检索结果-南通市图书馆

Chinese Chemical Letters 2024年第3期35卷 523-527页

作者： Pengfei Tan Chuanhui Zhu Jinjin Yang Shuang Zhao Tao Xia mei-Huan Zhao Tao han Zheng Deng Man-Rong Li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhou 510006China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Science Hainan UniversityHaikou 570228China

The intricate correlation between multiple degrees of freedom and physical properties is a fascinating area in solid state chemistry and condensed matter ***,we report a quantum-magnetic system BaNi_(2)V_(2)O_(8)(BNVO),in which the spin correlation was modulated by unusual oxidation state,leading to different magnetic *** BNVO was modified with topochemical reduction(TR)to yield TR-BNVO with partially reduced valance state of Ni^(+)in the two-dimensional NiO_(6)-honeycomb ***,the antiferromagnetic order is suppressed by the introduction of locally interposed Ni^(+)and oxygen vacancies,resulting in a ferromagnetic ground state with the transition temperature up to 710 K.A positive magnetoresistance(7.5%)was observed in the TR-BNVO at 40 K under 7 *** findings show that topological reduction is a powerful approach to engineer low-dimensional materials and accelerate the discovery of new quantum magnetism.

关键词： Layered honeycomb oxide Topochemical reduction Oxygen vacancies Ferromagnetism Magnetoresistance

Direct Regeneration of Spent Lithium-Ion Battery Cathodes:From Theoretical Study to Production Practice

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第10期16卷 304-336页

作者： meiting Huang mei Wang Liming Yang Zhihao Wang Haoxuan Yu Kechun Chen Fei han Liang Chen Chenxi Xu Lihua Wang Penghui Shao Xubiao Luo National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063People's Republic of China Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials School of Chemistry and Chemical EngineeringHunan Institute of Science and TechnologyYueyang 414006People's Republic of China College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha 410004People's Republic of China School of Life Science Jinggangshan UniversityJi'an 343009People's Republic of China

Direct regeneration method has been widely concerned by researchers in the field of battery recycling because of its advantages of in situ regeneration,short process and less pollutant *** this review,we firstly analyze the primary causes for the failure of three representative battery cathodes(lithium iron phosphate,layered lithium transition metal oxide and lithium cobalt oxide),targeting at illustrating their underlying regeneration mecha-nism and *** stripping of material from the collector to obtain pure cathode material has become a first challenge in recycling,for which we report several pretreatment methods currently available for subsequent regeneration *** review and discuss emphatically the research progress of five direct regeneration methods,including solid-state sintering,hydrothermal,eutectic molten salt,electrochemical and chemical lithiation ***,the application of direct regeneration technology in production practice is introduced,the problems exposed at the early stage of the industrialization of direct regeneration technol-ogy are revealed,and the prospect of future large-scale commercial production is *** is hoped that this review will give readers a comprehensive and basic understanding of direct regeneration methods for used lithium-ion batteries and promote the industrial application of direct regeneration technology.

关键词： Spent LIBs Failure reasons Cathode recycling Direct regeneration Production practice

Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第9期9卷 21-31页

作者： han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan fang Qiu-mei Lan Zi-Jun Zhou Yan-Heng Qiao Jie Li Yan-Ru Zhao Ming Pei Bo Yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

Countermeasure against blinding attack for single-photon detectors in quantum key distribution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第4期45卷 76-81页

作者： Lianjun Jiang Dongdong Li Yuqiang fang meisheng Zhao Ming Liu Zhilin Xie Yukang Zhao Yanlin Tang Wei Jiang Houlin fang Rui Ma Lei Cheng Weifeng Yang Songtao han Shibiao Tang QuantumCTek Co. Ltd.Hefei 230088China Shandong Institute of Quantum Science and Technology Co. Ltd.Jinan 250101China QuantumCTek(Beijing)Co. Ltd.Beijing 100193China School of Cyber Science and Technology University of Science and Technology of ChinaHefei 230027China Anhui Armed Police Force Hefei 230026China School of Electrical Engineering and Automation Anhui UniversityHefei 230601China

Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic ***,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon ***,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding *** strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding *** integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding *** method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security.

