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Evaluation of the value of combined detection of tumor markers CA724,carcinoembryonic antigen,CA242,and CA19-9 in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1737-1744页

作者： Chong-mei Zhou Shao-Hua Zhao Department of Clinical Laboratory Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUND Gastric cancer is a global health concern that poses a significant threat to human *** To detecting serum changes in carcinoembryonic antigen(CEA),carbohydrate antigens(CA)724,CA242,and CA19-9 expression among patients with gastric *** Eighty patients diagnosed with gastric cancer between January 2020 and January 2023 were included in the observation group,while 80 patients with benign gastric diseases were included in the control *** groups were tested for tumor markers(CA724,CEA,CA242,and CA19-9].Tumor marker indicators(CA724,CEA,CA242,and CA19-9)were compared between the two groups,assessing positive rates of tumor markers across various stages in the observation ***,single and combined detection of various tumor markers were *** The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value observed for the combined detection of CA724,CEA,CA242,and CA19-9 were higher than those of CA724,CEA,CA242,and CA19-9 ***,the combined detection of CA724,CEA,CA242,and CA19-9 has a high diagnostic accuracy and could reduce the occurrence of missed or misdiagnosed cases,facilitating the early diagnosis and treatment of *** CA724,CEA,CA242,and CA19-9 serum levels in gastric cancer patients significantly surpassed those in non-gastric cancer patients(P<0.05).Their combined detection can improve the diagnostic accuracy for gastric cancer,warranting clinical promotion.

关键词： Biomarkers Serum Gastric cancer Diagnostic value

Editorial:special issue on analysis and control of complex systems in honor of the 90th birthday of Professor Huashu Qin

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Control Theory and Technology 2024年第3期22卷 343-344页

作者： Yiguang Hong Shengwei mei Ping Yang Department of Control Science and Engineering Tongji UniversityShanghai200092China Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai200092China Department of Electrical Engineering and Applied Electronics Technology Tsinghua UniversityBeijing100084China School of Electric Power South China University of TechnologyGuangzhou510640GuangdongChina

It is our great pleasure to organize this special issue in Control Theory and Technology in honor of the 90th birthday of Professor Huashu *** is one of the pioneers in control theory and applications in China,and has made many truly outstanding contributions to the field including nonlinear dynamics and control,intelligent control,robotics and complex *** is no surprise that she was selected as a representative introduced significantly in“Women in Control”of IEEE Control Systems Magazine.

关键词： control honor analysis

Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3253-3258页

作者： Xue-mei Han Yi-Mai Zhou lu-Sha Cen Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina The First Clinical Medical College Zhejiang Chinese Medicine UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND In addition to the non-specific symptomatology of ocular rosacea,currently,there are no reliable diagnostic tests for the disease,which may lead to its ***,we report a case of ocular rosacea presenting with multiple recurrent chalazion on both *** SUMMARY A 63-year-old female patient presented with multiple chalazion and dry eyes in both eyes,with no facial *** management done were application of steroid eye ointment on both eyelids,hot compresses,and eyelid margin cleaning;noting that there was no relief of *** excision of the chalazion was done on both eyes,however,bilateral recurrence occurred *** pathological studies showed infiltration of a small amount of fibrous tissue with many chronic inflammatory *** studies were positive for *** of the chalazion occurred after oral administration of doxycycline and *** Our findings show that ophthalmologists should recognize the ocular manifestations of skin diseases.

关键词： Ocular rosacea Rosacea Recurrent chalazion Bilateral chalazion Multiple chalazion Case report

A new review of single-ion conducting polymer electrolytes in the light of ion transport mechanisms

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Journal of Energy Chemistry 2024年第2期89卷 543-556,I0012页

作者： Yuqi luo lu Gao Weimin Kang State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China

With the depletion of fossil fuels and the demand for high-performance energy storage devices,solidstate lithium metal batteries have received widespread attention due to their high energy density and safety *** them,the earliest developed organic solid-state polymer electrolyte has a promising future due to its advantages such as good mechanical flexibility,but its poor ion transport performance dramatically limits its performance ***,single-ion conducting polymer electrolytes(SICPEs)with high lithium-ion transport number,capable of improving the concentration polarization and inhibiting the growth of lithium dendrites,have been proposed,which provide a new direction for the further development of high-performance organic polymer *** view of this,lithium ions transport mechanisms and design principles in SICPEs are summarized and discussed in this *** modification principles currently used can be categorized into the following three types:enhancement of lithium salt anion-polymer interactions,weakening of lithium salt anion-cation interactions,and modulation of lithium ion-polymer *** addition,the advances in single-ion conductors of conventional and novel polymer electrolytes are summarized,and several typical highperformance single-ion conductors are enumerated and analyzed in what way they improve ionic conductivity,lithium ions mobility,and the ability to inhibit lithium ***,the advantages and design methodology of SICPEs are summarized again and the future directions are outlined.

