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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

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Young adults’ perceptions of breastfeeding in public: a focus group study

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Frontiers of nursing 2020年第3期

作者： Ka-Huen yip Yuk-Chiu yip Catherine Man-yin Lee mei-yi siu Shu-ying Ngai mei-Kuen Chow

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银杏叶提取物制剂的质量提升和应用安全

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中国新药杂志 2024年第4期33卷 339-344页

作者：梅隆李毅张威首都医科大学附属北京积水潭医院北京100035

银杏叶提取物制剂在国内医药市场销售的产品众多,管理类别既有中药也有西药,且被列入国家卫生健康委员会重点监控品种。厘清各种制剂的药学特性、质量标准和风险管控点,有助于合理遴选药品及安全用药,并达到一定的治疗目的。本文拟通过... 详细信息

银杏叶提取物制剂在国内医药市场销售的产品众多,管理类别既有中药也有西药,且被列入国家卫生健康委员会重点监控品种。厘清各种制剂的药学特性、质量标准和风险管控点,有助于合理遴选药品及安全用药,并达到一定的治疗目的。本文拟通过探究不同国家对银杏叶提取物制剂的质量管理及《中华人民共和国药典》相关标准的提升,帮助药师了解银杏叶提取物制剂的质量管理,明确上市后药品质量监控对临床获益大于风险的意义。

关键词：银杏叶提取物质量标准药典合理用药

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利用可信反事实的不平衡数据过采样方法

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计算机工程与应用 2024年第5期60卷 165-171页

作者：高峰宋媚祝义江苏师范大学计算机科学与技术学院江苏徐州221000

针对传统过采样方法不能充分利用数据集信息的缺陷,提出一种基于反事实(counterfactual,CF)的不平衡数据过采样方法,并进一步对生成的少数类合成样本进行了“可信”清除。其核心思想是依据数据集原有实例特征值合成新样本,相比传统过采... 详细信息

针对传统过采样方法不能充分利用数据集信息的缺陷,提出一种基于反事实(counterfactual,CF)的不平衡数据过采样方法,并进一步对生成的少数类合成样本进行了“可信”清除。其核心思想是依据数据集原有实例特征值合成新样本,相比传统过采样的插值法,更能充分挖掘数据中的边界决策信息,从而为分类器提供更多的有用信息,提高分类性能。在9个来自KEEL与UCI的不平衡数据集、5种不同分类器(SVM、DT、Logistic、RF、AdaBoost)上与4种传统过采样方法(SMOTE、B1-SMOTE、B2-SMOTE、ADASYN)进行了大量对比实验,结果表明,所提方法具有更高的AUC值、F1值和G-mean值,可以更为有效地解决类不平衡问题。

关键词：不平衡数据集分类器过采样反事实(CF)

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符号图下含扰动的多智能体系统预定时间二分一致性

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控制与决策 2024年第5期39卷 1517-1526页

作者：马小陆谭毅波梅宏安徽工业大学电气与信息工程学院安徽马鞍山243002 南京航空航天大学航天学院南京210000

研究符号图下具有扰动的多智能体系统二分一致性控制问题.考虑了线性系统、非线性不确定系统以及切换拓扑的情况,分别提出相应的预定时间控制器,各控制器可使系统在预定时间内实现二分一致性.通过Lyapunov稳定性理论、代数图论和矩阵分... 详细信息

研究符号图下具有扰动的多智能体系统二分一致性控制问题.考虑了线性系统、非线性不确定系统以及切换拓扑的情况,分别提出相应的预定时间控制器,各控制器可使系统在预定时间内实现二分一致性.通过Lyapunov稳定性理论、代数图论和矩阵分析等验证算法的准确性;仿真对比实验验证了所提算法的可行性和有效性;相较于有限时间控制算法,所提算法的收敛时间不依赖于初始状态,可以通过选择单一时间参数设定系统收敛时间上界;相较于固定时间控制算法,所提算法预设收敛时间与控制算法参数无关,设定简单,具有更低的保守性.

