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Chinese Science Bulletin 2006年第22期51卷 2724-2730页

作者： LI Xiao JIN Ningyi lian Hai GUAN Goufang SUN Lili LI Xue mei zheng Hongling Genetic Engineering Laboratory of PLA The Eleventh Institute ofAcademy of Military Medical Sciences of PLA Changchun 130062China Faculty of Agriculture Sciences of Jilin University Changchun 130062China The Second Hospital Bethune Faculty of Medical Sciences of JilinUniversity Changchun 130041 China

Hemagglutinin-neuramidinase (HN ) ，纽卡斯尔疾病导出病毒的蛋白质，不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动，劈开那些受体的一个部件的能力， N-acetylneuraminic 酸(NAcneu， sialic ) 。包括人，在哺乳动物的种... 详细信息

Hemagglutinin-neuramidinase (HN ) ，纽卡斯尔疾病导出病毒的蛋白质，不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动，劈开那些受体的一个部件的能力， N-acetylneuraminic 酸(NAcneu， sialic ) 。包括人，在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质，这被知道。在癌症基因治疗探索 HN 基因的使用，我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里，我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗，有 vFV-HN 的感染引起了显著细胞毒素的效果并且，与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且，有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外，从老鼠的淋巴节点的 T 房间种牛痘， Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了，显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。

关键词： NDV HN基因抗肿瘤蛋白质受体识别

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Error-heralded generation and self-assisted complete analysis of two-photon hyperentangled Bell states through single-sided quantum-dot-cavity systems

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Science China(Physics,Mechanics & Astronomy) 2019年第7期62卷 46-54页

作者： YanYan zheng LeiXia liang mei Zhang Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

Hyperentangled-Bell-state analysis(HBSA) is critical for high-capacity quantum communication. Based on a recent proposal by Wang et al. [Opt. Express 24, 28444(2016)], we design two independent schemes for error-heralded deterministic generation and self-assisted complete HBSA of two-photon systems entangled in both polarization and spatial-mode degrees of freedom(DOFs).Unlike previous programs, we firstly propose an error-heralded block with a singly charged quantum dot inside a single-sided optical microcavity, with which errors due to imperfect interactions between photons and quantum dot systems can be *** error-heralded block, ensures that the fidelity of the two schemes for hyperentangled-Bell-state generation and complete HBSA reaches unity. Moreover, hyperentanglement makes it possible to analyze the polarization state with the assistance of the measured spatial-mode state. The self-assisted mechanism of HBSA greatly simplifies the analytical process and significantly relaxes the requirements of nonlinearities. Therefore, these schemes promise to be implemented more easily in experiments,taking a step closer to long-distance high-capacity quantum communication.

关键词： quantum hyperentanglement error-heralded self-assisted high-capacity quantum communication

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Rate-dependent constitutive model of poly(ethylene terephthalate) for dynamic analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 811-816页

作者： Qiang LI Shu-lian LIU Shui-ying zheng Institute of Chemical Machinery Zhejiang University Hangzhou 310027 China Department of Electro-Mechanical Engineering Zhejiang University of Science and Technology Hangzhou 310023 China

Uniaxial tensile testing at strain rates ranging from 10-3 to 10-1 s-1 was carried out to study the rate-dependent me-chanical behavior for poly(ethylene terephthalate) (PET) used in the packaging industry. The experimental results show that a rate-dependent plastic behavior exists for PET material. The value of the yield strength was found to increase with the increasing strain rate. A new constitutive model based on the improved Cowper-Symonds rate-dependent constitutive model is proposed to describe the mechanical behavior of PET material in the strain rate ranging from 10-3 to 10-1 s-1, providing more accurate material data for the subsequent simulation analysis of drop test and dynamic buckling. The predictions obtained using the proposed model are compared with experimental results of the improved Cowper-Symonds model. The simulating results of the proposed model agree well with the experimental data. For a low strain rate, the predictions of this model are more precise than those obtained using the improved Cowper-Symonds model. This confirms that the new constitutive model is suitable for describing the me-chanical behavior of PET material at a low strain rate and modeling impact problem.