关键词： Lithium metal batteries Single-ion conductor Polymer electrolytes Ion transport mechanism Li-ion transport number

Evaluation of the effects of health education interventions for hypertensive patients based on the health belief model

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World Journal of Clinical Cases 2024年第15期12卷 2578-2585页

作者： Hong-mei Wang Ying Chen Yan-Hua Shen Xiao-mei Wang Department of Emergency Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of China Medical UniversityShenyang 110002Liaoning ProvinceChina

BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing *** education interventions based on the health belief model(HBM)can improve the knowledge,attitudes,and behaviors of patients with hypertension and help them control their blood *** To evaluate the effects of health education interventions based on the HBM in patients with hypertension in *** Between 2021 and 2023,140 patients with hypertension were randomly assigned to either the intervention or control *** intervention group received health education based on the HBM,including lectures,brochures,videos,and counseling sessions,whereas the control group received routine *** were measured at baseline,three months,and six months after the intervention and included blood pressure,medication adherence,self-efficacy,and perceived benefits,barriers,susceptibility,and *** The intervention group had significantly lower systolic blood pressure[mean difference(MD):-8.2 mmHg,P<0.001]and diastolic blood pressure(MD:-5.1 mmHg,P=0.002)compared to the control group at six *** intervention group also had higher medication adherence(MD:1.8,P<0.001),self-efficacy(MD:12.4,P<0.001),perceived benefits(MD:3.2,P<0.001),lower perceived barriers(MD:-2.6,P=0.001),higher perceived susceptibility(MD:2.8,P=0.002),and higher perceived severity(MD:3.1,P<0.001)than the control group at six *** Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.

关键词： Hypertension Health education Health belief model Blood pressure control Randomized controlled trial

Initial costates derived by near-optimal reference sequence and least-squares method

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Chinese Journal of Aeronautics 2024年第5期37卷 377-391页

作者： Shaozhao lu Yao ZHANG Quan HU School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

In this paper,we present a novel initial costates solver for initializing time-optimal trajectory problems in relative motion with continuous low *** proposed solver consists of two primary components:training a Multilayer Perceptron(MLP)for generating reference sequence and Time of Flight(TOF)to the target,and deriving a system of linear algebraic equations for obtaining the initial *** overcome the challenge of generating training samples for the MLP,the backward generation method is proposed to obtain five different training *** training database and sample form are determined by analyzing the input and output correlation using the Pearson correlation *** best-performing MLP is obtained by analyzing the training results with various hyper-parameter combinations.A reference sequence starting from the initial states is obtained by integrating forward with the near-optimal control vector from the output of ***,a system of linear algebraic equations for estimating the initial costates is derived using the reference sequence and the necessary conditions for *** results demonstrate that the proposed initial costates solver improves the convergence ratio and reduce the function calls of the shooting ***,Monte-Carlo simulation illustrates that the initial costates solver is applicable to different initial velocities,demonstrating excellent generalization ability.

关键词： Relative motion Expanding training database Multilayer perceptron Initial costates Least-squares method

Cooperative game penetration guidance for multiple hypersonic vehicles under safety critical framework

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Chinese Journal of Aeronautics 2024年第1期37卷 247-255页

作者： Jieqing CHEN Ruisheng SUN Yu lu School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China

The rapid development of the anti-missile weapon technology brings new challenges to the cooperative penetration strategy solution and the guidance law design for Hypersonic Vehicles(HVs).This paper studies the coordinated game penetration guidance problem for multiple hypersonic vehicles faced with space threat areas.A scheme for seeking cooperative game penetration guidance strategy under safety critical control framework is *** this scheme,a multiHV cooperative game model is proposed in a minimum optimization form which can simplify the solving process and accelerate the computing ***,a second-order control barrier function is developed to transform the implicit nonlinear constraints of the proposed model into linear *** order to obtain better performance of guidance strategy,a composite guidance law under the safety critical control framework is presented to allocate guidance strategies appropriately in the whole *** is shown that the proposed scheme can guarantee successful penetration while avoiding threat ***,a comparative simulation with a two-on-three game is conducted to verify the effectiveness of the proposed method.

关键词： Hypersonic vehicles Safety critical control Penetration game Space constraints Cooperative guidance

Molecular Generation and Optimization of Molecular Properties Using a Transformer Model

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Big Data Mining and Analytics 2024年第1期7卷 142-155页

作者： Zhongyin Xu Xiujuan Lei mei Ma Yi Pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** Matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 12365,1503,and 1570 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.

关键词： molecular optimization transformer Matched Molecular Pairs(MMPs) logD solubility

On Minor Left Prime Factorization Problem for Multivariate Polynomial Matrices

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Journal of Systems Science & Complexity 2024年第3期37卷 1295-1307页

作者： lu Dong WANG Dingkang XIAO Fanghui School of Mathematics Southwest Jiaotong UniversityChengdu 610031China KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China MOE-LCSM School of Mathematics and StatisticsHunan Normal UniversityChangsha 410081China

A new necessary and sufficient condition for the existence of minor left prime factorizations of multivariate polynomial matrices without full row rank is *** key idea is to establish a relationship between a matrix and any of its full row rank *** on the new result,the authors propose an algorithm for factorizing matrices and have implemented it on the computer algebra system *** examples are given to illustrate the effectiveness of the algorithm,and experimental data shows that the algorithm is efficient.

关键词： Free modules Grobner bases minor left prime(MLP) multivariate polynomial matrices polynomial matrix factorizations