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Influence of multi-stage heat treatment on the microstructure and mechanical properties of TC21 titanium alloy

International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 296-304页

作者： Wei Long Song Zhang Yi-long Liang mei-gui ou College of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Key Laboratory for Materials Structure and Strength of guizhou province Guizhou UniversityGuiyang 550025China National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology Guizhou UniversityGuiyang 550025China

Duplex-structured TC21 alloy samples were first solution-treated at a higher temperature in theα+βregion(940°C)with furnace cooling(FC),air cooling(AC),and water cooling(WC),followed by a second-stage solution treatment at a lower temperature in theα+βregion(900°C),and then finally aged at 590°C.The effects of the morphology and quantity ofαphases on the structure and properties of the TC21 alloy after the different heat treatments were analyzed.The in-situ tensile deformation process and crack propagation behavior were observed using scanning electron microscopy(SEM).The quantity of equiaxedαphases as well as the thickness of lamellarαphases reduced,the tensile strength increased firstly and then decreased,the elongation decreased with the increasing cooling rate after the first-stage solution treatment.The amount and size of lamellarαphases increased after the second-stage solution treatment because of sufficient diffusion of the alloying elements,thereby leading to increased tensile strength.The amount of dispersedαphases increased after the third-stage aging treatment owing to the increase in the nucleation rate,resulting in a noteworthy strengthening effect.After the third-stage aging treatment,the first-stage FC sample exhibited better mechanical properties because it contained more equiaxedαandβtrans phases than the first-stage AC and WC samples.

关键词： multi-stage heat treatment titanium alloy in-situ tension microstructure mechanical properties

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In situ deformation behavior of TC21 titanium alloy with different α morphologies(equiaxed/lamellar)

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Rare Metals 2021年第5期40卷 1173-1181页

作者： Wei Long mei-gui ou Xi-Qin Mao Yi-Long Liang College of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Key Laboratory for Materials Structure and Strength of guizhou Province Guizhou UniversityGuiyang 550025China National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology Guizhou UniversityGuiyang 550025China

To study the effect ofαphase morphology(equiaxedα(αE)/lamellarα(αL))on the in situ tensile behavior of TC21 alloy,the slip band,dislocation,crack initiation,and propagation were analyzed by scanning electron microscopy(SEM)with in situ tensile stage and transmission electron microscopy(TEM).The results show that the slip bands first concentrate in theαE phases and easily truncate at theα/βphase boundaries,whereas the slip bands move across theαlamellae in theαL phase.Microcracks are easily generated inαE orα/βphase boundaries with large plastic deformation.When the quantity ofαL is more thanαE,the crack tip is more easily deflected atαphases orαclusters with different orientations,making the main crack propagation path more zigzag.When the volume fraction ratio ofαE toαL is~3:4,i.e.,the volume fraction ofαE is close to that ofαL,TC21 alloy exhibits better strength and slower crack propagation rate.

关键词： In situ tensile TC21 alloy Equiaxed Lamellar αPhase

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Luminescence property and magnetic resonance imaging of Gd_(2)O_(3):Tb^(3+) nanocrystals doped with Zn^(2+),Li^(+)

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Rare Metals 2021年第8期40卷 2049-2058页

作者： Rong Fu Yan-Yan Hu Hui-Na Qiao Chun-Lin Yang Hao Yin mei-gui ou College of Materials and Metallurgy University of GuizhouGuiyang550025China National Local Co-construction Engineering Laboratory for High Performance Metal Structure Material and Manufacture Technology Guiyang550025China College of Chemistry and Materials Engineering Guiyang UniversityGuiyang550003China Department of Neurosurgery Guizhou Provincial People’s HospitalGuiyang550002China

Gd_(2)O_(3):Tb^(3+) nanocrystal co-doped with Zn^(2+)and Li^(+) was prepared by the combination of polyol and solid-phase methods.The synthesized nanoparticles were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),photoluminescence(PL)spectra and magnetic resonance imaging(MRI).The results revealed that both Gd_(2)O_(3):Tb^(3+)/Zn^(2+) and Gd_(2)O_(3):Tb^(3+)/Li^(+) had cubic unit structures with a spherical shape,and the fluorescence intensity of the nanoparticles reached a maximum at a doping concentration of0.050 mmol%for Zn^(2+) and 2 mol%for Li^(+),respectively.In addition,the T_(1)/T_(2)(longitudinal/transverse relaxation time)-weighted MRI signals got enhanced due to the increased longitudinal relaxivity(r1)and transverse relaxivity(r2)after the doping by metal ions.Therefore,the materials reported here can be used for fluorescence and MR bimodal imaging,as tracers and for fluorescence detections.

关键词： Gd_(2)O_(3):Tb^(3+) Zn^(2+)/Li^(+)doping Luminescent property Magnetic resonance imaging Nanomaterials

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Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang Sun mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments.Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low transcytosis.Here,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@V-NPs.With the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model mice.The combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy mice.Targeting Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

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Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao Yang ou mei Yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang Deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain elusive.Comparing reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways.The interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in hybrids.In compartment domain(CD)boundaries,the distal interactions were more in hybrids than their parents.In the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower H3K27me3.ChIP-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance interactions.In addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop regions.our findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

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Insight into Lithium–sulfur batteries performance enhancement: from metal nanoparticles to metal nanoclusters to single metal atoms

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Tungsten 2024年第3期6卷 504-521页

作者： Shuang Ma Qing-Ling Ruan Xue-Cheng Liu gui-Jun Zhu Die Yuan Ling-Qiao Hu Yu-mei Huang Xing-Xing Gu Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and Resources Chongqing Technology and Business University National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University

Lithium-sulfur(Li-S) batteries have attracted much attention and developed rapidly in recent years due to their high energy density,low cost,and environment-friendly.However,its commercialization process still encounters various obstacles.Among them,the sulfur cathode is easy to dissolve and shuttle,resulting in the loss of active substances and the severe growth of lithium anode dendrites,which is one of the biggest obstacles.Improving the redox conversion kinetics of sulfur cathode is expected to fundamentally alleviate the shuttle phenomenon of poly sulfides.Therefore,this paper reviews the effects of metal nanoparticles to metal nanoclusters to metal single-atom catalysts on improving the redox of Li-S batteries,to let researchers better understand the size effect on the kinetics of sulfur cathodes in Li-S batteries,which will provide important guidance for the future large-scale commercialization of Li-S batteries.

