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A partition-type tubular scaffold loaded with PDGF-releasing microspheres for spinal cord repair facilitates the directional migration and growth of cells

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Neural Regeneration Research 2018年第7期13卷 1231-1240页

作者： xue Chen mei-ling xu Cheng-Niu Wang Lu-Zhong Zhang Ya-Hong Zhao Chang-Lai Zhu Ying Chen Jian Wu Yu-Min Yang Xiao-Dong Wang School of Biology & Basic Medical Sciences Soochow University Department of Histology and Embryology Medical CollegeNantong University Wuxi School of Medicine Jiangnan University Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University

The best tissue-engineered spinal cord grafts not only match the structural characteristics of the spinal cord but also allow the seed cells to grow and function in ***-derived growth factor（PDGF） has been shown to promote the migration of bone marrow stromal cells;however,cytokines need to be released at a steady rate to maintain a stable concentration in ***,new methods are needed to maintain an optimal concentration of cytokines over an extended period of time to effectively promote seed cell localization,proliferation and *** the present study,a partition-type tubular scaffold matching the anatomical features of the thoracic 8–10 spinal cord of the rat was fabricated using chitosan and then subsequently loaded with chitosan-encapsulated PDGF-BB microspheres（PDGF-MSs）.The PDGF-MS-containing scaffold was then examined in vitro for sustained-release capacity,biocompatibility,and its effect on neural progenitor cells differentiated in vitro from multilineage-differentiating stress-enduring cells（MUSE-NPCs）.We found that pre-freezing for 2 hours at-20°C significantly increased the yield of partition-type tubular scaffolds,and 30 μL of 25% glutaraldehyde ensured optimal crosslinking of *** resulting PDGF-MSs cumulatively released 52% of the PDGF-BB at 4 weeks in vitro without burst *** PDGF-MS-containing tubular scaffold showed suitable biocompatibility towards MUSE-NPCs and could promote the directional migration and growth of these *** findings indicate that the combination of a partition-type tubular scaffold,PDGF-MSs and MUSENPCs may be a promising model for the fabrication of tissue-engineered spinal cord grafts.

关键词： nerve regeneration partition-type tubular scaffold microspheres platelet-derived growth factor muse cells neural precursor cells chitosan encapsulation efficiency bone marrow spinal cord injury tissue engineering neural regeneration

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Comparison of Placebo Effect between Asian and Caucasian Type 2 Diabetic Patients： A Meta-Analysis

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Chinese Medical Journal 2018年第13期131卷 1605-1612页

作者： Wei Guo Lin Nie Xi-Rui Wang mei-ling xu Wen-Jia Yang xue-Ying Gao Xiao-ling Cai Li-Nong Ji Department of Emergency Peking University People's Hospital Beijing 100044 China Department of Endocrinology and Metabolism Beijing Airport Hospital Beijing 101318 China Department of Endocrinology and Metabolism Peking University People's Hospital Beijing 100044 China

Background： Placebo was defined as any therapy that is used for its nonspecific psychological and physiologic effect but has no specific pharmacologic impact on the condition being treated. Besides medication therapies, studies have found that the optimal dietary approach as well as physical activity and education are useful to control hyperglycemia in patients with type 2 diabetes （T2DM）. The aim of this study was to evaluate the placebo effects ofantidiabetic therapies in Asian and Caucasian T2DM patients and make a comparison between the two ethnicities. Methods： A search using the MEDLINE database, EMBASE, and Cochrane Database was performed, from when recording began until December 2016. The main concepts searched in English were sulfonylurea （SU）; alpha glucosidase inhibitors （AGI）; metfornlin （MET）; thiazolidinediones （TZD）; dipeptidyl peptidase-4 inhibitors （DPP-4i）; sodium-glucose cotransporter 2 inhibitors （SGLT2i）; glucagon-like peptide- 1 receptor agonist （GLP- 1RA）; type 2 diabetes （T2DM）; placebo controlled; and randomized controlled trials. Using the Cochrane instrument, we evaluated the adequacy of randomization, allocation concealment procedures, and blinding. Results： This study included 63 studies with a total of 7096 Asian patients involved and 262 studies with a total of 27,477 Caucasian patients involved. In Caucasian population, the use of placebo led to significant redtlctions of glycosylated hemoglobin （HbAlc）, -0.683% （P - 0.008） in SU monotherapy treatment, -0.193% （P = 0.001） in DPP-4i treatment, and -0.230% （P 〈 0.001） in SGLT2i treatment, respectively. In Asian population, the use of placebo resulted in significant decreases ofHbA1c, 0.162% （P= 0.012） in DPP-4i treatment and -0.269% （P =0.028） in GLP-1RA add-on therapy, respectively. The placebo also significantly reduced body weight. In Caucasian population, placebo use resulted in 0.833 kg （P = 0.006） weight loss by SU treatment and 0.953 kg （P = 0.006） weight loss by GLP-I RA treatme

