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Comparison study of two diagnostic and grading systems for conjunctivochalasis

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Chinese Medical Journal 2013年第16期126卷 3118-3123页

作者： zhang Xing-ru ZOU Hai-dong LI Qing-song ZHOU Huan-ming LIU Bin HAN zhu-mei XIANG Min-hong zhang Zheng-yong WANG Han-min Department of Ophthalmology Putuo Hospital Shanghai TraditionalMedicine University Shanghai 200062 China Department of Ophthalmology Liqun Hospital Shanghai 200333China Department of Ophthalmology Shanghai First People's HospitalAffiliated to Shanghai Jiao Tong University Shanghai 200080 China Department of Ophthalmology Shanghai Eye DiseasesPrevention & Treatment Center Shanghai 200040 China

Background Different diagnostic and grading systems of conjunctivochalasis have resulted in apparent disparity between the prevalence rates of recent population-based *** study aimed to investigate the disparity between 4-level system cited from Meller and Tseng in 1998 （abbreviated here as Meller＇s system） and 5-level system modified from Meller＇s system cited from zhang and associates （abbreviated here as zhang＇s system） regarding the diagnosis and the patients＇ preferences for the treatment of conjunctivochalasis in the general *** A total of 546 senile residents living in the Guiyangyuan community of Shanghai,China,participated in the *** diagnostic criteria for conjunctivochalasis were based on two diagnostic grading systems：Meller＇s system and zhang＇s system,which was modified from Meller＇s *** participants＇ preference regarding medical treatment for conjunctivochalasis was determined according to the response to a *** year later,a follow-up interview determines whether the patient had undergone surgery for *** With Meller＇s system,398 participants were confirmed as having conjunctivochalasis,and the prevalence rate was 72.89％.According to zhang＇s system,only 213 participants were diagnosed as having conjunctivochalasis,and the prevalence rate was 39.01％.A total of 109 eyes underwent medical treatment or surgery for conjunctivochalasis in the following year,including eight eyes that were diagnosed as grade Ⅱ and 101 eyes that were diagnosed as grade Ⅲ according to Meller＇s system and five eyes that were diagnosed as grade Ⅰ,55 eyes that were diagnosed as grade Ⅱ,31 eyes that were diagnosed as grade Ⅲ,and 18 eyes that were diagnosed as grade Ⅳ according to zhang＇s *** Diagnoses of conjunctivochalasis using zhang＇s system are more consistent with patient requests and the medical treatment strategies used than diagnoses made using Meller＇s system.

关键词： conjunctivochalasis diagnosis grading system

Effect of high mobility group box-1 protein on immune cells and its regulatory mechanism

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中国应用生理学杂志 2012年第6期28卷 548-554页

作者： Ying-yi LUAN Feng-hua YAO Qing-hong zhang Xiao-mei zhu Ning DONG yong-ming YAO Burns Institute First Hospital Affiliated to the Chinese PLA General Hospital

High mobility group box-1 protein(HMGB1),which is a nuclear protein,participates in chromatin architecture and transcriptional *** released from cells,HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to *** the initial stage of injury,there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens,but this pro-inflammatory period is transient,and it is followed by a prolonged period of immune *** present,several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity,which may enhance the production of early proinflammatory mediators,and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated *** biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation,however,this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.

关键词：免疫细胞调控机制核蛋白迁移率 HMGB1 炎症介质基因转录调控免疫反应

Hyperisampsins N and O,two new benzoylated phloroglucinol derivatives from Hypericum sampsonii

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Chinese Chemical Letters 2017年第5期28卷 986-990页

作者： Hu-Cheng zhu Chun-mei Chen Jin-Wen zhang Yi Guo Dong-Dong Tan Guang-Zheng Wei Jing Yang Jian-Ping Wang Zeng-Wei Luo yong-Bo Xue yong-Hui zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204China

Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii,including two new ones named hyperisampsins N and O（1 and 2）.The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric *** absolute configurations were further determined by using TDDFT ECD *** 2,7,and 8 were evaluated for their cytotoxic activities against five human cancer cell lines,of which,2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines.

关键词： Hyperisampsin PPAPs ECD calculation Absolute configuration

Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing

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Bioactive Materials 2023年第6期24卷 96-111页

作者： Dun Liu Lei Li Ben-Long Shi Bo Shi Ming-Ding Li yong Qiu Di Zhao Qun-Dong shen Ze-zhang zhu Division of Spine Surgery Department of Orthopedic SurgeryAffiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Department of Polymer Science and Engineering Key Laboratory of High-Performance Polymer Materials and Technology of MOESchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Institute of Brain Science and Disease School of Basic MedicineQingdao UniversityQingdaoShandong266001China

Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial *** such,it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure ***,based on ultrasound-triggered piezocatalytic therapy,a multifunctional hydrogel is designed to promote bacteria-infected wound *** ultrasonic vibration,the surface of barium titanate(BaTiO_(3),BT)nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species(ROS)owing to the established strong built-in electric field,endowing the hydrogel with superior antibacterial *** modality shows intriguing advantages over conventional photodynamic therapy,such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of ***,the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide(THM),N-(3-aminopropyl)methacrylamide hydrochloride(APMH)and oxidized hyaluronic acid(OHA)exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound ***,compared with the widely reported mussel-inspired adhesive hydrogels,OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized,giving it long-term and repeatable adhesion ***,this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria,markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.

