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Bio-energy in s-Helix Protein Molecules with Three Properties of Soliton-Transported Channels

Communications in Theoretical Physics 2007年第2X期48卷 369-376页

作者： PANG Xiao-Feng LIU mei-jie Institute of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China International Center for Material Physics the Chinese Academy of Sciences Shenyang 110015 China

We study numerically the propagating properties of soliton-transported bio-energy excited in the a-helix protein molecules with three channels in the cases of the short-time and long-time motions and its features of collision at temperature T = 0 and biological temperature T = 300 K by the dynamic equations in the improved Davydov theory and fourth-order Runge-Kutta method, respectively. From these simulation experiments we see that the new solitons in the improved model can move without dispersion at a constant speed retaining its shape and energy in the cases of motion of both short-time or T = 0 and long time or T = 300 K and can go through each other without scattering in their collisions. In these cases its lifetime is, at least, 120 ps at 300 K, in which the soliton can travel over about 700 amino acid residues. This result is consistent with analytic result obtained by quantum perturbed theory in this model. In the meanwhile, the influences of structure disorder of a-helix protein molecules, including the inhomogeneous distribution of amino acids with different masses and fluctuations of spring constant, dipole-dipole interaction, exciton-phonon coupling constant and diagonal disorder, on the solitons are also studied by the fourth-order Runge-Kutta method. The results show that the soliton still is very robust against the structure disorders and thermal perturbation of proteins at biological temperature 300 K. Therefore we can conclude that the new soliton in the a-helix protein molecules with three channels is a possible carrier of bio-energy transport and the improved model is possibly a candidate for the mechanism of this transport.

关键词： bio-energy transport soliton protein molecule Runge-Kutta method thermal stabilization

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A survey and measurement study of GPU DVFS on energy conservation

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Digital Communications and Networks 2017年第2期3卷 89-100页

作者： Xinxin mei Qiang Wang Xiaowen chu Department of Computer Science Hong Kong Baptist University Hong Kong China Institute of Research and Continuing Education Hong Kong Baptist University Shenshen 518057 China

Energy efficiency has become one of the top design criteria for current computing systems. The Dynamic Voltage and Frequency Scaling （DVFS） has been widely adopted by laptop computers, servers, and mobile devices to conserve energy, while the GPU DVFS is still at a certain early age. This paper aims at exploring the impact of GPU DVFS on the application performance and power consumption, and furthermore, on energy conservation. We survey the state-of-the-art GPU DVFS characterizations, and then summarize recent research works on GPU power and performance models. We also conduct real GPU DVFS experiments on NVIDIA Fermi and Maxwell GPUs. According to our experimental results, GPU DVFS has significant potential for energy saving. The effect of scaling core voltage/frequency and memory voltage/frequency depends on not only the GPLI architectures, but also the characteristic of GPU applications.

关键词： Graphics processing unit Dynamic voltage and frequency scaling Energy efficiency

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Dynamics and screening characteristics of a vibrating screen with variable elliptical trace

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Mining Science and Technology 2009年第4期19卷 508-513页

作者： HE Xiao-mei LIU chu-sheng School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

The ideal motion characteristics for the vibrating screen was presented according to the principle of screening process with constant bed thickness.A new vibrating screen with variable elliptical trace was *** accurate mechanical model was constructed according to the required structural motion *** multi-degree-of-freedom vibration theory,characteristics of the vibrating screen was *** parameters of the vibrating screen which motion traces were linear,circular or elliptical were *** stable solutions of the dynamic equations gave the motions of the vibrating screen by means of computer *** parameters,including amplitude,movement velocity and throwing index,of five specific points along the screen surface were gained by theoretical *** results show that the traces of the new designed vibrating screen follow the ideal screening *** screening efficiency and processing capacity may thus be effectively improved.

关键词： variable elliptical trace screening process with constant bed thickness dynamic model motion characteristic screening characteristics

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Statistical virtual eye model based on wavefront aberration

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International Journal of Ophthalmology(English edition) 2012年第5期5卷 620-624页

作者： jie-mei Wang, Bing-jie Hu Department of Ophthalmology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Video and Image Processing Lab School of Computer Science and Engineering Sichuan University Chengdu 610041 Sichuan Province China

Wavefront aberration affects the quality of retinal image directly. This paper reviews the representation and reconstruction of wavefront aberration, as well as the construction of virtual eye model based on Zernike p... 详细信息

关键词： wavefront aberration wavefront reconstruction virtual eye Zernike polynomial

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Phylomitogenomics of Malacostraca(Arthropoda: Crustacea)

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Acta Oceanologica Sinica 2015年第2期34卷 84-92页

作者： SHEN Xin TIAN mei YAN Binlun chu Kahou Jiangsu Key Laboratory of Marine Biotechnology/College of Marine Science Huaihai Institute of Technology Beijing Institutes of Life Science Chinese Academy of Sciences Simon F.S.Li Marine Science Laboratory School of Life Sciences The Chinese University of Hong Kong