关键词： Asian Caucasiam Placebo Type 2 Diabetes Mellitus

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CHEMISTRY OF 1,2,4—TRIAZINES XIX THE ANOMALOUS SUBSTITUTED BENZENE SULFONATION AND PROPERTIES OF NUCLEOPHILIC ATTACK ON 6-CARBON OF 3-METHYLTHIO-5-HYDROXY-1,2,4-TRIAZINE

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Chinese Chemical Letters 1993年第9期4卷 771-774页

作者： mei HAN xu ling SHI Zhen Jun YANG Meng Shen CAI Tie Ming CHENG School of Pharmaceutical Sciences,Beijing Medical University,Beijing 100083

3-Methylthio-5-hydroxy-1,2,4-triazine(1c)reacted with substituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1,2,4-triazin-6-yl pyridinium betaine(4)in anhydrous *** when NaOH/H_2O/CH_3COCH_3 or NaOH/CH_3OH were used as reactant and solvent,3-methylthio-4-substituted benzenesulfonyl-5-oxo-6-hydroxy-1,4,5,6-tetrahydro-1,2,4-triazine(6)or 1-tosyl-3-methylthio-5-oxo-6-methyloxy-1,4,5,6-tetrahydro-1,2,4-triazine(7)was obtained *** above reactions show anomalous properties of nucleophilic attack on 6-carbon in 1,2,4-triazine ring.

关键词： NaOH CHEMISTRY OF 1,2,4 TRIAZINES XIX THE ANOMALOUS SUBSTITUTED BENZENE SULFONATION AND PROPERTIES OF NUCLEOPHILIC ATTACK ON 6-CARBON OF 3-METHYLTHIO-5-HYDROXY-1,2,4-TRIAZINE

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A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats

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Chinese Medical Journal 2008年第24期121卷 2544-2552页

作者： LI Man MA Ya-bing GAO Hai-qing LI Bao-ying CHENG mei xu ling LI Xiao-li LI Xian-hua Department of Geriatrics Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background Diabetic retinopathy （DR） is a leading cause of visual impairment and blindness among the people of occupational age. To prevent the progress of retina injury, effective therapies directed toward the key molecular target are required. Grape seed proanthocyanidin extracts （GSPE） have been reported to be effective in treating diabetic complications, while little is discussed about the functional protein changes. Methods We used streptozotocin （STZ） to induce diabetes in rats. GSPE （250 mg/kg body weight per day） were administrated to diabetic rats for 24 weeks. Serum glucose, glycated hemoglobin and advanced glycation end products （AGEs） were determined. Consequently, 2-D difference gel electrophoresis and mass spectrometry were used to investigate retina protein profiles among control, STZ-induced diabetic rats, and GSPE treated diabetic rats. Results GSPE significantly reduced the AGEs of diabetic rats （P 〈0.05）. Moreover, GSPE significantly suppressed the vascular lesions of central regions, decreased capillary enlargements and neovascularization, similar to those of the control rats under light microscope. Eighteen proteins were found either up-regulated or down-regulated in the retina of STZ-induced diabetic rats. And seven proteins in the retina of diabetic rats were found to be back-regulated to normal levels after GSPE therapy. These back-regulated proteins are involved in many important biological processes such as heat shock, ubiquitin-proteasome system, cell proliferation, cell growth and glucose metabolism. Conclusions These findings might promote a better understanding for the mechanism of DR, and provide novel targets for evaluating the effects of GSPE therapy.

关键词： grape seed proanthocyanidin extracts diabetic retinopathy advanced glycation end products proteomics

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PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong mei-ling xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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速度不可测的异构多智能体系统一致性分析

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计算机工程与科学 2017年第9期39卷 1729-1735页

作者：朱美玲赵蕊徐勇河北工业大学理学院天津300401

近年来,随着异构系统在实际中的广泛应用,异构多智能体系统一致性分析成为研究热点。针对一阶部分智能体控制输入有界、二阶智能体速度不可测的异构多智能体系统,在无向网络拓扑图下给出了无领导者和有领导者两种控制输入设计方法,基于... 详细信息

近年来,随着异构系统在实际中的广泛应用,异构多智能体系统一致性分析成为研究热点。针对一阶部分智能体控制输入有界、二阶智能体速度不可测的异构多智能体系统,在无向网络拓扑图下给出了无领导者和有领导者两种控制输入设计方法,基于图论知识和LaSalle不变集原理给出了该异构系统实现一致性的充分条件。最后,通过数值仿真验证了该理论的正确性。

关键词：异构多智能体系统一致性饱和输入速度不可测

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Effect of starfish sterol screened by human arrhythmic related gene on experimental atrial fibrillation

Effect of starfish sterol screened by human arrhythmic relat...

