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D53 represses rice blast resistance by directly targeting phenylalanine ammonia lyases

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Journal of Integrative Plant Biology 2024年第9期66卷 1827-1830页

作者： Haitao Ye qingqing Hou Haitao lv Hui Shi Duo Wang Yujie Chen Tangshuai Xu mei Wang Min He Junjie Yin Xiang Lu Yongyan Tang Xiaobo Zhu Lijuan Zou Xuewei Chen Jiayang Li Bing Wang Jing Wang State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Yazhouwan National Laboratory Sanya 572024China

Phytohormones play important roles in orchestrating plantimmune responses to pathogen ***(SLs),a group of carotenoid-derived phytohormones,modulate diverse biological processes in plants,including shoot branching,plant height,root architecture,leaf senescence,seed germination of parasitic plants,and symbiosis of arbuscular mycorrhizal fungi(Burger and Chory,2020).Recently,increasing evidence has indicated potential roles for SLs in regulating responses against biotic stresses,including defense responses against certain pathogenic fungi and bacteria in roots and leaves(Yi et al.,2023).

关键词： ammonia resistance branching

Radical innovation breakthroughs of biodegradation of plastics by insects:history,present and future perspectives

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 127-165页

作者： Shan-Shan Yang Wei-Min Wu Federica Bertocchini Mark Eric Benbow Suja P.Devipriya Hyung Joon Cha Bo-Yu Peng Meng-qi Ding Lei He mei-Xi Li Chen-Hao Cui Shao-Nan Shi Han-Jun Sun Ji-Wei Pang Defu He Yalei Zhang Jun Yang Deyi Hou De-Feng Xing Nan-qi Ren Jie Ding Craig S.Criddle State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering William&Cloy Codiga Resource Recovery CenterStanford UniversityStanfordCA 94305USA Plasticentropy rue Thiers 28Reims 51100France Department of Entomology and Department of Osteopathic Medical Specialties Michigan State UniversityEast LansingMI 48824USA School of Environmental Studies Cochin University of Science and TechnologyKochi 682022India Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Environmental Science and Engineering Tongji UniversityShanghai 200092China China Energy Conservation and Environmental Protection Group CECEP Talroad Technology Co.Ltd.Beijing 100096China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Environment Tsinghua UniversityBeijing 100084China

Insects damaging and penetrating plastic packaged materials has been reported since the *** innovation breakthroughs of plastic biodegradation have been initiated since the discovery of biodegradation of plastics by Tenebrio molitor larvae in 2015 followed by Galleria mellonella in *** we review updated studies on the insect-mediated biodegradation of *** biodegradation by insect larvae,mainly by some species of darkling beetles(Tenebrionidae)and pyralid moths(Pyralidae)is currently a highly active and potentially transformative area of *** the past eight years,publications have increased explosively,including discoveries of the ability of different insect species to biodegrade plastics,biodegradation performance,and the contribution of host and microbiomes,impacts of polymer types and their physic-chemical properties,and responsible enzymes secreted by the host and gut *** date,almost all major plastics including polyethylene(PE),polypropylene(PP),polyvinyl chloride(PVC),polyethylene terephthalate(PET),polyurethane(PUR),and polystyrene(PS)can be biodegraded by *** and ten other insect species representing the Tenebrionidae and Pyralidae *** biodegradation processes are symbiotic reactions or performed by synergistic efforts of both host and gut-microbes to rapidly depolymerize and biodegrade plastics with hourly *** digestive ezymens and bioreagents screted by the insects play an essential role in plasatic biodegradation in certain species of Tenebrionidae and Pyralidae *** research on the insect itself,gut microbiomes,transcriptomes,proteomes and metabolomes has evaluated the mechanisms of plastic biodegradation in *** conclude this review by discussing future research perspectives on insect-mediated biodegradation of plastics.

关键词： Plastics Biodegradation Insects Gut microbiomes Enzymes

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian qin Xinyue mei Shidong Deng Yingjiao Xia Jun Zhao Junxiang Wang Tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun qi Luo Jie Su Yunhui Zhang Nanshan Zhong Zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 159-170页

作者： Xiao-mei Zhao Zhi-Xin Wu Yan Wang Ying-Jie Xu Ye Xiu Xu Dong Jun-Jie Li Gui-Ji lv Si-Hao Wang Yu-Rong Li Zhao-Fang Bai Xiao-He Xiao Department of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Military Patient Management The Fifth Medical Center of PLA General HospitalBeijingChina Department of Hepatology China Military Institute of Chinese Materia The Fifth Medical Center of PLA General HospitalBeijingChina Departmentof Hepatology National Key Laboratory of Kidney DiseasesBeijingChina

Background: Idiosyncratic drug-induced liver injury(IDILI) is a serious side effect of drugs, Epimedii Folium(EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3(NLRP3) inflammasome. Fructus Ligustri Lucidi(FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity. Aims and Objectives: Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF. Materials and Methods: Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury. Results: Our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated. Conclusions: FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.