Along with the sequencing technology development and continual enthusiasm of researchers on the mitochondrial genomes, the number of metazoan mitochondrial genomes reported has a tremendous growth in the past decades. Phylomitogenomics—reconstruction of phylogenetic relationships based on mitochondrial genomic data—is now possible across large animal groups. Crustaceans in the class Malacostraca display a high diversity of body forms and include large number of ecologically and commercially important species. In this study, comprehensive and systematic analyses of the phylogenetic relationships within Malacostraca were conducted based on 86 mitochondrial genomes available from Gen Bank. Among 86 malacostracan mitochondrial genomes, 54 species have identical major gene arrangement（excluding t RNAs） to pancrustacean ground pattern,including six species from Stomatopoda, three species from Amphipoda, two krill, seven species from Dendrobranchiata（Decapoda）, and 36 species from Pleocyemata（Decapoda）. However, the other 32 mitochondrial genomes reported exhibit major gene rearrangements. Phylogenies based on Bayesian analyses of nucleotide sequences of the protein-coding genes produced a robust tree with 100% posterior probability at almost all nodes. The results indicate that Amphipoda and Isopoda cluster together（Edriophthalma）（BPP=100）.Phylomitogenomic analyses strong support that Euphausiacea is nested within Decapoda, and closely related to Dendrobranchiata, which is also consistent with the evidence from developmental biology. Yet the taxonomic sampling of mitochondrial genome from Malacostraca is very biased to the order Decapoda, with no complete mitochondrial genomes reported from 11 of the 16 orders. Future researches on sequencing the mitochondrial genomes from a wide variety of malacostracans are necessary to further elucidate the phylogeny of this important group of animals. With the increase in mitochondrial genomes available, phylomitogenomics will emerge

关键词： Malacostraca Crustacea Phylomitogenomics gene arrangement mitochondrial genome

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The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis

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Biomedical and Environmental Sciences 2022年第7期35卷 652-656页

作者： DONG Wen Zhu SHI Jin chu Ping LIU Rong mei WEN Shu An ZHANG Ting Ting PANG Yu LU jie Department of Infectious Diseases The First People's Hospital of ZiyangZiyang 641300SichuanChina Department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing 101149China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of Major Diseases in ChildrenBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 101149China

Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of ***(MTZ)is a 5-nitroimidazole antibiotic that is mainly used in the treatment of anaerobic and protozoal infections[2].The action of mechanism for metronidazole has not been fully *** a prodrug,MTZ is inactive until taken up and reduced by anaerobic bacteria and *** is possible that the reduction of Mtz leads to the production of toxic metabolites,which bind to deoxyribonucleic acid and electron-transport proteins of microbial pathogens,thus blocking nucleic acid synthesis[3].The impressive potency of MTZ against anaerobic bacteria indicates the potential for killing Mtb under anaerobic conditions.A previous in vitro study demonstrated that MTZ has potent activity against tubercle bacilli under anaerobic conditions[4].In a non-human primate model,MTZ has been shown to prevent reactivation of latent Mtb infection,indicating the in vivo role in targeting Mtb within an anaerobic environment[5].Although there is strong evidence for the role of MTZ in affecting anaerobic bacilli,the mechanism of action has not been elucidated in Mtb considering that MTZ must be catalyzed to a nitro-free radical form with endogenous *** provide insight=into how MTZ is activated in anaerobic Mtb bacilli,we first characterized the nitroreductase gene,Rv3131,and identified the key residue conferring the activation of MTZ in Mtb.

关键词： Tuberculosis action latent

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Optimization of pipe circuits in energy tunnels

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Underground Space 2023年第6期13卷 166-182页

作者： jie He mei Yin Xiangyang Wei Zhenhuang Wu College of Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Civil and Environmental Engineering Brunel UniversityUxbridgeLondon UB83PHUK

Geothermal energy is a kind of green and renewable ***,ground source heat pumps can be used to harvest geothermal energy from the *** reduce the initial investment,a good solution is to use tunnel linings as heat exchangers to extract/dump *** special infrastructure is called an energy *** addition to the thermal performance,the impact of pipe network configuration on thermal efficiency is still challenging in the design of energy *** solve this problem,this study makes the first attempt to carry out research on the optimization of pipe circuits in energy tunnels by a series of numerical analyses.A fully coupled thermo-hydraulic 3D finite element model is established to investigate the response of tunnel-soil interaction under cyclical thermal loading(initial soil temperature varies from 8C to 18C),as well as the thermal transient interactions among air,absorber pipe,tunnel linings and ground,to quantify the amount of useful heat that can be extracted from the tunnel and the *** the other hand,the influence of 3 various heat-carrying pipes layout is also *** is found that higher heat transfer efficiency can be obtained when the entrance and exit of pipelines are located below the tunnel in the *** spatial location of pipelines will also affect the exchanged heat output.