关键词： Multifunctional hydrogels Bioadhesiveness Self-healing Antibacterial ability Piezocatalytic therapy

Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China

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Biomedical and Environmental Sciences 2012年第5期25卷 562-568页

作者： zhu Xiao Hong JIAO Yang LI Hong mei WANG Ai Li WANG Gui Yan TONG Wei Jun zhang yong Hong Department of Epidemiology School of Public Health Medical College of Soochow University Suzhou 215123 Jiangsu China Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision) Suzhou 215021 Jiangsu China Department of Health Care Xiamen Maternal and ChiM Care Hospital Xiamen 361000 Fujian China

Abstract Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein （CRP）, soluble intracellular adhesion molecule1-1 （slCAM-1）, and angiotensin It （Ang Ⅱ）, in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants. Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension （21.0% and 6.0%, respectively） than in those with prehypertension （12.7% and 0.5%, respectively） or normotension （8.1% and 0.2%, respectively）. The multivariate adjusted odds ratios （95% confidence interval） of hypertension associated with increased levels of one, two or three biomarkers were 0.94 （0.72-1.22）, 1.42 （0.93-2.16）, and 11.08 （1.45-84.80）, respectively, compared with subjects with no increase in any biomarker. Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.

关键词： C-reactive protein Soluble intracellular adhesion molecule-i Angiotensin II Hypertension Mongolia

基于大刍草渗入系的玉米抗旱优异等位基因挖掘

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作物学报 2024年第8期50卷 1896-1906页

作者：刘爽李珅王东梅沙小茜何冠华张登峰李永祥刘旭洋王天宇黎裕李春辉作物基因资源与育种全国重点实验室/中国农业科学院作物科学研究所北京100081

干旱是影响玉米生产的主要非生物胁迫之一。为了挖掘玉米优异抗旱基因,本研究基于墨西哥大刍草和玉米自交系PH4CV构建的BC2F6群体,通过苗期抗旱性初步鉴定,筛选出抗旱性强的渗入系TP180。干旱胁迫后发现渗入系TP180较轮回亲本PH4CV萎蔫... 详细信息

干旱是影响玉米生产的主要非生物胁迫之一。为了挖掘玉米优异抗旱基因,本研究基于墨西哥大刍草和玉米自交系PH4CV构建的BC2F6群体,通过苗期抗旱性初步鉴定,筛选出抗旱性强的渗入系TP180。干旱胁迫后发现渗入系TP180较轮回亲本PH4CV萎蔫程度更小,并且复水后存活率显著高于PH4CV。全基因组基因型鉴定发现,渗入系TP180含有0.6%的墨西哥大刍草导入。通过开展TP180和PH4CV不同水分条件下的转录组测序,在渗入系TP180和PH4CV之间共鉴定了2307个差异表达基因,不同胁迫重叠差异表达基因共122个,这些基因涉及生长素途径,茉莉酸途径等,包含多个转录因子。整合差异表达基因和含大刍草导入区段分析,鉴定出2个抗旱候选基因Zm00001d033050和Zm00001d002025,并进一步开展了RT-PCR分析。本研究为挖掘大刍草中抗旱基因资源提供了重要材料和信息基础。

关键词：玉米大刍草渗入系抗旱转录组分析

植物精油对犊牛生长性能、血清免疫指标及血清抗氧化指标的影响

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饲料研究 2024年第15期47卷 1-5页

作者：朱元芳李伟韩永胜孙芳张建胜王艳菲姚美玲李青莹黑龙江省农业科学院畜牧兽医分院黑龙江齐齐哈尔161005 黑龙江省农业科学院畜牧研究所黑龙江哈尔滨150080

试验旨在研究植物精油对荷斯坦犊牛生长性能及血清指标的影响。选取60头年龄、体重相近的荷斯坦犊牛,随机分为2组,分别为对照组(基础精料)和试验组(基础精料+200 g/t植物精油),每组3个重复,每个重复10头牛。预试验7 d,正式试验期30 d。... 详细信息