关键词： Rate-dependent Tensile testing Constitutive model Strain rate Poly(ethylene terephthalate) (PET)

Microbial D-amino acids and marine carbon storage

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Science China Earth Sciences 2016年第1期59卷 17-24页

作者： ZHANG Zi lian zheng Qiang JIAO Nian Zhi State Key Laboratory of Marine Environmental Science Institute of Marine Microbes and EcospheresXiamen University

In nature, there are two conformational types of amino acids: L- and D-isomers. The L-amino acids are the predominant form and are used mainly for protein synthesis, while the D-amino acids are few in quantity but more diverse in terms of their biological functions. D-amino acids are produced by many marine microbes, which are important players in carbon and energy cycles in the ocean. As the major constituent of the marine organic carbon pool, D-amino acids can persist in the water column for a long time before being further transformed by chemical or biological processes or transported through physical processes(such as absorption and aggregation). This article reviews the microbial synthesis of D-amino acids, their physiological function and metabolism in microbes, and the contribution of D-amino acids as a carbon source to the oceanic carbon reservoir.

关键词： Microbe D-amino acid Dissolved organic carbon Marine carbon storage

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菰米研究现状及产业发展趋势

西南大学学报（自然科学版） 2025年第1期47卷 73-82页

作者：张玉杨狄芯芯练银银谭斌王梅索化夷西南大学食品科学学院重庆400715 西南大学食品科学与工程国家实验教学示范中心重庆400715 国家粮食和物资储备局科学研究院北京100037 重庆市蚕业科学技术研究院重庆400799

菰米作为营养均衡的无麸质全谷物食品,含有丰富的营养物质,具有重要的营养、保健和医学价值。该文系统总结了近年来在菰米的营养成分和加工应用方面的研究进展,指出菰米中富含的营养物质主要有碳水化合物、蛋白质、脂质、维生素、酚类... 详细信息

菰米作为营养均衡的无麸质全谷物食品,含有丰富的营养物质,具有重要的营养、保健和医学价值。该文系统总结了近年来在菰米的营养成分和加工应用方面的研究进展,指出菰米中富含的营养物质主要有碳水化合物、蛋白质、脂质、维生素、酚类化合物、植物甾醇、γ-谷维素和γ-氨基丁酸等,具有抗氧化和抗心脑血管疾病等活性。菰米现有加工方式单一,应用处于初级阶段,开展菰米新加工方式研究,拓展其应用特性是当前该领域的重要研究任务。展望了未来我国菰米深入研究与加工应用的发展方向,未来菰米需选育优良品种、扩大种植率;菰米加工可从主食食品、休闲食品和发酵食品三大类进行研发,也可作为膳食补充剂添加进食品中,提升产品营养价值。

关键词：菰米营养成分生物活性成分加工方式开发

Microcalorimetry studies on the antibacterial effect of crude monkshood polysaccharide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 563-567页

作者： Gui-mei LIN lian LIU Wei SHAO School of Pharmaceutical Science Shandong University Jinan 250012 China

In this paper,crude monkshood polysaccharide was isolated from Radix Aconiti Lateralis *** effects of crude monkshood polysaccharide on Escherichia coli and Staphylococcus aureus were investigated by *** power-time curves of the bacterial growth at various concentrations (c) of crude monkshood polysaccharide were plotted with a TAM air isothermal microcalorimeter at 37 °*** growth rate constant (μ),inhibitory ratio (I),peak-height (Pm),and peak-time (tm) were *** the data,the relationship between μ and c also was *** growth rate constant μ decreased with the increasing concentrations of crude monkshood ***,Pm reduced and tm increased with increasing *** experimental results revealed that crude monkshood polysaccharide had inhibitory activity towards *** and *** obtained from our study strongly suggest that microcalorimetry is a fast,simple,and more sensitive technology that can be easily performed to study the effect of drugs on bacteria.

关键词： Crude monkshood polysaccharide Microcalorimetry Escherichia coli Staphylococcus aureus Inhibitory