关键词： quantum key distribution single photon detector blinding attack pulsed blinding attack countermeasure quan-tum communication

rhIL-10对脂多糖攻击小鼠血及肝IL-6和TNF-α含量的影响

在线全文

学校读者我要写书评

暂无评论

中国病理生理杂志 2005年第6期21卷 1207-1209页

作者：杨红罗少洪梅寒芳李春梅广东药学院基础学院广东广州510224

目的:研究重组人白细胞介素-10(rhIL-10)对脂多糖(LPS)诱导的血、肝IL-6和TNF-α炎症介质含量变化的影响。方法:小鼠腹腔注射LPS建立炎症模型,并同时静脉注射不同剂量的rhIL-10,ELISA法测定12h、24h、48h和72h肝组织和血清IL-6和TNF-α... 详细信息

目的:研究重组人白细胞介素-10(rhIL-10)对脂多糖(LPS)诱导的血、肝IL-6和TNF-α炎症介质含量变化的影响。方法:小鼠腹腔注射LPS建立炎症模型,并同时静脉注射不同剂量的rhIL-10,ELISA法测定12h、24h、48h和72h肝组织和血清IL-6和TNF-α的含量。结果:注射rhIL-10后12h,肝组织和血清IL-6、TNF-α水平开始下调,24-48h抑制作用最明显(P<0.05),72h后抑制作用减弱,且呈剂量效应关系。结论:利用基因工程技术制备的重组人白细胞介素10(rhIL-10)显著下调肝组织和血清IL-6和TNF-α的水平。

关键词：白细胞介素10 白细胞介素6 肿瘤坏死因子

Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 72-74页

作者： Sha Yang mei Deng Yunbiao Xiong Bing Xiong Junwu Fu Jia Wang Jiqin Zhang Guoqiang han Jian Liu Ying Tan Guizhou University Medical College GuiyangGuizhou 550025China Department of Neurosurgery Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Anesthesiology Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Neurosurgery Chongqing Emergency Medical CenterChongqing400000China

The important role of immunogenic cell death(ICD)in many tumors is increasingly being ***,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well *** obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 *** used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.

关键词： immune Cancer prognosis

The role and research progress of MDSC in immune aging-related diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical Engineering Communications 2024年第2期3卷 4-9页

作者： Xi-Xing fang han-Zhou Li Xue-mei Piao Yu-Ming Wang Yu-Hong Bian Medical School Hubei Minzu UniversityEnshi 445099China College of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Nursing Department People's Hospital of Longjing CityLongjing 133499China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and *** individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by *** indicates that MDSC could serve as a potent inducer of immune *** senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and *** achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related ***,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting *** article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关键词： MDSC immunosenescence tumor progression pulmonary fibrosis immunosenescence therapy

Enhanced energy storage properties and good stability of novel(1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xCa(Mg_(1/3)Nb_(2/3))O_(3) relaxor ferroelectric ceramics prepared by chemical modification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materiomics 2024年第4期10卷 770-782页

作者： Ying Zhang Meng-han Yan Zhi-Fei Zhang Hai-Rui Bai Peng Li Wei-fang han Ji-Gong Hao Wei Li Yu-Chao Li Chun-Ming Wang Peng Fu School of Materials Science and Engineering Liaocheng UniversityLiaocheng252059China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing 300 Changjiang RoadYantai264006China School of Physics Shandong UniversityJinan250100China

The increase in energy consumption and its collateral damage on the environment has encouraged the development of environment-friendly ceramic materials with good energy storage *** this work,(1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xCa(Mg_(1/3)Nb_(2/3))O_(3) ceramics were synthesized by the solid-state reaction *** 0.88Na_(0.5)Bi_(0.5)TiO_(3)-0.12Ca(Mg_(1/3)Nb_(2/3))O_(3) ceramic exhibited a high recoverable energy storage density of 8.1 J/cm3 and energy storage efficiency of 82.4% at 550 kV/*** introduction of Ca(Mg_(1/3)Nb_(2/3))O_(3) reduced the grain size and increased the band gap,thereby enhancing the breakdown field strength of the ceramic *** method also resulted in good temperature stability(20–140℃),frequency stability(1–200 Hz),and fatigue stability over 106 *** addition,an ultrahigh power density of 187 MW/cm^(3) and a fast charge-discharge rate(t0.9=57.2 ns)can be obtained *** element method analysis revealed that the decrease of grain size was beneficial to the increase of breakdown field ***,the 0.88Na_(0.5)Bi_(0.5)TiO_(3)-0.12Ca(Mg_(1/3)Nb_(2/3))O_(3) ceramics resulted in high energy storage properties with good stability and were promising environment-friendly materials for advanced pulsed power systems applications.