试验旨在研究植物精油对荷斯坦犊牛生长性能及血清指标的影响。选取60头年龄、体重相近的荷斯坦犊牛,随机分为2组,分别为对照组(基础精料)和试验组(基础精料+200 g/t植物精油),每组3个重复,每个重复10头牛。预试验7 d,正式试验期30 d。结果显示,与对照组相比,试验组犊牛末重和平均日增重有所增加(P>0.05),体斜长和胸围均显著升高(P<0.05)。与对照组相比,试验组犊牛血清尿素氮(BUN)含量显著降低(P<0.05),免疫球蛋白A(IgA)、免疫球蛋白M(IgM)含量显著升高(P<0.05),总抗氧化能力(T-AOC)显著升高(P<0.05),丙二醛(MDA)含量显著降低(P<0.05)。与对照组相比,试验组犊牛腹泻率降低了20%,死亡率降低了7%。研究表明,本试验条件下,精料中添加植物精油能够增加犊牛平均日增重、体尺指标,增强犊牛免疫系统机能,提高抗氧化能力,减少腹泻率和死亡率。

关键词：犊牛植物精油血清指标腹泻生长性能

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Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data

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Current Medical Science 2021年第2期41卷 368-374页

作者： Yan zhang Yuan WU Zi-ying GONG Hai-dan YE Xiao kai ZHAO Jie-yi LI Xiao-mei zhang sheng LI Wei zhu mei WANG Ge-yu LIANG Yun LIU Xin GUAN Dao-yun zhang Bo shen Jiangsu Cancer Hospital Jiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Shanghai Yunying Medical Technology Co LtdShanghai 201612China Jiaxing Yunying Medical Inspection Co LtdJiaxing 314000China School of Medicine Jiangsu UniversityZhenjiang 212013China School of Public Health Southeast UniversityNanjing 211189China

Colorectal cancer (CRC) is the third most commonly diagnosed cancer *** studies have indicated that rectal cancer is significantly different from colon cancer interms of treatment, prognosis, and metastasis. Recently, the differential mRNA expression of coloncancer and rectal cancer has received a great deal of attention. The current study aimed to identifysignificant differences between colon cancer and rectal cancer based on RNA sequencing (RNA-seq)data via support vector machines (SVM). Here, 393 CRC samples from the The Cancer GenomeAtlas (TCGA) database were investigated, including 298 patients with colon cancer and 95 withrectal cancer. Following the random forest (RF) analysis of the mRNA expression data, 96 genessuch as HOXB13, PR4C, and BCLAFI were identified and utilized to build the SVM classificationmodel with the Leave-One-Out Cross-validation (LOOCV) algorithm. In the training (n= 196)and the validation cohorts (n=197), the accuracy (82. 1 % and 82.2 %, respectively) and the AUC(0.87 and 0.91, respectively) indicated that the established optimal SVM classification modeldistinguished colon cancer from rectal cancer reasonably. However, additional experiments arerequired to validate the predicted gene expression levels and functions.

关键词： colon cancer rectal cancer support vector machine classification gene selection

Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia： A Retrospective Study

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Chinese Medical Journal 2015年第20期128卷 2701-2706页

作者： Jing-Hong Dai Hui Li Wei shen Li-Yun Miao yong-Long Xiao mei Huang Meng-Shu Cao Yang Wang Bin zhu Fan-Qing Meng Hou-Rong Cai Department of Respiratory Medicine The Affiliated Drum Tower Hospital ol Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Radiology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

Background： Acute fibrinous and organizing pneumonia （AFOP） is a unique pathological entity with intra-alveolar fibrin in the form of ＂fibrin balls＂ and organizing pneumonia. It was divided into rare idiopathic interstitial pneumonia according to the classification notified by American Thoracic Society/European Respiratory Society in 2013. As a rare pathological entity, it is still not well known and recognized by clinicians. We reviewed the clinical features of 20 patients with AFOP diagnosed in a teaching hospital. Methods： The medical records of 20 patients with biopsy-proven diagnosis of AFOP were retrospectively reviewed. The patients＇ symptoms, duration of the disease, comorbidities, clinical laboratory data, pulmonary function testing, radiographic studies, and the response to treatment were extracted and analyzed. Results： Fever was the most common symptom and was manifested in 90% of AFOP patients. For clinical laboratory findings, systematic inflammatory indicators, including C-reactive protein and erythrocyte sedimentation rate, were significantly higher than normal ill AFOP patients. In accordance with this increased indicators, injured liver functions were common in AFOP patients. Inversely, AFOP patients had worse clinical conditions including anemia and hypoalbuminemia. For pulmonary function testing, AFOP patients showed the pattern of restrictive mixed with obstructive ventilation dysfunction. For high-resolution computerized tomography （HRCT） findings, the most common pattern for AFOP patients was lobar consolidation which was very similar to pneumonia. However, unlike pneumonia, AFOP patients responded well to glucocorticoids. Conclusion： Patients with AFOP manifest as acute inflammatory-like clinical laboratory parameters and lobar consolidation on HRCT, but respond well to steroid.

关键词： Acute Fibrinous and Organizing Pneumonia Clinical Features High-resolution Computerized Tomography InflammatoryIndicators