关键词： Epimedii Folium Fructus Ligustri Lucidi idiosyncratic drug-induced liver injury NOD-like receptor family pyrin domain containing 3 inflammasome traditional Chinese medicine

The main causes and corresponding solutions of skin pigmentation in the body

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and cosmetic technology 2024年第2期1卷 38-44页

作者： Benyue Li Huaqian mei Zhishan Zhou Jie Yang Yexiang Zhang Fengwei qi Shandong Huawutang Biotechnology Co. LtdJinan 250101ShandongChina

The skin's normal color is primarily determined by the quantity and distribution of pigment,the level of hemoglobin in the skin's blood vessels,and various optical ***,mechanical damage from clothing renders certain areas of the body more susceptible to hyperpigmentation,such as the elbows and *** to research,various factors such as gender and weight have been found to influence skin *** mechanism of body skin pigmentation has been extensively studied with a particular focus on melanogenesis and related signaling ***,this article primarily focuses on elucidating the mechanisms governing body pigmentation while discussing strategies for managing skin whitening,encompassing influential factors and whitening methods.

关键词： Body whitening Melanin synthesis Skin barrier Mechanical damage Cellular autophagy

数字经济与包容性就业——基于农民工群体的微观视角

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江西财经大学学报 2024年第1期 99-111页

作者：吕达奇周力南京农业大学经济管理学院江苏南京210095

基于中国2011—2018年城市级别的数据,从包容性的视角切入,探究数字经济发展对农民工就业的影响。研究发现,数字经济发展提升了整个社会就业的包容性。就业包容性体现在三个方面,第一,相比于城市户籍劳动力,数字经济对农民工就业的促进... 详细信息

基于中国2011—2018年城市级别的数据,从包容性的视角切入,探究数字经济发展对农民工就业的影响。研究发现,数字经济发展提升了整个社会就业的包容性。就业包容性体现在三个方面,第一,相比于城市户籍劳动力,数字经济对农民工就业的促进作用更大。第二,在农民工群体中,相比于中青年劳动者,数字经济更能促进中年及中老年农民工就业。第三,相比于高技能劳动者,数字经济更能促进低技能农民工就业。机制分析表明,一方面,数字经济通过互联网、自身寻找的方式,促进社会资本不足的农民工群体就业;另一方面,数字经济通过提升地区低技能服务业岗位需求,促进低技能、中年及中老年农民工群体就业。因此,从加快数字化转型、促进数字经济发展、提供技能培训、金融优化政策提升农民工群体包容性就业。

关键词：数字经济包容性就业农民工

Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang Mu-qi Wang Jiang Deng Ning Gao mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis

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Molecular Plant 2020年第2期13卷 336-350页

作者： Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-qing Liu mei-qi lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao Yunnan Institute of Tropical Crops Jinghong 666100China Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650204China University of Chinese Academy of Sciences Beijing 100049China BGI-qingdao Qingdao 266555China lnstitution of Genomics and Bioinformatics South China Agricultural UniversityGuangzhou 510642China Asia-Pacific Tropical Forestry Germplasm Institution Southwest China Forestry UniversityKunming 650224China School of Life Sciences Nanjing UniversityNanjing 210023China Novogene Bioinformatics Institute Beijing 100083China BGI-Shenzhen Shenzhen 518083China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA

The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw ***,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the～1.47-Gb genome assembly into 18 *** chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and *** show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by～65.88%(～970 Mbp)of the whole rubber tree genome since the divergence from *** identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains～15.7 million high-quality single-nucleotide *** identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber *** genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production.

关键词： rubber tree rubber biosynthesis chromosome evolution whole-genome duplication domestication

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农产品国际贸易新格局形成中的中国因素

华南农业大学学报（社会科学版） 2024年第3期23卷 78-93页

作者：熊启泉喻美辞华南农业大学广东农村经济研究中心广东广州510642

与2000年相比,2021年农产品国际贸易的产品集中度和国别集中度双双下降,发展中经济体扮演了更重要的角色。实证研究表明:从2000年到2021年,中国是全球农产品国际贸易新格局形成的重要推动力量。中国对全球农产品国际贸易规模增量的贡献... 详细信息

与2000年相比,2021年农产品国际贸易的产品集中度和国别集中度双双下降,发展中经济体扮演了更重要的角色。实证研究表明:从2000年到2021年,中国是全球农产品国际贸易新格局形成的重要推动力量。中国对全球农产品国际贸易规模增量的贡献为9.45%,降低了可贸易农产品的产品集中度和地理集中度,重构了全球农产品国际贸易的地理方向,提高了发展中国家在农产品国际贸易中的地位。另外,中国践行“确保谷物基本自给、口粮绝对安全”的新粮食安全观,遏制了谷物进口的过快增长,从而对稳定谷物国际贸易格局、维护世界粮食安全发挥了重要作用。

关键词：农产品国际贸易粮食安全比较优势中国因素