关键词： (1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xCa(Mg_(1/3)Nb_(2/3))O_(3)ceramics Relaxor ferroelectrics Breakdown field strength Energy storage properties Stability

Disitamab vedotin,a HER2-directed antibody-drug conjugate,in patients with HER2-overexpression and HER2-low advanced breast cancer:a phase I/Ib study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第7期44卷 833-851页

作者： Jiayu Wang Yunjiang Liu Qingyuan Zhang Wei Li Jifeng Feng XiaojiaWang Jianmin fang Yiqun han Binghe Xu Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Breast Center The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Breast Medicine Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Medical Oncology The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of Medical Oncology Jiangsu Cancer HospitalNanjingJiangsuP.R.China Department of Breast Medicine Zhejiang Cancer HospitalHangzhouZhejiangP.R.China School of Life Science and Technology Tongji UniversityShanghaiP.R.China

Background:Disitamab vedotin(DV;RC48-ADC)is an antibody-drug conjugate comprising a human epidermal growth factor receptor 2(HER2)-directed antibody,linker and monomethyl auristatin *** studies have shown that DV demonstrated potent antitumor activity in preclinical models of breast,gastric,and ovarian cancers with different levels of HER2 *** this pooled analysis,we report the safety and efficacy of DV in patients with HER2-overexpression and HER2-low advanced breast cancer(ABC).Methods:In the phase I dose-escalation study(C001 CANCER),HER2-overexpression ABC patients received DV at doses of 0.5-2.5 mg/kg once every two weeks(Q2W)until unacceptable toxicity or progressive *** dose range,safety,and pharmacokinetics(PK)were *** phase Ib dose-range and expansion study(C003 CANCER)enrolled two cohorts:HER2-overexpression ABC patients receiving DV at doses of 1.5-2.5 mg/kg Q2W,with the recommended phase 2 dose(RP2D)determined,andHER2-lowABC patients receiving DV at doses of 2.0 mg/kg Q2W to explore the efficacy and safety of DV in HER2-low ***:Twenty-four patients with HER2-overexpression ABC in C001 CANCER,46 patients with HER2-overexpressionABCand 66 patients with HER2-low ABC in C003 CANCER were *** 2.0 mg/kg RP2D Q2W,the confirmed objective response rates were 42.9%(9/21;95%confidence interval[CI]:21.8%-66.0%)and 33.3%(22/66;95%CI:22.2%-46.0%),with median progression-free survival(PFS)of 5.7 months(95%CI:5.3-8.4 months)and 5.1 months(95%CI:4.1-6.6 months)for HER2-overexpression and HER2-low ABC,***(≥5%)grade 3 or higher treatment-emergent adverse events included neutrophil count decreased(17.6%),gamma-glutamyl transferase increased(13.2%),asthenia(11.0%),white blood cell count decreased(9.6%),peripheral neuropathy such as hypoesthesia(5.9%)and neurotoxicity(0.7%),and pain(5.9%).Conclusion:DV demonstrated promising efficacy in HER2-overexpression and HER2-low ABC,with a favorable safety profile at

关键词： antibody-drug conjugate breast cancer clinical trials disitamab vedotin HER2-low HER2-overexpression

Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第8期51卷 811-823页

作者： Qiao Meng Jing Ning Jingjing Lu Jing Zhang Ming Zu Jing Zhang Xiurui han Huiling Zheng Yueqing Gong Xinyu Hao Ying Xiong fang Gu Wenling han Weiwei Fu Jun Wang Shigang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases(BZ0371) Beijing 100191China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterNHC Key Laboratory of Medical Immunology(Peking University)Beijing 100191China Peking University Center for Human Disease Genomics Beijing 100191China

The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis(UC),and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC ***,we find that the IL-17 receptor subunit,CMTM4,is reduced in UC patients and dextran sulfate sodium(DSS)-induced *** deletion of CMTM4(Cmtm4^(-/-))in mice leads to a higher susceptibility to DSS-induced colitis than in wild-type,and the gut microbiome significantly changes in *** causal role of the gut microbiome is confirmed with a cohousing *** further identify that S100a8/9 is significantly up-regulated in Cmtm4^(-/-)colitis,with the block of its receptor RAGE that reverses the phenotype associated with the CMTM4 ***4 deficiency rather suppresses S100a8/9 expression in vitro via the IL17 pathway,further supporting that the elevation of S100a8/9 in vivo is most likely a result of microbial *** together,the results suggest that CMTM4 is involved in the maintenance of intestinal homeostasis,suppression of S100a8/9,and prevention of colitis *** study further shows CMTM4 as a crucial innate immunity component,confirming its important role in UC development and providing insights into potential targets for the development of future therapies.

关键词： Ulcerative colitis CMTM4 Gut microbiota IL-17 receptor C(IL-17RC) S100a8/9