关键词：符号图多智能体系统二分一致性线性系统非线性不确定系统切换拓扑预定时间

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不可达系统的鲁棒贝叶斯估计方法

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控制理论与应用 2024年第2期41卷 221-228页

作者：易圣伦任雪梅北京理工大学自动化学院北京100081

本文针对模型扰动下的不可达系统,提出了一种新的针对退化分布下的极大极小博弈问题的求解和证明方法.首先,文章将有相对熵约束的极大极小博弈问题转换成了一个无约束的拉格朗日函数,并找到其在均值和奇异的方差矩阵方向上都为严格凹函... 详细信息

本文针对模型扰动下的不可达系统,提出了一种新的针对退化分布下的极大极小博弈问题的求解和证明方法.首先,文章将有相对熵约束的极大极小博弈问题转换成了一个无约束的拉格朗日函数,并找到其在均值和奇异的方差矩阵方向上都为严格凹函数的条件;其次,本文通过求解其均值和方差的极大值,得到所对应的鲁棒贝叶斯估计器和奇异的扰动状态误差协方差矩阵;最后,文章证明存在一个唯一的拉格朗日乘子满足其约束条件.微机电系统加速度计漂移估计仿真结果表明对所提算法的有效性.

关键词：鲁棒估计贝叶斯理论不可达系统极大极小博弈

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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei Meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui yi Xin-Yu Li yi Wang Yun-Shu Tang Min Xue mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

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白字戏乐语中的锣鼓乐形态与做乐

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音乐艺术（上海音乐学院学报） 2024年第2期 106-115页

作者：张毅萧梅中国音乐学院北京100875 上海音乐学院音乐系上海200031

在海陆丰地区的白字戏打击乐乐人口中,有一套包括行话、术语、口诀、谚语在内的民间乐语。围绕这些乐语不断展开追问便会发现,乐人早已用这些乐语生动形象地表达出地方音乐的深层文化特征。中国许多地区的戏曲锣鼓及民间乐种中都存在类... 详细信息

在海陆丰地区的白字戏打击乐乐人口中,有一套包括行话、术语、口诀、谚语在内的民间乐语。围绕这些乐语不断展开追问便会发现,乐人早已用这些乐语生动形象地表达出地方音乐的深层文化特征。中国许多地区的戏曲锣鼓及民间乐种中都存在类似乐语,这些乐语可集合成庞大的“近义民间乐语群”,这表明各地民间锣鼓乐之间具有一些较为共通的形态特征、创作规律和乐人思维方式。学习、理解、分析和研究这些乐语,既是认知传统音乐的重要途径,又是研究者与被研究者之间展开对话交流的重要媒介,也是丰富中国音乐话语体系的互惠方式。

关键词：民间乐语锣鼓乐白字戏音乐形态做乐

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Low cost and low density chloride solid electrolyte for all solid state cathode with high active material ratio

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Nano Research 2024年第10期17卷 8826-8833页

作者： Hao-Yuan Tan mei-Yu Zhou Zhongyuan Huang Jin-Da Luo Jing-Tian Yang Jian-Ping Wang Ye-Chao Wu Xiao-Bin Cheng Zi-Wei Wang Xu-Dong Hao Linjun Wang Ke Gong yi-Chen yin yinguo Xiao Hong-Bin Yao Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026China School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

Chloride solid electrolytes(SEs)have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode ***,the conventionally selected central metal elements(e.g.,In,Y and Ta)are usually rare and heavy,inevitably causing the high cost and high density of the obtained chloride ***,by choosing abundant and light Mg and Al as central metal elements,we develop a cheap and low density Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)SE for high active material ratio in all solid state *** replacement of Mg^(2+)by Al^(3+)in the framework yields vacancies and lowers the non-lithium metal ions occupancy at Mg/Li co-occupied 16d site,effectively relieving the blocking effects by Mg^(2+)in the pristine spinel Li_(2-2x)Mg_(1+x)Cl_(4).Thus,a significantly improved room-temperature conductivity of 3.08×10^(-4)S·cm^(-1)is achieved,two orders of magnitude higher than that of Li_(1.2)Mg_(1.4)Cl_(4).More attractively,its low density of only 1.98 g·cm-3 enables low SE mass ratio in cathodes(only 16 wt.%)with still effective electrolyte/cathode contact and lithium-ion conduction *** charged to potential of 4.30 V,the asfabricated Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)-based solid lithium battery with uncoated NCM523 cathode can be cycled for over 100 cycles with a capacity retention of 86.68%at room temperature.

关键词： chloride solid electrolytes low cost low density Li+conductivities

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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO Meng-ying FANG yi WU mei-zhu CHENG ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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