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中国海洋生化学术会议

作者： xu Dong-Rui Zhu ling mei xueting xu Shi-Bo (School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong Guangzhuo 510275)

AIM: To study the effectt of modified starfish steroid C03 screened by human arrhythmic related gene Kv1. 5 on experimental atrial fibrillation. METHODS: Kv1. 5 cDNA was translated into mRNA and microinjected into Xenopus oocyte. Models of atrial fibrillation was induced by electricity and drug. RESULTS: Pure and single IKur K+ current was expressed on oocytes, without other current pollution. Active material starfish steroid C03 blocking IKur current was screened by patch-clamp . CO3 has demonstrated significantly and dose-dependently, to increase AFT induced by electricity in cats, AFT of CO3 34.6mg ·kg-1 increased from (4. 78 ±0. 94)V to (10. 87±2. 38)V (P<0. 01), which is better than Amio;shorten time of improving and recovering induced by Aco, CO3 2. 7, 8. 1 and 24. 2mg ·kg-1 shortened the improving time (P<0. 01). CO3 8. 1 and 24. 2 mg ·kg-1 shortened the recovering time (P<0. 01);shorten time of improving and recovering induced by Ach, CO3 8.1 and 24.2 mg ·kg-1 shortened the improving time (P<0. 05), CO3 2.7, 8.1 and 24.2 mg ·kg-1 shortened the recovering time (P<0. 01). CONCLUSION:Starfish sterol CO3 produced a oharmacological effects against experimental atrial fibrillation. The model of application of arrhythmic related gene could be used for screening of class Ⅲantiarrhythmic drugs from ocean active materials.

关键词： Gene screening Kv1. 5 starfish sterol CO3 anti-arrhythmia atrial fibrillation.

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表面麻醉下小切口白内障超声乳化人工晶状体植入术

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国际眼科杂志 2009年第7期9卷 1344-1345页

作者：孙凤海许美玲贾建海洋石油总医院眼科中国天津市300452

目的:探讨表面麻醉下小切口白内障超声乳化人工晶状体植入术的临床效果和优点。方法:70例83眼采用表面麻醉下透明角膜小切口白内障超声乳化术并植入折叠式后房型人工晶状体。结果:术后1mo视力>0.3者77眼。术中1眼出现后囊破裂,但人工晶... 详细信息

目的:探讨表面麻醉下小切口白内障超声乳化人工晶状体植入术的临床效果和优点。方法:70例83眼采用表面麻醉下透明角膜小切口白内障超声乳化术并植入折叠式后房型人工晶状体。结果:术后1mo视力>0.3者77眼。术中1眼出现后囊破裂,但人工晶状体顺利植入;1眼外伤性白内障人工晶状体未能植入;糖尿病患者2眼出现并发症。结论:表面麻醉下小切口白内障超声乳化人工晶状体植入术具有术程短、术后视力恢复快的优点。

关键词：表面麻醉小切口超声乳化白内障人工晶状体

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非接触眼压计在健康检查中对高眼压的筛查

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国际眼科杂志 2009年第10期9卷 2036-2037页

作者：许美玲孙凤海马洪梅贾健中国海洋石油总医院眼科中国天津市300452

目的:应用美国产Reichert-AT555非接触眼压计在健康普查中,发现高眼压或眼压异常者,对其进行眼科临床跟踪检查及治疗。方法:检查发现所有单眼眼压>21mmHg或双眼眼压差>8mmHg被检者,嘱其近期进行复诊,在3d内的同一时间连续测量3次,并进... 详细信息

目的:应用美国产Reichert-AT555非接触眼压计在健康普查中,发现高眼压或眼压异常者,对其进行眼科临床跟踪检查及治疗。方法:检查发现所有单眼眼压>21mmHg或双眼眼压差>8mmHg被检者,嘱其近期进行复诊,在3d内的同一时间连续测量3次,并进行相关的眼科检查。结果:已完成测量3110例;其中高眼压或眼压异常者359眼;复诊有30例被确诊为青光眼患者,进行了相应的治疗。结论:非接触眼压计具有操作简便、测量迅速、自动打印检测结果、不直接接触眼球,被检者无任何痛苦等优点逐渐被越来越多的人认可和接受,适合大规模的健康检查。

关键词：非接触眼压计健康检查高眼压筛查

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石油工人挫伤性前房积血85例临床分析

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国际眼科杂志 2010年第7期10卷 1376-1377页

作者：孙凤海马洪梅贾健许美玲海洋石油总医院眼科中国天津市300452

目的:分析渤海地区石油工人挫伤性前房积血发生的特点,提出治疗和预防的措施。方法:通过对85例挫伤性前房积血的临床治疗,积极探寻对不同情况下前房积血的有效治疗方法。结果:85例患者治疗后,视力:56例恢复至1.0,19例达0.5～0.8,7例0.1... 详细信息

目的:分析渤海地区石油工人挫伤性前房积血发生的特点,提出治疗和预防的措施。方法:通过对85例挫伤性前房积血的临床治疗,积极探寻对不同情况下前房积血的有效治疗方法。结果:85例患者治疗后,视力:56例恢复至1.0,19例达0.5～0.8,7例0.1～0.4,3例<0.1。结论:前房积血早期药物或手术治疗均达到满意的疗效,积极预防是避免伤害发生的关键。

关键词：石油工人挫伤性前房积血

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