJYZ pilot with the fusant strain Fhhh in the carrier activated sludge process（ CASP）. Sludge loading rate（SLR） for Fhhh to COD of the wastewater was 1.09 d^-1 and to PTA in the wastewater was 0.29 d^-1. The results of bioassay at the pilot and calculation with software Ebis3 showed that the 48h-LC50 （median lethal concentration） to Daphnia magna for the PTA concentration in the wastewater was only 1/10 of that for the chemical PTA. There were .5 kinds of benzoate pollutants and their toxicities existing in the wastewater at least. The toxicity parameter value of the pure chemical PTA cannot be used to predicate the PTA wastewater toxicity. The toxicity of the NJYZ PTA wastewater will be discussed in detail in this paper.

关键词： fusant strain purified terephthalic acid wastewater biodegradation toxicity software

Numerical simulation and environmental impact prediction of karst groundwater in Sangu Spring Basin,China

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Journal of Groundwater Science and Engineering 2020年第3期8卷 210-222页

作者： ZHANG chun-chao HOU Xin-wei LI xiang-quan wang Zhen-xing gui chun-lei ZUO Xue-feng MA jian-fei GAO Ming Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China China University of Geosciences Beijing 100083China Key Laboratory of Groundwater Science and Engineering Ministry of Natural ResourcesShijiazhuang 050061China

The changes of development and utilization of karst groundwater in Sangu Spring Basin have made the original groundwater resource evaluation unable to meet the needs of future economic *** on analysis of existing data,combined with the characteristics of supplement,runoff and draining of regional karst groundwater,the Visual Modelflow software was used to build a numerical simulation model of Sangu spring *** amount of karst groundwater resource and groundwater environment of the Basin were evaluated under different exploitation schemes,and the changes of karst groundwater environment in the future ten years were also *** fitting error which is less than 0.5 m between the calculated value and measured value of the water level in the fitted borehole accounts for 93%.For the lithologically and structurally complex Sangu Spring Basin,the fitting effect of numerical simulation model was *** the basis of the current mining amount of 111.80 million m3/a,the total redistributed exploited amount in the spring region was 61.79 million m3/*** the condition that the quantity of recoverable resources reached 173.59 million m3/a and under different precipitation schemes,all constraint conditions were satisfied,such as regional water level drawdown,maximum allowable water level drawdown in every simulated water source area and the flow rate of Guobi *** results will provide a scientific basis for the rational development and utilization of karst groundwater in Sangu Spring Basin.

关键词： Sangu Spring Basin Karst groundwater Numerical simulation Constraints