关键词： Energy tunnel Thermal efficiency Finite element model Heat transfer

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Growth of carbon nanotubes on the novel FeCo-Al_2O_3 catalyst prepared by ultrasonic coprecipitation

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Journal of Natural Gas Chemistry 2010年第2期19卷 156-160页

作者： jie Wen Wei chu Chengfa Jiang Dongge Tong Department of Chemical Engineering Sichuan University Chengdu 610065 Sichuan China College of Materials and Chemistry ＆ Chemical Engineering Chengdu University of Technology Chengdu 610059 Sichuan China

FeCo-Al2O3 catalyst was prepared by an ultrasonic coprecipitation （UC） method for the growth of carbon nanotubes （CNTs） from catalytic decomposition of *** catalytic performance was compared with that of the FeCo-Al2O3 catalyst counterparts prepared by stepwise impregnation （I） and conventional coprecipitation （C） methods,*** structure and properties of the catalysts and the CNTs as produced thereon were investigated by means of XRD,XPS,TEM and N2 adsorption *** was found that the catalyst prepared by the ultrasonic coprecipitation method was more active,and the yield and purity of the synthesized CNTs were promoted *** XPS results revealed that there were more active components on the surface of the catalyst prepared by the ultrasonic coprecipitation *** the other hand,N2 adsorption demonstrated that the catalyst prepared by the ultrasonic coprecipitation method conferred larger specific surface area,which was beneficial to dispersion of active *** images further confirmed its higher *** factors could be responsible for its higher activity for the growth of CNTs from catalytic decomposition of methane.

关键词： carbon nanotubes ultrasonic coprecipitation FeCo-Al2O3 catalyst chemical vapor deposition (CVD)

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Micromechanical properties of poly(N-isopropylacrylamide)hydrogel microspheres determined using a simple method

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Particuology 2015年第2期13卷 164-172页

作者： mei Yuan Xiaojie Ju Rui Xie Wei Wang Liangyin chu School of Chemical Engineering Sichuan University

Temperature-responsive poly（N-isopropylacrylamide）（PNIPAM） hydrogel microspheres have attracted extensive attention because of their promising diverse biomedical applications. A quantitative understanding of the micromechanical properties of these microspheres is essential for their practical application. Here, we report a simple method for the characterization of the elastic properties of PNIPAM hydrogel microspheres. The results show that PNIPAM hydrogel microspheres exhibit elastic deformation and the obtained force-deformation experimental data fits the Hertz theory well. The moduli of elasticity of the PNIPAM hydrogel microspheres prepared under different conditions were systematically investigated in this work for the first time. The PN1PAM hydrogel microsphere composition significantly affects their micromechanical properties and their temperature sensitivity behavior. PNIPAM hydrogel microspheres with a larger equilibrium volume change have a lower modulus of elasticity. The modulus of elasticity of the PNIPAM hydrogel microspheres at body temperature （37 ℃, above the lower critical solution temperature （LCST） of PNIPAM） is much higher than that at room temperature （25 ℃, below the LCST of PNIPAM） because ofthermo-induced volume shrinkage and an increase in stiffness. These results provide valuable guidance for the design of smart materials for practical biomedical applications. Moreover, the simple microcompression method presented here also provides a versatile way to investigate the micromechanical properties of microscopic biomedical materials.

关键词： Poly(N-isopropylacrylamide) Microspheres Micromechanical properties Modulus of elasticity Temperature-responsive volume change Lower critical solution temperature

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Interaction of Mixed Porphyrin-polypyridyl Ru(II) Complex with Bovine Serum Albumin

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Chemical Research in Chinese Universities 2010年第5期26卷 693-698页

作者： XU Lei LIU Ya-nan mei Wen-jie HUANG Xiao-mei CHEN Tian-feng LIU jie ZHENG Wen-jie Department of Chemistry Jinan University Guangzhou 510632 P. R. China School of Pharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China

The interactions of mixed porphyrin-polypyridyl Ru（Ⅱ） complexes [m（Py-3＇）TPP-Ru（phen）2Cl]^＋（1） and its derivatives [Nim（Py-3＇）TPP-Ru（phen）2Cl]＋（2） and [Cum（Py-3＇）TPP-Ru（phen）2Cl]^＋（3）（phen=1,10-phenanthroline; m（Py-3＇）TPP=5-（3＇-pyridyl）-10,15,20-triphenylporphyrin） with bovine serum albumin（BSA） were investigated by fluorescence, UV-Vis and circular dichroism（CD） spectroscopies. The UV-Vis and CD spectral experiments indicated that the secondary structures of the protein were perturbed in the presence of the porphyrin Ru（Ⅱ） complex and the perturbation was enhanced under the irradiation with ultra-violet light. The fluorescence quenching mechanism of BSA by the three complexes was determined to be a static process, and the apparent binding constant K values for complexes 1, 2 and 3 measured by fluorescence quenching method were （3.86±0.03）×10^3 L/mol（n=0.94±0.04）, （5.69±0.04）× 103 L/mol（n=1.03±0.06）, and （6.54±0.02）× 10^3 L/mol（n=1.03±0.05）, respectively.

关键词： Porphyrin Bovine serum albumin(BSA) Ru(Ⅱ) complex Binding

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