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Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage

Neural Regeneration Research 2023年第6期18卷 1308-1315页

作者： Zi-Xian Zhou Qi Cui ying-mei zhang Jia-Xin Yang Wen-Jing Xiang Ning Tian Yan-Lin Jiang mei-Ling Chen Bin Yang Qing-Hua Li Ru-Jia Liao Laboratory of Neuroscience Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Neurology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Guangxi Clinical Research Center for Neurological Diseases Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Pharmacology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina

Recent studies have indicated that suppressing oxidative stress and ferroptosis can considerably improve the prognosis of intracerebral hemorrhage(ICH).Withaferin A(WFA),a natural compound,exhibits a positive effect on a number of neurological ***,the effects of WFA on oxidative stress and ferroptosis-mediated signaling pathways to ICH remain *** this study,we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and *** established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced *** was injected intracerebroventricularly at 0.1,1 or 5μg/kg once daily for 7 days,starting immediately after ICH *** markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral *** in vitro experiments,cell viability test showed that WFA protected SH-SY5Y neuronal cells against hemin-induced cell ***-linked immunosorbent assays in vitro and in vivo showed that WFA markedly decreased the level of malondialdehyde,an oxidative stress marker,and increased the activities of anti-oxidative stress markers superoxide dismutase and glutathione peroxidase after *** blot assay,quantitative polymerase chain reaction and immunofluorescence results demonstrated that WFA activated the nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling axis,promoted translocation of Nrf2 from the cytoplasm to nucleus,and increased HO-1 *** Nrf2 with siRNA completely reversed HO-1 expression,oxidative stress and protective effects of ***,WFA reduced hemin-induced ***,after treatment with an HO-1 inhibitor,the neuroprotective effects of WFA against hemin-induced ferroptosis were *** test results showed that WFA combined with ferrostatin-1

关键词： behavior brain injuries hemorrhagic stroke ferroptosis heme oxygenase-1 neuroprotection nuclear factor E2-related factor 2 nuclear translocator oxidative stress stroke

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A comparative study of data-driven battery capacity estimation based on partial charging curves

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Journal of Energy Chemistry 2024年第1期88卷 409-420,I0010页

作者： Chuanping Lin Jun Xu Delong Jiang Jiayang Hou ying Liang Xianggong zhang Enhu Li Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shaanxi Key Laboratory of Intelligent Robots School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Electrical Engineering and Automation Luoyang Institute of Science and TechnologyLuoyang 471023HenanChina Wuhan Institute of Marine Electric Propulsion China State Shipbuilding Corporation LimitedWuhan 430064HubeiChina Gresgying Digital Technology Ltd. Xi’an 710086ShaanxiChina

With its generality and practicality, the combination of partial charging curves and machine learning(ML) for battery capacity estimation has attracted widespread attention. However, a clear classification,fair comparison, and performance rationalization of these methods are lacking, due to the scattered existing studies. To address these issues, we develop 20 capacity estimation methods from three perspectives:charging sequence construction, input forms, and ML models. 22,582 charging curves are generated from 44 cells with different battery chemistry and operating conditions to validate the performance. Through comprehensive and unbiased comparison, the long short-term memory(LSTM) based neural network exhibits the best accuracy and robustness. Across all 6503 tested samples, the mean absolute percentage error(MAPE) for capacity estimation using LSTM is 0.61%, with a maximum error of only 3.94%. Even with the addition of 3 m V voltage noise or the extension of sampling intervals to 60 s, the average MAPE remains below 2%. Furthermore, the charging sequences are provided with physical explanations related to battery degradation to enhance confidence in their application. Recommendations for using other competitive methods are also presented. This work provides valuable insights and guidance for estimating battery capacity based on partial charging curves.

关键词： Lithium-ion battery Partial charging curves Capacity estimation Data-driven Sampling frequency

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Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： Lan-mei Wang Wei-Wei zhang ying-Yang Qiu Fang Wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

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Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

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Chinese Journal of Polymer Science 2024年第8期42卷 1185-1197页

作者： Zhi-ying Zhao Hao Jiang Xiao-Dong Li Xu-Dong zhang Xing Su mei-Shuai Zou School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external *** polyurethane microcellular elastomers(PUMEs)can absorb energy through cell collapse and molecular chain *** this study,PUMEs with different densities were investigated by scanning electron microscopy,dynamic mechanical analysis and dynamic compression *** exhibited significant im pact resistance and the maximum peak stress attenuation ratio reached 73.33%.The protective equipment was made by PUME with the optimal density of 600 kg/m^(3),and then the acceleration sensing device installed with the same protective equipment fell from a height of 3,5 and 10 m to evaluate the energy-absorbing property and reusability of *** results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%,with a maximum deviation of 9%between actual test and simulation,and shortened the impact time of first landing by 57.39%.In addition,the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance

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Study on the Effect of Ginaton on Reducing Cerebral Vasospasm and Early Brain Injury after Hemorrhagic Stroke by Inhibiting Inflammatory Response

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 33-39页

作者： Xue-Bo Pang Xiao-Lin zhang mei-Rong Wang ying Yuan Xiao zhang Department of Neurology Xingtai Third HospitalXingtaiChina

Objective:The objective of this study was to investigate the effects and possible mechanisms of action of ginseng on cerebral vasospasm and early brain injury(EBI)following hemorrhagic *** and Methods:Sprague-Dawley(SD)rats(n=48)were randomly divided into sham operation(sham group),subarachnoid hemorrhage(SAH)model(SAH group),normal saline(NS group),and Ginaton(Extract of Ginkgo Biloba Leaves Drops)intervention(gin group)***-1 m RNA and tumor necrosis factor levels were detected using reverse transcription-polymerase chain *** relative expression of m RNA was detected by Western ***:(1)Compared with the sham group,the SAH,NS,and gin groups had different degrees of neurological *** with the SAH and NS groups,the neurological deficits in the gin group were significantly improved(P<0.05).(2)Compared with the sham group,the relative expression levels of MCP-1 m RNA in the SAH,NS,and gin groups were 5.1±0.9,3.4±0.6,and 2.5±0.4,respectively;the relative expression levels of m RNA were 13.3±2.4,11.2±1.8,and 3.8±0.6,respectively.(3)The apoptosis rates of brain tissue in the sham,SAH,NS,and gin groups were 4.8±0.7,54.2±10.3,50.1±7.4,and 28.4±4.5,respectively.(4)Western blot showed that the relative expression levels of toll-like receptor-4(TLR-4)protein in the sham,SAH,NS,and gin groups were 0.29±0.03,0.87±0.15,0.65±0.13,and 0.41±0.17,respectively;the relative expression levels of B protein were 0.21±0.04,0.96±0.14,0.73±0.18,and 0.30±0.05,*** treatment could inhibit TLR-4 and nuclear factor-κB(NF-κB)protein ***:Dona tablets may inhibit activation of the NF-κB signaling pathway,and SAH-induced inflammatory response,so as to reduce cerebral vasospasm and EBI.

关键词： Cerebral hemorrhage early brain injury ginaton neurological deficit nuclear factor-κB

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Classification of knowledge graph completeness measurement techniques

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Journal of Systems Engineering and Electronics 2024年第1期35卷 154-162页

作者： zhang ying XIAO Gang Institute of Systems Engineering Academy of Military SciencesBeijing 100107China

At present,although knowledge graphs have been widely used in various fields such as recommendation systems,question and answer systems,and intelligent search,there are always quality problems such as knowledge omissions and *** assessment and control,as an important means to ensure the quality of knowledge,can make the applications based on knowledge graphs more complete and more accurate by reasonably assessing the knowledge graphs and fixing and improving the quality problems at the same ***,as an indispensable part of the knowledge graph construction process,the results of quality assessment and control determine the usefulness of the knowledge *** them,the assessment and enhancement of completeness,as an important part of the assessment and control phase,determine whether the knowledge graph can fully reflect objective phenomena and reveal potential connections among *** this paper,we review specific techniques of completeness assessment and classify completeness assessment techniques in terms of closed world assumptions,open world assumptions,and partial completeness *** purpose of this paper is to further promote the development of knowledge graph quality control and to lay the foundation for subsequent research on the completeness assessment of knowledge graphs by reviewing and classifying completeness assessment techniques.

关键词： quality assessment completeness assessment closed world assumptions open world assumption partial completeness assumption

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Deep Guided Attention Network for Joint Denoising and Demosaicing in Real Image

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Chinese Journal of Electronics 2024年第1期33卷 303-312页

作者： Tao zhang ying FU Jun zhang School of Computer Science and Technology Beijing Institute of Technology Advanced Reasearch Institute of Multidisciplinary Science Beijing Institute of Technology

Denoising(DN) and demosaicing(DM) are the first crucial stages in the image signal processing pipeline. Recently, researches pay more attention to solve DN and DM in a joint manner, which is an extremely undetermined inverse problem. Existing deep learning methods learn the desired prior on synthetic dataset, which limits the generalization of learned network to the real world data. Moreover, existing methods mainly focus on the raw data property of high green information sampling rate for DM, but occasionally exploit the high intensity and signalto-noise(SNR) of green channel. In this work, a deep guided attention network(DGAN) is presented for real image joint DN and DM(JDD), which considers both high SNR and high sampling rate of green information for DN and DM, respectively. To ease the training and fully exploit the data property of green channel, we first train DN and DM sub-networks sequentially and then learn them jointly, which can alleviate the error accumulation. Besides, in order to support the real image JDD, we collect paired raw clean RGB and noisy mosaic images to conduct a realistic dataset. The experimental results on real JDD dataset show the presented approach performs better than the state-of-the-art methods, in terms of both quantitative metrics and qualitative visualization.