关键词： Lithium–sulfur batteries Metal nanoparticles Metal nanoclusters Metal single atoms Size effects

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TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin ZHANG Zhao-xin LI Li-fei HE Feng CHEN Ming-long LIU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO Feng ZHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung cancer.However,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is unclear.This study aimed to evaluate the radiosensitization of TOPK knockdown in CRC cells.Methods The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western blotting.CCK-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC cells.Furthermore,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after radiotherapy.DNA damage was detected by the comet assay.Changes in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow cytometry.Results The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade 1.After irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated CRC.Moreover,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

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Network analysis of suicide ideation and depression-anxiety symptoms among Chinese adolescents

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General Psychiatry 2024年第2期37卷 216-223页

作者： Shuyin Xu Yumeng Ju Xiyu Wei Wenwen ou Mohan Ma Guanyi Lv Xiaotian Zhao Yaqi Qin Yunjing Li Liang Li mei Huang Siqi Yang Yimei Lu Yafei Chen Junwu Liu Jin Liu Bangshan Liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Technology Institute of PsychiatryHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina

Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide ideation.Aims The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and anxiety.Methods 1501 adolescents aged 12-19 years were assessed using the Patient Health Questionnaire(PHQ-9)and the Generalized Anxiety Disorder Scale,and 716 adolescents who scored≥5 on both scales were selected as participants.Network analysis was used to identify the network structure of depressive symptoms and anxiety symptoms.Participants were categorised into either the suicide ideation or non-suicide ideation groups based on their scoring on the suicide-related item in PHQ-9.A comparison was made between the depression-anxiety symptom networks of the two groups.Results‘Restlessness’,‘sad mood’and‘trouble relaxing’were the most prominent central symptoms in the depression-anxiety symptom network,and‘restlessness’,‘nervousness’and‘reduced movement’were the bridge symptoms in this network.‘Sad mood’was found to be directly related to‘suicide ideation’with the highest variance.The network structure was significantly different in properties between the suicide ideation group and the non-suicide ideation group,with‘restlessness’and‘sad mood’exhibiting significantly higher influence in the network of the suicide ideation group than that in the non-suicide ideation group.Conclusion Restlessness and sad mood could be targeted for the intervention of depression-anxiety symptoms among adolescents with suicide ideation.

关键词： symptoms adolescent assessed

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淬火冷速对51CrV4钢显微组织和力学性能的影响

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材料热处理学报 2024年第5期45卷 135-141页

作者：黄玮欧梅桂梁益龙马永涛贵州大学材料与冶金学院贵州贵阳550025 贵州省材料结构与强度重点实验室贵州贵阳550025 中车贵阳车辆有限公司贵州贵阳550025

采用油、HX-2000以及不同浓度PAG对51CrV4钢进行淬火冷却,借助光学显微镜、扫描电镜(SEM)、电子背散射衍射(EBSD)技术、拉伸实验和洛氏硬度计等研究了不同淬火冷速对51CrV4钢显微组织和力学性能的影响。结果表明:提高淬火冷速对马氏体... 详细信息

采用油、HX-2000以及不同浓度PAG对51CrV4钢进行淬火冷却,借助光学显微镜、扫描电镜(SEM)、电子背散射衍射(EBSD)技术、拉伸实验和洛氏硬度计等研究了不同淬火冷速对51CrV4钢显微组织和力学性能的影响。结果表明:提高淬火冷速对马氏体板条有明显细化效果,51CrV4钢的强塑积随着淬火冷速的提高呈先增后减的趋势。当使用13%PAG淬火及400℃回火保温100 min后,51CrV4钢的综合力学性能最佳:屈服强度和抗拉强度分别为1317.26和1560.89 MPa,断后伸长率和断面收缩率分别为10.50%和55.38%,硬度为47.4 HRC,强塑积达到16.39 GPa%。

关键词： 51CrV4钢淬火冷速显微组织力学性能

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Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 159-170页

作者： Xiao-mei Zhao Zhi-Xin Wu Yan Wang Ying-Jie Xu Ye Xiu Xu Dong Jun-Jie Li gui-Ji Lv Si-Hao Wang Yu-Rong Li Zhao-Fang Bai Xiao-He Xiao Department of Pharmacy Chengdu University of Traditional Chinese Medicine Department of Hepatology The Fifth Medical Center of PLA General Hospital Department of Military Patient Management The Fifth Medical Center of PLA General Hospital Department of Hepatology China Military Institute of Chinese Materia The Fifth Medical Center of PLA General Hospital Department of Hepatology National Key Laboratory of Kidney Diseases

Background: Idiosyncratic drug-induced liver injury(IDILI) is a serious side effect of drugs, Epimedii Folium(EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3(NLRP3) inflammasome. Fructus Ligustri Lucidi(FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity. Aims and Objectives: Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF. Materials and Methods: Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury. Results: our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated. Conclusions: FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.

关键词： Epimedii Folium Fructus Ligustri Lucidi idiosyncratic drug-induced liver injury NOD-like receptor family pyrin domain containing 3 inflammasome traditional Chinese medicine

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