关键词： Training Visualization Inverse problems Green products Noise reduction Pipelines Signal processing

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Characterizations of semihoops based on derivations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 291-310页

作者： WANG mei zhang Xiao-hong School of Electrical and Control Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Weinan Normal UniversityWeinan 714099China

In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of ***,we prove that every Heyting algebra is isomorphic to the algebra of all multiplicative derivations and show that every Boolean algebra is isomorphic to the algebra of all implicative ***,we show that the sets of multiplicative and implicative derivations on bounded regular idempotent semihoops are in oneto-one correspondence.

关键词： (prelinear)semihoop derivation Heyting algebra Galois connection

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Study on carbon emission calculation method and carbon reduction indexes of urban building stock

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Science China(Technological Sciences) 2024年第9期67卷 2706-2726页

作者： YANG Liu zhang Nan LU mei LUO ZhiXing DOU mei State Key Laboratory of Green Building Xi’an University of Architecture and TechnologyXi’an 710055China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China School of Language Literature and LawXi’an University of Architecture and TechnologyXi’an 710055China School of Management Xi’an University of Architecture and TechnologyXi’an 710055China China Southwest Architectural Design and Research Institute Corp.Ltd. Chengdu 610041China

Carbon emissions associated with buildings are a major source of urban emissions. To put forward the methods and strategies to curb carbon emissions from urban building stock, it is not only necessary to establish a carbon emission calculation method for fine statistical analysis, but also to evaluate carbon emissions of urban planning schemes with applicable indexes. Currently,researches mainly focus on carbon emissions of individual buildings. When expanded to urban building stock, the calculation faces the lack of basic data, inadequate spatial analysis and unspecific carbon reduction indexes. Therefore, this study proposes a bottom-up calculation method for urban building stock, conducts spatial analysis based on carbon balance of urban grids, reveals the coupling mechanism between urban carbon reduction indexes and grid carbon emissions, and systematically establishes a carbon-reduction-oriented urban planning method that comprises calculation, analysis and evaluation, which is applied to Xi'an,China. This study provides a theoretical reference for cities to formulate carbon reduction targets and implement planning strategies by evaluating and predicting carbon emissions from urban building stock.

关键词： carbon emissions urban building stock calculation method carbon reduction index

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Non-linear relationship between age and subfoveal choroidal thickness in Chinese patients with proliferative diabetic retinopathy

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World Journal of Diabetes 2024年第9期15卷 1903-1915页

作者： Chun-Yan Lei Jiang-ying Xie Qi-Bo Ran mei-Xia zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Sichuan University Operating Room Department of AnesthesiologyWest China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND No study has investigated the change regularity between age and subfoveal choroidal thickness(SFCT)in proliferative diabetic retinopathy(PDR).AIM To investigate the relationship between the SFCT and age in Chinese patients with *** This was a cross-sectional retrospective *** participants were hospitalized individuals with type 2 diabetes who underwent vitrectomy for *** eyes that met the criteria were included in the *** necessary laboratory tests were performed at the time of *** macular thickness(CMT)and SFCT were two quantitative assessments made using enhanced depth imaging optical coherence *** was measured automatically and SFCT was measured manually with digital calipers provided by the Heidelberg Eye Explorer *** The final analysis included a total of 234 individuals with *** average age was 55.60 years old±10.03 years old,and 57.69%of the population was *** analysis revealed a significant negative connection between age and SFCT in patients with PDR[β=-2.44,95%confidence interval(95%CI):-3.46 to-1.42;P<0.0001].In the fully adjusted model,the correlation between SFCT and age remained steady(β=-1.68,95%CI:-2.97 to-0.39;P=0.0117).Spline smoothing showed that the relationship between SFCT and age in patients with PDR was non-linear,with an inflection point at 54 years of *** Our findings suggest that age is a key determinant of choroidal *** non-linear link between SFCT and age in PDR patients should be taken into account.

关键词： Age Subfoveal choroidal thickness Proliferative diabetic retinopathy Optical coherence tomography Central macular thickness

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